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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Transitional cell carcinoma of the bladder is an aggressive tumor with a high potential for malignant progression&#46; Bacille Calmette-Gu&#233;rin &#40;BCG&#41; has been used to treat malignant diseases for more than 20 years&#44; and bladder cancer has been treated with it longer&#44; since 1976&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> BCG is an attenuated strain of <span class="elsevierStyleItalic">Mycobacterium bovis</span>&#59; instilled in solution to treat bladder cancer&#44; it delays recurrence and prevents the implantation of tumor cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> Most patients tolerate intravesical irrigation with BCG well&#44; but complications are not unusual&#46; Side effects consist mainly of local irritation and flu-like symptoms and are usually mild&#46; Various systemic and local infections have also been reported following instillation of BCG&#44; which is a live organism&#46; Such infections have included pneumonitis&#44; hepatitis&#44; granulomatous prostatitis&#44; epididymitis&#44; and renal parenchymal abscess&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4&#44;6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present a case of granulomatous balanoposthitis that followed intravesical BCG therapy to prevent recurrence after transurethral resection of a transitional cell carcinoma&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A 40-year-old man received intermittent cycles of intravesical BCG therapy to treat transitional cell carcinoma of the bladder starting in 2009&#46; At 48<span class="elsevierStyleHsp" style=""></span>hours from the sixth instillation&#44; which involved a difficult catheterization with slight extravasation of the product&#44; the patient presented with yellowish papular lesions on the glans penis&#44; large painful lymph nodes in the right groin&#44; and dysuria &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; A biopsy was performed and cultures were ordered&#46; In the differential diagnosis&#44; we considered infectious diseases &#40;herpetic primo-infection&#44; syphilis&#44; fungal infection&#44; skin infection due to BCG&#41; and neutrophilic diseases &#40;pyoderma gangrenosum&#44; Beh&#231;et disease&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Histology showed a substantial neutrophilic infiltrate in the dermis with no granulomas or multinucleated giant cells &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Ziehl-Neelsen and periodic acid-Schiff staining were negative for micro-organisms&#46; The culture&#44; which was negative for fungi&#44; grew only <span class="elsevierStyleItalic">Streptococcus salivarius</span> &#40;a saprophyte&#41;&#46; Despite the negative results of the acid-fast staining&#44; BCG infection was suspected because the other candidate diagnoses were unlikely&#46; Empirical treatment with isoniazid and rifampicin was ordered and by 15 days had reduced the spread of the lesions&#46; At this time&#44; isoniazid-resistant <span class="elsevierStyleItalic">M bovis</span> was isolated in the initial culture in Lowenstein medium&#46; Rifampicin&#44; ethambutol&#44; and moxifloxacin were then prescribed and the lesions had improved considerably after 2 weeks of treatment &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Intravesical BCG treatment is recognized as an effective therapy for superficial bladder cancer&#44; although numerous side effects have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The most common reactions are minor and include cystitis&#44; hematuria&#44; low-grade fever&#44; general malaise&#44; and nausea&#46; More serious side effects include fever&#44; granulomatous pneumonitis&#44; hepatitis&#44; renal abscess&#44; and even fatal sepsis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;7</span></a> Granulomatous reactions associated with BCG therapy can occur in the bladder&#44; epididymis&#44; prostate&#44; kidney&#44; lungs&#44; and liver&#46; However&#44; involvement of the glans penis and urethra is quite rare&#58; only 12 cases have been reported to date&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;8</span></a> In each case&#44; pathology showed granulomas and&#44; usually&#44; caseating necrosis&#46; These findings were not present in our patient&#44; perhaps because the biopsy was performed promptly&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A recently published study showed that polymorphonuclear cells play an essential role in the antitumor effect of BCG treatment&#46; Instillation of BCG starts a primarily neutrophilic inflammatory reaction that triggers the migration of effector cells &#40;lymphocytes and monocytes or macrophages&#41; to the bladder&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Patients who are immunocompromised&#44; have mucosal barrier disruption due to injury&#44; or have positive reactions on tuberculin skin testing are at higher risk of presenting BCG side effects&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4&#44;6&#44;7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Given the small number of published cases&#44; no standard treatment has emerged&#46; Some reviews recommend starting the treatment of prostatitis and granulomatous orchiepididymitis with 300<span class="elsevierStyleHsp" style=""></span>mg of oral isoniazid and 600<span class="elsevierStyleHsp" style=""></span>mg of rifampicin and continuing it for 3 to 6 months while discontinuing BCG therapy and testing for antibiotic resistance&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;7</span></a> Other authors recommend corticosteroid therapy at the start of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">This rare case of balanitis due to BCG demonstrates the need to consider this possible side effect when patients are undergoing BCG therapy&#46;</p></span>"
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Case and Research Letters
Granulomatous Balanitis After Intravesical Bacille Calmette-Guérin Instillation
Balanitis granulomatosa tras terapia intravesical con bacilo de Calmette-Guérin
M. García Baldovía,
Corresponding author
maria_gbaldovi@hotmail.com

Corresponding author.
, M. Pérez-Crespoa, J. Onrubiab, M. Moragóna
a Departamento de Dermatología, Hospital Clínico de San Juan de Alicante, Alicante, Spain
b Departamento de Dermatología Patológica, Hospital Clínico de San Juan de Alicante, Alicante, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Transitional cell carcinoma of the bladder is an aggressive tumor with a high potential for malignant progression&#46; Bacille Calmette-Gu&#233;rin &#40;BCG&#41; has been used to treat malignant diseases for more than 20 years&#44; and bladder cancer has been treated with it longer&#44; since 1976&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> BCG is an attenuated strain of <span class="elsevierStyleItalic">Mycobacterium bovis</span>&#59; instilled in solution to treat bladder cancer&#44; it delays recurrence and prevents the implantation of tumor cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> Most patients tolerate intravesical irrigation with BCG well&#44; but complications are not unusual&#46; Side effects consist mainly of local irritation and flu-like symptoms and are usually mild&#46; Various systemic and local infections have also been reported following instillation of BCG&#44; which is a live organism&#46; Such infections have included pneumonitis&#44; hepatitis&#44; granulomatous prostatitis&#44; epididymitis&#44; and renal parenchymal abscess&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;4&#44;6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present a case of granulomatous balanoposthitis that followed intravesical BCG therapy to prevent recurrence after transurethral resection of a transitional cell carcinoma&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A 40-year-old man received intermittent cycles of intravesical BCG therapy to treat transitional cell carcinoma of the bladder starting in 2009&#46; At 48<span class="elsevierStyleHsp" style=""></span>hours from the sixth instillation&#44; which involved a difficult catheterization with slight extravasation of the product&#44; the patient presented with yellowish papular lesions on the glans penis&#44; large painful lymph nodes in the right groin&#44; and dysuria &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; A biopsy was performed and cultures were ordered&#46; In the differential diagnosis&#44; we considered infectious diseases &#40;herpetic primo-infection&#44; syphilis&#44; fungal infection&#44; skin infection due to BCG&#41; and neutrophilic diseases &#40;pyoderma gangrenosum&#44; Beh&#231;et disease&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Histology showed a substantial neutrophilic infiltrate in the dermis with no granulomas or multinucleated giant cells &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Ziehl-Neelsen and periodic acid-Schiff staining were negative for micro-organisms&#46; The culture&#44; which was negative for fungi&#44; grew only <span class="elsevierStyleItalic">Streptococcus salivarius</span> &#40;a saprophyte&#41;&#46; Despite the negative results of the acid-fast staining&#44; BCG infection was suspected because the other candidate diagnoses were unlikely&#46; Empirical treatment with isoniazid and rifampicin was ordered and by 15 days had reduced the spread of the lesions&#46; At this time&#44; isoniazid-resistant <span class="elsevierStyleItalic">M bovis</span> was isolated in the initial culture in Lowenstein medium&#46; Rifampicin&#44; ethambutol&#44; and moxifloxacin were then prescribed and the lesions had improved considerably after 2 weeks of treatment &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Intravesical BCG treatment is recognized as an effective therapy for superficial bladder cancer&#44; although numerous side effects have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The most common reactions are minor and include cystitis&#44; hematuria&#44; low-grade fever&#44; general malaise&#44; and nausea&#46; More serious side effects include fever&#44; granulomatous pneumonitis&#44; hepatitis&#44; renal abscess&#44; and even fatal sepsis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;7</span></a> Granulomatous reactions associated with BCG therapy can occur in the bladder&#44; epididymis&#44; prostate&#44; kidney&#44; lungs&#44; and liver&#46; However&#44; involvement of the glans penis and urethra is quite rare&#58; only 12 cases have been reported to date&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;8</span></a> In each case&#44; pathology showed granulomas and&#44; usually&#44; caseating necrosis&#46; These findings were not present in our patient&#44; perhaps because the biopsy was performed promptly&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A recently published study showed that polymorphonuclear cells play an essential role in the antitumor effect of BCG treatment&#46; Instillation of BCG starts a primarily neutrophilic inflammatory reaction that triggers the migration of effector cells &#40;lymphocytes and monocytes or macrophages&#41; to the bladder&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Patients who are immunocompromised&#44; have mucosal barrier disruption due to injury&#44; or have positive reactions on tuberculin skin testing are at higher risk of presenting BCG side effects&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4&#44;6&#44;7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Given the small number of published cases&#44; no standard treatment has emerged&#46; Some reviews recommend starting the treatment of prostatitis and granulomatous orchiepididymitis with 300<span class="elsevierStyleHsp" style=""></span>mg of oral isoniazid and 600<span class="elsevierStyleHsp" style=""></span>mg of rifampicin and continuing it for 3 to 6 months while discontinuing BCG therapy and testing for antibiotic resistance&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;7</span></a> Other authors recommend corticosteroid therapy at the start of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">This rare case of balanitis due to BCG demonstrates the need to consider this possible side effect when patients are undergoing BCG therapy&#46;</p></span>"
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Article information
ISSN: 15782190
Original language: English
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