Clinical and Histopathologic Findings of Cutaneous Leiomyosarcoma: Correlation With Prognosis in 12 Patients

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Rodríguez-Lomba, I. Molina-López, V. Parra-Blanco, R. Suárez-Fernández, A. Pulido-Pérez" "autores" => array:5 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "Rodríguez-Lomba" "email" => array:1 [ 0 => "enriquerlomba@outlook.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "Molina-López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "V." "apellidos" => "Parra-Blanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "R." "apellidos" => "Suárez-Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Pulido-Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Leiomiosarcoma cutáneo: características clínicas, histopatológicas y correlación pronóstica en 12 pacientes" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 790 "Ancho" => 1500 "Tamanyo" => 246022 ] ] "descripcion" => array:1 [ "en" => "Reddish, infiltrated plaque measuring 6 × 3.5cm on the front of the left thigh. Fairly solid, ulcerated nodular formations overlie the lesion. Small hemorrhagic points can be seen." ] ] ] "textoCompleto" => "IntroductionSkin leiomyosarcomas are rare malignant neoplasms that derive from smooth muscle tissue. They account for around 2% to 3% of all soft-tissue sarcomas in skin and 0.04% of all neoplasms. They are currently thought to arise de novo from smooth muscle, even though there have been reports of tumors that derived from leiomyomas.<a class="elsevierStyleCrossRef" href="#bib0125">1</a>Leiomyosarcomas have traditionally been grouped in 3 large subtypes according to clinical and pathologic features that have prognostic implications: 1) cutaneous, or dermal forms; 2) subcutaneous, or hypodermal forms; and 3) secondary metastatic forms. The most important clinical and prognostic differences between the classes are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.<a class="elsevierStyleCrossRefs" href="#bib0130">2,3</a><elsevierMultimedia ident="tbl0005"></elsevierMultimedia>The origin of cutaneous leiomyosarcomas seems to be the pilorector muscle in the dermis. However, there have been reports of cases in which the tumor developed in the dartos, or its equivalent muscle in the vulva, or in the areola. This form is not usually aggressive but tends to recur locally after surgical excision with narrow margins. The risk of distant metastasis is considered low (5%–10%), and these tumors have therefore been called “atypical intradermal smooth muscle neoplasms.”<a class="elsevierStyleCrossRef" href="#bib0140">4</a> Subcutaneous leiomyosarcomas arise in the smooth muscle fibers of the tunica media of arteries and veins. Unlike more superficial, or dermal forms, these leiomyosarcomas have high rates of local–regional recurrence and metastasis (30%–40%), presenting a poor prognosis. Finally, metastatic leiomyosarcoma of the skin is associated with a particularly poor prognosis. Metastasis usually derives from a primary leiomyosarcoma in the retroperitoneum, the uterus, or the subfascial soft tissue of the extremities.<a class="elsevierStyleCrossRefs" href="#bib0145">5–7</a>Even though the World Health Organization's 2005 taxonomy distinguishes true cutaneous from subcutaneous forms<a class="elsevierStyleCrossRef" href="#bib0160">8</a> (the latter of which are included among soft-tissue tumors<a class="elsevierStyleCrossRef" href="#bib0165">9</a>), this distinction can become complicated in clinical practice because of overlap of histopathologic features with prognostic implications.<a class="elsevierStyleCrossRef" href="#bib0170">10</a> In addition, metastases of noncutaneous leiomyosarcomas to the skin simulate the features of primary subcutaneous leiomyosarcomas, a situation that makes metastasis a diagnosis of exclusion.<a class="elsevierStyleCrossRef" href="#bib0150">6</a>Because prognosis is difficult in some cases of leiomyosarcoma in the skin, we analyzed features of cases diagnosed in our hospital in the past 15 years. We included all leiomyosarcomas regardless of origin of the neoplasm, that is, both primary tumors and metastatic disease.Material and MethodsThis retrospective, descriptive, observational study included data from adults who received a histopathologic diagnosis of leiomyosarcoma between January 1, 2000, and December 31, 2015. Cases were compiled from the skin and soft-tissue sarcoma registry of our hospital's pathology department. We included skin leiomyosarcomas whether they were primary or metastatic. We excluded subfascial and visceral tumors and cases for which the clinical history was unavailable or incomplete.We collected the following data from the records of selected patients: age at presentation, sex, year diagnosed, clinical presentation (lesion type, number, size, and location), latency time (from diagnosis of the primary tumor until detection of metastatic disease in skin), length of follow-up, clinical course, and response to treatments (disease-free, recurrence, or death). Histologic features recorded were histologic form (cutaneous or subcutaneous primary tumor, or metastatic tumor), Ki-67 expression, mitotic index (number of mitoses per 10 high-power fields [HPF]), and positive reaction to immunohistochemical stains (including vimentin, desmin, HHF-35 [muscle-specific actin], smooth muscle actin [SMA], S100, and CD34).ResultsClinical and histopathologic data and clinical course recorded for the included cases are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>A total of 17 leiomyosarcomas in 12 patients (5 men, 41%; 7 women, 59%) were found in the registry. All patients were over 50 years of age at the time of diagnosis, and 45% were over the age of 70 years. The mean follow-up period after diagnosis of the cutaneous neoplasm (whether primary or metastatic) was 39.6 months.There were 4 cutaneous leiomyosarcomas (23%) in 4 patients, 2 subcutaneous leiomyosarcomas (11.5%) in 2 patients, and 11 metastatic leiomyosarcomas (65%) in the remaining 6 patients. The metastatic tumors derived from primary tumors in the subfascial plane; in smooth muscle of the uterus or bladder; or in the intra-abdominal or retroperitoneal spaces. Metastatic tumor cells were found at an average of 1.8 sites per patient during follow-up.The most frequent location at the time of diagnosis was the scalp in both the series as a whole (7/17, 41%) and in the subgroup of metastatic leiomyosarcomas. The lower limbs (3/17, 17%) and the trunk (3/17, 17%) were the next most common sites. The mean sizes of tumors on diagnosis in all 3 categories were as follows: cutaneous leiomyosarcomas, 2.6cm; subcutaneous leiomyosarcomas, 3.1cm; and metastatic leiomyosarcomas, 1.8cm.Histology found a mean of 11 mitotic figures per 10 HPF and Ki-67 protein expression of 30% in cutaneous tumors, 7.5 mitotic figures per 10 HPF and Ki-67 expression of 60% in subcutaneous forms, and 10.2 mitotic figures per 10 HPF and Ki-67 expression of 48% in metastatic forms. Immunohistochemical staining was positive for vimentin (>25% of cases), desmin (>50%), HHF-35 (>75%), and SMA (>75%). S100 staining was focally positive in 1 cutaneous leiomyosarcoma; CD34 staining was also positive in 1 cutaneous tumor.All the leiomyosarcomas in this series were excised surgically on diagnosis. Two of the cutaneous tumors did not recur after excision with margins greater than 1cm. However, the remaining cutaneous tumors did recur within 2 to 3 years after excision. The recurrences were excised, followed by radiation, and no further recurrences were registered during follow-up. One patient with a subcutaneous tumor remained free of disease. The second patient with this form developed multiple node, bone and muscle metastases and at the time of writing was receiving third-line chemotherapy (trabectedin).The first focus of metastatic leiomyosarcoma cells in the third subgroup occurred 2 to 18 months after diagnosis of the primary tumor. In 2 cases metastasis to skin preceded metastasis to other sites, whereas in 3 cases it occurred afterwards. The generalized metastasis that developed during the course of disease in the 6 patients with metastatic skin leiomyosarcoma usually involved the lung. The next most commonly involved organ was the liver (3 patients). Five of these 6 patients died within an average of 25 months after diagnosis of their skin metastasis, in spite of chemo- and radiotherapy.DiscussionCutaneous soft-tissue sarcomas—and leiomyosarcomas among them—are rare tumors. Because of the low incidence of these tumors, it is difficult to develop protocols for their diagnosis and management.Cutaneous leiomyosarcomas usually present as nodules or masses that are firm to the touch (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) in adults over the age of 50 years. Patients often consult the physician for pain, itching, or paresthesia in the area around the lesion (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Histology recognizes 2 architectural patterns. One is a nodular pattern characterized by cellularity, cell atypia, and mitotic figures. The other is a diffuse pattern with lower cellularity and a lower mitotic index. Because cell atypia is not always evident, a histologic diagnosis should be supported by the overall architecture of the lesion (infiltrative pattern and high cellularity). It is particularly important to obtain adequate samples for histopathology, and incisional biopsies that extend below the dermis are preferred. Immunohistochemistry is an essential tool for distinguishing these neoplasms from tumors with fusiform cells and for establishing lineage<a class="elsevierStyleCrossRef" href="#bib0175">11</a> (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).<elsevierMultimedia ident="fig0010"></elsevierMultimedia>To date most of the literature on cutaneous leiomyosarcoma in the skin consists of descriptions of single cases or small series. Prognostic factors are therefore hard to discern, as this neoplasm varies in its clinical behavior.Winchester et al<a class="elsevierStyleCrossRef" href="#bib0130">2</a> analyzed prognostic indicators in one of the largest series of cutaneous and subcutaneous leiomyosarcomas published. They described 71 cases occurring over a period of 50 years. The most common location of both types of skin leiomyosarcoma was the extensor surfaces of the lower limbs. The next most common was the trunk. They found significant differences in the 5-year recurrence rate between cutaneous (18%) and subcutaneous (28%) forms. The median follow-up after diagnosis was 4 years. Distant metastasis was observed for 12% percent of the cutaneous and 51% of the subcutaneous tumors. The median latency from initial diagnosis to metastasis was 3 years. They also reported specific mortality for cutaneous and subcutaneous tumors (6% and 40%, respectively). Metastasis in this retrospective cohort occurred in 10.4% of the cutaneous leiomyosarcomas, obliging the authors to question the appropriateness of the term “atypical intradermal smooth muscle neoplasms” proposed by Kraft et al.<a class="elsevierStyleCrossRef" href="#bib0140">4</a> Another group, Jensen et al,<a class="elsevierStyleCrossRef" href="#bib0180">12</a> also analyzed prognostic factors (among them tumor size, depth, and histologic grade) in a series of 41 cutaneous and subcutaneous leiomyosarcomas. Tumor size greater than 5cm at diagnosis was the only independent variable to survive as a prognostic factor on multivariate analysis.The features we report in our series are generally consistent with those earlier reports. However, the most frequent location in our patients was the head, attributable to our inclusion of metastatic leiomyosarcomas. In addition, we saw differences in the mitotic index, and the 2 recurring cutaneous leiomyosarcomas in our series had disease-free intervals of 2 and 3 years. One of our 2 patients with subcutaneous tumors remained free of disease after a year of follow-up in spite of an initial tumor size of 5cm. The higher mean mitotic index in cutaneous versus subcutaneous and metastatic tumors in our series was an interesting finding, although it is true that we have only been able to analyze a small number of cases.Leiomyosarcoma that metastasizes to the skin has been reported in the literature<a class="elsevierStyleCrossRefs" href="#bib0185">13-16</a> and an analysis of 21 such cases was recently published by Winchester et al.<a class="elsevierStyleCrossRef" href="#bib0145">5</a> Consistent with our observations, they found that the head was the most frequent location, probably because the high degree of vascularization in the scalp facilitates spread via the bloodstream. They also reported a mean age at diagnosis of the first metastatic tumor of 68 years, a median disease-free interval between tumor diagnosis and metastasis of 39 months, and a mean survival after the diagnosis of metastatic disease of 16 months. Our observations were similar. The mean age of our patients was 69.1 years, the median disease-free interval was 36 months after excision, and the mean survival after metastasis was 25 months—suggesting that metastasis to the skin from noncutaneous leiomyosarcomas indicates a poor prognosis.Surgical treatment is the gold standard for localized tumors.<a class="elsevierStyleCrossRefs" href="#bib0205">17–19</a> However, important structural limitations make it difficult to determine the optimal size of safety margins. Aggressive surgery, with margins ranging from 3 to 5cm are traditionally recommended, but time has shown that a more conservative approach taking margins of 1cm can give similar results without increasing the rate of local recurrence. Mohs micrographic surgery seems to have gained special importance in this setting. During follow-up in a series of 41 leiomyosarcomas treated with Mohs surgery, only 2 cases of recurrence and no cases of metastasis were observed.<a class="elsevierStyleCrossRefs" href="#bib0210">18–21</a> Nevertheless, prospective studies in larger series and longer periods of follow-up are needed to confirm those findings. The role of radiotherapy in leiomyosarcoma has not been clearly defined to date, but this option can prove important when we treat deep tumors with a poor prognosis or when the margins surrounding excised tumors are not disease-free.<a class="elsevierStyleCrossRefs" href="#bib0205">17,22</a> Neoadjuvant, adjuvant, or palliative therapy is currently indicated for nonresectable tumors or disseminated disease, depending on tumor stage.<a class="elsevierStyleCrossRefs" href="#bib0205">17,23,24</a> All lesions in our series could be removed with surgical margins between 3 and 5cm except in cases of confirmed metastasis, in which we removed tumors with 1-cm margins and prescribed chemotherapy.Prognosis depends mainly on subtype: true cutaneous forms, cutaneous forms that penetrate subcutaneous tissue, subcutaneous forms, and metastatic forms. For this reason cutaneous leiomyosarcomas have been excluded from the World Health Organization's classification system for soft-tissue sarcomas.<a class="elsevierStyleCrossRef" href="#bib0165">9</a> However, these distinctions are not present in the main diagnostic algorithms used in clinical practice (the 2016 version of the National Comprehensive Cancer Network Guidelines<a class="elsevierStyleCrossRef" href="#bib0205">17</a>), which refer to leiomyosarcomas without reference to subtypes, grouping them together with other high-grade, aggressive sarcomas. Therefore, given the lack of specific recommendations, the clinician must make individualized decisions when ordering images to evaluate tumor extension. Furthermore, even though metastatic skin involvement arising from leiomyosarcomas is even less frequent than primary leiomyosarcoma, the clinical and histopathologic differential diagnosis between these forms can be complicated (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The possibility of an unidentified primary visceral tumor should therefore be investigated in all cases of leiomyosarcoma confined to subcutaneous tissue. <a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a> shows a possible diagnostic algorithm for individualized diagnosis based on clinical and histopathologic features. The algorithm can provide guidance on choosing complementary tests and images to order early in the diagnostic process.<elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia>In conclusion, leiomyosarcoma of the skin is a rare malignancy with clearly defined prognostic differences according to histologic subtype and whether the tumor is primary or metastatic. Even though this series analyzes few cases and data was collected retrospectively, we have been able to construct an algorithm to guide diagnosis and management that we believe will be useful to dermatologists who must treat this rare but potentially aggressive tumor.Conflicts of InterestThe authors declare that they have no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres994294" "titulo" => "Abstract" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Material and methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Limitations" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec957552" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres994295" "titulo" => "Resumen" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0035" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0040" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0045" "titulo" => "Material y métodos" ] 3 => array:2 [ "identificador" => "abst0050" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0055" "titulo" => "Limitaciones" ] 5 => array:2 [ "identificador" => "abst0060" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec957553" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and Methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of Interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-05-03" "fechaAceptado" => "2017-08-31" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec957552" "palabras" => array:5 [ 0 => "Leiomyosarcoma" 1 => "Soft tissue" 2 => "Sarcoma" 3 => "Cutaneous metastasis" 4 => "Atypical intradermal smooth muscle neoplasm" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec957553" "palabras" => array:5 [ 0 => "Leiomiosarcoma" 1 => "Partes blandas" 2 => "Sarcoma" 3 => "Metástasis cutánea" 4 => "Neoplasia atípica intradérmica de músculo liso" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "IntroductionCutaneous leiomyosarcoma is a malignant neoplasm derived from smooth muscle cells. Its low incidence hampers the development of specific protocols for diagnosis and treatment. ObjectivesTo describe the clinical and histopathologic characteristics of a series of primary and secondary cutaneous leiomyosarcomas and to determine how these characteristics correlate with prognosis. Material and methodsWe performed an observational, descriptive, retrospective study based on 17 cutaneous leiomyosarcomas in 12 patients diagnosed between January 1, 2000 and December 31, 2015. We recorded demographic data, clinical and histopathologic characteristics, outcome, and response to treatment. ResultsWe included 5 men and 7 women, all aged more than 50 years at diagnosis. There were 4 cutaneous leiomyosarcomas (23%) in 4 patients, 2 subcutaneous leiomyosarcomas (11.5%) in 2 patients, and 11 skin metastases of leiomyosarcoma (65%) in 6 patients. The most frequently affected sites were the scalp (41%), lower limbs (17%), and trunk (17%). During follow-up, 50% of the cutaneous leiomyosarcomas recurred, 50% of the subcutaneous leiomyosarcomas presented distant metastases, and 83% of the patients with skin metastases of leiomyosarcoma died of their disease. LimitationsOurs was a retrospective review of a small case series at a single center. ConclusionsCutaneous leiomyosarcoma is an uncommon malignant neoplasm. Our approach to diagnosis and therapy must take into account the marked heterogeneity in the prognosis of the various subtypes." "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Material and methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Limitations" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "IntroducciónEl leiomiosarcoma de piel es una neoplasia maligna de estirpe muscular cuya baja incidencia dificulta el desarrollo de protocolos específicos de diagnóstico y manejo terapéutico. ObjetivosDescribir las características clínicas e histopatológicas de una serie de leiomiosarcomas cutáneos primarios y secundarios, junto con su correlación pronóstica. Material y métodosSe realizó un estudio retrospectivo, descriptivo y observacional. Se seleccionaron 17 casos de leiomiosarcoma cutáneo en 12 pacientes, diagnosticados entre el 1 de enero de 2000 y el 31 de diciembre de 2015. Se recogieron sus datos demográficos, características clínicas e histopatológicas, evolución y respuesta al tratamiento. ResultadosSe reclutaron 5 varones y 7 mujeres, todos ellos mayores de 50 años al diagnóstico. Se recogieron 4 leiomiosarcomas dérmicos (4/17, 23%) en 4 pacientes, 2 leiomiosarcomas hipodérmicos (2/17, 11,5%) en 2 pacientes, y 11 metástasis cutáneas de leiomiosarcoma (11/17, 65%) en 6 pacientes. Las localizaciones más frecuentes fueron cuero cabelludo (7/17, 41%), miembros inferiores (3/17, 17%) y tronco (3/17, 17%). Durante el seguimiento, un 50% de leiomiosarcomas dérmicos recidivaron, un 50% de leiomiosarcomas hipodérmicos presentaron metástasis a distancia y 5/6 pacientes con metástasis cutáneas de leiomiosarcoma (83%) fallecieron a causa de su enfermedad. LimitacionesEste estudio es una revisión retrospectiva de una serie de casos de tamaño limitado en un centro único. ConclusionesEl leiomiosarcoma cutáneo es una neoplasia maligna poco frecuente. A la hora de adoptar una actitud diagnóstico-terapéutica en estos pacientes debemos tener en cuenta la marcada heterogeneidad pronóstica entre sus diferentes subtipos." "secciones" => array:6 [ 0 => array:2 [ "identificador" => "abst0035" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0040" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0045" "titulo" => "Material y métodos" ] 3 => array:2 [ "identificador" => "abst0050" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0055" "titulo" => "Limitaciones" ] 5 => array:2 [ "identificador" => "abst0060" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Rodríguez-Lomba E, Molina-López I, Parra-Blanco V, Suárez-Fernández R, Pulido-Pérez A. Leiomiosarcoma cutáneo: características clínicas, histopatológicas y correlación pronóstica en 12 pacientes. Actas Dermosifiliogr. 2018;109:140–147." ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 790 "Ancho" => 1500 "Tamanyo" => 246022 ] ] "descripcion" => array:1 [ "en" => "Reddish, infiltrated plaque measuring 6 × 3.5cm on the front of the left thigh. Fairly solid, ulcerated nodular formations overlie the lesion. Small hemorrhagic points can be seen." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 953 "Ancho" => 1500 "Tamanyo" => 429054 ] ] "descripcion" => array:1 [ "en" => "Diffuse, poorly defined fascicles interspersed with smooth muscle fibers composed of fusiform cells with cigar-shaped nuclei (elongated with rounded tips), marked pleomorphism, and an eosinophilic cytoplasm. Hematoxylin-eosin, magnification: A, ×10; B, ×20; C, ×40." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 844 "Ancho" => 1500 "Tamanyo" => 401687 ] ] "descripcion" => array:1 [ "en" => "A, Primary subcutaneous leiomyosarcoma. B, Skin metastasis from a noncutaneous leiomyosarcoma." ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 3799 "Ancho" => 2708 "Tamanyo" => 486224 ] ] "descripcion" => array:1 [ "en" => "Algorithm to guide the diagnosis and management of leiomyosarcomas of the skin. CT refers to computed tomography; PET-CT, positron emission CT." ] ] 4 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Sources: Winchester et al,<a class="elsevierStyleCrossRef" href="#bib0130">2</a> Aneiros-Fernández et al,<a class="elsevierStyleCrossRef" href="#bib0135">3</a> Kraft et al,<a class="elsevierStyleCrossRef" href="#bib0140">4</a> and Winchester et al.<a class="elsevierStyleCrossRef" href="#bib0145">5</a>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cutaneous Leiomyosarcoma \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Subcutaneous Leiomyosarcoma \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Metastasis of Noncutaneous Leiomyosarcoma \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Incidence, by sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Men 3: women 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Men = women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="4" align="left" valign="top">Age at presentation Origin</td><td class="td" title="table-entry " align="left" valign="top">50–70 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">50–80 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">>60 y \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Piloerector muscle \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">Vascular tunica media</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">Primary tumor in extremities, retroperitoneal cavity, uterus, etc.</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dartos \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Areola \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Size \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">About 2–3 cm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Most often >3 cm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Most often >3 cm \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Most common location \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lower limbs in 50%–85% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lower limbs, in 50%–85% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Scalp (>75%) and trunk \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Recurrence \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">30%–40% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">50%–70% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Metastasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5%–10% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">30%–40% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Prognosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Good \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Poor \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Poor \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1685874.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Characteristics of Cutaneous, Subcutaneous, and Metastatic Forms of Leiomyosarcoma." ] ] 5 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Abbreviation: HPF, high-power field; NA, not applicable." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cutaneous Leiomyosarcoma (n=11) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Subcutaneous Leiomyosarcoma (n=4) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Metastatic Leiomyosarcoma (n=11) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age, mean (range), y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">62 (45–83) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">70.5 (59–82) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">69.1 (51–92) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Men:women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2:2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1:1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2:4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Size, mean (range), cm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2.6 (0.4–4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.1 (0.7-6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.8 (1–2.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Location, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 (23.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 (11.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">11 (65) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Head and neck, n \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Trunk, n \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Extremities, n \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mitotic figures/10 HPF, mean \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ki-67 expression, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">48 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3-y recurrence, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2/4 (50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0/2 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3-y metastasis, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0/4 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1/2 (50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tumor-specific mortality, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0/4 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0/2 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5/6 (83) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Follow-up time, mean (range), mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">70.5 (6–120) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">21 (12–30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">25.3 (5–48) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1685875.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Clinical and Histopathologic Features in 17 Cutaneous, Subcutaneous and Metastatic Leiomyosarcomas." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib0125" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous leiomyosarcoma with coexistent superficial angioleiomyoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I.R. White" 1 => "D.M. Macdonald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol." "fecha" => "1981" "volumen" => "6" "paginaInicial" => "333" "paginaFinal" => "337" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7296963" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0130" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leiomyosarcoma of the skin: clinical, histopathologic, and prognostic factors that influence outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.S. Winchester" 1 => "T.L. Hocker" 2 => "J.D. Brewer" 3 => "C.L. Baum" 4 => "P.C. Hochwalt" 5 => "C.J. Arpey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2014.07.020" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2014" "volumen" => "71" "paginaInicial" => "919" "paginaFinal" => "925" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25174541" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0135" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous and subcutaneous leiomyosarcomas: review of their evolution and prognostic factors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Aneiros-Fernandez" 1 => "J. Antonio Retamero" 2 => "H. Husein-Elahmed" 3 => "F. Ovalle" 4 => "J. Aneiros-Cachaza" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1684/ejd.2015.2681" "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol." "fecha" => "2016" "volumen" => "26" "paginaInicial" => "9" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26678649" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0140" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous leiomyosarcoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Kraft" 1 => "C.D. Fletcher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Surg Pathol." "fecha" => "2011" "volumen" => "25" "paginaInicial" => "599" "paginaFinal" => "607" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0145" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin metastases of leiomyosarcoma (LMS): a retrospective review of 21 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.S. Winchester" 1 => "T.L. Hocker" 2 => "R.K. Roenigk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2015.01.033" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2015" "volumen" => "72" "paginaInicial" => "910" "paginaFinal" => "912" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25890461" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0150" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastasis of leiomyosarcoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Vandergriff" 1 => "R.A. Krathen" 2 => "L. Orengo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4725.2007.33127.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg." "fecha" => "2007" "volumen" => "33" "paginaInicial" => "634" "paginaFinal" => "637" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17451591" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0155" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoma metastases to the skin: a clinicopathologic study of 65 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.L. Wang" 1 => "R.A. Bones-Valentin" 2 => "V.G. Prieto" 3 => "R.E. Pollock" 4 => "D.C. Lev" 5 => "A.J. Lazar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.26590" "Revista" => array:6 [ "tituloSerie" => "Cancer." "fecha" => "2012" "volumen" => "118" "paginaInicial" => "2900" "paginaFinal" => "2904" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21989966" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0160" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathology and genetics of tumours of the skin." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. LeBoit" 1 => "G. Burg" 2 => "D. Weedon" 3 => "A. Sarasin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2005" "editorial" => "IARC Press" "editorialLocalizacion" => "Lyon" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0165" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "WHO Classification of Tumours of Soft Tissue and Bone." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.D.M. Fletcher" 1 => "J.A. Bridge" 2 => "P.C.W. Hogendoorn" 3 => "F. Mertens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2013" "editorial" => "IARC Press" "editorialLocalizacion" => "Lyon" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0170" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Massi" 1 => "A. Franchi" 2 => "L. Alos" 3 => "M. Cook" 4 => "S. Di Palma" 5 => "A.B. Enguita" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2559.2009.03471.x" "Revista" => array:6 [ "tituloSerie" => "Histopathology." "fecha" => "2010" "volumen" => "56" "paginaInicial" => "251" "paginaFinal" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20102404" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0175" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cluster analysis of immunohistochemical markers in leiomyosarcoma delineates specific anatomic and gender subgroups" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.C. Carvalho" 1 => "D.G. Thomas" 2 => "D.R. Lucas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer." "fecha" => "2009" "volumen" => "115" "paginaInicial" => "1186" "paginaFinal" => "1195" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0180" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intradermal and subcutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 41 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.L. Jensen" 1 => "O.M. Jensen" 2 => "W. Michalski" 3 => "O.S. Nielsen" 4 => "J. Keller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Cutan Pathol." "fecha" => "1996" "volumen" => "23" "paginaInicial" => "454" "paginaFinal" => "463" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0185" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástasis cutáneas por leiomiosarcoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.M. Diaz" 1 => "T. Lázaro" 2 => "A.B. Piteiro" 3 => "M. Hervella" 4 => "M. Bergón" 5 => "F. Contreras" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr." "fecha" => "2003" "volumen" => "94" "paginaInicial" => "414" "paginaFinal" => "416" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0190" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metástasis cutáneas de leiomiosarcoma de útero" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Garcia-Arpa" 1 => "J. Salamanca" 2 => "P.L. Ortiz" 3 => "J.L. Rodríguez-Peralto" 4 => "A. Martín-Gallardo" 5 => "L. Iglesias" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr." "fecha" => "2003" "volumen" => "94" "paginaInicial" => "666" "paginaFinal" => "668" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0195" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous scalp metastasis as the first indication of a clinically silent retroperitoneal leiomyosarcoma and of its further relapse as metastatic widespread disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Tomasini" 1 => "A. Niccoli" 2 => "F. Crivelli" 3 => "I. Scandroglio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1684/ejd.2014.2290" "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol." "fecha" => "2014" "volumen" => "24" "paginaInicial" => "264" "paginaFinal" => "265" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24682588" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0200" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leiomiosarcoma dérmico metastásico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Alcántara-Luna" 1 => "L. Ferrándiz-Pulido" 2 => "J.J. Ríos-Martín" 3 => "D. Moreno-Ramírez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Piel." "fecha" => "2013" "volumen" => "28" "paginaInicial" => "205" "paginaFinal" => "207" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0205" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Soft Tissue Sarcoma. Version 2.2016 [cited 2017 Jun]. Available from: https://www.nccn.org/professionals/physician_gls/f_guidelines.asp" ] ] ] 17 => array:3 [ "identificador" => "bib0210" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leiomyosarcoma of the skin. Treatment of 34 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.C. Bernstein" 1 => "R.K. Roenigk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg." "fecha" => "1996" "volumen" => "22" "paginaInicial" => "631" "paginaFinal" => "635" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8680785" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0215" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous leiomyosarcoma: treatment outcomes with a standardized margin of excision" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.L. Deneve" 1 => "J.L. Messina" 2 => "M.M. Bui" 3 => "S.S. Marzban" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/107327481302000408" "Revista" => array:6 [ "tituloSerie" => "Cancer Control" "fecha" => "2013" "volumen" => "20" "paginaInicial" => "307" "paginaFinal" => "312" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24077407" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0220" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Superficial leiomyosarcoma treated with Mohs micrographic surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.R. Humphries" 1 => "D.H. Finkelstein" 2 => "J.B. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2004" "volumen" => "30" "paginaInicial" => "108" "paginaFinal" => "112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14692939" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0225" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.JIII Startling" 1 => "B.M. 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Original Article

Clinical and Histopathologic Findings of Cutaneous Leiomyosarcoma: Correlation With Prognosis in 12 Patients

Leiomiosarcoma cutáneo: características clínicas, histopatológicas y correlación pronóstica en 12 pacientes

E. Rodríguez-Lombaa,

Corresponding author

enriquerlomba@outlook.com

Corresponding author.

, I. Molina-Lópeza, V. Parra-Blancob, R. Suárez-Fernándeza, A. Pulido-Péreza

a Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain

b Servicio de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid, Spain

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        "titulo" => "Leiomiosarcoma cut&#225;neo&#58; caracter&#237;sticas cl&#237;nicas&#44; histopatol&#243;gicas y correlaci&#243;n pron&#243;stica en 12 pacientes"
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Reddish&#44; infiltrated plaque measuring 6 &#215; 3&#46;5<span class="elsevierStyleHsp" style=""></span>cm on the front of the left thigh&#46; Fairly solid&#44; ulcerated nodular formations overlie the lesion&#46; Small hemorrhagic points can be seen&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Skin leiomyosarcomas are rare malignant neoplasms that derive from smooth muscle tissue&#46; They account for around 2&#37; to 3&#37; of all soft-tissue sarcomas in skin and 0&#46;04&#37; of all neoplasms&#46; They are currently thought to arise de novo from smooth muscle&#44; even though there have been reports of tumors that derived from leiomyomas&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Leiomyosarcomas have traditionally been grouped in 3 large subtypes according to clinical and pathologic features that have prognostic implications&#58; 1&#41; cutaneous&#44; or dermal forms&#59; 2&#41; subcutaneous&#44; or hypodermal forms&#59; and 3&#41; secondary metastatic forms&#46; The most important clinical and prognostic differences between the classes are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2&#44;3</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The origin of cutaneous leiomyosarcomas seems to be the pilorector muscle in the dermis&#46; However&#44; there have been reports of cases in which the tumor developed in the dartos&#44; or its equivalent muscle in the vulva&#44; or in the areola&#46; This form is not usually aggressive but tends to recur locally after surgical excision with narrow margins&#46; The risk of distant metastasis is considered low &#40;5&#37;&#8211;10&#37;&#41;&#44; and these tumors have therefore been called &#8220;atypical intradermal smooth muscle neoplasms&#46;&#8221;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">4</span></a> Subcutaneous leiomyosarcomas arise in the smooth muscle fibers of the tunica media of arteries and veins&#46; Unlike more superficial&#44; or dermal forms&#44; these leiomyosarcomas have high rates of local&#8211;regional recurrence and metastasis &#40;30&#37;&#8211;40&#37;&#41;&#44; presenting a poor prognosis&#46; Finally&#44; metastatic leiomyosarcoma of the skin is associated with a particularly poor prognosis&#46; Metastasis usually derives from a primary leiomyosarcoma in the retroperitoneum&#44; the uterus&#44; or the subfascial soft tissue of the extremities&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">5&#8211;7</span></a>Even though the World Health Organization&#39;s 2005 taxonomy distinguishes true cutaneous from subcutaneous forms<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> &#40;the latter of which are included among soft-tissue tumors<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a>&#41;&#44; this distinction can become complicated in clinical practice because of overlap of histopathologic features with prognostic implications&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">10</span></a> In addition&#44; metastases of noncutaneous leiomyosarcomas to the skin simulate the features of primary subcutaneous leiomyosarcomas&#44; a situation that makes metastasis a diagnosis of exclusion&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Because prognosis is difficult in some cases of leiomyosarcoma in the skin&#44; we analyzed features of cases diagnosed in our hospital in the past 15 years&#46; We included all leiomyosarcomas regardless of origin of the neoplasm&#44; that is&#44; both primary tumors and metastatic disease&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Material and Methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">This retrospective&#44; descriptive&#44; observational study included data from adults who received a histopathologic diagnosis of leiomyosarcoma between January 1&#44; 2000&#44; and December 31&#44; 2015&#46; Cases were compiled from the skin and soft-tissue sarcoma registry of our hospital&#39;s pathology department&#46; We included skin leiomyosarcomas whether they were primary or metastatic&#46; We excluded subfascial and visceral tumors and cases for which the clinical history was unavailable or incomplete&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We collected the following data from the records of selected patients&#58; age at presentation&#44; sex&#44; year diagnosed&#44; clinical presentation &#40;lesion type&#44; number&#44; size&#44; and location&#41;&#44; latency time &#40;from diagnosis of the primary tumor until detection of metastatic disease in skin&#41;&#44; length of follow-up&#44; clinical course&#44; and response to treatments &#40;disease-free&#44; recurrence&#44; or death&#41;&#46; Histologic features recorded were histologic form &#40;cutaneous or subcutaneous primary tumor&#44; or metastatic tumor&#41;&#44; Ki-67 expression&#44; mitotic index &#40;number of mitoses per 10 high-power fields &#91;HPF&#93;&#41;&#44; and positive reaction to immunohistochemical stains &#40;including vimentin&#44; desmin&#44; HHF-35 &#91;muscle-specific actin&#93;&#44; smooth muscle actin &#91;SMA&#93;&#44; S100&#44; and CD34&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><p id="par0035" class="elsevierStylePara elsevierViewall">Clinical and histopathologic data and clinical course recorded for the included cases are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">A total of 17 leiomyosarcomas in 12 patients &#40;5 men&#44; 41&#37;&#59; 7 women&#44; 59&#37;&#41; were found in the registry&#46; All patients were over 50 years of age at the time of diagnosis&#44; and 45&#37; were over the age of 70 years&#46; The mean follow-up period after diagnosis of the cutaneous neoplasm &#40;whether primary or metastatic&#41; was 39&#46;6 months&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">There were 4 cutaneous leiomyosarcomas &#40;23&#37;&#41; in 4 patients&#44; 2 subcutaneous leiomyosarcomas &#40;11&#46;5&#37;&#41; in 2 patients&#44; and 11 metastatic leiomyosarcomas &#40;65&#37;&#41; in the remaining 6 patients&#46; The metastatic tumors derived from primary tumors in the subfascial plane&#59; in smooth muscle of the uterus or bladder&#59; or in the intra-abdominal or retroperitoneal spaces&#46; Metastatic tumor cells were found at an average of 1&#46;8 sites per patient during follow-up&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The most frequent location at the time of diagnosis was the scalp in both the series as a whole &#40;7&#47;17&#44; 41&#37;&#41; and in the subgroup of metastatic leiomyosarcomas&#46; The lower limbs &#40;3&#47;17&#44; 17&#37;&#41; and the trunk &#40;3&#47;17&#44; 17&#37;&#41; were the next most common sites&#46; The mean sizes of tumors on diagnosis in all 3 categories were as follows&#58; cutaneous leiomyosarcomas&#44; 2&#46;6<span class="elsevierStyleHsp" style=""></span>cm&#59; subcutaneous leiomyosarcomas&#44; 3&#46;1<span class="elsevierStyleHsp" style=""></span>cm&#59; and metastatic leiomyosarcomas&#44; 1&#46;8<span class="elsevierStyleHsp" style=""></span>cm&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Histology found a mean of 11 mitotic figures per 10 HPF and Ki-67 protein expression of 30&#37; in cutaneous tumors&#44; 7&#46;5 mitotic figures per 10 HPF and Ki-67 expression of 60&#37; in subcutaneous forms&#44; and 10&#46;2 mitotic figures per 10 HPF and Ki-67 expression of 48&#37; in metastatic forms&#46; Immunohistochemical staining was positive for vimentin &#40;&#62;25&#37; of cases&#41;&#44; desmin &#40;&#62;50&#37;&#41;&#44; HHF-35 &#40;&#62;75&#37;&#41;&#44; and SMA &#40;&#62;75&#37;&#41;&#46; S100 staining was focally positive in 1 cutaneous leiomyosarcoma&#59; CD34 staining was also positive in 1 cutaneous tumor&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">All the leiomyosarcomas in this series were excised surgically on diagnosis&#46; Two of the cutaneous tumors did not recur after excision with margins greater than 1<span class="elsevierStyleHsp" style=""></span>cm&#46; However&#44; the remaining cutaneous tumors did recur within 2 to 3 years after excision&#46; The recurrences were excised&#44; followed by radiation&#44; and no further recurrences were registered during follow-up&#46; One patient with a subcutaneous tumor remained free of disease&#46; The second patient with this form developed multiple node&#44; bone and muscle metastases and at the time of writing was receiving third-line chemotherapy &#40;trabectedin&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The first focus of metastatic leiomyosarcoma cells in the third subgroup occurred 2 to 18 months after diagnosis of the primary tumor&#46; In 2 cases metastasis to skin preceded metastasis to other sites&#44; whereas in 3 cases it occurred afterwards&#46; The generalized metastasis that developed during the course of disease in the 6 patients with metastatic skin leiomyosarcoma usually involved the lung&#46; The next most commonly involved organ was the liver &#40;3 patients&#41;&#46; Five of these 6 patients died within an average of 25 months after diagnosis of their skin metastasis&#44; in spite of chemo- and radiotherapy&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discussion</span><p id="par0070" class="elsevierStylePara elsevierViewall">Cutaneous soft-tissue sarcomas&#8212;and leiomyosarcomas among them&#8212;are rare tumors&#46; Because of the low incidence of these tumors&#44; it is difficult to develop protocols for their diagnosis and management&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Cutaneous leiomyosarcomas usually present as nodules or masses that are firm to the touch &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; in adults over the age of 50 years&#46; Patients often consult the physician for pain&#44; itching&#44; or paresthesia in the area around the lesion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Histology recognizes 2 architectural patterns&#46; One is a nodular pattern characterized by cellularity&#44; cell atypia&#44; and mitotic figures&#46; The other is a diffuse pattern with lower cellularity and a lower mitotic index&#46; Because cell atypia is not always evident&#44; a histologic diagnosis should be supported by the overall architecture of the lesion &#40;infiltrative pattern and high cellularity&#41;&#46; It is particularly important to obtain adequate samples for histopathology&#44; and incisional biopsies that extend below the dermis are preferred&#46; Immunohistochemistry is an essential tool for distinguishing these neoplasms from tumors with fusiform cells and for establishing lineage<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">To date most of the literature on cutaneous leiomyosarcoma in the skin consists of descriptions of single cases or small series&#46; Prognostic factors are therefore hard to discern&#44; as this neoplasm varies in its clinical behavior&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Winchester et al<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">2</span></a> analyzed prognostic indicators in one of the largest series of cutaneous and subcutaneous leiomyosarcomas published&#46; They described 71 cases occurring over a period of 50 years&#46; The most common location of both types of skin leiomyosarcoma was the extensor surfaces of the lower limbs&#46; The next most common was the trunk&#46; They found significant differences in the 5-year recurrence rate between cutaneous &#40;18&#37;&#41; and subcutaneous &#40;28&#37;&#41; forms&#46; The median follow-up after diagnosis was 4 years&#46; Distant metastasis was observed for 12&#37; percent of the cutaneous and 51&#37; of the subcutaneous tumors&#46; The median latency from initial diagnosis to metastasis was 3 years&#46; They also reported specific mortality for cutaneous and subcutaneous tumors &#40;6&#37; and 40&#37;&#44; respectively&#41;&#46; Metastasis in this retrospective cohort occurred in 10&#46;4&#37; of the cutaneous leiomyosarcomas&#44; obliging the authors to question the appropriateness of the term &#8220;atypical intradermal smooth muscle neoplasms&#8221; proposed by Kraft et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">4</span></a> Another group&#44; Jensen et al&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> also analyzed prognostic factors &#40;among them tumor size&#44; depth&#44; and histologic grade&#41; in a series of 41 cutaneous and subcutaneous leiomyosarcomas&#46; Tumor size greater than 5<span class="elsevierStyleHsp" style=""></span>cm at diagnosis was the only independent variable to survive as a prognostic factor on multivariate analysis&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The features we report in our series are generally consistent with those earlier reports&#46; However&#44; the most frequent location in our patients was the head&#44; attributable to our inclusion of metastatic leiomyosarcomas&#46; In addition&#44; we saw differences in the mitotic index&#44; and the 2 recurring cutaneous leiomyosarcomas in our series had disease-free intervals of 2 and 3 years&#46; One of our 2 patients with subcutaneous tumors remained free of disease after a year of follow-up in spite of an initial tumor size of 5<span class="elsevierStyleHsp" style=""></span>cm&#46; The higher mean mitotic index in cutaneous versus subcutaneous and metastatic tumors in our series was an interesting finding&#44; although it is true that we have only been able to analyze a small number of cases&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Leiomyosarcoma that metastasizes to the skin has been reported in the literature<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">13-16</span></a> and an analysis of 21 such cases was recently published by Winchester et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> Consistent with our observations&#44; they found that the head was the most frequent location&#44; probably because the high degree of vascularization in the scalp facilitates spread via the bloodstream&#46; They also reported a mean age at diagnosis of the first metastatic tumor of 68 years&#44; a median disease-free interval between tumor diagnosis and metastasis of 39 months&#44; and a mean survival after the diagnosis of metastatic disease of 16 months&#46; Our observations were similar&#46; The mean age of our patients was 69&#46;1 years&#44; the median disease-free interval was 36 months after excision&#44; and the mean survival after metastasis was 25 months&#8212;suggesting that metastasis to the skin from noncutaneous leiomyosarcomas indicates a poor prognosis&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Surgical treatment is the gold standard for localized tumors&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">17&#8211;19</span></a> However&#44; important structural limitations make it difficult to determine the optimal size of safety margins&#46; Aggressive surgery&#44; with margins ranging from 3 to 5<span class="elsevierStyleHsp" style=""></span>cm are traditionally recommended&#44; but time has shown that a more conservative approach taking margins of 1<span class="elsevierStyleHsp" style=""></span>cm can give similar results without increasing the rate of local recurrence&#46; Mohs micrographic surgery seems to have gained special importance in this setting&#46; During follow-up in a series of 41 leiomyosarcomas treated with Mohs surgery&#44; only 2 cases of recurrence and no cases of metastasis were observed&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">18&#8211;21</span></a> Nevertheless&#44; prospective studies in larger series and longer periods of follow-up are needed to confirm those findings&#46; The role of radiotherapy in leiomyosarcoma has not been clearly defined to date&#44; but this option can prove important when we treat deep tumors with a poor prognosis or when the margins surrounding excised tumors are not disease-free&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">17&#44;22</span></a> Neoadjuvant&#44; adjuvant&#44; or palliative therapy is currently indicated for nonresectable tumors or disseminated disease&#44; depending on tumor stage&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">17&#44;23&#44;24</span></a> All lesions in our series could be removed with surgical margins between 3 and 5<span class="elsevierStyleHsp" style=""></span>cm except in cases of confirmed metastasis&#44; in which we removed tumors with 1-cm margins and prescribed chemotherapy&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Prognosis depends mainly on subtype&#58; true cutaneous forms&#44; cutaneous forms that penetrate subcutaneous tissue&#44; subcutaneous forms&#44; and metastatic forms&#46; For this reason cutaneous leiomyosarcomas have been excluded from the World Health Organization&#39;s classification system for soft-tissue sarcomas&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a> However&#44; these distinctions are not present in the main diagnostic algorithms used in clinical practice &#40;the 2016 version of the National Comprehensive Cancer Network Guidelines<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a>&#41;&#44; which refer to leiomyosarcomas without reference to subtypes&#44; grouping them together with other high-grade&#44; aggressive sarcomas&#46; Therefore&#44; given the lack of specific recommendations&#44; the clinician must make individualized decisions when ordering images to evaluate tumor extension&#46; Furthermore&#44; even though metastatic skin involvement arising from leiomyosarcomas is even less frequent than primary leiomyosarcoma&#44; the clinical and histopathologic differential diagnosis between these forms can be complicated &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The possibility of an unidentified primary visceral tumor should therefore be investigated in all cases of leiomyosarcoma confined to subcutaneous tissue&#46; <a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a> shows a possible diagnostic algorithm for individualized diagnosis based on clinical and histopathologic features&#46; The algorithm can provide guidance on choosing complementary tests and images to order early in the diagnostic process&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">In conclusion&#44; leiomyosarcoma of the skin is a rare malignancy with clearly defined prognostic differences according to histologic subtype and whether the tumor is primary or metastatic&#46; Even though this series analyzes few cases and data was collected retrospectively&#44; we have been able to construct an algorithm to guide diagnosis and management that we believe will be useful to dermatologists who must treat this rare but potentially aggressive tumor&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflicts of Interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous leiomyosarcoma is a malignant neoplasm derived from smooth muscle cells&#46; Its low incidence hampers the development of specific protocols for diagnosis and treatment&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To describe the clinical and histopathologic characteristics of a series of primary and secondary cutaneous leiomyosarcomas and to determine how these characteristics correlate with prognosis&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We performed an observational&#44; descriptive&#44; retrospective study based on 17 cutaneous leiomyosarcomas in 12 patients diagnosed between January 1&#44; 2000 and December 31&#44; 2015&#46; We recorded demographic data&#44; clinical and histopathologic characteristics&#44; outcome&#44; and response to treatment&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We included 5 men and 7 women&#44; all aged more than 50 years at diagnosis&#46; There were 4 cutaneous leiomyosarcomas &#40;23&#37;&#41; in 4 patients&#44; 2 subcutaneous leiomyosarcomas &#40;11&#46;5&#37;&#41; in 2 patients&#44; and 11 skin metastases of leiomyosarcoma &#40;65&#37;&#41; in 6 patients&#46; The most frequently affected sites were the scalp &#40;41&#37;&#41;&#44; lower limbs &#40;17&#37;&#41;&#44; and trunk &#40;17&#37;&#41;&#46; During follow-up&#44; 50&#37; of the cutaneous leiomyosarcomas recurred&#44; 50&#37; of the subcutaneous leiomyosarcomas presented distant metastases&#44; and 83&#37; of the patients with skin metastases of leiomyosarcoma died of their disease&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Limitations</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Ours was a retrospective review of a small case series at a single center&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclusions</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cutaneous leiomyosarcoma is an uncommon malignant neoplasm&#46; Our approach to diagnosis and therapy must take into account the marked heterogeneity in the prognosis of the various subtypes&#46;</p></span>"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introducci&#243;n</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El leiomiosarcoma de piel es una neoplasia maligna de estirpe muscular cuya baja incidencia dificulta el desarrollo de protocolos espec&#237;ficos de diagn&#243;stico y manejo terap&#233;utico&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Objetivos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Describir las caracter&#237;sticas cl&#237;nicas e histopatol&#243;gicas de una serie de leiomiosarcomas cut&#225;neos primarios y secundarios&#44; junto con su correlaci&#243;n pron&#243;stica&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Material y m&#233;todos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio retrospectivo&#44; descriptivo y observacional&#46; Se seleccionaron 17 casos de leiomiosarcoma cut&#225;neo en 12 pacientes&#44; diagnosticados entre el 1 de enero de 2000 y el 31 de diciembre de 2015&#46; Se recogieron sus datos demogr&#225;ficos&#44; caracter&#237;sticas cl&#237;nicas e histopatol&#243;gicas&#44; evoluci&#243;n y respuesta al tratamiento&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Se reclutaron 5 varones y 7 mujeres&#44; todos ellos mayores de 50 a&#241;os al diagn&#243;stico&#46; Se recogieron 4 leiomiosarcomas d&#233;rmicos &#40;4&#47;17&#44; 23&#37;&#41; en 4 pacientes&#44; 2 leiomiosarcomas hipod&#233;rmicos &#40;2&#47;17&#44; 11&#44;5&#37;&#41; en 2 pacientes&#44; y 11 met&#225;stasis cut&#225;neas de leiomiosarcoma &#40;11&#47;17&#44; 65&#37;&#41; en 6 pacientes&#46; Las localizaciones m&#225;s frecuentes fueron cuero cabelludo &#40;7&#47;17&#44; 41&#37;&#41;&#44; miembros inferiores &#40;3&#47;17&#44; 17&#37;&#41; y tronco &#40;3&#47;17&#44; 17&#37;&#41;&#46; Durante el seguimiento&#44; un 50&#37; de leiomiosarcomas d&#233;rmicos recidivaron&#44; un 50&#37; de leiomiosarcomas hipod&#233;rmicos presentaron met&#225;stasis a distancia y 5&#47;6 pacientes con met&#225;stasis cut&#225;neas de leiomiosarcoma &#40;83&#37;&#41; fallecieron a causa de su enfermedad&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Limitaciones</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Este estudio es una revisi&#243;n retrospectiva de una serie de casos de tama&#241;o limitado en un centro &#250;nico&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusiones</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">El leiomiosarcoma cut&#225;neo es una neoplasia maligna poco frecuente&#46; A la hora de adoptar una actitud diagn&#243;stico-terap&#233;utica en estos pacientes debemos tener en cuenta la marcada heterogeneidad pron&#243;stica entre sus diferentes subtipos&#46;</p></span>"
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            "identificador" => "abst0040"
            "titulo" => "Objetivos"
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          2 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Material y m&#233;todos"
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            "identificador" => "abst0050"
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            "identificador" => "abst0055"
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    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Rodr&#237;guez-Lomba E&#44; Molina-L&#243;pez I&#44; Parra-Blanco V&#44; Su&#225;rez-Fern&#225;ndez R&#44; Pulido-P&#233;rez A&#46; Leiomiosarcoma cut&#225;neo&#58; caracter&#237;sticas cl&#237;nicas&#44; histopatol&#243;gicas y correlaci&#243;n pron&#243;stica en 12 pacientes&#46; Actas Dermosifiliogr&#46; 2018&#59;109&#58;140&#8211;147&#46;</p>"
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Reddish&#44; infiltrated plaque measuring 6 &#215; 3&#46;5<span class="elsevierStyleHsp" style=""></span>cm on the front of the left thigh&#46; Fairly solid&#44; ulcerated nodular formations overlie the lesion&#46; Small hemorrhagic points can be seen&#46;</p>"
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Diffuse&#44; poorly defined fascicles interspersed with smooth muscle fibers composed of fusiform cells with cigar-shaped nuclei &#40;elongated with rounded tips&#41;&#44; marked pleomorphism&#44; and an eosinophilic cytoplasm&#46; Hematoxylin-eosin&#44; magnification&#58; A&#44; &#215;10&#59; B&#44; &#215;20&#59; C&#44; &#215;40&#46;</p>"
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          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">A&#44; Primary subcutaneous leiomyosarcoma&#46; B&#44; Skin metastasis from a noncutaneous leiomyosarcoma&#46;</p>"
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          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Algorithm to guide the diagnosis and management of leiomyosarcomas of the skin&#46; CT refers to computed tomography&#59; PET-CT&#44; positron emission CT&#46;</p>"
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Sources&#58; Winchester et al&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">2</span></a> Aneiros-Fern&#225;ndez et al&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">3</span></a> Kraft et al&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">4</span></a> and Winchester et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a></p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cutaneous Leiomyosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Subcutaneous Leiomyosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Metastasis of Noncutaneous Leiomyosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Incidence&#44; by sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Men 3&#58; women 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Men &#61; women&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="4" align="left" valign="top">Age at presentation<br>Origin</td><td class="td" title="table-entry  " align="left" valign="top">50&#8211;70 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#8211;80 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#62;<span class="elsevierStyleHsp" style=""></span>60 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Piloerector muscle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Vascular tunica media</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Primary tumor in extremities&#44; retroperitoneal cavity&#44; uterus&#44; etc&#46;</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dartos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Areola&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Size&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">About 2&#8211;3 cm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Most often &#62;<span class="elsevierStyleHsp" style=""></span>3 cm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Most often &#62;<span class="elsevierStyleHsp" style=""></span>3 cm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Most common location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lower limbs in 50&#37;&#8211;85&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lower limbs&#44; in 50&#37;&#8211;85&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Scalp &#40;&#62;<span class="elsevierStyleHsp" style=""></span>75&#37;&#41; and trunk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Recurrence&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#37;&#8211;40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#37;&#8211;70&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Metastasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#37;&#8211;10&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#37;&#8211;40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Prognosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Good&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Poor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Poor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Characteristics of Cutaneous&#44; Subcutaneous&#44; and Metastatic Forms of Leiomyosarcoma&#46;</p>"
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        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; HPF&#44; high-power field&#59; NA&#44; not applicable&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cutaneous Leiomyosarcoma &#40;n&#61;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Subcutaneous Leiomyosarcoma &#40;n&#61;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Metastatic Leiomyosarcoma &#40;n&#61;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age&#44; mean &#40;range&#41;&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62 &#40;45&#8211;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&#46;5 &#40;59&#8211;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&#46;1 &#40;51&#8211;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Men&#58;women&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#58;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#58;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#58;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Size&#44; mean &#40;range&#41;&#44; cm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;6 &#40;0&#46;4&#8211;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;1 &#40;0&#46;7-6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;8 &#40;1&#8211;2&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Location&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;23&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;11&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;65&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Head and neck&#44; n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Trunk&#44; n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Extremities&#44; n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mitotic figures&#47;10 HPF&#44; mean&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ki-67 expression&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3-y recurrence&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#47;4 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#47;2 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3-y metastasis&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#47;4 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#47;2 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tumor-specific mortality&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#47;4 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#47;2 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#47;6 &#40;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Follow-up time&#44; mean &#40;range&#41;&#44; mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&#46;5 &#40;6&#8211;120&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21 &#40;12&#8211;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#46;3 &#40;5&#8211;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Clinical and Histopathologic Features in 17 Cutaneous&#44; Subcutaneous and Metastatic Leiomyosarcomas&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:24 [
            0 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous leiomyosarcoma with coexistent superficial angioleiomyoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46;R&#46; White"
                            1 => "D&#46;M&#46; Macdonald"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol&#46;"
                        "fecha" => "1981"
                        "volumen" => "6"
                        "paginaInicial" => "333"
                        "paginaFinal" => "337"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7296963"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leiomyosarcoma of the skin&#58; clinical&#44; histopathologic&#44; and prognostic factors that influence outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;S&#46; Winchester"
                            1 => "T&#46;L&#46; Hocker"
                            2 => "J&#46;D&#46; Brewer"
                            3 => "C&#46;L&#46; Baum"
                            4 => "P&#46;C&#46; Hochwalt"
                            5 => "C&#46;J&#46; Arpey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2014.07.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2014"
                        "volumen" => "71"
                        "paginaInicial" => "919"
                        "paginaFinal" => "925"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25174541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary cutaneous and subcutaneous leiomyosarcomas&#58; review of their evolution and prognostic factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Aneiros-Fernandez"
                            1 => "J&#46; Antonio Retamero"
                            2 => "H&#46; Husein-Elahmed"
                            3 => "F&#46; Ovalle"
                            4 => "J&#46; Aneiros-Cachaza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1684/ejd.2015.2681"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol&#46;"
                        "fecha" => "2016"
                        "volumen" => "26"
                        "paginaInicial" => "9"
                        "paginaFinal" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26678649"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atypical intradermal smooth muscle neoplasms&#58; clinicopathologic analysis of 84 cases and a reappraisal of cutaneous leiomyosarcoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Kraft"
                            1 => "C&#46;D&#46; Fletcher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Surg Pathol&#46;"
                        "fecha" => "2011"
                        "volumen" => "25"
                        "paginaInicial" => "599"
                        "paginaFinal" => "607"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skin metastases of leiomyosarcoma &#40;LMS&#41;&#58; a retrospective review of 21 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;S&#46; Winchester"
                            1 => "T&#46;L&#46; Hocker"
                            2 => "R&#46;K&#46; Roenigk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2015.01.033"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "72"
                        "paginaInicial" => "910"
                        "paginaFinal" => "912"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25890461"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous metastasis of leiomyosarcoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Vandergriff"
                            1 => "R&#46;A&#46; Krathen"
                            2 => "L&#46; Orengo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1524-4725.2007.33127.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg&#46;"
                        "fecha" => "2007"
                        "volumen" => "33"
                        "paginaInicial" => "634"
                        "paginaFinal" => "637"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17451591"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sarcoma metastases to the skin&#58; a clinicopathologic study of 65 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "W&#46;L&#46; Wang"
                            1 => "R&#46;A&#46; Bones-Valentin"
                            2 => "V&#46;G&#46; Prieto"
                            3 => "R&#46;E&#46; Pollock"
                            4 => "D&#46;C&#46; Lev"
                            5 => "A&#46;J&#46; Lazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.26590"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer&#46;"
                        "fecha" => "2012"
                        "volumen" => "118"
                        "paginaInicial" => "2900"
                        "paginaFinal" => "2904"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21989966"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology and genetics of tumours of the skin&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; LeBoit"
                            1 => "G&#46; Burg"
                            2 => "D&#46; Weedon"
                            3 => "A&#46; Sarasin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2005"
                        "editorial" => "IARC Press"
                        "editorialLocalizacion" => "Lyon"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "WHO Classification of Tumours of Soft Tissue and Bone&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;D&#46;M&#46; Fletcher"
                            1 => "J&#46;A&#46; Bridge"
                            2 => "P&#46;C&#46;W&#46; Hogendoorn"
                            3 => "F&#46; Mertens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2013"
                        "editorial" => "IARC Press"
                        "editorialLocalizacion" => "Lyon"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary cutaneous leiomyosarcoma&#58; clinicopathological analysis of 36 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Massi"
                            1 => "A&#46; Franchi"
                            2 => "L&#46; Alos"
                            3 => "M&#46; Cook"
                            4 => "S&#46; Di Palma"
                            5 => "A&#46;B&#46; Enguita"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2559.2009.03471.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Histopathology&#46;"
                        "fecha" => "2010"
                        "volumen" => "56"
                        "paginaInicial" => "251"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20102404"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cluster analysis of immunohistochemical markers in leiomyosarcoma delineates specific anatomic and gender subgroups"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;C&#46; Carvalho"
                            1 => "D&#46;G&#46; Thomas"
                            2 => "D&#46;R&#46; Lucas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer&#46;"
                        "fecha" => "2009"
                        "volumen" => "115"
                        "paginaInicial" => "1186"
                        "paginaFinal" => "1195"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intradermal and subcutaneous leiomyosarcoma&#58; a clinicopathological and immunohistochemical study of 41 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;L&#46; Jensen"
                            1 => "O&#46;M&#46; Jensen"
                            2 => "W&#46; Michalski"
                            3 => "O&#46;S&#46; Nielsen"
                            4 => "J&#46; Keller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cutan Pathol&#46;"
                        "fecha" => "1996"
                        "volumen" => "23"
                        "paginaInicial" => "454"
                        "paginaFinal" => "463"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Met&#225;stasis cut&#225;neas por leiomiosarcoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;M&#46; Diaz"
                            1 => "T&#46; L&#225;zaro"
                            2 => "A&#46;B&#46; Piteiro"
                            3 => "M&#46; Hervella"
                            4 => "M&#46; Berg&#243;n"
                            5 => "F&#46; Contreras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2003"
                        "volumen" => "94"
                        "paginaInicial" => "414"
                        "paginaFinal" => "416"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Met&#225;stasis cut&#225;neas de leiomiosarcoma de &#250;tero"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Garcia-Arpa"
                            1 => "J&#46; Salamanca"
                            2 => "P&#46;L&#46; Ortiz"
                            3 => "J&#46;L&#46; Rodr&#237;guez-Peralto"
                            4 => "A&#46; Mart&#237;n-Gallardo"
                            5 => "L&#46; Iglesias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2003"
                        "volumen" => "94"
                        "paginaInicial" => "666"
                        "paginaFinal" => "668"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous scalp metastasis as the first indication of a clinically silent retroperitoneal leiomyosarcoma and of its further relapse as metastatic widespread disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Tomasini"
                            1 => "A&#46; Niccoli"
                            2 => "F&#46; Crivelli"
                            3 => "I&#46; Scandroglio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1684/ejd.2014.2290"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol&#46;"
                        "fecha" => "2014"
                        "volumen" => "24"
                        "paginaInicial" => "264"
                        "paginaFinal" => "265"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24682588"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leiomiosarcoma d&#233;rmico metast&#225;sico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Alc&#225;ntara-Luna"
                            1 => "L&#46; Ferr&#225;ndiz-Pulido"
                            2 => "J&#46;J&#46; R&#237;os-Mart&#237;n"
                            3 => "D&#46; Moreno-Ram&#237;rez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel&#46;"
                        "fecha" => "2013"
                        "volumen" => "28"
                        "paginaInicial" => "205"
                        "paginaFinal" => "207"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "National Comprehensive Cancer Network&#46; NCCN Clinical Practice Guidelines in Oncology &#40;NCCN Guidelines&#41;&#46; Soft Tissue Sarcoma&#46; Version 2&#46;2016 &#91;cited 2017 Jun&#93;&#46; Available from&#58; https&#58;&#47;&#47;www&#46;nccn&#46;org&#47;professionals&#47;physician&#95;gls&#47;f&#95;guidelines&#46;asp"
                ]
              ]
            ]
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              "identificador" => "bib0210"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leiomyosarcoma of the skin&#46; Treatment of 34 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;C&#46; Bernstein"
                            1 => "R&#46;K&#46; Roenigk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg&#46;"
                        "fecha" => "1996"
                        "volumen" => "22"
                        "paginaInicial" => "631"
                        "paginaFinal" => "635"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8680785"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous leiomyosarcoma&#58; treatment outcomes with a standardized margin of excision"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;L&#46; Deneve"
                            1 => "J&#46;L&#46; Messina"
                            2 => "M&#46;M&#46; Bui"
                            3 => "S&#46;S&#46; Marzban"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/107327481302000408"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Control"
                        "fecha" => "2013"
                        "volumen" => "20"
                        "paginaInicial" => "307"
                        "paginaFinal" => "312"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24077407"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Superficial leiomyosarcoma treated with Mohs micrographic surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;R&#46; Humphries"
                            1 => "D&#46;H&#46; Finkelstein"
                            2 => "J&#46;B&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg"
                        "fecha" => "2004"
                        "volumen" => "30"
                        "paginaInicial" => "108"
                        "paginaFinal" => "112"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14692939"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;JIII Startling"
                            1 => "B&#46;M&#46; Coldiron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2010.11.051"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2011"
                        "volumen" => "64"
                        "paginaInicial" => "1119"
                        "paginaFinal" => "1122"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21571171"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Svarvar"
                            1 => "T&#46; B&#246;hling"
                            2 => "O&#46; Berlin"
                            3 => "P&#46; Gustafson"
                            4 => "G&#46; Folleras"
                            5 => "B&#46; Bjerkehagen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.22395"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer&#46;"
                        "fecha" => "2007"
                        "volumen" => "109"
                        "paginaInicial" => "282"
                        "paginaFinal" => "291"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17154171"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0235"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Gemcitabine-based chemotherapy in sarcomas&#58; A systematic review of published trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Ducoulombier"
                            1 => "S&#46; Cousin"
                            2 => "N&#46; Kotecki"
                            3 => "N&#46; Penel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.critrevonc.2015.10.020"
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                        "tituloSerie" => "Crit Rev Oncol Hematol&#46;"
                        "fecha" => "2016"
                        "volumen" => "98"
                        "paginaInicial" => "73"
                        "paginaFinal" => "80"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26555460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trabectedin for inoperable or recurrent soft tissue sarcoma in adult patients&#58; a retrospective cohort study"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46;A&#46; Angarita"
                            1 => "A&#46;J&#46; Cannel"
                            2 => "A&#46;R&#46; Abdul Razak"
                            3 => "B&#46;C&#46; Dickson"
                            4 => "M&#46;E&#46; Blackstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "doi" => "10.1186/s12885-016-2054-2"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Cancer&#46;"
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                        "volumen" => "16"
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                        "link" => array:1 [
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Article information

ISSN: 15782190
Original language: English

DOI:10.1016/j.adengl.2017.12.008

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Year/Month	Html	Pdf	Total

2024 November	12	11	23
2024 October	125	43	168
2024 September	135	32	167
2024 August	168	55	223
2024 July	144	26	170
2024 June	147	37	184
2024 May	104	31	135
2024 April	98	32	130
2024 March	111	37	148
2024 February	110	42	152
2024 January	109	38	147
2023 December	102	27	129
2023 November	121	26	147
2023 October	124	26	150
2023 September	105	37	142
2023 August	88	14	102
2023 July	102	34	136
2023 June	73	22	95
2023 May	87	30	117
2023 April	59	24	83
2023 March	109	36	145
2023 February	103	29	132
2023 January	89	36	125
2022 December	89	50	139
2022 November	51	38	89
2022 October	39	26	65
2022 September	40	36	76
2022 August	38	39	77
2022 July	34	40	74
2022 June	38	28	66
2022 May	97	48	145
2022 April	88	60	148
2022 March	104	67	171
2022 February	90	45	135
2022 January	111	53	164
2021 December	91	56	147
2021 November	78	63	141
2021 October	80	59	139
2021 September	82	45	127
2021 August	116	52	168
2021 July	83	36	119
2021 June	73	47	120
2021 May	83	73	156
2021 April	208	148	356
2021 March	141	48	189
2021 February	135	49	184
2021 January	98	57	155
2020 December	82	54	136
2020 November	63	55	118
2020 October	81	37	118
2020 September	59	28	87
2020 August	63	38	101
2020 July	84	30	114
2020 June	61	53	114
2020 May	52	19	71
2020 April	47	20	67
2020 March	21	16	37
2020 February	2	0	2
2020 January	4	0	4
2019 December	8	0	8
2019 November	4	0	4
2019 September	8	0	8
2019 August	4	0	4
2019 July	4	0	4
2019 June	4	0	4
2019 May	6	1	7
2019 April	2	0	2
2019 March	2	0	2
2019 February	2	0	2
2019 January	1	0	1
2018 December	2	0	2
2018 November	2	0	2
2018 October	2	0	2
2018 September	1	0	1
2018 March	1	0	1
2018 February	9	9	18
2018 January	6	6	12

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