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for which she was on treatment with amlodipine&#46; She described no temporal relationship between taking amlodipine or other drugs and onset of the hyperpigmentation&#44; and she denied taking other drugs or applying topical products to the area&#46; No treatment had been performed&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient&#44; with skin phototype <span class="elsevierStyleSmallCaps">V</span>&#44; presented multiple confluent macules of a few millimeters in diameter on her forehead&#44; also extending into both parietal regions&#44; grouped so as to form a large&#44; poorly defined&#44; bluish-gray macule of mottled appearance&#46; The macule was not infiltrated and no superficial desquamation was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No lesions were observed in the conjunctiva or on the oral mucosa&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Biopsy revealed a proliferation of dendritic melanocytes in the mid dermis&#44; with no atypia &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; confirmed with Masson-Fontana stain&#46; No nonmelanic pigment deposits were observed&#46; All the findings were compatible with Hori nevus&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Hori nevus&#44; also known as ABNOM &#40;acquired bilateral nevus of Ota-like macules&#41;&#44; is one of the most common acquired facial dermal melanocytoses&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> It was first described by Hori et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> in 1984&#46; It usually affects Asian women in the fourth or fifth decade of life&#46; Familial cases have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">4</span></a> Hori nevus presents as blue-gray-brown macules with a bilateral distribution on the forehead&#44; frontoparietal regions&#44; eyelids&#44; cheeks&#44; and nose&#46; There is no associated ocular or mucosal involvement&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> although a case with mucosal involvement has recently been described&#46; We consider that the clinical and pathologic findings of that case with mucosal involvement could correspond to a nevus of Ota&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The origin of this alteration is unknown&#46; The etiology and pathogenesis of Hori nevus appear to require the presence of poorly melanized ectopic melanocytes in the dermis&#44; by descent or migration from the epidermis or hair bulb &#40;<span class="elsevierStyleItalic">dropping off</span>&#41; or by disturbances of migration during embryologic development&#44; and the activation of these cells by UV radiation&#44; hormones&#44; chronic inflammation&#44; or other as yet undefined factors&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> Diagnosis is mainly clinical&#46; Histopathology reveals melanocytes in the mid and upper dermis&#44; with no fibrosis or alterations of normal dermal structure&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> Ultrastructurally&#44; these melanocytes are fully developed&#44; with stage <span class="elsevierStyleSmallCaps">II</span>&#44; <span class="elsevierStyleSmallCaps">III</span> and <span class="elsevierStyleSmallCaps">IV</span> melanosomes&#44; and are surrounded by an extracellular sheath whose thickness increases over time&#44; leading to lesion stability&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The main differential diagnoses are nevus of Ota&#44; Riehl melanosis&#44; ochronosis&#44; and melasma&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> Nevus of Ota is differentiated by an earlier age at onset&#44; a unilateral presentation&#44; and mucosal involvement&#46; Riehl melanosis and exogenous ochronosis are associated with a history of application of topical products prior to appearance of the lesions&#46; In endogenous ochronosis&#44; nonmelanic pigment is observed in the dermis&#46; Melasma shares certain clinical characteristics&#44; such as a female predominance&#44; involvement typically of the malar region&#44; and a common pathogenesis with increased expression of the SCF&#47;c-kit pathway&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> but the bluish-gray color of Hori nevus is not observed&#44;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">3&#44;7</span></a> and histopathologic findings are also different&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">8&#44;9</span></a> Histopathologic studies with healthy controls&#44; the reported findings characteristic of melasma are increased melanin deposits in the epidermis&#44; with normal or increased presence of epidermal melanocytes&#44; which can appear larger than usual&#44; with prominent dendrites&#44; sometimes associated with an increase in the number of melanophages&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">8&#44;9</span></a> Based on these findings&#44; although melasma has been subclassified into epidermal and dermal&#44; it is likely that the purely dermal forms are actually Hori nevus&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">With regard to treatment&#44; some authors report improvement with various Q-switched &#40;QS&#41; lasers &#40;QS yttrium-aluminium-garnet laser &#91;1064<span class="elsevierStyleHsp" style=""></span>nm&#93;&#44; QS alexandrite laser &#91;755<span class="elsevierStyleHsp" style=""></span>nm&#93;&#44; and QS ruby laser &#91;694<span class="elsevierStyleHsp" style=""></span>nm&#93;&#41;&#44; though results are variable and a transitory residual hyperpigmentation is the norm&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1&#44;10&#8211;13</span></a> To reduce this residual hyperpigmentation combined treatments with QS laser and bleaching agents&#44; dermabrasion&#44; or carbon dioxide laser have been used&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1&#44;12</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; Hori nevus is a cause of acquired facial hyperpigmentation that should be considered in daily clinical practice&#46;</p></span>"
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Case and Research Letters
Acquired Symmetric Facial Hyperpigmentation
Hiperpigmentación facial simétrica adquirida
M. González-Olivares
Corresponding author
mgonzalezo@salud.madrid.org

Corresponding author.
, L. Castillo-Fernández, B. Echeverría
Servicio de Dermatología y Anatomía Patológica, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0050" class="elsevierStylePara elsevierViewall">Dermal melanocytoses are a broad group of congenital or acquired melanocytic lesions that share the histopathologic feature of dendritic melanocytes in the dermis&#44; with variable degrees of pigmentation and with or without dermal melanophages&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> This group includes the mongolian spot&#44; blue nevus&#44; nevus of Ota&#44; nevus of Ito&#44; Hori nevus and other less frequent entities&#44; known as atypical dermal melanocytoses&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 35-year-old Nigerian woman who consulted for progressive asymptomatic facial hyperpigmentation that had started to develop on her forehead 2 years earlier&#46; The only finding in her past medical history was systemic hypertension&#44; for which she was on treatment with amlodipine&#46; She described no temporal relationship between taking amlodipine or other drugs and onset of the hyperpigmentation&#44; and she denied taking other drugs or applying topical products to the area&#46; No treatment had been performed&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient&#44; with skin phototype <span class="elsevierStyleSmallCaps">V</span>&#44; presented multiple confluent macules of a few millimeters in diameter on her forehead&#44; also extending into both parietal regions&#44; grouped so as to form a large&#44; poorly defined&#44; bluish-gray macule of mottled appearance&#46; The macule was not infiltrated and no superficial desquamation was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No lesions were observed in the conjunctiva or on the oral mucosa&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Biopsy revealed a proliferation of dendritic melanocytes in the mid dermis&#44; with no atypia &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; confirmed with Masson-Fontana stain&#46; No nonmelanic pigment deposits were observed&#46; All the findings were compatible with Hori nevus&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Hori nevus&#44; also known as ABNOM &#40;acquired bilateral nevus of Ota-like macules&#41;&#44; is one of the most common acquired facial dermal melanocytoses&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> It was first described by Hori et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> in 1984&#46; It usually affects Asian women in the fourth or fifth decade of life&#46; Familial cases have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">4</span></a> Hori nevus presents as blue-gray-brown macules with a bilateral distribution on the forehead&#44; frontoparietal regions&#44; eyelids&#44; cheeks&#44; and nose&#46; There is no associated ocular or mucosal involvement&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> although a case with mucosal involvement has recently been described&#46; We consider that the clinical and pathologic findings of that case with mucosal involvement could correspond to a nevus of Ota&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The origin of this alteration is unknown&#46; The etiology and pathogenesis of Hori nevus appear to require the presence of poorly melanized ectopic melanocytes in the dermis&#44; by descent or migration from the epidermis or hair bulb &#40;<span class="elsevierStyleItalic">dropping off</span>&#41; or by disturbances of migration during embryologic development&#44; and the activation of these cells by UV radiation&#44; hormones&#44; chronic inflammation&#44; or other as yet undefined factors&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> Diagnosis is mainly clinical&#46; Histopathology reveals melanocytes in the mid and upper dermis&#44; with no fibrosis or alterations of normal dermal structure&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> Ultrastructurally&#44; these melanocytes are fully developed&#44; with stage <span class="elsevierStyleSmallCaps">II</span>&#44; <span class="elsevierStyleSmallCaps">III</span> and <span class="elsevierStyleSmallCaps">IV</span> melanosomes&#44; and are surrounded by an extracellular sheath whose thickness increases over time&#44; leading to lesion stability&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The main differential diagnoses are nevus of Ota&#44; Riehl melanosis&#44; ochronosis&#44; and melasma&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> Nevus of Ota is differentiated by an earlier age at onset&#44; a unilateral presentation&#44; and mucosal involvement&#46; Riehl melanosis and exogenous ochronosis are associated with a history of application of topical products prior to appearance of the lesions&#46; In endogenous ochronosis&#44; nonmelanic pigment is observed in the dermis&#46; Melasma shares certain clinical characteristics&#44; such as a female predominance&#44; involvement typically of the malar region&#44; and a common pathogenesis with increased expression of the SCF&#47;c-kit pathway&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> but the bluish-gray color of Hori nevus is not observed&#44;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">3&#44;7</span></a> and histopathologic findings are also different&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">8&#44;9</span></a> Histopathologic studies with healthy controls&#44; the reported findings characteristic of melasma are increased melanin deposits in the epidermis&#44; with normal or increased presence of epidermal melanocytes&#44; which can appear larger than usual&#44; with prominent dendrites&#44; sometimes associated with an increase in the number of melanophages&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">8&#44;9</span></a> Based on these findings&#44; although melasma has been subclassified into epidermal and dermal&#44; it is likely that the purely dermal forms are actually Hori nevus&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">With regard to treatment&#44; some authors report improvement with various Q-switched &#40;QS&#41; lasers &#40;QS yttrium-aluminium-garnet laser &#91;1064<span class="elsevierStyleHsp" style=""></span>nm&#93;&#44; QS alexandrite laser &#91;755<span class="elsevierStyleHsp" style=""></span>nm&#93;&#44; and QS ruby laser &#91;694<span class="elsevierStyleHsp" style=""></span>nm&#93;&#41;&#44; though results are variable and a transitory residual hyperpigmentation is the norm&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1&#44;10&#8211;13</span></a> To reduce this residual hyperpigmentation combined treatments with QS laser and bleaching agents&#44; dermabrasion&#44; or carbon dioxide laser have been used&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">1&#44;12</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; Hori nevus is a cause of acquired facial hyperpigmentation that should be considered in daily clinical practice&#46;</p></span>"
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