array:24 [
  "pii" => "S1578219015002000"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.07.002"
  "estado" => "S300"
  "fechaPublicacion" => "2015-10-01"
  "aid" => "1083"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2015;106:667-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 688
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 422
      "PDF" => 218
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S000173101400475X"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.11.002"
      "estado" => "S300"
      "fechaPublicacion" => "2015-10-01"
      "aid" => "1083"
      "copyright" => "Elsevier España, S.L.U. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2015;106:667-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 656
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 396
          "PDF" => 258
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
        "titulo" => "&#191;Qu&#233; genodermatosis es&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "667"
            "paginaFinal" => "668"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Can You Identify the Genodermatosis&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:6 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 500
                "Ancho" => 605
                "Tamanyo" => 89864
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "R&#46; Santesteban Muruz&#225;bal, M&#46; Hervella Garc&#233;s, C&#46; Ros Mart&#237;n"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Santesteban Muruz&#225;bal"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Hervella Garc&#233;s"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Ros Mart&#237;n"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002000"
          "doi" => "10.1016/j.adengl.2015.07.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002000?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101400475X?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000008/v1_201510020746/S000173101400475X/v1_201510020746/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002152"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.017"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1200"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2015;106:669-71"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1231
      "formatos" => array:3 [
        "EPUB" => 59
        "HTML" => 577
        "PDF" => 595
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Videos of Surgical Procedures in Dermatology</span>"
      "titulo" => "Parascapular Perforating Flap to Treat Severe Axillary Hidradenitis Suppurativa"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "669"
          "paginaFinal" => "671"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Colgajo paraescapular perforante para tratamiento de la hidradenitis axilar grave"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1373
              "Ancho" => 990
              "Tamanyo" => 303170
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Appearance immediately after the en bloc excision of the affected axillary skin&#44; with a surgical margin&#46; B&#44; Surgical wound after removal of the drain 4 days after the operation&#46; C&#44; Healthy axilla 2 years after the operation&#46; D&#44; Partial view of the donor site 2 years after the operation&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Tercedor-S&#225;nchez, J&#46;M&#46; R&#243;denas-L&#243;pez, P&#46; Ram&#243;n-Faba, F&#46; Mu&#241;oz-Romero"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Tercedor-S&#225;nchez"
            ]
            1 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "R&#243;denas-L&#243;pez"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Ram&#243;n-Faba"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Mu&#241;oz-Romero"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015002690"
        "doi" => "10.1016/j.ad.2015.05.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002690?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002152?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002152/v1_201510011018/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015002073"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.009"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1164"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2015;106:e41-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 739
      "formatos" => array:3 [
        "EPUB" => 52
        "HTML" => 451
        "PDF" => 236
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">e-Case Report</span>"
      "titulo" => "Usefulness of Confocal Microscopy in Distinguishing Between Basal Cell Carcinoma and Intradermal Melanocytic Nevus on the Face"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "e41"
          "paginaFinal" => "e44"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Utilidad de la microscopia confocal en el diagn&#243;stico diferencial de epiteliomas basocelulares y nevus melanoc&#237;ticos intrad&#233;rmicos de localizaci&#243;n facial"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1228
              "Ancho" => 1668
              "Tamanyo" => 356796
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Confocal microscopy image measuring 0&#46;75<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>mm&#46; Note the tumor nests &#40;yellow arrows&#41; separated from the stroma by dark clefts &#40;white arrows&#41;&#46; There are reflective cells inside &#40;red asterisk&#41; and outside &#40;yellow asterisk&#41; the nests&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Gamo, U&#46; Flor&#237;stan, A&#46; Pamp&#237;n, D&#46; Caro, F&#46; Pinedo, J&#46;L&#46; L&#243;pez-Estebaranz"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Gamo"
            ]
            1 => array:2 [
              "nombre" => "U&#46;"
              "apellidos" => "Flor&#237;stan"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Pamp&#237;n"
            ]
            3 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Caro"
            ]
            4 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Pinedo"
            ]
            5 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "L&#243;pez-Estebaranz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015001726"
        "doi" => "10.1016/j.ad.2015.03.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001726?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002073?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002073/v1_201510011018/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>"
    "titulo" => "Can You Identify the Genodermatosis&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "667"
        "paginaFinal" => "668"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46; Santesteban Muruz&#225;bal, M&#46; Hervella Garc&#233;s, C&#46; Ros Mart&#237;n"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "R&#46;"
            "apellidos" => "Santesteban Muruz&#225;bal"
            "email" => array:1 [
              0 => "raquel&#46;santesteban&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Hervella Garc&#233;s"
          ]
          2 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Ros Mart&#237;n"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de Navarra&#44; Complejo Hospitalario de Navarra&#44; Pamplona&#44; Navarre&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#191;Qu&#233; genodermatosis es&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 500
            "Ancho" => 977
            "Tamanyo" => 227116
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Hematoxylin-eosin&#44; original magnification &#215;100&#46; B&#44; Hematoxylin-eosin&#44; original magnification &#215;200&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Patient History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 5-year-old boy from Colombia with no known family history of skin disease presented with asymptomatic lesions on the limbs&#44; predominantly in acral regions and areas around the joints&#46; His family reported slow&#44; peripheral growth of the lesions over the past few months but were unable to specify exactly when the clinical signs first appeared&#46; No other associated symptoms were present at any level&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination revealed keratotic&#44; lichenoid plaques with mild peripheral erythema affecting the hips&#44; acral regions&#44; and areas around the joints on all 4 limbs&#44; especially on extensor surfaces &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The development of the boy was normal for his age&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histologic examination revealed hyperkeratosis with focal parakeratosis&#44; hypergranulosis&#44; and acanthosis with elongated rete ridges &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Progressive symmetric erythrokeratoderma &#40;PSEK&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">Topical treatment was started with 20&#37; urea cream and systemic treatment was started with oral acitretin at a dose of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46; Patient tolerance was good&#46; Over several months&#44; the lesions clearly involuted until they were limited to the acral regions of the limbs and the flexures&#44; with a minimal effective dose of 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46; Periodic blood tests were carried out at follow-up visits&#44; and no abnormalities caused by the treatment were observed&#46; Adherence to treatment has been erratic over several years of follow-up at our dermatology clinic&#59; periods of evident exacerbation have coincided with the voluntary withdrawal of the medication&#46; The patient&#44; now 14 years old&#44; continues to receive treatment with acitretin at a minimum effective dose of 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Erythrokeratodermas are a clinically and genetically heterogeneous group of skin diseases characterized by well-defined erythematous-keratotic plaques&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> There are various subtypes&#44; the most important of which are PSEK and erythrokeratoderma variabilis&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#8211;6</span></a> PSEK is a rare genodermatosis that has been associated with a mutation in the loricrin gene on chromosome 1q21&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4&#44;5</span></a> although it is genetically heterogeneous&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In most cases&#44; PSEK is hereditary&#44; with autosomal dominant inheritance&#44; incomplete penetrance&#44; and variable expressivity&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a> although sporadic cases<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;6</span></a> and cases with a recessive inheritance pattern<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> have also been reported&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Clinically&#44; PSEK is characterized by the appearance of large&#44; erythematous&#44; orange-colored&#44; well-defined&#44; symmetrical plaques that in some cases can have a keratotic or verrucous appearance&#44; usually located on the buttocks&#44; cheeks&#44; and limbs&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;6</span></a> Palmoplantar involvement has been reported in up to 50&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;6</span></a> The lesions usually appear in the first years of life and spread slowly or remain stable during the following years&#59; spontaneous improvement sometimes occurs&#44; usually during puberty&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Histologic findings are nonspecific&#44; with foci of parakeratosis and marked acanthosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a> Perinuclear vacuolization can be observed in the granular cell layer&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">PSEK is treated symptomatically&#46; Topical treatments&#8212;including emollients and keratolytic agents&#8212;are reserved for the mildest cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a> For severe cases&#44; systemic treatment&#8212;oral retinoids&#44; such as acitretin at a dose of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#8212;is usually added&#46; Psoralen-UV-A phototherapy has also been used&#44; with variable clinical responses&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">We have presented a new case of PSEK&#44; a rare entity&#46; The case is unusual because it is sporadic&#44; autosomal dominant inheritance being more common in this disease&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:8 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Patient History"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Physical Examination"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Histopathology"
        ]
        3 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Diagnosis"
        ]
        4 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Clinical Course and Treatment"
        ]
        5 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Comment"
        ]
        6 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflicts of Interest"
        ]
        7 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Santesteban Muruz&#225;bal R&#44; Hervella Garc&#233;s M&#44; Ros Mart&#237;n C&#46; &#191;Qu&#233; genodermatosis es&#63;&#46; Actas Dermosifiliogr&#46; 2014&#59;106&#58;667&#8211;668&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 500
            "Ancho" => 913
            "Tamanyo" => 109098
          ]
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 500
            "Ancho" => 977
            "Tamanyo" => 227116
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Hematoxylin-eosin&#44; original magnification &#215;100&#46; B&#44; Hematoxylin-eosin&#44; original magnification &#215;200&#46;</p>"
        ]
      ]
      2 => array:6 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 500
            "Ancho" => 605
            "Tamanyo" => 87637
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progressive symmetrical erythrokeratoderma - response to topical calcipotriol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Bilgin"
                            1 => "K&#46;E&#46; Bozdag"
                            2 => "S&#46; Uysal"
                            3 => "M&#46; Ermete"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3315/jdcr.2011.1075"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Case Rep"
                        "fecha" => "2011"
                        "volumen" => "5"
                        "paginaInicial" => "50"
                        "paginaFinal" => "52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22187580"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progressive symmetrical erythrokeratoderma&#58; Report of a Turkish family and evaluation for loricrin and connexin gene mutations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Akman"
                            1 => "M&#46; Masse"
                            2 => "E&#46; Mihci"
                            3 => "G&#46; Richard"
                            4 => "A&#46;M&#46; Christano"
                            5 => "B&#46;J&#46; Balle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2230.2008.02728.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2008"
                        "volumen" => "33"
                        "paginaInicial" => "582"
                        "paginaFinal" => "584"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18462442"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progressive symmetrical erythrokeratoderma&#58; Report of two Chinese families and evaluation for mutations in the loricrin&#44; connexin 30&#46;3 and connexin 31 genes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46;R&#46; Guo"
                            1 => "L&#46;D&#46; Sun"
                            2 => "Y&#46; Cui"
                            3 => "S&#46; Yang"
                            4 => "X&#46;J&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.12135"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2013"
                        "volumen" => "38"
                        "paginaInicial" => "925"
                        "paginaFinal" => "927"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23678955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Symmetric progressive erythrokeratoderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; &#193;lvarez-Vieitez"
                            1 => "A&#46; Torrelo"
                            2 => "I&#46;G&#46; Medeiro"
                            3 => "A&#46; Zambrano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "1999"
                        "volumen" => "90"
                        "paginaInicial" => "633"
                        "paginaFinal" => "635"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The molecular pathology of progressive symmetric erythrokeratoderma&#58; A frameshift mutation in the loricrin gene and perturbations in the cornified cell envelope"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Ishida-Yamamoto"
                            1 => "J&#46;A&#46; McGrath"
                            2 => "H&#46; Lam"
                            3 => "H&#46; Iizuka"
                            4 => "R&#46;A&#46; Friedman"
                            5 => "A&#46;M&#46; Christiano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/515518"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "1997"
                        "volumen" => "61"
                        "paginaInicial" => "581"
                        "paginaFinal" => "589"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9326323"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Generalized progressive symmetric erythrokeratoderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Rodero"
                            1 => "A&#46; Torrelo"
                            2 => "I&#46;G&#46; Medeiro"
                            3 => "A&#46; Zambrano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2001"
                        "volumen" => "92"
                        "paginaInicial" => "207"
                        "paginaFinal" => "209"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002000/v1_201510011018/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6154"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case for Diagnosis"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000008/v1_201510011018/S1578219015002000/v1_201510011018/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002000?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case for Diagnosis
Can You Identify the Genodermatosis?
¿Qué genodermatosis es?
R. Santesteban Muruzábal
Corresponding author
raquel.santesteban@hotmail.com

Corresponding author.
, M. Hervella Garcés, C. Ros Martín
Servicio de Dermatología, Hospital de Navarra, Complejo Hospitalario de Navarra, Pamplona, Navarre, Spain
Read
6070
Times
was read the article
2096
Total PDF
3974
Total HTML
Share statistics
 array:24 [
  "pii" => "S1578219015002000"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.07.002"
  "estado" => "S300"
  "fechaPublicacion" => "2015-10-01"
  "aid" => "1083"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2015;106:667-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 688
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 422
      "PDF" => 218
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S000173101400475X"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.11.002"
      "estado" => "S300"
      "fechaPublicacion" => "2015-10-01"
      "aid" => "1083"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2015;106:667-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 656
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 396
          "PDF" => 258
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
        "titulo" => "&#191;Qu&#233; genodermatosis es&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "667"
            "paginaFinal" => "668"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Can You Identify the Genodermatosis&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:6 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 500
                "Ancho" => 605
                "Tamanyo" => 89864
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "R&#46; Santesteban Muruz&#225;bal, M&#46; Hervella Garc&#233;s, C&#46; Ros Mart&#237;n"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Santesteban Muruz&#225;bal"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Hervella Garc&#233;s"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Ros Mart&#237;n"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002000"
          "doi" => "10.1016/j.adengl.2015.07.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002000?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101400475X?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000008/v1_201510020746/S000173101400475X/v1_201510020746/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002152"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.017"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1200"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2015;106:669-71"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1231
      "formatos" => array:3 [
        "EPUB" => 59
        "HTML" => 577
        "PDF" => 595
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Videos of Surgical Procedures in Dermatology</span>"
      "titulo" => "Parascapular Perforating Flap to Treat Severe Axillary Hidradenitis Suppurativa"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "669"
          "paginaFinal" => "671"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Colgajo paraescapular perforante para tratamiento de la hidradenitis axilar grave"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1373
              "Ancho" => 990
              "Tamanyo" => 303170
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#44; Appearance immediately after the en bloc excision of the affected axillary skin&#44; with a surgical margin&#46; B&#44; Surgical wound after removal of the drain 4 days after the operation&#46; C&#44; Healthy axilla 2 years after the operation&#46; D&#44; Partial view of the donor site 2 years after the operation&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Tercedor-S&#225;nchez, J&#46;M&#46; R&#243;denas-L&#243;pez, P&#46; Ram&#243;n-Faba, F&#46; Mu&#241;oz-Romero"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Tercedor-S&#225;nchez"
            ]
            1 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "R&#243;denas-L&#243;pez"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Ram&#243;n-Faba"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Mu&#241;oz-Romero"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015002690"
        "doi" => "10.1016/j.ad.2015.05.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002690?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002152?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002152/v1_201510011018/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015002073"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.009"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1164"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2015;106:e41-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 739
      "formatos" => array:3 [
        "EPUB" => 52
        "HTML" => 451
        "PDF" => 236
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">e-Case Report</span>"
      "titulo" => "Usefulness of Confocal Microscopy in Distinguishing Between Basal Cell Carcinoma and Intradermal Melanocytic Nevus on the Face"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "e41"
          "paginaFinal" => "e44"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Utilidad de la microscopia confocal en el diagn&#243;stico diferencial de epiteliomas basocelulares y nevus melanoc&#237;ticos intrad&#233;rmicos de localizaci&#243;n facial"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1228
              "Ancho" => 1668
              "Tamanyo" => 356796
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Confocal microscopy image measuring 0&#46;75<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>mm&#46; Note the tumor nests &#40;yellow arrows&#41; separated from the stroma by dark clefts &#40;white arrows&#41;&#46; There are reflective cells inside &#40;red asterisk&#41; and outside &#40;yellow asterisk&#41; the nests&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Gamo, U&#46; Flor&#237;stan, A&#46; Pamp&#237;n, D&#46; Caro, F&#46; Pinedo, J&#46;L&#46; L&#243;pez-Estebaranz"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Gamo"
            ]
            1 => array:2 [
              "nombre" => "U&#46;"
              "apellidos" => "Flor&#237;stan"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Pamp&#237;n"
            ]
            3 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Caro"
            ]
            4 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Pinedo"
            ]
            5 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "L&#243;pez-Estebaranz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015001726"
        "doi" => "10.1016/j.ad.2015.03.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015001726?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002073?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002073/v1_201510011018/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>"
    "titulo" => "Can You Identify the Genodermatosis&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "667"
        "paginaFinal" => "668"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46; Santesteban Muruz&#225;bal, M&#46; Hervella Garc&#233;s, C&#46; Ros Mart&#237;n"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "R&#46;"
            "apellidos" => "Santesteban Muruz&#225;bal"
            "email" => array:1 [
              0 => "raquel&#46;santesteban&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Hervella Garc&#233;s"
          ]
          2 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Ros Mart&#237;n"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital de Navarra&#44; Complejo Hospitalario de Navarra&#44; Pamplona&#44; Navarre&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#191;Qu&#233; genodermatosis es&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 500
            "Ancho" => 977
            "Tamanyo" => 227116
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Hematoxylin-eosin&#44; original magnification &#215;100&#46; B&#44; Hematoxylin-eosin&#44; original magnification &#215;200&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Patient History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 5-year-old boy from Colombia with no known family history of skin disease presented with asymptomatic lesions on the limbs&#44; predominantly in acral regions and areas around the joints&#46; His family reported slow&#44; peripheral growth of the lesions over the past few months but were unable to specify exactly when the clinical signs first appeared&#46; No other associated symptoms were present at any level&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination revealed keratotic&#44; lichenoid plaques with mild peripheral erythema affecting the hips&#44; acral regions&#44; and areas around the joints on all 4 limbs&#44; especially on extensor surfaces &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The development of the boy was normal for his age&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Histologic examination revealed hyperkeratosis with focal parakeratosis&#44; hypergranulosis&#44; and acanthosis with elongated rete ridges &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Progressive symmetric erythrokeratoderma &#40;PSEK&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">Topical treatment was started with 20&#37; urea cream and systemic treatment was started with oral acitretin at a dose of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46; Patient tolerance was good&#46; Over several months&#44; the lesions clearly involuted until they were limited to the acral regions of the limbs and the flexures&#44; with a minimal effective dose of 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46; Periodic blood tests were carried out at follow-up visits&#44; and no abnormalities caused by the treatment were observed&#46; Adherence to treatment has been erratic over several years of follow-up at our dermatology clinic&#59; periods of evident exacerbation have coincided with the voluntary withdrawal of the medication&#46; The patient&#44; now 14 years old&#44; continues to receive treatment with acitretin at a minimum effective dose of 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Erythrokeratodermas are a clinically and genetically heterogeneous group of skin diseases characterized by well-defined erythematous-keratotic plaques&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#8211;3</span></a> There are various subtypes&#44; the most important of which are PSEK and erythrokeratoderma variabilis&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#8211;6</span></a> PSEK is a rare genodermatosis that has been associated with a mutation in the loricrin gene on chromosome 1q21&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4&#44;5</span></a> although it is genetically heterogeneous&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In most cases&#44; PSEK is hereditary&#44; with autosomal dominant inheritance&#44; incomplete penetrance&#44; and variable expressivity&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a> although sporadic cases<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;6</span></a> and cases with a recessive inheritance pattern<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> have also been reported&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Clinically&#44; PSEK is characterized by the appearance of large&#44; erythematous&#44; orange-colored&#44; well-defined&#44; symmetrical plaques that in some cases can have a keratotic or verrucous appearance&#44; usually located on the buttocks&#44; cheeks&#44; and limbs&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;6</span></a> Palmoplantar involvement has been reported in up to 50&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;6</span></a> The lesions usually appear in the first years of life and spread slowly or remain stable during the following years&#59; spontaneous improvement sometimes occurs&#44; usually during puberty&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Histologic findings are nonspecific&#44; with foci of parakeratosis and marked acanthosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a> Perinuclear vacuolization can be observed in the granular cell layer&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">PSEK is treated symptomatically&#46; Topical treatments&#8212;including emollients and keratolytic agents&#8212;are reserved for the mildest cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a> For severe cases&#44; systemic treatment&#8212;oral retinoids&#44; such as acitretin at a dose of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#8212;is usually added&#46; Psoralen-UV-A phototherapy has also been used&#44; with variable clinical responses&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">We have presented a new case of PSEK&#44; a rare entity&#46; The case is unusual because it is sporadic&#44; autosomal dominant inheritance being more common in this disease&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:8 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Patient History"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Physical Examination"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Histopathology"
        ]
        3 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Diagnosis"
        ]
        4 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Clinical Course and Treatment"
        ]
        5 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Comment"
        ]
        6 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflicts of Interest"
        ]
        7 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Santesteban Muruz&#225;bal R&#44; Hervella Garc&#233;s M&#44; Ros Mart&#237;n C&#46; &#191;Qu&#233; genodermatosis es&#63;&#46; Actas Dermosifiliogr&#46; 2014&#59;106&#58;667&#8211;668&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 500
            "Ancho" => 913
            "Tamanyo" => 109098
          ]
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 500
            "Ancho" => 977
            "Tamanyo" => 227116
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Hematoxylin-eosin&#44; original magnification &#215;100&#46; B&#44; Hematoxylin-eosin&#44; original magnification &#215;200&#46;</p>"
        ]
      ]
      2 => array:6 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 500
            "Ancho" => 605
            "Tamanyo" => 87637
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progressive symmetrical erythrokeratoderma - response to topical calcipotriol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Bilgin"
                            1 => "K&#46;E&#46; Bozdag"
                            2 => "S&#46; Uysal"
                            3 => "M&#46; Ermete"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3315/jdcr.2011.1075"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Case Rep"
                        "fecha" => "2011"
                        "volumen" => "5"
                        "paginaInicial" => "50"
                        "paginaFinal" => "52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22187580"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progressive symmetrical erythrokeratoderma&#58; Report of a Turkish family and evaluation for loricrin and connexin gene mutations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Akman"
                            1 => "M&#46; Masse"
                            2 => "E&#46; Mihci"
                            3 => "G&#46; Richard"
                            4 => "A&#46;M&#46; Christano"
                            5 => "B&#46;J&#46; Balle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2230.2008.02728.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2008"
                        "volumen" => "33"
                        "paginaInicial" => "582"
                        "paginaFinal" => "584"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18462442"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progressive symmetrical erythrokeratoderma&#58; Report of two Chinese families and evaluation for mutations in the loricrin&#44; connexin 30&#46;3 and connexin 31 genes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46;R&#46; Guo"
                            1 => "L&#46;D&#46; Sun"
                            2 => "Y&#46; Cui"
                            3 => "S&#46; Yang"
                            4 => "X&#46;J&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ced.12135"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2013"
                        "volumen" => "38"
                        "paginaInicial" => "925"
                        "paginaFinal" => "927"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23678955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Symmetric progressive erythrokeratoderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; &#193;lvarez-Vieitez"
                            1 => "A&#46; Torrelo"
                            2 => "I&#46;G&#46; Medeiro"
                            3 => "A&#46; Zambrano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "1999"
                        "volumen" => "90"
                        "paginaInicial" => "633"
                        "paginaFinal" => "635"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The molecular pathology of progressive symmetric erythrokeratoderma&#58; A frameshift mutation in the loricrin gene and perturbations in the cornified cell envelope"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Ishida-Yamamoto"
                            1 => "J&#46;A&#46; McGrath"
                            2 => "H&#46; Lam"
                            3 => "H&#46; Iizuka"
                            4 => "R&#46;A&#46; Friedman"
                            5 => "A&#46;M&#46; Christiano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/515518"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "1997"
                        "volumen" => "61"
                        "paginaInicial" => "581"
                        "paginaFinal" => "589"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9326323"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Generalized progressive symmetric erythrokeratoderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Rodero"
                            1 => "A&#46; Torrelo"
                            2 => "I&#46;G&#46; Medeiro"
                            3 => "A&#46; Zambrano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2001"
                        "volumen" => "92"
                        "paginaInicial" => "207"
                        "paginaFinal" => "209"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002000/v1_201510011018/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6154"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case for Diagnosis"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000008/v1_201510011018/S1578219015002000/v1_201510011018/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002000?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 6 8 14
2024 October 63 48 111
2024 September 58 34 92
2024 August 82 46 128
2024 July 76 52 128
2024 June 78 36 114
2024 May 67 47 114
2024 April 82 22 104
2024 March 79 41 120
2024 February 77 31 108
2024 January 62 33 95
2023 December 64 21 85
2023 November 80 32 112
2023 October 71 35 106
2023 September 76 40 116
2023 August 54 25 79
2023 July 83 43 126
2023 June 57 40 97
2023 May 65 42 107
2023 April 96 22 118
2023 March 70 22 92
2023 February 88 27 115
2023 January 41 44 85
2022 December 61 48 109
2022 November 39 29 68
2022 October 31 29 60
2022 September 39 32 71
2022 August 28 40 68
2022 July 30 42 72
2022 June 22 25 47
2022 May 88 36 124
2022 April 101 61 162
2022 March 88 53 141
2022 February 53 33 86
2022 January 74 41 115
2021 December 64 42 106
2021 November 72 64 136
2021 October 81 51 132
2021 September 51 31 82
2021 August 43 24 67
2021 July 48 31 79
2021 June 58 29 87
2021 May 55 26 81
2021 April 154 52 206
2021 March 125 21 146
2021 February 89 28 117
2021 January 54 20 74
2020 December 74 18 92
2020 November 49 19 68
2020 October 44 9 53
2020 September 84 19 103
2020 August 36 26 62
2020 July 32 18 50
2020 June 26 33 59
2020 May 21 19 40
2020 April 35 15 50
2020 March 25 17 42
2020 February 3 8 11
2020 January 6 0 6
2019 December 8 1 9
2019 November 4 1 5
2019 October 0 3 3
2019 September 4 0 4
2019 August 4 7 11
2019 July 4 3 7
2019 June 4 14 18
2019 May 6 10 16
2019 April 2 9 11
2019 March 4 4 8
2019 February 0 2 2
2019 January 2 2 4
2018 December 5 5 10
2018 November 1 2 3
2018 October 2 0 2
2018 September 6 0 6
2018 March 0 1 1
2018 February 20 5 25
2018 January 24 3 27
2017 December 28 12 40
2017 November 17 3 20
2017 October 21 7 28
2017 September 16 2 18
2017 August 22 7 29
2017 July 16 8 24
2017 June 25 5 30
2017 May 22 11 33
2017 April 19 5 24
2017 March 6 5 11
2017 February 19 11 30
2017 January 13 2 15
2016 December 24 6 30
2016 November 29 11 40
2016 October 29 14 43
2016 September 0 2 2
2016 July 2 3 5
2016 June 4 2 6
2016 May 0 4 4
2016 April 4 1 5
2016 March 0 7 7
2016 February 0 1 1
2016 January 0 10 10
2015 December 0 1 1
2015 November 0 4 4
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?