Resident's Forum
RF–Burning Mouth Syndrome: New Treatments
FR–Glosodinia: novedades terapéuticas
H. Cembrero-Saralegui, A. Imbernón-Moya
Corresponding author
Servicio de Dermatología, del Hospital Universitario Severo Ochoa, Leganés, Madrid, España
Read
7558
Timeswas read the article
2547
Total PDF
5011
Total HTML
Share statistics
array:24 [ "pii" => "S1578219016302736" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.11.003" "estado" => "S300" "fechaPublicacion" => "2017-01-01" "aid" => "1506" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2016" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2017;108:63-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1034 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 688 "PDF" => 308 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731016303143" "issn" => "00017310" "doi" => "10.1016/j.ad.2016.08.005" "estado" => "S300" "fechaPublicacion" => "2017-01-01" "aid" => "1506" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2017;108:63-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 475 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 323 "PDF" => 149 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Foro de Residentes</span>" "titulo" => "FR–Glosodinia: novedades terapéuticas" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "63" "paginaFinal" => "64" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "RF–Burning Mouth Syndrome: New Treatments" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "H. Cembrero-Saralegui, A. Imbernón-Moya" "autores" => array:2 [ 0 => array:2 [ "nombre" => "H." "apellidos" => "Cembrero-Saralegui" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Imbernón-Moya" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219016302736" "doi" => "10.1016/j.adengl.2016.11.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302736?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016303143?idApp=UINPBA000044" "url" => "/00017310/0000010800000001/v1_201612270122/S0001731016303143/v1_201612270122/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219016302827" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.11.004" "estado" => "S300" "fechaPublicacion" => "2017-01-01" "aid" => "1483" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:65-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1132 "formatos" => array:3 [ "EPUB" => 60 "HTML" => 801 "PDF" => 271 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Vídeos de cirugía dermatológica</span>" "titulo" => "Screening for Anal Intraepithelial Neoplasia: High-Resolution Anoscopy-Guided Biopsy of the Anal Canal" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "65" "paginaFinal" => "66" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Despistaje de la neoplasia intraepitelial anal. Biopsia de canal anal guiada por anoscopia de alta resolución" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.B. Repiso-Jiménez, L. Padilla-Espana, T. Fernández-Morano, M. de Troya-Martín" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.B." "apellidos" => "Repiso-Jiménez" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Padilla-Espana" ] 2 => array:2 [ "nombre" => "T." "apellidos" => "Fernández-Morano" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "de Troya-Martín" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016302824" "doi" => "10.1016/j.ad.2016.07.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016302824?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302827?idApp=UINPBA000044" "url" => "/15782190/0000010800000001/v1_201612300037/S1578219016302827/v1_201612300037/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219016303031" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.11.016" "estado" => "S300" "fechaPublicacion" => "2017-01-01" "aid" => "1414" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2017;108:61-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 800 "formatos" => array:3 [ "EPUB" => 53 "HTML" => 540 "PDF" => 207 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>" "titulo" => "Indurated Plaque on the Upper Lip of a Patient With Multiple Myeloma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "61" "paginaFinal" => "62" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Placa infiltrada en labio superior de paciente con mieloma múltiple" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 415 "Ancho" => 990 "Tamanyo" => 152627 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, CD3 ×4. B, CD20 ×20. gr2.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Ramos-Rodríguez, L. González-López, M. García-Arpa" "autores" => array:3 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Ramos-Rodríguez" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "González-López" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "García-Arpa" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016300710" "doi" => "10.1016/j.ad.2015.09.027" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016300710?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016303031?idApp=UINPBA000044" "url" => "/15782190/0000010800000001/v1_201612300037/S1578219016303031/v1_201612300037/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Resident's Forum</span>" "titulo" => "RF–Burning Mouth Syndrome: New Treatments" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "63" "paginaFinal" => "64" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "H. Cembrero-Saralegui, A. Imbernón-Moya" "autores" => array:2 [ 0 => array:2 [ "nombre" => "H." "apellidos" => "Cembrero-Saralegui" ] 1 => array:4 [ "nombre" => "A." "apellidos" => "Imbernón-Moya" "email" => array:1 [ 0 => "adrian_imber88@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, del Hospital Universitario Severo Ochoa, Leganés, Madrid, España" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "FR–Glosodinia: novedades terapéuticas" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Glossodynia is a medical disease of unknown etiology and pathogenesis, in which interest has grown in the last decade. Its exact prevalence is not known, but is estimated to be between 0.7% and 15% of the general population; it is most common in postmenopausal women.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Glossodynia is defined clinically as a subjective sensation of burning, soreness, or pain that occurs daily and may occasionally be associated with dysgeusia or xerostomia, with no detectable lesions on the oral mucosa. The condition is characterized by its chronic course, the absence of local or systemic disease, and the high prevalence of psychiatric comorbidities, the most common of which are depression and anxiety.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">No guidelines exist regarding treatment. However, a number of therapeutic alternatives have been employed, based on scant scientific evidence of limited quality, with modest results. The results of clinical trials are difficult to compare because of the lack of uniformity of patient selection criteria, treatments, doses, and therapeutic response measures.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The various topical and oral treatments that have been used are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. The treatments with greatest scientific evidence are currently α-lipoic acid and clonazepam.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">α-Lipoic acid is an antioxidant and neuroprotective agent that, at a dose of 600<span class="elsevierStyleHsp" style=""></span>mg/d, has been shown to provide a short-term improvement of symptoms, with an efficacy between 55% and 90%, depending on the study.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3,4</span></a> Clonazepam can lead to partial improvement, between 70% and 80%, with a duration of effect of 6 months.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3,5</span></a> Factors predicting a better therapeutic response to clonazepam include increased saliva flow, more intense symptoms, and the absence of concomitant use of other psychotropic drugs.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">A 6-month course of cognitive therapy has been useful in reducing symptom intensity in 27% of patients.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Selective serotonin reuptake inhibitors (SSRI), including paroxetine and sertraline, can be useful in patients with associated depression; higher levels of evidence are found for paroxetine, with a partial response in 80% of patients after 12 weeks. Another advantage of the SSRIs is the absence of anticholinergic effects, such as dryness of the mouth.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The tricyclic antidepressants, such as amitriptyline and nortriptyline, and dual inhibitors, such as duloxetine, are often used in neuropathic disorders, and it has been suggested that they may be effective, but no studies are available to support this assertion.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Nor do studies exist to support the efficacy of gabapentin and pregabalin.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Several studies show a partial improvement with topical 0.02% capsaicin due to blockade of substance P. This can be given as mouthrinses with tabasco dissolved in water in a ratio between 1:8 and 1:1, though results are not highly significant.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1,4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion, glossodynia is a common cause for consultation. Management is complex and should be multidisciplinary, with a group of specialists in which the dermatologist is a key element. Data available at the present time are insufficient to establish specific management recommendations, and individualized treatment will vary according to patient characteristics, comorbid conditions, duration and intensity of the symptoms, and the presence of xerostomia.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-05-28" "fechaAceptado" => "2016-08-12" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec782736" "palabras" => array:5 [ 0 => "Glossodynia" 1 => "Burning mouth syndrome" 2 => "Treatment" 3 => "α-Lipoic acid" 4 => "Clonazepam" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Cembrero-Saralegui H, Imbernón-Moya A. FR–Glosodinia: novedades terapéuticas. Actas Dermosifiliogr. 2017;108:63–64.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Topical Treatments \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Oral Treatments \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">0.025% capsaicin cream \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">α-Lipoic acid, 600–800<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tabasco diluted 1:8–1:1 in water \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Clonazepam, 0.5–2<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2% lidocaine gel \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Paroxetine, 10–30<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Clonazepam, 0.5-1<span class="elsevierStyleHsp" style=""></span>mg up to 3 times/d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Sertraline, 50<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Doxepine, 10<span class="elsevierStyleHsp" style=""></span>mg/ml aqueous solution \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Amitriptyline, 5–100<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sucralfate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Duloxetine, 30–60<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Artificial saliva \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Amisulpiride 10–150<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sialogogue spray with 1% malic acid \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Gabapentin, 300–900<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Saliva substitutes (carboxymethycellulose and mucin) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pregabalin, 25–300<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Capsaicin, 0.25% capsules \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pilocarpine, 5–30<span class="elsevierStyleHsp" style=""></span>mg/d \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1302790.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Most Widely Used Therapeutic Options Described in the Literature.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapeutic options in idiopathic burning mouth syndrome: Literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I. Miziara" 1 => "A. Chagury" 2 => "C. Vargas" 3 => "L. Freitas" 4 => "A. Mahmoud" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-0034-1378138" "Revista" => array:6 [ "tituloSerie" => "Int Arch Otorhinolaryngol" "fecha" => "2015" "volumen" => "19" "paginaInicial" => "86" "paginaFinal" => "89" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25992157" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Burning mouth syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.A. Kamala" 1 => "S. Sankethguddad" 2 => "S.G. Sujith" 3 => "P. Tantradi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/0973-1075.173942" "Revista" => array:6 [ "tituloSerie" => "Indian J Palliat Care" "fecha" => "2016" "volumen" => "22" "paginaInicial" => "74" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26962284" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Burning mouth syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Zakrzewska" 1 => "J.A. Buchanan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "BMJ Clin Evid" "fecha" => "2016" "volumen" => "2016" "paginaInicial" => "1301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26745781" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Síndrome de la boca urente" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Brufau-Redondo" 1 => "R. Martín-Brufau" 2 => "R. Corbalán-Velez" 3 => "A. de Concepción-Salesa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "431" "paginaFinal" => "440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18558051" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An overview of burning mouth syndrome for the dermatologist" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.K. Lewis" 1 => "S.S. Prime" 2 => "S.N. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ced.12808" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "2016" "volumen" => "41" "paginaInicial" => "119" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26871710" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010800000001/v1_201612300037/S1578219016302736/v1_201612300037/en/main.assets" "Apartado" => array:4 [ "identificador" => "34945" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Resident's Forum" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010800000001/v1_201612300037/S1578219016302736/v1_201612300037/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302736?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 5 | 11 |
| 2024 October | 94 | 46 | 140 |
| 2024 September | 100 | 32 | 132 |
| 2024 August | 112 | 62 | 174 |
| 2024 July | 98 | 35 | 133 |
| 2024 June | 129 | 50 | 179 |
| 2024 May | 115 | 39 | 154 |
| 2024 April | 105 | 36 | 141 |
| 2024 March | 127 | 35 | 162 |
| 2024 February | 107 | 35 | 142 |
| 2024 January | 68 | 48 | 116 |
| 2023 December | 88 | 19 | 107 |
| 2023 November | 126 | 38 | 164 |
| 2023 October | 118 | 45 | 163 |
| 2023 September | 149 | 41 | 190 |
| 2023 August | 78 | 19 | 97 |
| 2023 July | 83 | 42 | 125 |
| 2023 June | 90 | 25 | 115 |
| 2023 May | 80 | 27 | 107 |
| 2023 April | 58 | 23 | 81 |
| 2023 March | 61 | 28 | 89 |
| 2023 February | 62 | 34 | 96 |
| 2023 January | 38 | 31 | 69 |
| 2022 December | 57 | 60 | 117 |
| 2022 November | 26 | 38 | 64 |
| 2022 October | 51 | 26 | 77 |
| 2022 September | 43 | 39 | 82 |
| 2022 August | 35 | 39 | 74 |
| 2022 July | 35 | 43 | 78 |
| 2022 June | 41 | 33 | 74 |
| 2022 May | 56 | 37 | 93 |
| 2022 April | 90 | 41 | 131 |
| 2022 March | 110 | 46 | 156 |
| 2022 February | 74 | 30 | 104 |
| 2022 January | 84 | 39 | 123 |
| 2021 December | 52 | 49 | 101 |
| 2021 November | 82 | 69 | 151 |
| 2021 October | 97 | 83 | 180 |
| 2021 September | 49 | 51 | 100 |
| 2021 August | 84 | 44 | 128 |
| 2021 July | 64 | 60 | 124 |
| 2021 June | 62 | 46 | 108 |
| 2021 May | 86 | 51 | 137 |
| 2021 April | 168 | 67 | 235 |
| 2021 March | 121 | 60 | 181 |
| 2021 February | 65 | 49 | 114 |
| 2021 January | 82 | 50 | 132 |
| 2020 December | 56 | 47 | 103 |
| 2020 November | 44 | 32 | 76 |
| 2020 October | 52 | 25 | 77 |
| 2020 September | 64 | 24 | 88 |
| 2020 August | 52 | 39 | 91 |
| 2020 July | 78 | 32 | 110 |
| 2020 June | 67 | 39 | 106 |
| 2020 May | 45 | 23 | 68 |
| 2020 April | 30 | 15 | 45 |
| 2020 March | 27 | 18 | 45 |
| 2020 February | 2 | 0 | 2 |
| 2020 January | 4 | 0 | 4 |
| 2019 December | 6 | 0 | 6 |
| 2019 November | 4 | 0 | 4 |
| 2019 September | 7 | 0 | 7 |
| 2019 August | 4 | 0 | 4 |
| 2019 July | 4 | 0 | 4 |
| 2019 June | 6 | 0 | 6 |
| 2019 May | 4 | 0 | 4 |
| 2019 April | 2 | 11 | 13 |
| 2019 March | 2 | 0 | 2 |
| 2019 February | 4 | 0 | 4 |
| 2019 January | 4 | 0 | 4 |
| 2018 December | 8 | 0 | 8 |
| 2018 November | 6 | 0 | 6 |
| 2018 October | 3 | 0 | 3 |
| 2018 September | 4 | 0 | 4 |
| 2018 May | 0 | 1 | 1 |
| 2018 March | 0 | 1 | 1 |
| 2018 February | 30 | 6 | 36 |
| 2018 January | 40 | 9 | 49 |
| 2017 December | 44 | 10 | 54 |
| 2017 November | 33 | 9 | 42 |
| 2017 October | 24 | 14 | 38 |
| 2017 September | 26 | 5 | 31 |
| 2017 August | 31 | 13 | 44 |
| 2017 July | 25 | 5 | 30 |
| 2017 June | 56 | 14 | 70 |
| 2017 May | 47 | 10 | 57 |
| 2017 April | 47 | 14 | 61 |
| 2017 March | 53 | 34 | 87 |
| 2017 February | 71 | 62 | 133 |
| 2017 January | 78 | 50 | 128 |
| 2016 December | 11 | 35 | 46 |
| 2016 November | 0 | 5 | 5 |
Show all
