Case and Research Letter
Allergic Contact Dermatitis Due to Capryloyl Salicylic Acid
Dermatitis alérgica de contacto por ácido capriloil salicílico
R. González-Pérez
, L. Carnero-González, M.I. Martínez-González
Corresponding author
Servicio de Dermatología, Hospital Universitario Araba, Vitoria-Gasteiz, Araba, Spain
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González-Pérez, L. Carnero-González, M.I. Martínez-González" "autores" => array:3 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "González-Pérez" "email" => array:1 [ 0 => "ricardo.gonzalezperez@osakidetza.eus" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Carnero-González" ] 2 => array:2 [ "nombre" => "M.I." "apellidos" => "Martínez-González" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Araba, Vitoria-Gasteiz, Araba, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatitis alérgica de contacto por ácido capriloil salicílico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 602 "Ancho" => 803 "Tamanyo" => 65070 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Positive allergic reaction to capryloyl salicylic acid.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">When cosmetic allergy is suspected, it is essential to include the personal care products used by the patient in the patch tests as not only will this facilitate a more exact diagnosis, but also it may make it possible to identify new allergens. The collaboration of the pharmaceutical and cosmetics industries is fundamental to this approach, as it is those companies that will have to supply us with the components of the specific products. We present a case of allergic contact dermatitis to capryloyl salicylic acid present in an antiwrinkle cream. A 40-year-old woman consulted for a pruritic erythematous rash that arose on her face 10 days after starting to apply an antiwrinkle cream (Revitalift Laser X3 Day Cream by L’Oreal). The condition resolved after interruption of the use of the cream and a week of treatment with a topical corticosteroid. Patch testing was performed using the standard series of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC), a cosmetics series (Chemotechnique, Sweden), and the specific cream used by the patient, with readings taken at 48 and 96<span class="elsevierStyleHsp" style=""></span>hours, in accordance with the recommendations of the European Society of Contact Dermatitis (ESCD). In the final reading at 96<span class="elsevierStyleHsp" style=""></span>hours, a positive reaction (++) was observed to the specific cream used by the patient and negative reactions to the other allergens in the standard and cosmetics series. We contacted the company that marketed the cream involved and they provided us with the 27 ingredients of the cream, thus enabling us to complete the study. A positive allergic reaction (++) to 1% capryloyl salicylic acid in alcohol was observed in the readings taken at 48 and 96<span class="elsevierStyleHsp" style=""></span>hours (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). This same substance showed no allergic responses after patch testing in 15 healthy controls.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Capryloyl salicylic acid (5-capryloyl salicylic acid, CAS no. 78418-01-6, also known as 2-hydroxy-5-octanoylbenzoic acid) is a lipophilic derivative of salicylic acid that promotes epidermal renewal, stimulates collagen formation, combats chronic actinic photodamage,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> and increases skin resilience to UV radiation. It is attributed comedolytic,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> antiacne,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> antibacterial, and anti-inflammatory<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> properties. This substance is widely used, mainly by the French cosmetics industry, and it can be included in facial emollients, antiaging formulations, products for the treatment of acne, sunscreens, and facial hygiene products.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">De Groot et al.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> recently published the first 2 cases of contact allergy to capryloyl salicylic acid, using 1% capryloyl salicylic acid in alcohol in the patch testing of their patients. According to those authors, the allergenicity of this substance may derive more from the salicylic or benzoic part of the molecule that from the caprylic acid fraction. However, Roberts et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> concluded that 5-capryloyl salicylic acid was probably not the agent responsible for the allergy of the patients described by de Groot et al.; in their opinion, the allergy was due to its 3-capryloyl salicylic acid isomer, a contaminant of 5-capryloyl salicylic acid.</p><p id="par0020" class="elsevierStylePara elsevierViewall">We have described a third case of allergic contact dermatitis to capryloyl salicylic acid, the diagnosis of which was made possible by patch testing the ingredients provided by the company marketing the cream used by the patient, as these substances are not included in other test series. The description of further cases in which capryloyl salicylic acid is implicated will clarify the allergenic potential of this substance.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: González-Pérez R, Carnero-González L, Martínez-González MI. Dermatitis alérgica de contacto por ácido capriloil salicílico. Actas Dermosifiliogr. 2016;107:694–695.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 602 "Ancho" => 803 "Tamanyo" => 65070 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Positive allergic reaction to capryloyl salicylic acid.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. 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Verschoore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1473-2165.2007.00296.x" "Revista" => array:6 [ "tituloSerie" => "J Cosmet Dermatol" "fecha" => "2007" "volumen" => "6" "paginaInicial" => "59" "paginaFinal" => "65" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17348998" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact allergy to capryloyl salicylic acid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. De Groot" 1 => "T. Rustemeyer" 2 => "D. Hissink" 3 => "M. Bakker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cod.12239" "Revista" => array:7 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2014" "volumen" => "71" "paginaInicial" => "185" "paginaFinal" => "187" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25155078" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0302283808002947" "estado" => "S300" "issn" => "03022838" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact allergy to capryloyl salicylic acid: A mechanistic chemistry and structure-activity perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.W. Roberts" 1 => "A.O. Aptula" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cod.12368" "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2015" "volumen" => "72" "paginaInicial" => "347" "paginaFinal" => "351" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25720316" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010700000008/v2_201704100057/S1578219016301603/v2_201704100057/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000008/v2_201704100057/S1578219016301603/v2_201704100057/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016301603?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 13 | 9 | 22 |
| 2024 October | 176 | 47 | 223 |
| 2024 September | 181 | 24 | 205 |
| 2024 August | 226 | 58 | 284 |
| 2024 July | 220 | 32 | 252 |
| 2024 June | 184 | 25 | 209 |
| 2024 May | 212 | 37 | 249 |
| 2024 April | 208 | 21 | 229 |
| 2024 March | 202 | 27 | 229 |
| 2024 February | 187 | 36 | 223 |
| 2024 January | 170 | 32 | 202 |
| 2023 December | 146 | 28 | 174 |
| 2023 November | 271 | 63 | 334 |
| 2023 October | 197 | 24 | 221 |
| 2023 September | 242 | 43 | 285 |
| 2023 August | 236 | 31 | 267 |
| 2023 July | 233 | 42 | 275 |
| 2023 June | 170 | 40 | 210 |
| 2023 May | 133 | 69 | 202 |
| 2023 April | 143 | 25 | 168 |
| 2023 March | 137 | 43 | 180 |
| 2023 February | 110 | 31 | 141 |
| 2023 January | 74 | 32 | 106 |
| 2022 December | 75 | 38 | 113 |
| 2022 November | 47 | 23 | 70 |
| 2022 October | 51 | 22 | 73 |
| 2022 September | 24 | 37 | 61 |
| 2022 August | 28 | 34 | 62 |
| 2022 July | 33 | 38 | 71 |
| 2022 June | 31 | 35 | 66 |
| 2022 May | 78 | 42 | 120 |
| 2022 April | 101 | 43 | 144 |
| 2022 March | 99 | 56 | 155 |
| 2022 February | 89 | 31 | 120 |
| 2022 January | 123 | 35 | 158 |
| 2021 December | 84 | 40 | 124 |
| 2021 November | 94 | 61 | 155 |
| 2021 October | 116 | 57 | 173 |
| 2021 September | 94 | 46 | 140 |
| 2021 August | 90 | 40 | 130 |
| 2021 July | 79 | 29 | 108 |
| 2021 June | 99 | 28 | 127 |
| 2021 May | 80 | 38 | 118 |
| 2021 April | 181 | 34 | 215 |
| 2021 March | 121 | 29 | 150 |
| 2021 February | 111 | 36 | 147 |
| 2021 January | 83 | 19 | 102 |
| 2020 December | 77 | 16 | 93 |
| 2020 November | 64 | 20 | 84 |
| 2020 October | 80 | 16 | 96 |
| 2020 September | 74 | 27 | 101 |
| 2020 August | 56 | 21 | 77 |
| 2020 July | 71 | 17 | 88 |
| 2020 June | 58 | 33 | 91 |
| 2020 May | 68 | 24 | 92 |
| 2020 April | 68 | 21 | 89 |
| 2020 March | 28 | 16 | 44 |
| 2020 February | 5 | 4 | 9 |
| 2020 January | 6 | 0 | 6 |
| 2019 December | 8 | 0 | 8 |
| 2019 November | 4 | 0 | 4 |
| 2019 September | 4 | 0 | 4 |
| 2019 August | 6 | 0 | 6 |
| 2019 July | 4 | 0 | 4 |
| 2019 June | 4 | 0 | 4 |
| 2019 May | 7 | 1 | 8 |
| 2019 April | 6 | 6 | 12 |
| 2019 March | 4 | 0 | 4 |
| 2019 February | 1 | 0 | 1 |
| 2019 January | 2 | 0 | 2 |
| 2018 December | 5 | 0 | 5 |
| 2018 November | 1 | 0 | 1 |
| 2018 October | 3 | 0 | 3 |
| 2018 September | 2 | 0 | 2 |
| 2018 April | 0 | 1 | 1 |
| 2018 February | 81 | 3 | 84 |
| 2018 January | 65 | 13 | 78 |
| 2017 December | 78 | 8 | 86 |
| 2017 November | 68 | 8 | 76 |
| 2017 October | 66 | 9 | 75 |
| 2017 September | 46 | 8 | 54 |
| 2017 August | 42 | 9 | 51 |
| 2017 July | 31 | 6 | 37 |
| 2017 June | 34 | 19 | 53 |
| 2017 May | 43 | 16 | 59 |
| 2017 April | 49 | 14 | 63 |
| 2017 March | 37 | 17 | 54 |
| 2017 February | 32 | 16 | 48 |
| 2017 January | 29 | 13 | 42 |
| 2016 December | 26 | 26 | 52 |
| 2016 November | 34 | 25 | 59 |
| 2016 October | 68 | 32 | 100 |
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