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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Erosive pustular dermatosis of the scalp is a rare inflammatory skin disease that mainly affects older patients and is characterized by the presence of sterile pustules and scabs&#46; Recently&#44; several authors have reported the usefulness of photodynamic therapy in the treatment of this condition&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 79-year-old man with skin phototype III and actinic keratosis of the face and scalp&#44; occasionally treated with cryotherapy&#44; after which the patient would complain of painful erosions in the treated area&#46; On one of his check-up visits he had an outbreak of pustules and scabs that mainly affected the posterior part of the parietal region&#46; The pustules had an erythematous base&#44; and painful erosions and scabs were also visible&#46; Biopsy revealed areas of fibrosis&#44; a predominantly perifollicular neutrophil infiltrate&#44; and areas of scarring&#46; The diagnosis was erosive pustular dermatosis of the scalp&#44; which responded favorably to topical treatment with fusidic acid plus betamethasone cream and healed with scarring alopecia&#46; Thereafter&#44; actinic keratoses in this patient were successfully treated with topical imiquimod to prevent outbreaks of pustulosis&#46; During follow-up&#44; however&#44; he presented with hypertrophic actinic keratoses in the occipital region and numerous pustules that coalesced into lakes of pus &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; These actinic keratoses did not respond to imiquimod and the erosive pustular dermatosis of the scalp worsened with the use of this agent&#46; It was then decided to try treatment with photodynamic therapy &#40;PDT&#41;&#46; At the first session&#44; curettage of the most hypertrophic actinic keratoses was performed and this was followed by an application of Metvix<span class="elsevierStyleSup">&#174;</span> &#40;160<span class="elsevierStyleHsp" style=""></span>mg&#47;g methyl aminolevulinate hydrochloride cream&#59; manufactured by Penn Pharmaceutical Services Ltd&#44; distributed by Galderma&#41; under occlusion for 3<span class="elsevierStyleHsp" style=""></span>hours&#46; Wood light showed intense uptake in the area &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; which was then infiltrated with local anesthetic&#46; Irradiation was by red light &#40;Aktilite CL128&#44; Photocure ASA&#44; Oslo&#44; Norway&#41; at a wavelength of 630&#160;nm&#44; with a fluence of 37<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#46; A good response was observed after a week but several actinic keratoses and pustules still remained&#46; A second session 3 weeks later cleared the actinic keratoses and the erosive pustular dermatosis of the scalp was rendered inactive &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Six months later&#44; the improvement in the treated area was maintained and the patient is currently awaiting a further session on the occipital region to treat new actinic keratoses&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Erosive pustular dermatoses are rare inflammatory skin diseases of unknown origin that typically arise either on the legs or on the scalp&#46; Erosive pustular dermatosis of the scalp mainly affects older patients&#46; It is characterized by confluent sterile pustules&#44; erosions&#44; and scabs on the scalp that heal with scarring alopecia&#46; Factors such as local trauma&#44; cryotherapy&#44; and radiotherapy<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> can trigger or worsen this condition&#46; The differential diagnosis includes bacterial folliculitis&#44; inflammatory tinea&#44; blistering diseases such as cicatricial pemphigoid&#44; dissecting cellulitis&#44; and pyoderma gangrenosum&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Treatment is complex and the disease tends to recur&#46; Medium- to high-potency topical corticosteroids have been used successfully&#44; sometimes in conjunction with a topical antibiotic&#46; Topical tacrolimus can also be effective<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and prevents the adverse effects of long-term topical corticosteroid therapy&#46; Other treatments include oral corticosteroids&#44; dapsone&#44; oral retinoids &#40;isotretinoin&#41;&#44; and topical calcipotriol&#46; In our patient&#44; treatment of actinic keratoses with cryotherapy probably worsened the erosive pustular dermatosis of the scalp&#44; and cryotherapy was therefore avoided after this second diagnosis was made&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">PDT is a well-established treatment for actinic keratoses and other premalignant or malignant conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> It is particularly useful for the treatment of actinic keratoses in patients with multiple lesions or frequent recurrences&#46; There is evidence of the value of PDT in erosive pustular dermatosis of the scalp&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> attributed to its immunomodulatory effect on inflammatory cells&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Meyer et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> reported the case of a 75-year-old woman with erosive pustular dermatosis of the scalp successfully treated with PDT&#46; Recently&#44; Eleftheriou et al<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> published a case similar to ours of a 72-year-old man with actinic keratoses and underlying erosive pustular dermatosis of the scalp&#46; Two sessions of PDT separated by 12 weeks led to resolution of the lesions&#46; However&#44; Guarneri et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> described the case of a 93-year-old woman who had an outbreak of erosive pustular dermatosis of the scalp after 2 sessions of PDT for actinic keratoses in the same area&#46; Their patient received a higher fluence than ours &#40;75<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> compared to 37<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#44; respectively&#41;&#44; and this may have resulted in the appearance of erosive pustular dermatosis of the scalp&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We report a patient with erosive pustular dermatosis of the scalp and multiple hypertrophic actinic keratoses on the scalp&#59; both conditions responded to treatment with PDT&#46; Two sessions of PDT led to considerable improvement&#44; which was maintained at the 6-month follow-up&#46; Experience of using PDT in inflammatory dermatoses like erosive pustular dermatosis of the scalp is limited&#44; but our case provides more evidence that it can be a good therapeutic option for a disorder that is difficult to manage&#46;</p></span>"
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Case and Research Letter
Response to Photodynamic Therapy for Pustular Dermatosis of the Scalp and Hypertrophic Actinic Keratosis
Respuesta a terapia fotodinámica en paciente con dermatosis pustulosa del cuero cabelludo y queratosis actínicas hipertróficas
A.F. Monteagudo
Corresponding author
almudenamonteagudo@gmail.com

Corresponding author.
, I. Belinchón, N. Latorre, J.F. Silvestre
Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain
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    "titulo" => "Response to Photodynamic Therapy for Pustular Dermatosis of the Scalp and Hypertrophic Actinic Keratosis"
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        "titulo" => "Respuesta a terapia fotodin&#225;mica en paciente con dermatosis pustulosa del cuero cabelludo y queratosis act&#237;nicas hipertr&#243;ficas"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Intense uptake by actinic keratoses as well as by the lesions of erosive pustular dermatosis of the scalp&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Erosive pustular dermatosis of the scalp is a rare inflammatory skin disease that mainly affects older patients and is characterized by the presence of sterile pustules and scabs&#46; Recently&#44; several authors have reported the usefulness of photodynamic therapy in the treatment of this condition&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 79-year-old man with skin phototype III and actinic keratosis of the face and scalp&#44; occasionally treated with cryotherapy&#44; after which the patient would complain of painful erosions in the treated area&#46; On one of his check-up visits he had an outbreak of pustules and scabs that mainly affected the posterior part of the parietal region&#46; The pustules had an erythematous base&#44; and painful erosions and scabs were also visible&#46; Biopsy revealed areas of fibrosis&#44; a predominantly perifollicular neutrophil infiltrate&#44; and areas of scarring&#46; The diagnosis was erosive pustular dermatosis of the scalp&#44; which responded favorably to topical treatment with fusidic acid plus betamethasone cream and healed with scarring alopecia&#46; Thereafter&#44; actinic keratoses in this patient were successfully treated with topical imiquimod to prevent outbreaks of pustulosis&#46; During follow-up&#44; however&#44; he presented with hypertrophic actinic keratoses in the occipital region and numerous pustules that coalesced into lakes of pus &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; These actinic keratoses did not respond to imiquimod and the erosive pustular dermatosis of the scalp worsened with the use of this agent&#46; It was then decided to try treatment with photodynamic therapy &#40;PDT&#41;&#46; At the first session&#44; curettage of the most hypertrophic actinic keratoses was performed and this was followed by an application of Metvix<span class="elsevierStyleSup">&#174;</span> &#40;160<span class="elsevierStyleHsp" style=""></span>mg&#47;g methyl aminolevulinate hydrochloride cream&#59; manufactured by Penn Pharmaceutical Services Ltd&#44; distributed by Galderma&#41; under occlusion for 3<span class="elsevierStyleHsp" style=""></span>hours&#46; Wood light showed intense uptake in the area &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; which was then infiltrated with local anesthetic&#46; Irradiation was by red light &#40;Aktilite CL128&#44; Photocure ASA&#44; Oslo&#44; Norway&#41; at a wavelength of 630&#160;nm&#44; with a fluence of 37<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#46; A good response was observed after a week but several actinic keratoses and pustules still remained&#46; A second session 3 weeks later cleared the actinic keratoses and the erosive pustular dermatosis of the scalp was rendered inactive &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Six months later&#44; the improvement in the treated area was maintained and the patient is currently awaiting a further session on the occipital region to treat new actinic keratoses&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Erosive pustular dermatoses are rare inflammatory skin diseases of unknown origin that typically arise either on the legs or on the scalp&#46; Erosive pustular dermatosis of the scalp mainly affects older patients&#46; It is characterized by confluent sterile pustules&#44; erosions&#44; and scabs on the scalp that heal with scarring alopecia&#46; Factors such as local trauma&#44; cryotherapy&#44; and radiotherapy<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> can trigger or worsen this condition&#46; The differential diagnosis includes bacterial folliculitis&#44; inflammatory tinea&#44; blistering diseases such as cicatricial pemphigoid&#44; dissecting cellulitis&#44; and pyoderma gangrenosum&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Treatment is complex and the disease tends to recur&#46; Medium- to high-potency topical corticosteroids have been used successfully&#44; sometimes in conjunction with a topical antibiotic&#46; Topical tacrolimus can also be effective<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and prevents the adverse effects of long-term topical corticosteroid therapy&#46; Other treatments include oral corticosteroids&#44; dapsone&#44; oral retinoids &#40;isotretinoin&#41;&#44; and topical calcipotriol&#46; In our patient&#44; treatment of actinic keratoses with cryotherapy probably worsened the erosive pustular dermatosis of the scalp&#44; and cryotherapy was therefore avoided after this second diagnosis was made&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">PDT is a well-established treatment for actinic keratoses and other premalignant or malignant conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> It is particularly useful for the treatment of actinic keratoses in patients with multiple lesions or frequent recurrences&#46; There is evidence of the value of PDT in erosive pustular dermatosis of the scalp&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> attributed to its immunomodulatory effect on inflammatory cells&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Meyer et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> reported the case of a 75-year-old woman with erosive pustular dermatosis of the scalp successfully treated with PDT&#46; Recently&#44; Eleftheriou et al<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> published a case similar to ours of a 72-year-old man with actinic keratoses and underlying erosive pustular dermatosis of the scalp&#46; Two sessions of PDT separated by 12 weeks led to resolution of the lesions&#46; However&#44; Guarneri et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> described the case of a 93-year-old woman who had an outbreak of erosive pustular dermatosis of the scalp after 2 sessions of PDT for actinic keratoses in the same area&#46; Their patient received a higher fluence than ours &#40;75<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span> compared to 37<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#44; respectively&#41;&#44; and this may have resulted in the appearance of erosive pustular dermatosis of the scalp&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We report a patient with erosive pustular dermatosis of the scalp and multiple hypertrophic actinic keratoses on the scalp&#59; both conditions responded to treatment with PDT&#46; Two sessions of PDT led to considerable improvement&#44; which was maintained at the 6-month follow-up&#46; Experience of using PDT in inflammatory dermatoses like erosive pustular dermatosis of the scalp is limited&#44; but our case provides more evidence that it can be a good therapeutic option for a disorder that is difficult to manage&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Monteagudo AF&#44; et al&#46; Respuesta a terapia fotodin&#225;mica en paciente con der-matosis pustulosa del cuero cabelludo y queratosis act&#237;nicas hipertr&#243;ficas&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;351&#8211;2&#46;</p>"
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Article information
ISSN: 15782190
Original language: English
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2017 October 77 7 84
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2017 August 65 17 82
2017 July 79 3 82
2017 June 61 27 88
2017 May 54 4 58
2017 April 52 13 65
2017 March 40 39 79
2017 February 134 4 138
2017 January 84 6 90
2016 December 68 5 73
2016 November 139 5 144
2016 October 144 18 162
2016 September 210 11 221
2016 August 163 7 170
2016 July 63 5 68
2016 June 5 3 8
2016 May 5 11 16
2016 April 4 6 10
2016 March 8 2 10
2016 February 10 9 19
2016 January 6 12 18
2015 December 13 8 21
2015 November 11 12 23
2015 October 10 15 25
2015 September 16 5 21
2015 August 12 1 13
2015 July 117 131 248
2015 June 89 8 97
2015 May 111 16 127
2015 April 51 7 58
2015 March 56 5 61
2015 February 57 4 61
2015 January 59 2 61
2014 December 63 5 68
2014 November 49 2 51
2014 October 60 1 61
2014 September 40 2 42
2014 August 48 6 54
2014 July 40 3 43
2014 June 52 6 58
2014 May 52 6 58
2014 April 43 3 46
2014 March 43 9 52
2014 February 40 4 44
2014 January 33 9 42
2013 December 37 6 43
2013 November 31 7 38
2013 October 21 3 24
2013 September 21 2 23
2013 August 24 5 29
2013 July 11 5 16
2013 June 2 0 2
2013 May 4 3 7
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Idiomas
Actas Dermo-Sifiliográficas
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?