Case and Research Letter
Large Asymmetric Pigmented Nodule in a 27-Year-Old Female
Nódulo pigmentado asimétrico de gran tamaño en una mujer de 27 años
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Osório, A. Margarida Barros, O. Ferreira, F. Azevedo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "F." "apellidos" => "Osório" "email" => array:1 [ 0 => "filipaosorio@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Margarida Barros" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "O." "apellidos" => "Ferreira" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "Azevedo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Dermatology and Venereology, Centro Hospitalar de São João EPE, Porto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Faculty of Medicine of University of Porto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nódulo pigmentado asimétrico de gran tamaño en una mujer de 27 años" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2027 "Ancho" => 1500 "Tamanyo" => 246945 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic picture (20×): central dark hyperpigmented area with a predominant globular pattern (thick arrow), an eccentric thickened pigment network (thin arrow) and a blue-whitish-veil (*), surrounded by a rim of thin regular pigment network (**).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 27-year-old female presented with an asymptomatic nodule on the left thigh. She reported a smaller pigmented lesion since birth, with significant growth in the last 5 years. The patient had no personal or family history of skin cancer. She was otherwise healthy and had no systemic symptoms. She was doing oral contraception and no other medications.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination revealed a smooth nodular dome-shaped lesion measuring 1<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>cm, with central hyperpigmented and peripheral erythematous areas, located on the medium third of the anterior left thigh (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). There was no regional lymphadenopathy.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Dermoscopically there was a central dark hyperpigmented area surrounded by a rim of thin regular pigment network (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). In the central area we observed a predominant globular pattern, an eccentric thickened pigment network and a blue-whitish-veil.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Excision was performed. Histological examination revealed a compound (predominantly intradermal) melanocytic nevus with congenital-like growth pattern and a dermatofibroma, with no signs of malignancy (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Nevus cells involved deep dermal appendages and neurovascular structures and they became progressively smaller in deeper portions of the lesion suggesting maturation and benignity. Intermingled with melanocytes, there was a proliferation of spindle fibro-histiocytic cells characteristic of dermatofibroma.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Collision tumors result from the combination of two or more benign and/or malignant neoplasms in a single lesion.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> As it is unknown whether the association is a random event or whether there is, in fact, a pathogenic relationship in the development of two distinctive neoplasms together, some authors propose the designation of compound tumor instead of collision tumor because the last one suggests the association is incidental.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Collision tumors are not rare. Boyd and Rapini performed a retrospective evaluation of approximately 40,000 cutaneous biopsies, yielding 69 collision tumors.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Cascajo and colleagues found 54 collision tumors of malignant cutaneous neoplasms associated with seborrheic keratoses in 85,000 biopsies.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The most common combinations found by Boyd and Rapini included basal cell carcinoma and nevus (14), basal cell carcinoma and seborrheic keratosis (8), nevus and seborrheic keratosis (14), actinic keratosis and nevus (7), and basal cell carcinoma and neurofibroma (4).<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Another commonly described association is that of melanocytic nevus with desmoplastic trichoepithelioma.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Our patient had a compound tumor of congenital nevus and dermatofibroma. As far as we know, this is the first reported case of such a combination.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Furthermore this tumor clinically and dermoscopically mimicked malignant melanoma. Although in some cases dermoscopy can help with collision tumor diagnosis,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> this was not the case. In fact, according to Giorgi and colleagues cutaneous collision tumors are extremely difficult to diagnose preoperatively, even with the help of dermoscopy, in particular when one of the lesions is melanocytic.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The presence of a pigment network, the pathognomonic sign of the melanocytic lesion, allows dermatologists to use dermoscopic algorithms, which in this case ended up in the wrong preoperative diagnosis of a malignant lesion.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Osório F, et al. Large Asymmetric Pigmented Nodule in a 27-Year-Old Female. Actas Dermosifi- liogr. 2013; 104:165-6.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1277 "Ancho" => 1500 "Tamanyo" => 192999 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Asymmetric pigmented nodule (1<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>cm) on the left anterior thigh.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2027 "Ancho" => 1500 "Tamanyo" => 246945 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic picture (20×): central dark hyperpigmented area with a predominant globular pattern (thick arrow), an eccentric thickened pigment network (thin arrow) and a blue-whitish-veil (*), surrounded by a rim of thin regular pigment network (**).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1127 "Ancho" => 1500 "Tamanyo" => 366921 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological picture (H&E, 4×): collision tumor of congenital nevus and dermatofibroma.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Collision of malignant melanoma (lentigo maligna type) with squamous cell carcinoma in solar-damaged skin of the face" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V. Ahlgrimm-Siess" 1 => "R. Hofmann-Wellenhof" 2 => "I. Zalaudek" 3 => "L. Cerroni" 4 => "H. Kerl" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4725.2007.33023.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2007" "volumen" => "33" "paginaInicial" => "122" "paginaFinal" => "124" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17214694" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant neoplasms associated with seborrheic keratoses: an analysis of 54 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.D. Cascajo" 1 => "M. Reichel" 2 => "J.L. Sanchez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "1996" "volumen" => "18" "paginaInicial" => "278" "paginaFinal" => "282" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8806962" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0002939412004369" "estado" => "S300" "issn" => "00029394" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous collision tumors. An analysis of 69 cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.S. Boyd" 1 => "R.P. Rapini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "1994" "volumen" => "16" "paginaInicial" => "253" "paginaFinal" => "257" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7943631" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermoscopy is useful for the recognition of benign–malignant compound tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Zaballos" 1 => "A. Llambrich" 2 => "S. Puig" 3 => "J. Malvehy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2005.06717.x" "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2005" "volumen" => "153" "paginaInicial" => "653" "paginaFinal" => "656" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16120160" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0161642009010653" "estado" => "S300" "issn" => "01616420" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous collision tumour (melanocytic naevus, basal cell carcinoma, seborrheic keratosis): a clinical, dermoscopic and pathological case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V. Giorgi" 1 => "D. Massi" 2 => "S. Sestini" 3 => "B. Alfaioli" 4 => "G. Carelli" 5 => "P. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 6 | 15 |
| 2024 October | 53 | 34 | 87 |
| 2024 September | 61 | 30 | 91 |
| 2024 August | 92 | 79 | 171 |
| 2024 July | 60 | 38 | 98 |
| 2024 June | 86 | 42 | 128 |
| 2024 May | 62 | 32 | 94 |
| 2024 April | 70 | 32 | 102 |
| 2024 March | 74 | 40 | 114 |
| 2024 February | 79 | 34 | 113 |
| 2024 January | 53 | 43 | 96 |
| 2023 December | 67 | 20 | 87 |
| 2023 November | 59 | 35 | 94 |
| 2023 October | 56 | 28 | 84 |
| 2023 September | 46 | 29 | 75 |
| 2023 August | 33 | 27 | 60 |
| 2023 July | 37 | 42 | 79 |
| 2023 June | 45 | 25 | 70 |
| 2023 May | 46 | 25 | 71 |
| 2023 April | 43 | 18 | 61 |
| 2023 March | 43 | 25 | 68 |
| 2023 February | 46 | 14 | 60 |
| 2023 January | 38 | 23 | 61 |
| 2022 December | 58 | 28 | 86 |
| 2022 November | 39 | 21 | 60 |
| 2022 October | 33 | 18 | 51 |
| 2022 September | 37 | 39 | 76 |
| 2022 August | 30 | 35 | 65 |
| 2022 July | 36 | 30 | 66 |
| 2022 June | 39 | 31 | 70 |
| 2022 May | 36 | 28 | 64 |
| 2022 April | 34 | 35 | 69 |
| 2022 March | 33 | 50 | 83 |
| 2022 February | 35 | 25 | 60 |
| 2022 January | 33 | 27 | 60 |
| 2021 December | 21 | 44 | 65 |
| 2021 November | 27 | 41 | 68 |
| 2021 October | 31 | 42 | 73 |
| 2021 September | 24 | 38 | 62 |
| 2021 August | 18 | 19 | 37 |
| 2021 July | 11 | 27 | 38 |
| 2021 June | 16 | 32 | 48 |
| 2021 May | 39 | 35 | 74 |
| 2021 April | 33 | 94 | 127 |
| 2021 March | 73 | 26 | 99 |
| 2021 February | 44 | 27 | 71 |
| 2021 January | 25 | 16 | 41 |
| 2020 December | 26 | 9 | 35 |
| 2020 November | 20 | 12 | 32 |
| 2020 October | 18 | 8 | 26 |
| 2020 September | 18 | 5 | 23 |
| 2020 August | 16 | 21 | 37 |
| 2020 July | 22 | 5 | 27 |
| 2020 June | 21 | 20 | 41 |
| 2020 May | 15 | 24 | 39 |
| 2020 April | 27 | 15 | 42 |
| 2020 March | 18 | 17 | 35 |
| 2020 February | 7 | 2 | 9 |
| 2020 January | 4 | 0 | 4 |
| 2019 December | 8 | 3 | 11 |
| 2019 November | 4 | 0 | 4 |
| 2019 October | 0 | 2 | 2 |
| 2019 September | 10 | 1 | 11 |
| 2019 August | 4 | 1 | 5 |
| 2019 July | 4 | 3 | 7 |
| 2019 June | 4 | 0 | 4 |
| 2019 May | 7 | 9 | 16 |
| 2019 April | 2 | 6 | 8 |
| 2019 March | 0 | 8 | 8 |
| 2019 February | 4 | 1 | 5 |
| 2018 December | 2 | 1 | 3 |
| 2018 November | 1 | 0 | 1 |
| 2018 October | 0 | 1 | 1 |
| 2018 September | 2 | 0 | 2 |
| 2018 July | 0 | 1 | 1 |
| 2018 June | 0 | 1 | 1 |
| 2018 May | 0 | 1 | 1 |
| 2018 April | 0 | 3 | 3 |
| 2018 March | 1 | 4 | 5 |
| 2018 February | 22 | 5 | 27 |
| 2018 January | 30 | 5 | 35 |
| 2017 December | 44 | 7 | 51 |
| 2017 November | 28 | 4 | 32 |
| 2017 October | 27 | 6 | 33 |
| 2017 September | 32 | 2 | 34 |
| 2017 August | 43 | 10 | 53 |
| 2017 July | 42 | 8 | 50 |
| 2017 June | 70 | 26 | 96 |
| 2017 May | 36 | 8 | 44 |
| 2017 April | 31 | 5 | 36 |
| 2017 March | 46 | 34 | 80 |
| 2017 February | 29 | 16 | 45 |
| 2017 January | 15 | 6 | 21 |
| 2016 December | 22 | 9 | 31 |
| 2016 November | 39 | 5 | 44 |
| 2016 October | 48 | 23 | 71 |
| 2016 September | 93 | 17 | 110 |
| 2016 August | 35 | 7 | 42 |
| 2016 July | 25 | 8 | 33 |
| 2016 June | 8 | 13 | 21 |
| 2016 May | 10 | 4 | 14 |
| 2016 April | 7 | 0 | 7 |
| 2016 March | 12 | 1 | 13 |
| 2016 February | 7 | 4 | 11 |
| 2016 January | 5 | 0 | 5 |
| 2015 December | 8 | 1 | 9 |
| 2015 November | 12 | 4 | 16 |
| 2015 October | 9 | 1 | 10 |
| 2015 September | 6 | 4 | 10 |
| 2015 August | 9 | 0 | 9 |
| 2015 July | 36 | 6 | 42 |
| 2015 June | 59 | 5 | 64 |
| 2015 May | 69 | 12 | 81 |
| 2015 April | 45 | 7 | 52 |
| 2015 March | 42 | 9 | 51 |
| 2015 February | 19 | 3 | 22 |
| 2015 January | 15 | 2 | 17 |
| 2014 December | 17 | 5 | 22 |
| 2014 November | 9 | 3 | 12 |
| 2014 October | 24 | 3 | 27 |
| 2014 September | 15 | 2 | 17 |
| 2014 August | 13 | 4 | 17 |
| 2014 July | 10 | 4 | 14 |
| 2014 June | 20 | 2 | 22 |
| 2014 May | 20 | 7 | 27 |
| 2014 April | 21 | 2 | 23 |
| 2014 March | 34 | 8 | 42 |
| 2014 February | 30 | 7 | 37 |
| 2014 January | 16 | 8 | 24 |
| 2013 December | 18 | 7 | 25 |
| 2013 November | 14 | 2 | 16 |
| 2013 October | 13 | 2 | 15 |
| 2013 September | 7 | 1 | 8 |
| 2013 August | 3 | 4 | 7 |
| 2013 July | 5 | 9 | 14 |
| 2013 June | 5 | 8 | 13 |
| 2013 May | 9 | 8 | 17 |
| 2013 April | 6 | 11 | 17 |
| 2013 March | 7 | 5 | 12 |
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