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Daylight Photodynamic Therapy
FR - Terapia fotodinámica luz de día
T. Salas-García
, A. López-Gómez, M. Dorado-Fernández, J. Ruiz-Martínez
Corresponding author
Servicio de Dermatología, Hospital General Universitario Reina Sofía, Murcia, Spain
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Salas-García, A. López-Gómez, M. Dorado-Fernández, J. Ruiz-Martínez" "autores" => array:4 [ 0 => array:4 [ "nombre" => "T." "apellidos" => "Salas-García" "email" => array:1 [ 0 => "tania.sgg@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "López-Gómez" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Dorado-Fernández" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Ruiz-Martínez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Reina Sofía, Murcia, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "FR - Terapia fotodinámica luz de día" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Photodynamic therapy (PDT) is one of the treatment options for nonmelanoma skin cancer and is considered to be the first-line treatment for multiple actinic keratoses (AKs) and field cancerization.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Various studies in recent years have described the use of daylight PDT in the treatment of nonhyperkeratotic AKs. The technique has also been reviewed in a consensus statement by the International Society for Photodynamic Therapy in Dermatology.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">As we know, PDT consists in applying of a photosensitizer that causes the accumulation of protoporphyrin <span class="elsevierStyleSmallCaps">IX</span> (PpIX) in the cell interior and then using light of an appropriate wavelength to activate the PpIX, causing cell death. PpIX has its highest absorption peak at 410<span class="elsevierStyleHsp" style=""></span>nm as well as other peaks in the visible spectrum. It is therefore possible to activate PpIX with the blue light (440-500<span class="elsevierStyleHsp" style=""></span>nm) and red light (625-740<span class="elsevierStyleHsp" style=""></span>nm) lamps that are normally used, as well as with visible light (400-700<span class="elsevierStyleHsp" style=""></span>nm).</p><p id="par0020" class="elsevierStylePara elsevierViewall">Studies on the use of daylight PDT have reported similar results to those obtained with conventional PDT in the treatment of grade <span class="elsevierStyleSmallCaps">I</span> or <span class="elsevierStyleSmallCaps">II</span> AKs (71% reduction in lesions with conventional PDT vs 79% with daylight PDT).<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> Daylight PDT is also less painful for the patient and less laborious and time-consuming for health professionals. The main limitations of daylight PDT are the difficulty of planning due to weather variations and the climate in some geographical areas<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> and the loss of medical control during the irradiation period.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The first studies on the use of this new PDT modality in the treatment of AKs were carried out in Nordic countries.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> Later studies carried out in Australia,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> Spain,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> Brazil,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> and Italy<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> obtained similar results and the same safety levels, despite the fact that solar radiation is stronger in these countries.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The first step in administering daylight PDT is to apply organic sunscreen to the treatment area as well as all other exposed skin. The purpose is to avoid exposure to UV radiation, which is unnecessary for PDT and inadvisable for patients with severe actinic damage. The second step is curettage of the lesions and application of the photosensitizer. After this, the patient must receive 2<span class="elsevierStyleHsp" style=""></span>hours of exposure to daylight.</p><p id="par0035" class="elsevierStylePara elsevierViewall">One of the possible limitations of daylight PDT is the weather. Studies have shown that a minimum fluence of 8<span class="elsevierStyleHsp" style=""></span>J/cm<span class="elsevierStyleSup">2</span> must be reached in the PpIX absorption range within the solar radiation spectrum in order for an adequate response to be achieved. Studies have shown that it could be possible to reach the necessary dose year round in Spain.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Daylight PDT is mainly appropriate for patients who have multiple grade <span class="elsevierStyleSmallCaps">I</span> or <span class="elsevierStyleSmallCaps">II</span> AKs in sun-exposed areas.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Some studies, albeit with fewer cases, have reported acceptable results with daylight PDT in the treatment of other skin lesions, such as basal cell carcinoma<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> and actinic cheilitis<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> (the latter study described only 2 cases).</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-09-30" "fechaAceptado" => "2015-05-05" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec577805" "palabras" => array:2 [ 0 => "Photodynamic therapy" 1 => "Actinic keratosis" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Salas-García T, López-Gómez A, Dorado-Fernández M, Ruiz-Martínez J. FR - Terapia fotodinámica luz de día. Actas Dermosifiliogr. 2014;106:672–673.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Daylight photodynamic therapy for actinic keratosis: An international consensus. International Society for Photodynamic Therapy in Dermatology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.R. Wiegell" 1 => "H.C. Wulf" 2 => "R.M. Szeimies" 3 => "N. Basset-Seguin" 4 => "R. Bissonnette" 5 => "M.J. Gerritsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2011.04386.x" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2012" "volumen" => "26" "paginaInicial" => "673" "paginaFinal" => "679" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22211665" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0055" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; A randomized, controlled, single-blinded study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.R. Wiegell" 1 => "M. Haedersdal" 2 => "P.A. Philipsen" 3 => "P. Eriksen" 4 => "C.D. Enk" 5 => "H.C. Wulf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2008.08450.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2008" "volumen" => "158" "paginaInicial" => "740" "paginaFinal" => "746" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18294318" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0060" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapia fotodinámica con luz de día en España: ventajas y limitaciones" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Pérez Pérez" 1 => "J. García Gavín" 2 => "Y. Gilaberte" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2013.10.021" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2014" "volumen" => "105" "paginaInicial" => "663" "paginaFinal" => "674" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24726043" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0065" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized, multicentre study of directed daylight exposure times of 1½ vs 2½ h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.R. Wiegell" 1 => "S. Fabricius" 2 => "I.M. Stender" 3 => "B. Berne" 4 => "S. Kroon" 5 => "B.L. Andersen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2011.10209.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2011" "volumen" => "164" "paginaInicial" => "1083" "paginaFinal" => "1090" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21219287" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0070" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of face and scalp solar (actinic) keratosis with daylight-mediated photodynamic therapy is possible throughout the year in Australia: evidence from a clinical and meteorological study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Spelman" 1 => "D. Rubel" 2 => "D.F. Murrell" 3 => "J.A. See" 4 => "D. Hewitt" 5 => "P. Foley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Australas J Dermatol" "fecha" => "2015" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0075" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Daylight photodynamic therapy for actinic keratosis in Sao Paulo, Brazil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B.M. Grinblat" 1 => "C. Festa Neto" 2 => "J.A.JJr. Sanches" 3 => "R.M. Szeimies" 4 => "A.P. Oliveira" 5 => "L.A. Torezan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Photodermatol Phtotoimmunol Photomed" "fecha" => "2015" "volumen" => "31" "paginaInicial" => "54" "paginaFinal" => "56" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0080" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Daylight photodynamic therapy with methyl aminolevulinate in patients with actinic keratoses: A preliminary experience in southern Italy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Fai" 1 => "I. Romano" 2 => "C. Fai" 3 => "N. Cassano" 4 => "G.A. Vena" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "G Ital Dermatol Venereol" "fecha" => "2014" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0085" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Daylight-mediated photodynamic therapy of basal cell carcinomas - an explorative study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.R. Wiegell" 1 => "V. Skodt" 2 => "H.C. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 10 | 15 |
| 2024 October | 77 | 43 | 120 |
| 2024 September | 71 | 44 | 115 |
| 2024 August | 94 | 62 | 156 |
| 2024 July | 81 | 27 | 108 |
| 2024 June | 75 | 28 | 103 |
| 2024 May | 58 | 34 | 92 |
| 2024 April | 64 | 21 | 85 |
| 2024 March | 56 | 25 | 81 |
| 2024 February | 54 | 30 | 84 |
| 2024 January | 54 | 29 | 83 |
| 2023 December | 46 | 17 | 63 |
| 2023 November | 65 | 25 | 90 |
| 2023 October | 73 | 26 | 99 |
| 2023 September | 58 | 28 | 86 |
| 2023 August | 43 | 13 | 56 |
| 2023 July | 24 | 37 | 61 |
| 2023 June | 16 | 9 | 25 |
| 2023 May | 43 | 23 | 66 |
| 2023 April | 32 | 20 | 52 |
| 2023 March | 54 | 12 | 66 |
| 2023 February | 50 | 21 | 71 |
| 2023 January | 30 | 20 | 50 |
| 2022 December | 47 | 35 | 82 |
| 2022 November | 34 | 23 | 57 |
| 2022 October | 31 | 20 | 51 |
| 2022 September | 24 | 34 | 58 |
| 2022 August | 21 | 30 | 51 |
| 2022 July | 25 | 32 | 57 |
| 2022 June | 19 | 25 | 44 |
| 2022 May | 40 | 30 | 70 |
| 2022 April | 41 | 43 | 84 |
| 2022 March | 48 | 41 | 89 |
| 2022 February | 27 | 21 | 48 |
| 2022 January | 35 | 34 | 69 |
| 2021 December | 30 | 37 | 67 |
| 2021 November | 31 | 43 | 74 |
| 2021 October | 35 | 61 | 96 |
| 2021 September | 32 | 48 | 80 |
| 2021 August | 32 | 25 | 57 |
| 2021 July | 29 | 16 | 45 |
| 2021 June | 29 | 28 | 57 |
| 2021 May | 47 | 29 | 76 |
| 2021 April | 87 | 52 | 139 |
| 2021 March | 57 | 24 | 81 |
| 2021 February | 62 | 31 | 93 |
| 2021 January | 49 | 19 | 68 |
| 2020 December | 32 | 14 | 46 |
| 2020 November | 20 | 15 | 35 |
| 2020 October | 20 | 8 | 28 |
| 2020 September | 39 | 12 | 51 |
| 2020 August | 27 | 19 | 46 |
| 2020 July | 21 | 14 | 35 |
| 2020 June | 44 | 34 | 78 |
| 2020 May | 31 | 19 | 50 |
| 2020 April | 23 | 21 | 44 |
| 2020 March | 27 | 20 | 47 |
| 2020 February | 4 | 9 | 13 |
| 2020 January | 0 | 9 | 9 |
| 2019 December | 0 | 5 | 5 |
| 2019 November | 2 | 2 | 4 |
| 2019 October | 0 | 1 | 1 |
| 2019 September | 3 | 1 | 4 |
| 2019 July | 0 | 12 | 12 |
| 2019 June | 0 | 38 | 38 |
| 2019 May | 1 | 58 | 59 |
| 2019 April | 0 | 16 | 16 |
| 2019 March | 1 | 6 | 7 |
| 2019 February | 0 | 3 | 3 |
| 2018 December | 1 | 3 | 4 |
| 2018 November | 1 | 3 | 4 |
| 2018 October | 4 | 1 | 5 |
| 2018 September | 8 | 1 | 9 |
| 2018 August | 0 | 5 | 5 |
| 2018 July | 0 | 10 | 10 |
| 2018 June | 0 | 3 | 3 |
| 2018 May | 0 | 4 | 4 |
| 2018 April | 0 | 3 | 3 |
| 2018 March | 3 | 0 | 3 |
| 2018 February | 55 | 5 | 60 |
| 2018 January | 26 | 5 | 31 |
| 2017 December | 67 | 7 | 74 |
| 2017 November | 31 | 9 | 40 |
| 2017 October | 30 | 8 | 38 |
| 2017 September | 15 | 10 | 25 |
| 2017 August | 28 | 15 | 43 |
| 2017 July | 20 | 14 | 34 |
| 2017 June | 33 | 27 | 60 |
| 2017 May | 26 | 13 | 39 |
| 2017 April | 25 | 9 | 34 |
| 2017 March | 30 | 45 | 75 |
| 2017 February | 19 | 6 | 25 |
| 2017 January | 17 | 13 | 30 |
| 2016 December | 31 | 17 | 48 |
| 2016 November | 35 | 23 | 58 |
| 2016 October | 25 | 24 | 49 |
| 2016 September | 0 | 6 | 6 |
| 2016 August | 0 | 2 | 2 |
| 2016 July | 0 | 2 | 2 |
| 2016 June | 3 | 2 | 5 |
| 2016 May | 1 | 0 | 1 |
| 2016 March | 1 | 0 | 1 |
| 2015 November | 0 | 7 | 7 |
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