array:24 [
  "pii" => "S1578219015002681"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.10.008"
  "estado" => "S300"
  "fechaPublicacion" => "2015-12-01"
  "aid" => "1224"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2015;106:852-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 839
    "formatos" => array:3 [
      "EPUB" => 54
      "HTML" => 512
      "PDF" => 273
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015003282"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2015.04.017"
      "estado" => "S300"
      "fechaPublicacion" => "2015-12-01"
      "aid" => "1224"
      "copyright" => "Elsevier España, S.L.U. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2015;106:852-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 553
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 312
          "PDF" => 238
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Cartas cient&#237;fico-cl&#237;nicas</span>"
        "titulo" => "Enfermedad de Hailey-Hailey recalcitrante con buena respuesta a terapia fotodin&#225;mica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "852"
            "paginaFinal" => "854"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Refractory Hailey-Hailey Disease That Responded Well to Photodynamic Therapy"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 1210
                "Ancho" => 975
                "Tamanyo" => 116532
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Lesiones axilares resueltas tras realizar una sesi&#243;n con TFD&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Lobato-Berezo, A&#46; Imbern&#243;n-Moya, A&#46; Aguilar-Mart&#237;nez"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Lobato-Berezo"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Imbern&#243;n-Moya"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Aguilar-Mart&#237;nez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002681"
          "doi" => "10.1016/j.adengl.2015.10.008"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002681?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003282?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000010/v1_201512080105/S0001731015003282/v1_201512080105/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002693"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.10.009"
    "estado" => "S300"
    "fechaPublicacion" => "2015-12-01"
    "aid" => "1227"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2015;106:854-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1575
      "formatos" => array:3 [
        "EPUB" => 51
        "HTML" => 797
        "PDF" => 727
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Mast Cells and Scarring Alopecia&#58; Is There a Clear Pathophysiological Relationship&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "854"
          "paginaFinal" => "857"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Mastocitos y alopecia cicatricial&#58; &#191;hay una clara relaci&#243;n fisiopatol&#243;gica&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1194
              "Ancho" => 1800
              "Tamanyo" => 435750
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44;<span class="elsevierStyleHsp" style=""></span>Presence of fibrosis replacing and destroying the follicle&#44; and absence of epidermal involvement &#40;hematoxylin-eosin&#44; original magnification &#215; 10&#41;&#46; B&#44;<span class="elsevierStyleHsp" style=""></span>Difference between follicular fibrosis and normal&#44; interwoven collagen fibers &#40;hematoxylin-eosin&#44; original magnification &#215; 40&#41;&#46; C&#44;<span class="elsevierStyleHsp" style=""></span>Absence of lymphocytic infiltrate&#46; Presence of elevated numbers of mast cells &#40;hematoxylin-eosin&#44; original magnification &#215; 200&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Almodovar-Real, M&#46;A&#46; Diaz-Martinez, R&#46; Ruiz-Villaverde, R&#46; Naranjo-Sintes"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Almodovar-Real"
            ]
            1 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "Diaz-Martinez"
            ]
            2 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz-Villaverde"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Naranjo-Sintes"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015003312"
        "doi" => "10.1016/j.ad.2015.03.021"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003312?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002693?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000010/v1_201512060022/S1578219015002693/v1_201512060022/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S157821901500267X"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.10.007"
    "estado" => "S300"
    "fechaPublicacion" => "2015-12-01"
    "aid" => "1223"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2015;106:850-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 987
      "formatos" => array:3 [
        "EPUB" => 50
        "HTML" => 532
        "PDF" => 405
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Giant Vascular Eccrine Spiradenoma"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "850"
          "paginaFinal" => "852"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Espiradenoma ecrino vascular gigante"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1300
              "Ancho" => 975
              "Tamanyo" => 435538
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Organoid pattern of cell nests&#44; some of basaloid appearance with hyperchromatic nuclei and others with large clear cytoplasms&#44; separated by fibrous tracts containing abundant dilated and congestive vascular structures &#40;hematoxylin-eosin<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E&#46; Jorquera Barquero, C&#46; Lara Boh&#243;rquez, I&#46; de Alba Rioja"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Jorquera Barquero"
            ]
            1 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Lara Boh&#243;rquez"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "de Alba Rioja"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015003270"
        "doi" => "10.1016/j.ad.2015.03.019"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003270?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901500267X?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000010/v1_201512060022/S157821901500267X/v1_201512060022/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Refractory Hailey-Hailey Disease That Responded Well to Photodynamic Therapy"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "852"
        "paginaFinal" => "854"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Lobato-Berezo, A&#46; Imbern&#243;n-Moya, A&#46; Aguilar-Mart&#237;nez"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Lobato-Berezo"
            "email" => array:1 [
              0 => "allobe&#64;hotmail&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Imbern&#243;n-Moya"
          ]
          2 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Aguilar-Mart&#237;nez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Hospital Universitario Severo Ochoa&#44; Legan&#233;s&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Enfermedad de Hailey-Hailey recalcitrante con buena respuesta a terapia fotodin&#225;mica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1210
            "Ancho" => 975
            "Tamanyo" => 119528
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Resolution of axillary lesions following a single photodyamic therapy session&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Hailey-Hailey disease or familial benign pemphigus is a rare hereditary skin disease&#46; This chronic and recurrent condition can cause severe discomfort and be difficult to control with conventional treatments&#46; Photodynamic therapy &#40;PDT&#41; could offer an alternative in cases in which other treatment options have failed&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 56-year-old male who for 30 years had experienced several outbreaks a year of stinging&#44; itching&#44; and burning lesions located on the neck and armpits&#46; The lesions interfered with his daily activities and had a negative impact on his quality of life&#46; Physical examination revealed bright&#44; well-defined&#44; highly exudative&#44; eroded&#44; and erythematous plaques with some surface crusts located in both armpits and on the lateral aspects of the neck &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Histological study of a biopsied sample from one of the lesions demonstrated an epidermis with erosions and intraepidermal blisters&#44; marked acantholysis&#44; and the typical appearance of a dilapidated brick wall&#46; The patient had been diagnosed with Hailey-Hailey disease and had received multiple treatments with astringents such as copper and zinc sulfate &#40;1&#58;1000&#41;&#44; topical and systemic steroids&#44; topical vitamin D derivatives&#44; topical tacrolimus&#44; and acitretin&#46; Response to treatment had always been partial with a disease-free interval between flares lasting only a few weeks&#46; These shortcomings represented an important limitation for the patient&#46; He agreed to undergo a single session of PDT to see what the response would be and to assess the tolerability of the treatment&#46; First&#44; both underarms were cleaned with physiological saline solution and methyl aminolevulinate &#40;MAL&#41; cream was applied under occlusion for 3<span class="elsevierStyleHsp" style=""></span>hours&#46; The underarms were then irradiated with a red light &#40;Aktilite at 37<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#41; for 7&#46;5 minutes&#46; During the period of exposure&#44; the patient experienced a slight sensation of pain and burning&#44; which was well tolerated&#46; The response on follow-up at 2 weeks was excellent&#58; the erosions had healed&#44; the exudate and erythema had disappeared&#44; and the patient reported an improvement in his quality of life &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Six months later&#44; the patient is still free of lesions and has not undergone any other treatment&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Hailey-Hailey disease or familial benign pemphigus is an autosomal dominant genodermatosis caused by a mutation in the <span class="elsevierStyleItalic">ATP2C1</span> gene&#46; It is characterized by the appearance of vesicles&#44; blisters&#44; and erosions in flexural areas&#44; including the neck and axillas as well as the inframammary and inguinal folds&#46; Typically&#44; patients experience recurrent flares and&#44; occasionally&#44; spontaneous remission&#46; Among the best known precipitating factors are exposure to UV light&#44; sweat&#44; friction&#44; stress&#44; skin infections&#44; and pregnancy&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Many treatments have been used to control the disease with varying results&#46; Medical treatments include topical and systemic corticosteroids&#44; topical and systemic antibiotics&#44; topical vitamin D analogs&#44; topical 5-fluorouracil&#44; dapsone&#44; psoralen and UV-A light therapy&#44; systemic retinoids&#44; ciclosporin&#44; methotrexate&#44; and oral glycopyrrolate&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">2&#44;3</span></a> A number of invasive treatments have been attempted&#44; including infiltration with botulinum toxin&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> carbon dioxide laser&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">5&#44;6</span></a> erbium&#58; yttrium aluminium garnet laser&#44; and dermabrasion&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In the literature&#44; we found only 2 articles &#40;referring to 5 patients&#41; on Hailey-Hailey disease treated with PDT &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The age of the 5 patients ranged from 28 to 51 years and all but one were women&#46; The time elapsed since diagnosis ranged from 8 months to 24 years&#44; and all 5 patients had undergone prior treatment with topical corticosteroids and a topical vitamin D analog or an antibiotic&#46; Two of the patients had a complete response followed by a disease-free interval of 19 and 25 months&#44; respectively&#59; a further 2 patients showed partial improvement of their lesions&#44; and the remaining patient did not improve&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">7&#44;8</span></a> In the cases reported by Ruiz-Rodriguez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> PDT was well tolerated because lidocaine 1&#37; was administered in the treatment site as a local anesthetic&#46; By contrast&#44; the 3 patients reported by Fern&#225;ndez-Guarinoet al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> experienced pain&#44; erythema and&#47;or edema during and after treatment and none of them wished to undergo another PDT session&#46; Topical anesthetics could interfere with the effectiveness of PDT treatment because they have an alkaline pH that destabilizes the aminolevulinic acid&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> It remains unclear why patients with Hailey-Hailey disease improve with PDT&#44; but the good response is thought to be due to intracellular accumulation of protoporphyrin IX in epidermal keratinocytes&#44; which interferes with structures such as mitochondria&#44; lysosomes&#44; and endoplasmic reticulum&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Providing it is tolerated&#44; PDT may represent an alternative treatment option in cases of Hailey-Hailey disease refractory to first-line therapies&#44; since durable remissions can be achieved that can improve the patient&#39;s quality of life&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lobato-Berezo A&#44; Imbern&#243;n-Moya A&#44; Aguilar-Mart&#237;nez A&#46; Enfermedad de Hailey-Hailey recalcitrante con buena respuesta a terapia fotodin&#225;mica&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;852&#8211;854&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 818
            "Ancho" => 1500
            "Tamanyo" => 218091
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous&#44; erosive&#44; and highly exudative plaques with surface crusts in the axillas&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1210
            "Ancho" => 975
            "Tamanyo" => 119528
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Resolution of axillary lesions following a single photodyamic therapy session&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Reference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Duration of Disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Site Affected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Prior Treatments&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Disease-Free Interval After PDT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ruiz-Rodr&#237;guez et al&#46;&#44; 2002<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9792;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Axillas&#44; groin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Topical and systemic corticosteroids&#44; topical and systemic antibiotics&#44; dermabrasion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Complete response&#44; 19 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9792;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Groin&#44; vulva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Topical and systemic corticosteroids&#44; topical and systemic antibiotics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Complete response&#44; 25 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fern&#225;ndez Guarino et al&#46;&#44; 2008<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9792;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Axillas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Topical corticosteroids and vitamin D analogs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No response&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9794;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Perianal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Corticosteroids&#44; vitamin D analogs&#44; topical immunomodulator&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial response&#44; 6 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9792;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Vulva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Corticosteroids&#44; vitamin D analogs&#44; topical immunomodulator&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial response&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lobato-Berezo&#44; 2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9794;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Axillas&#44; neck&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Copper and zinc sulfate&#44; topical and systemic corticosteroids&#44; vitamin D analogs&#44; topical tacrolimus&#44; acitretin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Complete response&#44; 6 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab957402.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cases of Hailey-Hailey Disease Treated with Photodynamic Therapy&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hailey-Hailey disease exacerbated by multiple pregnancies&#58; Case report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;H&#46; Mauzo"
                            1 => "D&#46;J&#46; Sulit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2014"
                        "volumen" => "20"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hailey-Hailey disease responding to thalidomide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;B&#46; Nanda"
                            1 => "C&#46;S&#46; Saldanha"
                            2 => "M&#46; Jacintha"
                            3 => "G&#46; Kamath"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0019-5154.127684"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Dermatol&#46;"
                        "fecha" => "2014"
                        "volumen" => "59"
                        "paginaInicial" => "190"
                        "paginaFinal" => "192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24700941"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral glycopyrrolate for the treatment of Hailey-Hailey Disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Kaniszewska"
                            1 => "R&#46; Rovner"
                            2 => "A&#46; Arshanapalli"
                            3 => "R&#46; Tung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "JAMA Dermatol&#46;"
                        "fecha" => "2015"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Successful botulinum toxin &#40;onabotulinumtoxina&#41; treatment of Hailey-Hailey disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Ho"
                            1 => "J&#46; Jagdeo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Drugs Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "14"
                        "paginaInicial" => "68"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25607910"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hailey-Hailey disease improved by fractional CO<span class="elsevierStyleInf">2</span> laser"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;E&#46; Campuzano-Garc&#237;a"
                            1 => "B&#46; Torres-Alvarez"
                            2 => "D&#46; Hern&#225;ndez-Blanco"
                            3 => "J&#46;P&#46; Castanedo-C&#225;zares"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cosmet Laser Ther&#46;"
                        "fecha" => "2015"
                        "volumen" => "13"
                        "paginaInicial" => "1"
                        "paginaFinal" => "3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carbon dioxide laser treatment in Hailey-Hailey disease&#58; A series of 8 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Pretel-Irazabal"
                            1 => "J&#46;M&#46; Lera-Imbuluzqueta"
                            2 => "A&#46; Espa&#241;a-Alonso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.adengl.2013.03.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2013"
                        "volumen" => "104"
                        "paginaInicial" => "325"
                        "paginaFinal" => "333"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23582735"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photodynamic therapy with 5-aminolevulinic acid for recalcitrant familial benign pemphigus &#40;Hailey-Hailey disease&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Ruiz-Rodriguez"
                            1 => "J&#46;G&#46; Alvarez"
                            2 => "P&#46; Ja&#233;n"
                            3 => "A&#46; Acevedo"
                            4 => "S&#46; C&#243;rdoba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2002"
                        "volumen" => "47"
                        "paginaInicial" => "740"
                        "paginaFinal" => "742"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12399767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experience with photodynamic therapy in Hailey-Hailey disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Fern&#225;ndez Guarino"
                            1 => "A&#46;M&#46; Ryan"
                            2 => "A&#46; Harto"
                            3 => "B&#46; P&#233;rez-Garc&#237;a"
                            4 => "J&#46;M&#46; Arr&#225;zola"
                            5 => "P&#46; Ja&#233;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/09546630801958220"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatolog Treat&#46;"
                        "fecha" => "2008"
                        "volumen" => "19"
                        "paginaInicial" => "288"
                        "paginaFinal" => "290"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18608733"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000010/v1_201512060022/S1578219015002681/v1_201512060022/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000010/v1_201512060022/S1578219015002681/v1_201512060022/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002681?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case and Research Letters
Refractory Hailey-Hailey Disease That Responded Well to Photodynamic Therapy
Enfermedad de Hailey-Hailey recalcitrante con buena respuesta a terapia fotodinámica
A. Lobato-Berezo
Corresponding author
allobe@hotmail.es

Corresponding author.
, A. Imbernón-Moya, A. Aguilar-Martínez
Departamento de Dermatología, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain
Read
7336
Times
was read the article
2193
Total PDF
5143
Total HTML
Share statistics
 array:24 [
  "pii" => "S1578219015002681"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.10.008"
  "estado" => "S300"
  "fechaPublicacion" => "2015-12-01"
  "aid" => "1224"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2015;106:852-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 839
    "formatos" => array:3 [
      "EPUB" => 54
      "HTML" => 512
      "PDF" => 273
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015003282"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2015.04.017"
      "estado" => "S300"
      "fechaPublicacion" => "2015-12-01"
      "aid" => "1224"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2015;106:852-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 553
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 312
          "PDF" => 238
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Cartas cient&#237;fico-cl&#237;nicas</span>"
        "titulo" => "Enfermedad de Hailey-Hailey recalcitrante con buena respuesta a terapia fotodin&#225;mica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "852"
            "paginaFinal" => "854"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Refractory Hailey-Hailey Disease That Responded Well to Photodynamic Therapy"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 1210
                "Ancho" => 975
                "Tamanyo" => 116532
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Lesiones axilares resueltas tras realizar una sesi&#243;n con TFD&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Lobato-Berezo, A&#46; Imbern&#243;n-Moya, A&#46; Aguilar-Mart&#237;nez"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Lobato-Berezo"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Imbern&#243;n-Moya"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Aguilar-Mart&#237;nez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002681"
          "doi" => "10.1016/j.adengl.2015.10.008"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002681?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003282?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000010/v1_201512080105/S0001731015003282/v1_201512080105/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002693"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.10.009"
    "estado" => "S300"
    "fechaPublicacion" => "2015-12-01"
    "aid" => "1227"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2015;106:854-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1575
      "formatos" => array:3 [
        "EPUB" => 51
        "HTML" => 797
        "PDF" => 727
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Mast Cells and Scarring Alopecia&#58; Is There a Clear Pathophysiological Relationship&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "854"
          "paginaFinal" => "857"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Mastocitos y alopecia cicatricial&#58; &#191;hay una clara relaci&#243;n fisiopatol&#243;gica&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1194
              "Ancho" => 1800
              "Tamanyo" => 435750
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44;<span class="elsevierStyleHsp" style=""></span>Presence of fibrosis replacing and destroying the follicle&#44; and absence of epidermal involvement &#40;hematoxylin-eosin&#44; original magnification &#215; 10&#41;&#46; B&#44;<span class="elsevierStyleHsp" style=""></span>Difference between follicular fibrosis and normal&#44; interwoven collagen fibers &#40;hematoxylin-eosin&#44; original magnification &#215; 40&#41;&#46; C&#44;<span class="elsevierStyleHsp" style=""></span>Absence of lymphocytic infiltrate&#46; Presence of elevated numbers of mast cells &#40;hematoxylin-eosin&#44; original magnification &#215; 200&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Almodovar-Real, M&#46;A&#46; Diaz-Martinez, R&#46; Ruiz-Villaverde, R&#46; Naranjo-Sintes"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Almodovar-Real"
            ]
            1 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "Diaz-Martinez"
            ]
            2 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz-Villaverde"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Naranjo-Sintes"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015003312"
        "doi" => "10.1016/j.ad.2015.03.021"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003312?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002693?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000010/v1_201512060022/S1578219015002693/v1_201512060022/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S157821901500267X"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.10.007"
    "estado" => "S300"
    "fechaPublicacion" => "2015-12-01"
    "aid" => "1223"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2015;106:850-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 987
      "formatos" => array:3 [
        "EPUB" => 50
        "HTML" => 532
        "PDF" => 405
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Giant Vascular Eccrine Spiradenoma"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "850"
          "paginaFinal" => "852"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Espiradenoma ecrino vascular gigante"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1300
              "Ancho" => 975
              "Tamanyo" => 435538
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Organoid pattern of cell nests&#44; some of basaloid appearance with hyperchromatic nuclei and others with large clear cytoplasms&#44; separated by fibrous tracts containing abundant dilated and congestive vascular structures &#40;hematoxylin-eosin<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E&#46; Jorquera Barquero, C&#46; Lara Boh&#243;rquez, I&#46; de Alba Rioja"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Jorquera Barquero"
            ]
            1 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Lara Boh&#243;rquez"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "de Alba Rioja"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015003270"
        "doi" => "10.1016/j.ad.2015.03.019"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015003270?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821901500267X?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000010/v1_201512060022/S157821901500267X/v1_201512060022/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Refractory Hailey-Hailey Disease That Responded Well to Photodynamic Therapy"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">To the Editor&#58;</span>"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "852"
        "paginaFinal" => "854"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Lobato-Berezo, A&#46; Imbern&#243;n-Moya, A&#46; Aguilar-Mart&#237;nez"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Lobato-Berezo"
            "email" => array:1 [
              0 => "allobe&#64;hotmail&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Imbern&#243;n-Moya"
          ]
          2 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Aguilar-Mart&#237;nez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Hospital Universitario Severo Ochoa&#44; Legan&#233;s&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Enfermedad de Hailey-Hailey recalcitrante con buena respuesta a terapia fotodin&#225;mica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1210
            "Ancho" => 975
            "Tamanyo" => 119528
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Resolution of axillary lesions following a single photodyamic therapy session&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Hailey-Hailey disease or familial benign pemphigus is a rare hereditary skin disease&#46; This chronic and recurrent condition can cause severe discomfort and be difficult to control with conventional treatments&#46; Photodynamic therapy &#40;PDT&#41; could offer an alternative in cases in which other treatment options have failed&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 56-year-old male who for 30 years had experienced several outbreaks a year of stinging&#44; itching&#44; and burning lesions located on the neck and armpits&#46; The lesions interfered with his daily activities and had a negative impact on his quality of life&#46; Physical examination revealed bright&#44; well-defined&#44; highly exudative&#44; eroded&#44; and erythematous plaques with some surface crusts located in both armpits and on the lateral aspects of the neck &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Histological study of a biopsied sample from one of the lesions demonstrated an epidermis with erosions and intraepidermal blisters&#44; marked acantholysis&#44; and the typical appearance of a dilapidated brick wall&#46; The patient had been diagnosed with Hailey-Hailey disease and had received multiple treatments with astringents such as copper and zinc sulfate &#40;1&#58;1000&#41;&#44; topical and systemic steroids&#44; topical vitamin D derivatives&#44; topical tacrolimus&#44; and acitretin&#46; Response to treatment had always been partial with a disease-free interval between flares lasting only a few weeks&#46; These shortcomings represented an important limitation for the patient&#46; He agreed to undergo a single session of PDT to see what the response would be and to assess the tolerability of the treatment&#46; First&#44; both underarms were cleaned with physiological saline solution and methyl aminolevulinate &#40;MAL&#41; cream was applied under occlusion for 3<span class="elsevierStyleHsp" style=""></span>hours&#46; The underarms were then irradiated with a red light &#40;Aktilite at 37<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#41; for 7&#46;5 minutes&#46; During the period of exposure&#44; the patient experienced a slight sensation of pain and burning&#44; which was well tolerated&#46; The response on follow-up at 2 weeks was excellent&#58; the erosions had healed&#44; the exudate and erythema had disappeared&#44; and the patient reported an improvement in his quality of life &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Six months later&#44; the patient is still free of lesions and has not undergone any other treatment&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Hailey-Hailey disease or familial benign pemphigus is an autosomal dominant genodermatosis caused by a mutation in the <span class="elsevierStyleItalic">ATP2C1</span> gene&#46; It is characterized by the appearance of vesicles&#44; blisters&#44; and erosions in flexural areas&#44; including the neck and axillas as well as the inframammary and inguinal folds&#46; Typically&#44; patients experience recurrent flares and&#44; occasionally&#44; spontaneous remission&#46; Among the best known precipitating factors are exposure to UV light&#44; sweat&#44; friction&#44; stress&#44; skin infections&#44; and pregnancy&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Many treatments have been used to control the disease with varying results&#46; Medical treatments include topical and systemic corticosteroids&#44; topical and systemic antibiotics&#44; topical vitamin D analogs&#44; topical 5-fluorouracil&#44; dapsone&#44; psoralen and UV-A light therapy&#44; systemic retinoids&#44; ciclosporin&#44; methotrexate&#44; and oral glycopyrrolate&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">2&#44;3</span></a> A number of invasive treatments have been attempted&#44; including infiltration with botulinum toxin&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> carbon dioxide laser&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">5&#44;6</span></a> erbium&#58; yttrium aluminium garnet laser&#44; and dermabrasion&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In the literature&#44; we found only 2 articles &#40;referring to 5 patients&#41; on Hailey-Hailey disease treated with PDT &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The age of the 5 patients ranged from 28 to 51 years and all but one were women&#46; The time elapsed since diagnosis ranged from 8 months to 24 years&#44; and all 5 patients had undergone prior treatment with topical corticosteroids and a topical vitamin D analog or an antibiotic&#46; Two of the patients had a complete response followed by a disease-free interval of 19 and 25 months&#44; respectively&#59; a further 2 patients showed partial improvement of their lesions&#44; and the remaining patient did not improve&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">7&#44;8</span></a> In the cases reported by Ruiz-Rodriguez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> PDT was well tolerated because lidocaine 1&#37; was administered in the treatment site as a local anesthetic&#46; By contrast&#44; the 3 patients reported by Fern&#225;ndez-Guarinoet al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> experienced pain&#44; erythema and&#47;or edema during and after treatment and none of them wished to undergo another PDT session&#46; Topical anesthetics could interfere with the effectiveness of PDT treatment because they have an alkaline pH that destabilizes the aminolevulinic acid&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> It remains unclear why patients with Hailey-Hailey disease improve with PDT&#44; but the good response is thought to be due to intracellular accumulation of protoporphyrin IX in epidermal keratinocytes&#44; which interferes with structures such as mitochondria&#44; lysosomes&#44; and endoplasmic reticulum&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Providing it is tolerated&#44; PDT may represent an alternative treatment option in cases of Hailey-Hailey disease refractory to first-line therapies&#44; since durable remissions can be achieved that can improve the patient&#39;s quality of life&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lobato-Berezo A&#44; Imbern&#243;n-Moya A&#44; Aguilar-Mart&#237;nez A&#46; Enfermedad de Hailey-Hailey recalcitrante con buena respuesta a terapia fotodin&#225;mica&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;852&#8211;854&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 818
            "Ancho" => 1500
            "Tamanyo" => 218091
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous&#44; erosive&#44; and highly exudative plaques with surface crusts in the axillas&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1210
            "Ancho" => 975
            "Tamanyo" => 119528
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Resolution of axillary lesions following a single photodyamic therapy session&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Reference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Duration of Disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Site Affected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Prior Treatments&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Disease-Free Interval After PDT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ruiz-Rodr&#237;guez et al&#46;&#44; 2002<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9792;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Axillas&#44; groin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Topical and systemic corticosteroids&#44; topical and systemic antibiotics&#44; dermabrasion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Complete response&#44; 19 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9792;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Groin&#44; vulva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Topical and systemic corticosteroids&#44; topical and systemic antibiotics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Complete response&#44; 25 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fern&#225;ndez Guarino et al&#46;&#44; 2008<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9792;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Axillas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Topical corticosteroids and vitamin D analogs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No response&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9794;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Perianal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Corticosteroids&#44; vitamin D analogs&#44; topical immunomodulator&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial response&#44; 6 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9792;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Vulva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Corticosteroids&#44; vitamin D analogs&#44; topical immunomodulator&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial response&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lobato-Berezo&#44; 2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#9794;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Axillas&#44; neck&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Copper and zinc sulfate&#44; topical and systemic corticosteroids&#44; vitamin D analogs&#44; topical tacrolimus&#44; acitretin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Complete response&#44; 6 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab957402.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cases of Hailey-Hailey Disease Treated with Photodynamic Therapy&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hailey-Hailey disease exacerbated by multiple pregnancies&#58; Case report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;H&#46; Mauzo"
                            1 => "D&#46;J&#46; Sulit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2014"
                        "volumen" => "20"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hailey-Hailey disease responding to thalidomide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;B&#46; Nanda"
                            1 => "C&#46;S&#46; Saldanha"
                            2 => "M&#46; Jacintha"
                            3 => "G&#46; Kamath"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0019-5154.127684"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Dermatol&#46;"
                        "fecha" => "2014"
                        "volumen" => "59"
                        "paginaInicial" => "190"
                        "paginaFinal" => "192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24700941"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral glycopyrrolate for the treatment of Hailey-Hailey Disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Kaniszewska"
                            1 => "R&#46; Rovner"
                            2 => "A&#46; Arshanapalli"
                            3 => "R&#46; Tung"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "JAMA Dermatol&#46;"
                        "fecha" => "2015"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Successful botulinum toxin &#40;onabotulinumtoxina&#41; treatment of Hailey-Hailey disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Ho"
                            1 => "J&#46; Jagdeo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Drugs Dermatol&#46;"
                        "fecha" => "2015"
                        "volumen" => "14"
                        "paginaInicial" => "68"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25607910"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hailey-Hailey disease improved by fractional CO<span class="elsevierStyleInf">2</span> laser"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;E&#46; Campuzano-Garc&#237;a"
                            1 => "B&#46; Torres-Alvarez"
                            2 => "D&#46; Hern&#225;ndez-Blanco"
                            3 => "J&#46;P&#46; Castanedo-C&#225;zares"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cosmet Laser Ther&#46;"
                        "fecha" => "2015"
                        "volumen" => "13"
                        "paginaInicial" => "1"
                        "paginaFinal" => "3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carbon dioxide laser treatment in Hailey-Hailey disease&#58; A series of 8 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Pretel-Irazabal"
                            1 => "J&#46;M&#46; Lera-Imbuluzqueta"
                            2 => "A&#46; Espa&#241;a-Alonso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.adengl.2013.03.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2013"
                        "volumen" => "104"
                        "paginaInicial" => "325"
                        "paginaFinal" => "333"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23582735"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photodynamic therapy with 5-aminolevulinic acid for recalcitrant familial benign pemphigus &#40;Hailey-Hailey disease&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Ruiz-Rodriguez"
                            1 => "J&#46;G&#46; Alvarez"
                            2 => "P&#46; Ja&#233;n"
                            3 => "A&#46; Acevedo"
                            4 => "S&#46; C&#243;rdoba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2002"
                        "volumen" => "47"
                        "paginaInicial" => "740"
                        "paginaFinal" => "742"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12399767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experience with photodynamic therapy in Hailey-Hailey disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Fern&#225;ndez Guarino"
                            1 => "A&#46;M&#46; Ryan"
                            2 => "A&#46; Harto"
                            3 => "B&#46; P&#233;rez-Garc&#237;a"
                            4 => "J&#46;M&#46; Arr&#225;zola"
                            5 => "P&#46; Ja&#233;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/09546630801958220"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatolog Treat&#46;"
                        "fecha" => "2008"
                        "volumen" => "19"
                        "paginaInicial" => "288"
                        "paginaFinal" => "290"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18608733"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000010/v1_201512060022/S1578219015002681/v1_201512060022/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000010/v1_201512060022/S1578219015002681/v1_201512060022/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002681?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 11 4 15
2024 October 106 35 141
2024 September 159 49 208
2024 August 156 76 232
2024 July 149 48 197
2024 June 126 38 164
2024 May 103 44 147
2024 April 92 30 122
2024 March 100 20 120
2024 February 98 32 130
2024 January 104 41 145
2023 December 110 30 140
2023 November 120 42 162
2023 October 139 37 176
2023 September 97 33 130
2023 August 104 24 128
2023 July 107 38 145
2023 June 86 30 116
2023 May 126 36 162
2023 April 103 27 130
2023 March 94 29 123
2023 February 70 28 98
2023 January 70 45 115
2022 December 85 42 127
2022 November 46 46 92
2022 October 48 25 73
2022 September 26 33 59
2022 August 40 29 69
2022 July 24 48 72
2022 June 31 31 62
2022 May 86 49 135
2022 April 72 35 107
2022 March 115 37 152
2022 February 116 26 142
2022 January 118 80 198
2021 December 60 39 99
2021 November 73 46 119
2021 October 85 46 131
2021 September 104 37 141
2021 August 137 23 160
2021 July 97 30 127
2021 June 82 40 122
2021 May 73 18 91
2021 April 139 54 193
2021 March 83 28 111
2021 February 76 43 119
2021 January 58 10 68
2020 December 39 23 62
2020 November 42 24 66
2020 October 27 17 44
2020 September 44 16 60
2020 August 36 32 68
2020 July 16 11 27
2020 June 32 30 62
2020 May 26 15 41
2020 April 34 19 53
2020 March 28 21 49
2020 February 4 8 12
2020 January 0 20 20
2019 December 2 2 4
2019 October 0 2 2
2019 September 4 3 7
2019 August 0 2 2
2019 July 0 6 6
2019 June 2 25 27
2019 May 1 8 9
2019 April 0 11 11
2019 March 2 6 8
2019 February 1 2 3
2019 January 4 3 7
2018 December 0 7 7
2018 November 1 0 1
2018 October 3 0 3
2018 September 53 0 53
2018 February 37 5 42
2018 January 41 5 46
2017 December 38 9 47
2017 November 24 3 27
2017 October 30 6 36
2017 September 22 5 27
2017 August 38 11 49
2017 July 24 9 33
2017 June 24 5 29
2017 May 23 6 29
2017 April 24 6 30
2017 March 10 9 19
2017 February 15 8 23
2017 January 10 7 17
2016 December 18 11 29
2016 November 33 23 56
2016 October 25 16 41
2016 September 0 5 5
2016 August 0 5 5
2016 July 0 2 2
2016 June 2 1 3
2016 May 0 1 1
2016 April 0 4 4
2016 February 0 2 2
2016 January 0 5 5
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?