array:24 [
  "pii" => "S1578219013000139"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.02.008"
  "estado" => "S300"
  "fechaPublicacion" => "2013-03-01"
  "aid" => "673"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2013;104:170-2"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 6999
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 5418
      "PDF" => 1533
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731012003006"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2012.02.017"
      "estado" => "S300"
      "fechaPublicacion" => "2013-03-01"
      "aid" => "673"
      "copyright" => "Elsevier España, S.L. y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2013;104:170-2"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 11096
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 8686
          "PDF" => 2408
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Dermatosis acantol&#237;tica papular del &#225;rea genitocrural&#58; &#191;forma localizada de Darier o Hailey-Hailey&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "170"
            "paginaFinal" => "172"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Papular Acantholytic Dermatosis in the Genito-Crural Region&#58; A Localized Form of Darier Disease or Hailey-Hailey Disease&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 750
                "Ancho" => 1000
                "Tamanyo" => 136264
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Hematoxilina-eosina &#40;x 63&#41;&#58; disqueratosis con cuerpos redondos y granos&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M&#46;C&#46; Montis-Palos, E&#46; Acebo-Mari&#241;as, B&#46; Cat&#243;n-Santar&#233;n, R&#46; Soloeta-Arechavala"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "M&#46;C&#46;"
                "apellidos" => "Montis-Palos"
              ]
              1 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Acebo-Mari&#241;as"
              ]
              2 => array:2 [
                "nombre" => "B&#46;"
                "apellidos" => "Cat&#243;n-Santar&#233;n"
              ]
              3 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Soloeta-Arechavala"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219013000139"
          "doi" => "10.1016/j.adengl.2012.02.008"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000139?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003006?idApp=UINPBA000044"
      "url" => "/00017310/0000010400000002/v1_201304241237/S0001731012003006/v1_201304241237/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219013000140"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.10.004"
    "estado" => "S300"
    "fechaPublicacion" => "2013-03-01"
    "aid" => "753"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:173-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2232
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 1514
        "PDF" => 676
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Pigmented Fungiform Papillae of the Tongue in Laugier Disease &#40;or Laugier-Hunziker Syndrome&#41;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "173"
          "paginaFinal" => "174"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Pigmentaci&#243;n de las papilas fungiformes linguales en la enfermedad de Laugier &#40;o s&#237;ndrome de Laugier-Hunziker&#41;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#46; Urbina, E&#46; Sudy"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Urbina"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Sudy"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012004838"
        "doi" => "10.1016/j.ad.2012.10.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004838?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000140?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000140/v1_201304241618/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219013000127"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.02.007"
    "estado" => "S300"
    "fechaPublicacion" => "2013-03-01"
    "aid" => "672"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:168-70"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3119
      "formatos" => array:3 [
        "EPUB" => 43
        "HTML" => 2424
        "PDF" => 652
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Allergic Contact Dermatitis Caused by Methyl Aminolevulinate"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "168"
          "paginaFinal" => "170"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Dermatitis al&#233;rgica de contacto a metil aminolevulinato"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1247
              "Ancho" => 1667
              "Tamanyo" => 207836
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous&#44; edematous rash with a linear distribution on the lateral aspect of the trunk&#44; limited to the area treated with methyl aminolevulinate cream&#46; There are macular lesions of residual postinflammatory hypopigmentation secondary to segmental Darier disease&#46; The distribution follows the Blaschko lines&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;A&#46; Pastor-Nieto, E&#46; Jim&#233;nez-Bl&#225;zquez, C&#46; S&#225;nchez-Herreros, P&#46; Belmar-Flores"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "Pastor-Nieto"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Jim&#233;nez-Bl&#225;zquez"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "S&#225;nchez-Herreros"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Belmar-Flores"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012002992"
        "doi" => "10.1016/j.ad.2012.02.016"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012002992?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000127?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000127/v1_201304241618/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and research letter</span>"
    "titulo" => "Papular Acantholytic Dermatosis in the Genito-Crural Region&#58; A Localized Form of Darier Disease or Hailey-Hailey Disease&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "170"
        "paginaFinal" => "172"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46;C&#46; Montis-Palos, E&#46; Acebo-Mari&#241;as, B&#46; Cat&#243;n-Santar&#233;n, R&#46; Soloeta-Arechavala"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "M&#46;C&#46;"
            "apellidos" => "Montis-Palos"
            "email" => array:1 [
              0 => "mmontis&#64;aedv&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Acebo-Mari&#241;as"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "B&#46;"
            "apellidos" => "Cat&#243;n-Santar&#233;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Soloeta-Arechavala"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Santiago&#44; Vitoria&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Santiago&#44; Vitoria&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Dermatosis acantol&#237;tica papular del &#225;rea genitocrural&#58; &#191;forma localizada de Darier o Hailey-Hailey&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1250
            "Ancho" => 1667
            "Tamanyo" => 329066
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mild epidermal hyperplasia with hyperkeratosis&#44; parakeratosis&#44; acanthosis&#44; and focal acantholysis with suprabasal clefts&#46; Hematoxylin-eosin&#44; original magnification &#215;40&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">To the Editor</span>&#58;</p><p id="par0905" class="elsevierStylePara elsevierViewall">Papular acantholytic dyskeratosis &#40;PAD&#41; is a skin condition that typically presents as multiple&#44; small whitish papular lesions that may coalesce into plaques&#59; more rarely it is seen as solitary papules&#46; Involvement of the vulva was first described by Chorzelski et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in 1984&#59; this form is most frequently observed on the labia majora of middle-aged women with no familial history of the disease&#46; Cases of PAD of the penis&#44; anal canal&#44; and inguinal skin folds have also been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> The condition is usually asymptomatic&#44; although intense pruritus may develop&#46; Histopathological changes include acantholysis with variable degrees of dyskeratosis&#44; and direct and indirect immunofluorescence have been negative in almost all cases studied&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present a 58-year-old woman with no past medical history or family history of interest&#46; She was referred to the dermatology department for pruritic lesions that had developed 2 months earlier in the genital region&#46; She did not report any contact allergies or at-risk sexual activities&#46; Physical examination revealed multiple&#44; shiny whitish papules of 2 to 3<span class="elsevierStyleHsp" style=""></span>mm in diameter in a cobblestone pattern on the medial aspect of the thigh&#44; on the labia majora&#44; on the perineum&#44; and in the perianal region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were no similar lesions on other areas of the skin or mucosas and no nail changes&#46; Laboratory tests &#40;routine blood tests&#59; serology for hepatitis B and C viruses&#44; human immunodeficiency virus&#44; and antinuclear&#44; antibasement membrane&#44; and antidesmoglein 1 and 3 antibodies&#59; and cultures for bacteria and fungi&#41; were normal or negative&#46; Biopsy findings included mild epidermal hyperplasia with hyperkeratosis&#44; parakeratosis&#44; acanthosis&#44; focal acantholysis with suprabasal clefts &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; and dyskeratosis with corps ronds and grains &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#59; a mild perivascular mononuclear inflammatory infiltrate was present in the papillary dermis&#46; Direct immunofluorescence with immunoglobulin &#40;Ig&#41; M&#44; IgG&#44; IgA&#44; complement components C3 and C1q&#44; and fibrinogen antisera was negative&#46; With a diagnosis of PAD of the genitocrural region&#44; treatment was started with topical clobetasol&#44; which produced an improvement in the pruritus&#44; though the lesions persisted&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The main differential diagnosis of PAD is with Hailey-Hailey disease and Darier disease&#44; which are hereditary genodermatoses in which loss of function mutations of the <span class="elsevierStyleItalic">ATP2C1</span> and <span class="elsevierStyleItalic">ATP2A2</span> calcium pump genes&#44; respectively&#44; have been reported in peripheral blood DNA samples&#46; Darier disease&#44; with very similar histopathological findings to those observed in our patient&#44; usually develops in adolescence and is characterized by verrucous papules and plaques in seborrheic regions&#44; with punctate palmoplantar keratoderma&#44; verrucous papules on the dorsum of the hands and the feet&#44; and characteristic nail changes&#46; Hailey-Hailey disease can also show histological similarities with reported cases of PAD but&#44; in contrast to Darier disease&#44; there is a predominance of acantholysis and the dyskeratosis is very mild or absent&#59; the disease typically presents in young adults&#44; with painful erosions in the skin folds&#46; Transient acantholytic dermatosis &#40;Grover disease&#41; should also be included in the differential diagnosis because of its histopathological similarities with PAD&#44; although it typically presents in adults as transient confluent pruritic papules on the trunk&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The individual responses of patients with PAD to treatment with corticosteroids&#44; topical retinoids&#44; cryotherapy&#44; electrocoagulation&#44; or surgery have been reported as variable&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In a recent study&#44; laser therapy achieved lasting symptomatic improvement&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The issues we have discussed regarding the classification of PAD as a separate entity from Darier or Hailey-Hailey disease arise because there have been reports of cases of Darier and Hailey-Hailey disease localized to the genitocrural region that have been histologically similar to PAD&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> The fact that Hailey-Hailey disease can show a variable degree of penetration and can present at different ages leads to even greater confusion&#46; Two recent publications have reported a mutation in <span class="elsevierStyleItalic">ATP2C1</span> in 3 cases of PAD of the genitocrural area&#44; suggesting that at least some cases of PAD could be localized variants of Hailey-Hailey disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;10</span></a> It was not possible to perform a genetic study in our patient&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; we believe that PAD has not yet been fully defined&#44; and that its final characterization will require genetic study to exclude localized Darier or Hailey-Hailey disease&#44; as there may be clinical and histopathological overlap&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Montis-Palos MC&#44; et al&#46; Dermatosis acantol&#237;tica papular del &#225;rea genitocrural&#58; &#191;forma localizada de Darier o Hailey-Hailey&#63; Actas Dermosifiliogr&#46; 2013&#59;104&#58;170&#8211;2&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1112
            "Ancho" => 1667
            "Tamanyo" => 145550
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple&#44; shiny whitish papules of 2 to 3<span class="elsevierStyleHsp" style=""></span>mm in diameter in a cobblestone pattern on the medial aspect of the thigh&#44; on the labia majora&#44; on the perineum&#44; and in the perianal region&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1250
            "Ancho" => 1667
            "Tamanyo" => 329066
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mild epidermal hyperplasia with hyperkeratosis&#44; parakeratosis&#44; acanthosis&#44; and focal acantholysis with suprabasal clefts&#46; Hematoxylin-eosin&#44; original magnification &#215;40&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1250
            "Ancho" => 1667
            "Tamanyo" => 207804
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dyskeratosis with corps ronds and grains&#46; Hematoxylin-eosin&#44; original magnification &#215;63&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is papular acantholytic dyskeratosis of the vulva a new entity&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;P&#46; Chorzelski"
                            1 => "J&#46; Kudejko"
                            2 => "S&#46; Jablonska"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1984"
                        "volumen" => "6"
                        "paginaInicial" => "557"
                        "paginaFinal" => "560"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6524638"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Papular acantholytic dyskeratosis of the penis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;C&#46;J&#46; Van der Putte"
                            1 => "H&#46;B&#46; Oey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1986"
                        "volumen" => "8"
                        "paginaInicial" => "365"
                        "paginaFinal" => "366"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3766928"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Focal acantholytic dyskeratosis of the anal canal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;L&#46; Wakel"
                            1 => "R&#46;M&#46; Jager"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1986"
                        "volumen" => "4"
                        "paginaInicial" => "362"
                        "paginaFinal" => "363"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acantholytic dermatosis of the crural folds with ATP2C1 mutation is a possible variant of Hailey-Hailey disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;B&#46; Lipoff"
                            1 => "A&#46;V&#46; Mudgil"
                            2 => "S&#46; Young"
                            3 => "P&#46; Chu"
                            4 => "S&#46;R&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Med Surg"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "paginaInicial" => "151"
                        "paginaFinal" => "154"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19426624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acantholytic dermatosis localized to the vulvocrural area"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;H&#46; Cooper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cut Pathol"
                        "fecha" => "1989"
                        "volumen" => "16"
                        "paginaInicial" => "81"
                        "paginaFinal" => "84"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Papular acantholytic dyskeratosis of the vulva"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;K&#46; Bell"
                            1 => "C&#46;W&#46; Farrar"
                            2 => "R&#46;K&#46; Curley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2001"
                        "volumen" => "26"
                        "paginaInicial" => "386"
                        "paginaFinal" => "388"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11488821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Successful laser therapy of a papular acantholytic dyskeratosis of the vulva&#58; case report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;J&#46; Dittmer"
                            1 => "A&#46; Hornemann"
                            2 => "C&#46; Rose"
                            3 => "K&#46; Diedrich"
                            4 => "M&#46; Thill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00404-009-1313-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Gynecol Obstet"
                        "fecha" => "2010"
                        "volumen" => "281"
                        "paginaInicial" => "723"
                        "paginaFinal" => "725"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20012979"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Placas erosivas y verrugosas en pliegues inguinales"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Chavarria"
                            1 => "J&#46;M&#46; Hernaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2005"
                        "volumen" => "96"
                        "paginaInicial" => "703"
                        "paginaFinal" => "705"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476325"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genital benign chronic pemphigus &#40;Hailey-Hailey disease&#41; presenting as condylomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Langenberg"
                            1 => "T&#46;G&#46; Berger"
                            2 => "M&#46; Cardelli"
                            3 => "O&#46;G&#46; Rodman"
                            4 => "S&#46; Estes"
                            5 => "D&#46;R&#46; Barron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1992"
                        "volumen" => "26"
                        "paginaInicial" => "951"
                        "paginaFinal" => "955"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1607414"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genitoperineal popular acantholytic dyskeratosis is allelic to Hailey-Hailey disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Pernet"
                            1 => "D&#46; Bessis"
                            2 => "M&#46; Savignac"
                            3 => "E&#46; Tron"
                            4 => "B&#46; Guillot"
                            5 => "A&#46; Hovnanian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2012.10810.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2012"
                        "volumen" => "167"
                        "paginaInicial" => "210"
                        "paginaFinal" => "212"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22229453"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000139/v1_201304241618/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000002/v1_201304241618/S1578219013000139/v1_201304241618/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000139?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case and research letter
Papular Acantholytic Dermatosis in the Genito-Crural Region: A Localized Form of Darier Disease or Hailey-Hailey Disease?
Dermatosis acantolítica papular del área genitocrural: ¿forma localizada de Darier o Hailey-Hailey?
M.C. Montis-Palosa,
Corresponding author
mmontis@aedv.es

Corresponding author.
, E. Acebo-Mariñasa, B. Catón-Santarénb, R. Soloeta-Arechavalaa
a Servicio de Dermatología, Hospital Santiago, Vitoria, Spain
b Servicio de Anatomía Patológica, Hospital Santiago, Vitoria, Spain
Read
13783
Times
was read the article
3944
Total PDF
9839
Total HTML
Share statistics
 array:24 [
  "pii" => "S1578219013000139"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2012.02.008"
  "estado" => "S300"
  "fechaPublicacion" => "2013-03-01"
  "aid" => "673"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2013;104:170-2"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 6999
    "formatos" => array:3 [
      "EPUB" => 48
      "HTML" => 5418
      "PDF" => 1533
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731012003006"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2012.02.017"
      "estado" => "S300"
      "fechaPublicacion" => "2013-03-01"
      "aid" => "673"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2013;104:170-2"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 11096
        "formatos" => array:3 [
          "EPUB" => 2
          "HTML" => 8686
          "PDF" => 2408
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Dermatosis acantol&#237;tica papular del &#225;rea genitocrural&#58; &#191;forma localizada de Darier o Hailey-Hailey&#63;"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "170"
            "paginaFinal" => "172"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Papular Acantholytic Dermatosis in the Genito-Crural Region&#58; A Localized Form of Darier Disease or Hailey-Hailey Disease&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 750
                "Ancho" => 1000
                "Tamanyo" => 136264
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Hematoxilina-eosina &#40;x 63&#41;&#58; disqueratosis con cuerpos redondos y granos&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M&#46;C&#46; Montis-Palos, E&#46; Acebo-Mari&#241;as, B&#46; Cat&#243;n-Santar&#233;n, R&#46; Soloeta-Arechavala"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "M&#46;C&#46;"
                "apellidos" => "Montis-Palos"
              ]
              1 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Acebo-Mari&#241;as"
              ]
              2 => array:2 [
                "nombre" => "B&#46;"
                "apellidos" => "Cat&#243;n-Santar&#233;n"
              ]
              3 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Soloeta-Arechavala"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219013000139"
          "doi" => "10.1016/j.adengl.2012.02.008"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000139?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012003006?idApp=UINPBA000044"
      "url" => "/00017310/0000010400000002/v1_201304241237/S0001731012003006/v1_201304241237/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219013000140"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.10.004"
    "estado" => "S300"
    "fechaPublicacion" => "2013-03-01"
    "aid" => "753"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:173-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2232
      "formatos" => array:3 [
        "EPUB" => 42
        "HTML" => 1514
        "PDF" => 676
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Pigmented Fungiform Papillae of the Tongue in Laugier Disease &#40;or Laugier-Hunziker Syndrome&#41;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "173"
          "paginaFinal" => "174"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Pigmentaci&#243;n de las papilas fungiformes linguales en la enfermedad de Laugier &#40;o s&#237;ndrome de Laugier-Hunziker&#41;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#46; Urbina, E&#46; Sudy"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Urbina"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Sudy"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012004838"
        "doi" => "10.1016/j.ad.2012.10.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012004838?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000140?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000140/v1_201304241618/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219013000127"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2012.02.007"
    "estado" => "S300"
    "fechaPublicacion" => "2013-03-01"
    "aid" => "672"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2013;104:168-70"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3119
      "formatos" => array:3 [
        "EPUB" => 43
        "HTML" => 2424
        "PDF" => 652
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Allergic Contact Dermatitis Caused by Methyl Aminolevulinate"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "168"
          "paginaFinal" => "170"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Dermatitis al&#233;rgica de contacto a metil aminolevulinato"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1247
              "Ancho" => 1667
              "Tamanyo" => 207836
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous&#44; edematous rash with a linear distribution on the lateral aspect of the trunk&#44; limited to the area treated with methyl aminolevulinate cream&#46; There are macular lesions of residual postinflammatory hypopigmentation secondary to segmental Darier disease&#46; The distribution follows the Blaschko lines&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;A&#46; Pastor-Nieto, E&#46; Jim&#233;nez-Bl&#225;zquez, C&#46; S&#225;nchez-Herreros, P&#46; Belmar-Flores"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "Pastor-Nieto"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Jim&#233;nez-Bl&#225;zquez"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "S&#225;nchez-Herreros"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Belmar-Flores"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731012002992"
        "doi" => "10.1016/j.ad.2012.02.016"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012002992?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000127?idApp=UINPBA000044"
    "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000127/v1_201304241618/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and research letter</span>"
    "titulo" => "Papular Acantholytic Dermatosis in the Genito-Crural Region&#58; A Localized Form of Darier Disease or Hailey-Hailey Disease&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "170"
        "paginaFinal" => "172"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46;C&#46; Montis-Palos, E&#46; Acebo-Mari&#241;as, B&#46; Cat&#243;n-Santar&#233;n, R&#46; Soloeta-Arechavala"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "M&#46;C&#46;"
            "apellidos" => "Montis-Palos"
            "email" => array:1 [
              0 => "mmontis&#64;aedv&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Acebo-Mari&#241;as"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "B&#46;"
            "apellidos" => "Cat&#243;n-Santar&#233;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Soloeta-Arechavala"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Santiago&#44; Vitoria&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Santiago&#44; Vitoria&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Dermatosis acantol&#237;tica papular del &#225;rea genitocrural&#58; &#191;forma localizada de Darier o Hailey-Hailey&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1250
            "Ancho" => 1667
            "Tamanyo" => 329066
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mild epidermal hyperplasia with hyperkeratosis&#44; parakeratosis&#44; acanthosis&#44; and focal acantholysis with suprabasal clefts&#46; Hematoxylin-eosin&#44; original magnification &#215;40&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">To the Editor</span>&#58;</p><p id="par0905" class="elsevierStylePara elsevierViewall">Papular acantholytic dyskeratosis &#40;PAD&#41; is a skin condition that typically presents as multiple&#44; small whitish papular lesions that may coalesce into plaques&#59; more rarely it is seen as solitary papules&#46; Involvement of the vulva was first described by Chorzelski et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> in 1984&#59; this form is most frequently observed on the labia majora of middle-aged women with no familial history of the disease&#46; Cases of PAD of the penis&#44; anal canal&#44; and inguinal skin folds have also been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> The condition is usually asymptomatic&#44; although intense pruritus may develop&#46; Histopathological changes include acantholysis with variable degrees of dyskeratosis&#44; and direct and indirect immunofluorescence have been negative in almost all cases studied&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We present a 58-year-old woman with no past medical history or family history of interest&#46; She was referred to the dermatology department for pruritic lesions that had developed 2 months earlier in the genital region&#46; She did not report any contact allergies or at-risk sexual activities&#46; Physical examination revealed multiple&#44; shiny whitish papules of 2 to 3<span class="elsevierStyleHsp" style=""></span>mm in diameter in a cobblestone pattern on the medial aspect of the thigh&#44; on the labia majora&#44; on the perineum&#44; and in the perianal region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were no similar lesions on other areas of the skin or mucosas and no nail changes&#46; Laboratory tests &#40;routine blood tests&#59; serology for hepatitis B and C viruses&#44; human immunodeficiency virus&#44; and antinuclear&#44; antibasement membrane&#44; and antidesmoglein 1 and 3 antibodies&#59; and cultures for bacteria and fungi&#41; were normal or negative&#46; Biopsy findings included mild epidermal hyperplasia with hyperkeratosis&#44; parakeratosis&#44; acanthosis&#44; focal acantholysis with suprabasal clefts &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; and dyskeratosis with corps ronds and grains &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#59; a mild perivascular mononuclear inflammatory infiltrate was present in the papillary dermis&#46; Direct immunofluorescence with immunoglobulin &#40;Ig&#41; M&#44; IgG&#44; IgA&#44; complement components C3 and C1q&#44; and fibrinogen antisera was negative&#46; With a diagnosis of PAD of the genitocrural region&#44; treatment was started with topical clobetasol&#44; which produced an improvement in the pruritus&#44; though the lesions persisted&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The main differential diagnosis of PAD is with Hailey-Hailey disease and Darier disease&#44; which are hereditary genodermatoses in which loss of function mutations of the <span class="elsevierStyleItalic">ATP2C1</span> and <span class="elsevierStyleItalic">ATP2A2</span> calcium pump genes&#44; respectively&#44; have been reported in peripheral blood DNA samples&#46; Darier disease&#44; with very similar histopathological findings to those observed in our patient&#44; usually develops in adolescence and is characterized by verrucous papules and plaques in seborrheic regions&#44; with punctate palmoplantar keratoderma&#44; verrucous papules on the dorsum of the hands and the feet&#44; and characteristic nail changes&#46; Hailey-Hailey disease can also show histological similarities with reported cases of PAD but&#44; in contrast to Darier disease&#44; there is a predominance of acantholysis and the dyskeratosis is very mild or absent&#59; the disease typically presents in young adults&#44; with painful erosions in the skin folds&#46; Transient acantholytic dermatosis &#40;Grover disease&#41; should also be included in the differential diagnosis because of its histopathological similarities with PAD&#44; although it typically presents in adults as transient confluent pruritic papules on the trunk&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The individual responses of patients with PAD to treatment with corticosteroids&#44; topical retinoids&#44; cryotherapy&#44; electrocoagulation&#44; or surgery have been reported as variable&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In a recent study&#44; laser therapy achieved lasting symptomatic improvement&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The issues we have discussed regarding the classification of PAD as a separate entity from Darier or Hailey-Hailey disease arise because there have been reports of cases of Darier and Hailey-Hailey disease localized to the genitocrural region that have been histologically similar to PAD&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> The fact that Hailey-Hailey disease can show a variable degree of penetration and can present at different ages leads to even greater confusion&#46; Two recent publications have reported a mutation in <span class="elsevierStyleItalic">ATP2C1</span> in 3 cases of PAD of the genitocrural area&#44; suggesting that at least some cases of PAD could be localized variants of Hailey-Hailey disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;10</span></a> It was not possible to perform a genetic study in our patient&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; we believe that PAD has not yet been fully defined&#44; and that its final characterization will require genetic study to exclude localized Darier or Hailey-Hailey disease&#44; as there may be clinical and histopathological overlap&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Montis-Palos MC&#44; et al&#46; Dermatosis acantol&#237;tica papular del &#225;rea genitocrural&#58; &#191;forma localizada de Darier o Hailey-Hailey&#63; Actas Dermosifiliogr&#46; 2013&#59;104&#58;170&#8211;2&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1112
            "Ancho" => 1667
            "Tamanyo" => 145550
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple&#44; shiny whitish papules of 2 to 3<span class="elsevierStyleHsp" style=""></span>mm in diameter in a cobblestone pattern on the medial aspect of the thigh&#44; on the labia majora&#44; on the perineum&#44; and in the perianal region&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1250
            "Ancho" => 1667
            "Tamanyo" => 329066
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mild epidermal hyperplasia with hyperkeratosis&#44; parakeratosis&#44; acanthosis&#44; and focal acantholysis with suprabasal clefts&#46; Hematoxylin-eosin&#44; original magnification &#215;40&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1250
            "Ancho" => 1667
            "Tamanyo" => 207804
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dyskeratosis with corps ronds and grains&#46; Hematoxylin-eosin&#44; original magnification &#215;63&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is papular acantholytic dyskeratosis of the vulva a new entity&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;P&#46; Chorzelski"
                            1 => "J&#46; Kudejko"
                            2 => "S&#46; Jablonska"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1984"
                        "volumen" => "6"
                        "paginaInicial" => "557"
                        "paginaFinal" => "560"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6524638"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Papular acantholytic dyskeratosis of the penis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;C&#46;J&#46; Van der Putte"
                            1 => "H&#46;B&#46; Oey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1986"
                        "volumen" => "8"
                        "paginaInicial" => "365"
                        "paginaFinal" => "366"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3766928"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Focal acantholytic dyskeratosis of the anal canal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;L&#46; Wakel"
                            1 => "R&#46;M&#46; Jager"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1986"
                        "volumen" => "4"
                        "paginaInicial" => "362"
                        "paginaFinal" => "363"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acantholytic dermatosis of the crural folds with ATP2C1 mutation is a possible variant of Hailey-Hailey disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;B&#46; Lipoff"
                            1 => "A&#46;V&#46; Mudgil"
                            2 => "S&#46; Young"
                            3 => "P&#46; Chu"
                            4 => "S&#46;R&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Med Surg"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "paginaInicial" => "151"
                        "paginaFinal" => "154"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19426624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acantholytic dermatosis localized to the vulvocrural area"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;H&#46; Cooper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cut Pathol"
                        "fecha" => "1989"
                        "volumen" => "16"
                        "paginaInicial" => "81"
                        "paginaFinal" => "84"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Papular acantholytic dyskeratosis of the vulva"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;K&#46; Bell"
                            1 => "C&#46;W&#46; Farrar"
                            2 => "R&#46;K&#46; Curley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2001"
                        "volumen" => "26"
                        "paginaInicial" => "386"
                        "paginaFinal" => "388"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11488821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Successful laser therapy of a papular acantholytic dyskeratosis of the vulva&#58; case report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;J&#46; Dittmer"
                            1 => "A&#46; Hornemann"
                            2 => "C&#46; Rose"
                            3 => "K&#46; Diedrich"
                            4 => "M&#46; Thill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00404-009-1313-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Gynecol Obstet"
                        "fecha" => "2010"
                        "volumen" => "281"
                        "paginaInicial" => "723"
                        "paginaFinal" => "725"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20012979"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Placas erosivas y verrugosas en pliegues inguinales"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Chavarria"
                            1 => "J&#46;M&#46; Hernaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2005"
                        "volumen" => "96"
                        "paginaInicial" => "703"
                        "paginaFinal" => "705"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476325"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genital benign chronic pemphigus &#40;Hailey-Hailey disease&#41; presenting as condylomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Langenberg"
                            1 => "T&#46;G&#46; Berger"
                            2 => "M&#46; Cardelli"
                            3 => "O&#46;G&#46; Rodman"
                            4 => "S&#46; Estes"
                            5 => "D&#46;R&#46; Barron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1992"
                        "volumen" => "26"
                        "paginaInicial" => "951"
                        "paginaFinal" => "955"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1607414"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genitoperineal popular acantholytic dyskeratosis is allelic to Hailey-Hailey disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Pernet"
                            1 => "D&#46; Bessis"
                            2 => "M&#46; Savignac"
                            3 => "E&#46; Tron"
                            4 => "B&#46; Guillot"
                            5 => "A&#46; Hovnanian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2012.10810.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2012"
                        "volumen" => "167"
                        "paginaInicial" => "210"
                        "paginaFinal" => "212"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22229453"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010400000002/v1_201304241618/S1578219013000139/v1_201304241618/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010400000002/v1_201304241618/S1578219013000139/v1_201304241618/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219013000139?idApp=UINPBA000044"
]
Article information
ISSN: 15782190
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 26 16 42
2024 October 143 47 190
2024 September 154 36 190
2024 August 155 93 248
2024 July 138 37 175
2024 June 141 35 176
2024 May 114 51 165
2024 April 100 27 127
2024 March 113 30 143
2024 February 99 37 136
2024 January 105 41 146
2023 December 98 27 125
2023 November 103 37 140
2023 October 79 37 116
2023 September 106 29 135
2023 August 86 22 108
2023 July 83 45 128
2023 June 69 29 98
2023 May 83 26 109
2023 April 77 49 126
2023 March 91 45 136
2023 February 72 26 98
2023 January 64 35 99
2022 December 78 61 139
2022 November 51 24 75
2022 October 46 36 82
2022 September 32 42 74
2022 August 41 57 98
2022 July 37 40 77
2022 June 47 37 84
2022 May 87 52 139
2022 April 96 44 140
2022 March 91 68 159
2022 February 55 55 110
2022 January 87 60 147
2021 December 55 73 128
2021 November 88 71 159
2021 October 91 70 161
2021 September 81 64 145
2021 August 83 54 137
2021 July 43 38 81
2021 June 52 59 111
2021 May 62 45 107
2021 April 77 99 176
2021 March 76 43 119
2021 February 93 43 136
2021 January 90 43 133
2020 December 69 35 104
2020 November 58 28 86
2020 October 57 28 85
2020 September 46 16 62
2020 August 46 28 74
2020 July 59 14 73
2020 June 39 30 69
2020 May 35 27 62
2020 April 42 34 76
2020 March 25 30 55
2020 February 16 9 25
2020 January 4 11 15
2019 December 8 10 18
2019 November 2 9 11
2019 October 0 13 13
2019 September 11 14 25
2019 August 5 5 10
2019 July 5 28 33
2019 June 4 48 52
2019 May 8 143 151
2019 April 11 53 64
2019 March 1 24 25
2019 February 7 18 25
2019 January 4 14 18
2018 December 5 7 12
2018 November 6 8 14
2018 October 2 6 8
2018 September 10 5 15
2018 August 0 14 14
2018 July 0 11 11
2018 June 0 11 11
2018 May 0 4 4
2018 April 0 7 7
2018 March 18 16 34
2018 February 82 20 102
2018 January 97 23 120
2017 December 108 17 125
2017 November 79 21 100
2017 October 107 19 126
2017 September 78 40 118
2017 August 78 26 104
2017 July 103 22 125
2017 June 93 28 121
2017 May 74 31 105
2017 April 80 23 103
2017 March 71 25 96
2017 February 66 16 82
2017 January 81 15 96
2016 December 175 37 212
2016 November 175 22 197
2016 October 188 17 205
2016 September 259 30 289
2016 August 207 21 228
2016 July 70 17 87
2016 June 7 24 31
2016 May 5 18 23
2016 April 4 3 7
2016 March 7 6 13
2016 February 8 14 22
2016 January 8 20 28
2015 December 11 1 12
2015 November 10 1 11
2015 October 11 1 12
2015 September 2 14 16
2015 August 9 4 13
2015 July 273 24 297
2015 June 252 14 266
2015 May 236 31 267
2015 April 216 18 234
2015 March 241 21 262
2015 February 163 8 171
2015 January 140 14 154
2014 December 141 7 148
2014 November 132 6 138
2014 October 125 8 133
2014 September 84 4 88
2014 August 101 5 106
2014 July 98 8 106
2014 June 109 9 118
2014 May 100 8 108
2014 April 113 7 120
2014 March 111 21 132
2014 February 95 16 111
2014 January 69 11 80
2013 December 64 12 76
2013 November 21 13 34
2013 October 8 9 17
2013 September 6 19 25
2013 August 7 39 46
2013 July 11 19 30
2013 June 3 33 36
2013 May 11 29 40
2013 April 7 43 50
2013 March 8 19 27
Show all

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?