Case and Research Letter
Need to Screen for Chagas Disease and Strongyloides Infestation in Non-endemic Countries Prior to Treatment With Biologics
Necesidad de cribado de enfermedad de Chagas y de infestación por Strongyloides previo a inicio de terapia biológica en países no endémicos
Read
5449
Timeswas read the article
1715
Total PDF
3734
Total HTML
Share statistics
array:24 [ "pii" => "S1578219017300471" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.02.018" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1552" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2016" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:373-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 753 "formatos" => array:3 [ "EPUB" => 49 "HTML" => 550 "PDF" => 154 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731016303684" "issn" => "00017310" "doi" => "10.1016/j.ad.2016.10.013" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1552" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:373-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 257 "formatos" => array:3 [ "EPUB" => 4 "HTML" => 217 "PDF" => 36 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENTÍFICO-CLÍNICA</span>" "titulo" => "Necesidad de cribado de enfermedad de Chagas y de infestación por <span class="elsevierStyleItalic">Strongyloides</span> previo a inicio de terapia biológica en países no endémicos" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "373" "paginaFinal" => "375" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Need to screen for Chagas disease and <span class="elsevierStyleItalic">Strongyloides</span> infestation in non-endemic countries prior to treatment with biologics" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. González-Ramos, M.L. Alonso-Pacheco, M. Mora-Rillo, P. Herranz-Pinto" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "González-Ramos" ] 1 => array:2 [ "nombre" => "M.L." "apellidos" => "Alonso-Pacheco" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Mora-Rillo" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Herranz-Pinto" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219017300471" "doi" => "10.1016/j.adengl.2017.02.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300471?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016303684?idApp=UINPBA000044" "url" => "/00017310/0000010800000004/v2_201705020105/S0001731016303684/v2_201705020105/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219017300653" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.10.006" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1550" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:376-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 676 "formatos" => array:3 [ "EPUB" => 54 "HTML" => 505 "PDF" => 117 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Basal Cell Carcinoma in Young Adults" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "376" "paginaFinal" => "377" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma basocelular en pacientes jóvenes" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Garcias-Ladaria, F.J. Morales-Morato, M. Cuadrado Rosón, V. Rocamora" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Garcias-Ladaria" ] 1 => array:2 [ "nombre" => "F.J." "apellidos" => "Morales-Morato" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Cuadrado Rosón" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Rocamora" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016303660" "doi" => "10.1016/j.ad.2016.10.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016303660?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300653?idApp=UINPBA000044" "url" => "/15782190/0000010800000004/v1_201704280927/S1578219017300653/v1_201704280927/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219017300677" "issn" => "15782190" "doi" => "10.1016/j.adengl.2017.03.013" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "1553" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:371-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 547 "formatos" => array:3 [ "EPUB" => 66 "HTML" => 353 "PDF" => 128 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Pilot Study to Evaluate Postsurgical Dehiscence After Continuous Suture by Tissue Planes" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "371" "paginaFinal" => "372" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio piloto de valoración de dehiscencias posquirúrgicas tras sutura continua por planos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Tercedor-Sánchez, A. Martinez-Lopez, I. Pérez-López, R. Ruiz-Villaverde" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Tercedor-Sánchez" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Martinez-Lopez" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Pérez-López" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Ruiz-Villaverde" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016303696" "doi" => "10.1016/j.ad.2016.10.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016303696?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300677?idApp=UINPBA000044" "url" => "/15782190/0000010800000004/v1_201704280927/S1578219017300677/v1_201704280927/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Need to Screen for Chagas Disease and <span class="elsevierStyleItalic">Strongyloides</span> Infestation in Non-endemic Countries Prior to Treatment With Biologics" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "373" "paginaFinal" => "375" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. González-Ramos, M.L. Alonso-Pacheco, M. Mora-Rillo, P. Herranz-Pinto" "autores" => array:4 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "González-Ramos" "email" => array:1 [ 0 => "gnzalezramosjessica@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.L." "apellidos" => "Alonso-Pacheco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Mora-Rillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "P." "apellidos" => "Herranz-Pinto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Necesidad de cribado de enfermedad de Chagas y de infestación por <span class="elsevierStyleItalic">Strongyloides</span> previo a inicio de terapia biológica en países no endémicos" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We describe the case of a 54-year-old Bolivian woman who had lived in Spain for 14 years. The patient a history of hypertension, asthma, and urticaria with chronic angioedema that had first appeared 6 years earlier; she had been assessed and treated for the urticaria and angioedema at another care facility. In March 2012, the patient started receiving subcutaneous etanercept (50<span class="elsevierStyleHsp" style=""></span>mg/wk) for treatment of psoriasis and psoriatic arthritis that had not responded to treatment with methotrexate and oral corticosteroids. After 3 months, complete response was achieved in the skin and partial response was achieved in the joints. Because of persistent peripheral blood eosinophilia (> 1000/μL), the patient underwent screening for associated diseases. The serologic findings (enzyme-linked immunosorbent assay was positive for IgG) indicated <span class="elsevierStyleItalic">Strongyloides stercoralis</span> infestation, which was treated with oral ivermectin (200<span class="elsevierStyleHsp" style=""></span>μg/kg/d for 2 days) in February 2013. Direct parasitological stool examination and stool cultures performed in triplicate were negative before and after treatment. One year later, during follow-up, the patient was screened for Chagas disease, with positive findings in blood tests (enzyme immunoassay and indirect immunofluorescence) and polymerase chain reaction (PCR). Organ involvement was ruled out by a standardized test and the disease stage was classified as indeterminate. Because of the risk of reactivation, etanercept was withdrawn and treatment was initiated with oral benznidazole (5<span class="elsevierStyleHsp" style=""></span>mg/kg/d for 60 days) and biologic therapy was subsequently resumed. In the past 18 months, no reactivation of the infection has been observed (PCR remains negative and serology is positive with lower titers) despite ongoing treatment with etanercept.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Chagas disease, caused by the <span class="elsevierStyleItalic">Trypanosoma cruzi</span> parasite, affects approximately 10 million people worldwide, especially in South America, where it causes thousands of deaths each year. In recent decades, because of migratory flows, the disease has spread to nonendemic areas such as Spain, where the use of biologic therapy is on the rise. In our area, most patients are diagnosed with Chagas disease of indeterminate stage (positive serology, fluctuating parasitemia, and absence of symptoms) and can remain in that stage indefinitely or progress to the symptomatic chronic stage after 10 to 30 years.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Immunosuppression alters the natural history of the disease, facilitating reactivation and progression to advanced stages. Reactivation is defined as an increase in parasitemia that can be detected by PCR, with the methods of choice being quantitative PCR (a mode not available in our case) or direct examination. The disease can be associated with severe symptoms of organ involvement, such as myocarditis or meningoencephalitis, or it can be asymptomatic. Reactivation has been widely reported in patients with human immunodeficiency virus (HIV) infection, transplant recipients, and patients receiving conventional immunosuppressive therapy. Currently, there is no evidence that corticosteroids at immunosuppressive doses increase the risk of reactivation. In immunosuppressed patients, treatment with benznidazole or nifurtimox is indicated (recommendation grade BII).<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Criteria of cure are not well defined, although the patient is assumed to be cured if successive PCR tests are negative after treatment. Serologic testing is not useful because it can take years to achieve negative seroconversion.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Anti-TNF agents have been associated with an increased risk of opportunistic infections. In the French RATIO registry of nontuberculous opportunistic infections in patients receiving anti-TNF therapy, 45 cases of such infections were detected over a 3-year period. The risk of infection was not statistically significant with any drug, although it was higher with infliximab and adalimumab than with etanercept.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> This risk is still being assessed and more data on reactivation rates of parasitic infections are needed. Only 2 cases of reactivation of Chagas disease in patients receiving biologic therapy have been reported; both patients had psoriasis and were receiving treatment with infliximab and adalimumab, respectively (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,5</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Little information is available on the need for serologic screening for Chagas disease before the initiation of biological treatment. Salvador et al. recommend screening patients from endemic areas and performing prior treatment with benznidazole in infected patients. During follow-up, the authors recommend closely monitoring patients with PCR for early detection of reactivation.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The prevalence of infection with <span class="elsevierStyleItalic">S stercoralis</span>, a human intestinal nematode, has also increased in recent years in Spain. The infestation is endemic in tropical and subtropical regions, but there are also endemic areas in Spain, especially on the Mediterranean coast. Diagnosis is made by stool culture on agar plate and/or serologic testing. Immunosuppressed patients are at risk of hyperinfestation syndrome, which is associated with high mortality.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Four cases have been reported in patients receiving anti-TNF therapy (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7–10</span></a> In patients from endemic areas, it appears that screening for <span class="elsevierStyleItalic">S stercoralis</span> before the start of biologic therapy would be advisable and, in the event of infestation, treatment should be initiated with oral ivermectin (200<span class="elsevierStyleHsp" style=""></span>μg/kg/d for 2 consecutive days), which has been shown to be the most effective therapy.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, we consider that pre-screening for Chagas disease and <span class="elsevierStyleItalic">Strongyloides</span> infestation, as is already established for detection of latent tuberculosis infection in international clinical guidelines for biologic therapy, is necessary in patients from endemic areas or who have lived in endemic areas (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). The aim of this screening is to decrease the morbidity and mortality that these diseases could bring to our area in the coming years.</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:2 [ "identificador" => "xack280253" "titulo" => "Acknowledgments" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as: González-Ramos J, Alonso-Pacheco ML, Mora-Rillo M, Herranz-Pinto P. Necesidad de cribado de enfermedad de Chagas y de infestación por <span class="elsevierStyleItalic">Strongyloides</span> previo a inicio de terapia biológica en países no endémicos. Actas Dermosifiliogr. 2017;108:373–375.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: F, female; M, male.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case/Year \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex/Age, y \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Country \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Primary Disease \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Biologic Agent \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Concomitant Immunosuppressive Treatments \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Interval<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Management \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1/2015<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M/57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Argentina \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Psoriatic erythroderma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Infliximab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Methylprednisolone 20<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Benznidazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">None reported \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2/2015<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M/52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Chile \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Psoriasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Adalimumab 40<span class="elsevierStyleHsp" style=""></span>mg twice weekly \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Benznidazole 5-7<span class="elsevierStyleHsp" style=""></span>mg/kg/d<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Adalimumab treatment was resumed. No reactivation in 1 year. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Present case/2016 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F/54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Bolivia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Psoriasis<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>psoriatic arthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Etanercept 50<span class="elsevierStyleHsp" style=""></span>mg/wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Methotrexate 25<span class="elsevierStyleHsp" style=""></span>mg/wk, prednisone 5<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">27 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Benznidazole 5<span class="elsevierStyleHsp" style=""></span>mg/kg/d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Etanercept treatment was resumed. No reactivation in 2 years. \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1406725.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Time elapsed from the start of biologic therapy to the diagnosis of the infection.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Reported Cases of Reactivation of Chagas Disease in Patients Receiving Biologic Therapy and Management.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: F, female; M, male.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case/Year \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex/Age, y \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Country \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Primary Disease \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Biologic Agent \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Concomitant Immunosuppressive Treatments \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Interval<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1/2005<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M/56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Spent time in Vietnam and Mississippi \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Rheumatoid arthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Etanercept \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Prednisone 5<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Intravenous ivermectin 200<span class="elsevierStyleHsp" style=""></span>μg/kg/d <span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2 d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2/2007<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M/63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Philippines \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Rheumatoid arthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Adalimumab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Methotrexate 15<span class="elsevierStyleHsp" style=""></span>mg/wk and prednisone 5<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Ivermectin 200<span class="elsevierStyleHsp" style=""></span>μg/kg/d<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2 d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3/2008<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M/29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Ecuador \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Rheumatoid arthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Etanercept \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">None \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 and 30 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Albendazole 400<span class="elsevierStyleHsp" style=""></span>mg/12<span class="elsevierStyleHsp" style=""></span>h, followed by ivermectin 12<span class="elsevierStyleHsp" style=""></span>mg (single dose) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4/2013<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M/55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">None reported \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Ankylosing spondylitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Infliximab \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Oral corticosteroids \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Albendazole 400<span class="elsevierStyleHsp" style=""></span>mg/d<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>7 d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Present case/2016 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F/54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Bolivia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Psoriasis<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>psoriatic arthritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Etanercept \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Methotrexate 25<span class="elsevierStyleHsp" style=""></span>mg/wk, prednisone 5<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">11 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Oral ivermectin 200<span class="elsevierStyleHsp" style=""></span>μg/kg/d<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2 d \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1406723.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Time elapsed from the start of biologic therapy to the diagnosis of the infection.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Reported Cases of <span class="elsevierStyleItalic">Strongyloides stercoralis</span> Infestation in Patients Receiving Biologic Therapy and Treatment.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Abbreviation: PCR, polymerase chain reaction.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Infectious Agent \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnostic Methods \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Strongyloides stercoralis</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Direct stool examination, stool culture, serologic testing \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Trypanosoma cruzi</span> (Chagas disease) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 different blood tests. PCR (only if serology is positive) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Plasmodium falciparum</span> (if the patient has been in Spain<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>2 y) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Peripheral blood smear, immunochromatography, PCR \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Entamoeba histolytica</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Serology \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Human T-lymphotrophic virus type 1</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Serology \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Endemic mycoses (<span class="elsevierStyleItalic">Histoplasma, Coccidioides, Paracoccidioides, Blastomyces)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Serology \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1406724.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Screening for Nontuberculous Opportunistic Infections Recommended in Patients From Endemic Areas Before Initiation of Biologic Therapy.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chagas’ disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Bern" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra1410150" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2015" "volumen" => "373" "paginaInicial" => "456" "paginaFinal" => "466" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26222561" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunosuppression and Chagas disease: A management challenge" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.J. Pinazo" 1 => "G. Espinosa" 2 => "C. Cortes-Lletget" 3 => "E. de J. Posada" 4 => "E. Aldasoro" 5 => "I. Oliveira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pntd.0001965" "Revista" => array:5 [ "tituloSerie" => "PLoS Negl Trop Dis" "fecha" => "2013" "volumen" => "7" "paginaInicial" => "e1965" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23349998" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Uncommon infections to consider when prescribing biological agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Rivera" 1 => "F. Vanaclocha" 2 => "M. Lizasoaín" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Piel (Barc)" "fecha" => "2013" "volumen" => "28" "paginaInicial" => "31" "paginaFinal" => "36" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Valledor A, Fernandez V, Stanek V, Barcan L. Primer reporte de reactivación de enfermedad de Chagas asociado a infliximab. Communication presented at XV Congreso Argentino de la Sociedad Argentina de Infectología. Buenos Aires, May 28–30, 2015. Sociedad Argentina de Infectología." ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of tumor necrosis factor alpha (TNF-α) antagonists in a patient with psoriasis and Chagas disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Navarrete-Dechent" 1 => "D. Majerson" 2 => "M. Torres" 3 => "D. Armijo" 4 => "M. Patel" 5 => "A. Menter" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/abd1806-4841.20153538" "Revista" => array:7 [ "tituloSerie" => "An Bras Dermatol" "fecha" => "2015" "volumen" => "90" "numero" => "S 1" "paginaInicial" => "171" "paginaFinal" => "174" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26312707" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunosuppression and Chagas disease; experience from a non-endemic country" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Salvador" 1 => "A. Sánchez-Montalvá" 2 => "L. Valerio" 3 => "N. Serre" 4 => "S. Roure" 5 => "B. Treviño" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cmi.2015.05.033" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Infect" "fecha" => "2015" "volumen" => "21" "paginaInicial" => "854" "paginaFinal" => "860" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26055418" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical infection with <span class="elsevierStyleItalic">Strongyloides stercoralis</span> following etanercept use for rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.D. Boatright" 1 => "B.W. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.20882" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2005" "volumen" => "52" "paginaInicial" => "1336" "paginaFinal" => "1337" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15818680" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Strongyloides stercoralis</span> hyperinfection in a patient with rheumatoid arthritis after anti-TNF-alpha therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Krishnamurthy" 1 => "H.E. Dincer" 2 => "D. Whittemore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/RHU.0b013e3180690933" "Revista" => array:6 [ "tituloSerie" => "J Clin Rheumatol" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "150" "paginaFinal" => "152" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17551383" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Strongyloides stercolaris</span> in a patient with rheumatoid arthritis undergoing treatment with etanercept" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Revuelta Evrard" 1 => "P.V. García Morales" 2 => "A. Gallego Flores" 3 => "A. Sánchez Trenado" 4 => "C. Rubio Caja" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1699-258X(08)71805-9" "Revista" => array:6 [ "tituloSerie" => "Reumatol Clin" "fecha" => "2008" "volumen" => "4" "paginaInicial" => "77" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21794503" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Strongyloides stercoralis</span> in a patient with ankylosing spondylitis: Case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K. Yanık" 1 => "A. Karadağ" 2 => "H. Odabaşı" 3 => "N. Unal" 4 => "L. Altıntop" 5 => "M. Hökelek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5152/tpd.2013.31" "Revista" => array:6 [ "tituloSerie" => "Turkiye Parazitol Derg" "fecha" => "2013" "volumen" => "37" "paginaInicial" => "143" "paginaFinal" => "146" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23955914" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack280253" "titulo" => "Acknowledgments" "texto" => "<p id="par0040" class="elsevierStylePara elsevierViewall">We thank the Microbiology Department of Hospital Universitario La Paz for collaboration on this article.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010800000004/v1_201704280927/S1578219017300471/v1_201704280927/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010800000004/v1_201704280927/S1578219017300471/v1_201704280927/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300471?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 4 | 12 |
| 2024 October | 70 | 34 | 104 |
| 2024 September | 81 | 23 | 104 |
| 2024 August | 114 | 54 | 168 |
| 2024 July | 97 | 23 | 120 |
| 2024 June | 111 | 32 | 143 |
| 2024 May | 60 | 40 | 100 |
| 2024 April | 106 | 20 | 126 |
| 2024 March | 82 | 33 | 115 |
| 2024 February | 60 | 28 | 88 |
| 2024 January | 56 | 33 | 89 |
| 2023 December | 60 | 23 | 83 |
| 2023 November | 63 | 30 | 93 |
| 2023 October | 74 | 24 | 98 |
| 2023 September | 49 | 39 | 88 |
| 2023 August | 60 | 12 | 72 |
| 2023 July | 74 | 40 | 114 |
| 2023 June | 86 | 30 | 116 |
| 2023 May | 58 | 21 | 79 |
| 2023 April | 50 | 27 | 77 |
| 2023 March | 69 | 20 | 89 |
| 2023 February | 52 | 10 | 62 |
| 2023 January | 39 | 26 | 65 |
| 2022 December | 74 | 37 | 111 |
| 2022 November | 48 | 30 | 78 |
| 2022 October | 28 | 16 | 44 |
| 2022 September | 23 | 35 | 58 |
| 2022 August | 62 | 35 | 97 |
| 2022 July | 60 | 33 | 93 |
| 2022 June | 23 | 27 | 50 |
| 2022 May | 62 | 38 | 100 |
| 2022 April | 97 | 26 | 123 |
| 2022 March | 111 | 43 | 154 |
| 2022 February | 105 | 34 | 139 |
| 2022 January | 80 | 31 | 111 |
| 2021 December | 55 | 40 | 95 |
| 2021 November | 74 | 44 | 118 |
| 2021 October | 50 | 45 | 95 |
| 2021 September | 40 | 33 | 73 |
| 2021 August | 33 | 32 | 65 |
| 2021 July | 31 | 26 | 57 |
| 2021 June | 31 | 26 | 57 |
| 2021 May | 26 | 31 | 57 |
| 2021 April | 61 | 34 | 95 |
| 2021 March | 60 | 20 | 80 |
| 2021 February | 57 | 26 | 83 |
| 2021 January | 20 | 14 | 34 |
| 2020 December | 35 | 19 | 54 |
| 2020 November | 30 | 23 | 53 |
| 2020 October | 27 | 20 | 47 |
| 2020 September | 35 | 12 | 47 |
| 2020 August | 37 | 22 | 59 |
| 2020 July | 22 | 12 | 34 |
| 2020 June | 32 | 28 | 60 |
| 2020 May | 21 | 11 | 32 |
| 2020 April | 23 | 14 | 37 |
| 2020 March | 28 | 18 | 46 |
| 2020 February | 4 | 0 | 4 |
| 2020 January | 4 | 0 | 4 |
| 2019 December | 4 | 0 | 4 |
| 2019 November | 3 | 0 | 3 |
| 2019 September | 7 | 0 | 7 |
| 2019 August | 4 | 0 | 4 |
| 2019 July | 4 | 0 | 4 |
| 2019 June | 5 | 0 | 5 |
| 2019 May | 6 | 1 | 7 |
| 2019 April | 15 | 3 | 18 |
| 2019 March | 2 | 0 | 2 |
| 2019 February | 4 | 0 | 4 |
| 2019 January | 2 | 0 | 2 |
| 2018 December | 10 | 0 | 10 |
| 2018 November | 3 | 0 | 3 |
| 2018 October | 3 | 1 | 4 |
| 2018 September | 5 | 0 | 5 |
| 2018 February | 57 | 4 | 61 |
| 2018 January | 51 | 3 | 54 |
| 2017 December | 100 | 8 | 108 |
| 2017 November | 31 | 6 | 37 |
| 2017 October | 24 | 6 | 30 |
| 2017 September | 29 | 19 | 48 |
| 2017 August | 29 | 29 | 58 |
| 2017 July | 25 | 19 | 44 |
| 2017 June | 45 | 9 | 54 |
| 2017 May | 55 | 29 | 84 |
| 2017 April | 22 | 12 | 34 |
| 2017 March | 1 | 5 | 6 |
Show all
