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1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Several lesions were biopsied&#46; All revealed the presence of dilated vascular lumens in the papillary dermis in intimate contact with the epidermis&#44; which was hyperplastic and hyperkeratotic&#46; There was evidence of thrombosis and recanalization of some of the blood vessels &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">We were able to obtain a small blood sample from the dilated scrotal vessels&#44; which allowed us to compare the levels of cortisol in the scrotal blood with those of the general circulation&#46; The cortisol concentration in the scrotal blood was 20&#46;6&#160;&#956;g&#47;dL&#44; considerably higher than that of the general circulation &#40;15&#46;3&#160;&#956;g&#47;dL&#59; normal range&#44; 6&#46;2-19&#46;4&#160;&#956;g&#47;dL&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The urology department confirmed the presence of a grade II varicocele on the left side of the scrotum&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Fordyce first described this type of angiokeratoma in 1896 in a 60-year-old man with bilateral varicocele&#46; They are the most common form of angiokeratoma&#46; They typically arise on the scrotum bilaterally&#44; although they have been reported at other sites&#44; such as the vulva<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and on the body of the penis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis of scrotal angiokeratomas have not been clarified&#46; It has been suggested that increased venous pressure could favor their appearance&#44; and this would explain the association with varicocele&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> However&#44; a study by Orvieto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> found no association between varicocele and angiokeratomas&#46; A limitation of that study was that the maximum age of inclusion was 55 years and the data were obtained by means of a questionnaire&#46; Some authors consider that alterations of the blood vessel wall must be present for angiokeratomas to develop&#44; though this may not be the only factor&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Varicocele more commonly affects the left testicle&#46; This is attributed to anatomical differences in the venous drainage of the testicles&#46; While the right testicular vein &#40;also known as the internal spermatic vein&#41; follows an oblique trajectory to drain directly into the inferior vena cava&#44; the vein from the left testicle ascends vertically to the left renal vein&#44; which means it is 8 to 10<span class="elsevierStyleHsp" style=""></span>cm longer than the vein on the right side&#46; This leads to greater resistance to venous drainage on the left side&#46; Varicocele is associated with testicular dysfunction&#44; and sterility can develop due to the associated testicular hyperthermia&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Another factor that could be important is retrograde blood flow from the left renal vein&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> although the results of relevant studies are contradictory&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In our patient&#44; higher cortisol levels were detected in the testicular region than in the general circulation&#46; As the testicles do not produce cortisol&#44; these values would support the hypothesis of retrograde flow in this patient&#46; The suprarenal glands secrete various hormones&#44; including estrogens and adrenomedullin&#44; a potent vasodilator&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Retrograde blood flow in cases of varicocele could lead to higher hormone levels in the testicles than in the general circulation&#59; this situation would favor vascular dilatation and&#44; thus&#44; the appearance of angiokeratomas&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Unilateral angiokeratomas are very rare&#59; we have only found 2 reports describing this situation&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> The details of those cases are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Although the patient described by Pande et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> did not present a clinically evident varicocele&#44; it is recognized that up to 60&#37; of varicoceles are not detected on physical examination and require ultrasound study for diagnosis<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#59; we cannot therefore rule out the possible presence of a subclinical varicocele&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">There are anastomoses between the left and right testicular circulations&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> If hormone levels do influence the development of angiokeratomas&#44; these connections could explain the appearance of bilateral lesions&#44; while unilateral disease may be due to abnormalities of the anastomoses&#46; Another possible explanation would be the presence of mosaicism&#44; which&#44; in association with other factors such as increased pressure and high hormone levels&#44; would cause angiokeratomas to develop only in genetically susceptible areas&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In summary&#44; we have presented a patient with unilateral angiokeratomas of Fordyce in whom we detected higher cortisol levels in the scrotal circulation than in the systemic circulation&#46; Studies with a larger number of patients are required to determine whether retrograde blood flow with high concentrations of suprarenal hormones could play a role in the etiology and pathogenesis of these angiokeratomas&#46;</p></span>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Piqu&#233;-Duran E&#44; et al&#46; Angioqueratoma de Fordyce unilateral&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;163&#8211;4&#46;</p>"
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      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
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          0 => array:4 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical appearance of the lesions&#44; which affect only the left half of the scrotum&#46; The right side is unaffected&#46;</p>"
        ]
      ]
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        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histological appearance of a lesion&#44; showing a pedunculated papule with grossly dilated blood vessels&#46; Signs of thrombosis and recanalization can be seen&#46; Acanthosis and hyperkeratosis are present in the epidermis&#46; Some vessels appear to be included within the epidermis&#46; Hematoxylin-eosin&#44; original magnification &#215;40&#46;</p>"
        ]
      ]
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; Nd&#58;YAG&#44; neodymium&#58;yttrium aluminum garnet&#46;</p>"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Reference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Age&#44; y&#47;Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Duration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Side Affected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Varicocele&#47;Examinations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#47;Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subclinical&#47;Diagnosed by echo-Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carbon dioxide laser and Nd&#58;YAG laser&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#47;Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&#47;Physical examination&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Electrocautery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Present case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#47;Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grade 2 varicocele&#47;Ultrasound&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Shaving of the larger lesions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cases of Unilateral Angiokeratomas of Fordyce&#46;</p>"
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Case and Research Letters
Unilateral Angiokeratoma of Fordyce
Angioqueratoma de Fordyce unilateral
E. Piqué-Durana,
Corresponding author
epiqued@medynet.com

Corresponding author.
, J.A. Pérez-Cejudob, D. Cameselle-Martínezb, O. García-Vázquezb
a Servicio de Dermatología, Hospital Dr. José Molina Orosa, Lanzarote, Spain
b Servicio de Patología, Hospital Dr. José Molina Orosa, Lanzarote, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">To the Editor&#58;</span></p><p id="par1005" class="elsevierStylePara elsevierViewall">We present the case of a 66-year-old man with a past history of ischemic heart disease&#44; systemic hypertension&#44; and type 2 diabetes mellitus&#44; who consulted for the appearance 8 months earlier of multiple lesions on the left side of the scrotum&#46; The lesions had progressively increased in number and size&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">On physical examination there were numerous&#44; sessile&#44; erythematous-purpuric unilocular papules of vascular appearance that only affected the left side of the scrotum and did not cross the midline&#46; In some areas the lesions grouped together to form clusters&#46; In addition&#44; bluish cords were observed&#44; which indicated dilatation of superficial blood vessels &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Several lesions were biopsied&#46; All revealed the presence of dilated vascular lumens in the papillary dermis in intimate contact with the epidermis&#44; which was hyperplastic and hyperkeratotic&#46; There was evidence of thrombosis and recanalization of some of the blood vessels &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">We were able to obtain a small blood sample from the dilated scrotal vessels&#44; which allowed us to compare the levels of cortisol in the scrotal blood with those of the general circulation&#46; The cortisol concentration in the scrotal blood was 20&#46;6&#160;&#956;g&#47;dL&#44; considerably higher than that of the general circulation &#40;15&#46;3&#160;&#956;g&#47;dL&#59; normal range&#44; 6&#46;2-19&#46;4&#160;&#956;g&#47;dL&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The urology department confirmed the presence of a grade II varicocele on the left side of the scrotum&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Fordyce first described this type of angiokeratoma in 1896 in a 60-year-old man with bilateral varicocele&#46; They are the most common form of angiokeratoma&#46; They typically arise on the scrotum bilaterally&#44; although they have been reported at other sites&#44; such as the vulva<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and on the body of the penis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis of scrotal angiokeratomas have not been clarified&#46; It has been suggested that increased venous pressure could favor their appearance&#44; and this would explain the association with varicocele&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> However&#44; a study by Orvieto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> found no association between varicocele and angiokeratomas&#46; A limitation of that study was that the maximum age of inclusion was 55 years and the data were obtained by means of a questionnaire&#46; Some authors consider that alterations of the blood vessel wall must be present for angiokeratomas to develop&#44; though this may not be the only factor&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Varicocele more commonly affects the left testicle&#46; This is attributed to anatomical differences in the venous drainage of the testicles&#46; While the right testicular vein &#40;also known as the internal spermatic vein&#41; follows an oblique trajectory to drain directly into the inferior vena cava&#44; the vein from the left testicle ascends vertically to the left renal vein&#44; which means it is 8 to 10<span class="elsevierStyleHsp" style=""></span>cm longer than the vein on the right side&#46; This leads to greater resistance to venous drainage on the left side&#46; Varicocele is associated with testicular dysfunction&#44; and sterility can develop due to the associated testicular hyperthermia&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Another factor that could be important is retrograde blood flow from the left renal vein&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> although the results of relevant studies are contradictory&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In our patient&#44; higher cortisol levels were detected in the testicular region than in the general circulation&#46; As the testicles do not produce cortisol&#44; these values would support the hypothesis of retrograde flow in this patient&#46; The suprarenal glands secrete various hormones&#44; including estrogens and adrenomedullin&#44; a potent vasodilator&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Retrograde blood flow in cases of varicocele could lead to higher hormone levels in the testicles than in the general circulation&#59; this situation would favor vascular dilatation and&#44; thus&#44; the appearance of angiokeratomas&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Unilateral angiokeratomas are very rare&#59; we have only found 2 reports describing this situation&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> The details of those cases are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Although the patient described by Pande et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> did not present a clinically evident varicocele&#44; it is recognized that up to 60&#37; of varicoceles are not detected on physical examination and require ultrasound study for diagnosis<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#59; we cannot therefore rule out the possible presence of a subclinical varicocele&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">There are anastomoses between the left and right testicular circulations&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> If hormone levels do influence the development of angiokeratomas&#44; these connections could explain the appearance of bilateral lesions&#44; while unilateral disease may be due to abnormalities of the anastomoses&#46; Another possible explanation would be the presence of mosaicism&#44; which&#44; in association with other factors such as increased pressure and high hormone levels&#44; would cause angiokeratomas to develop only in genetically susceptible areas&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In summary&#44; we have presented a patient with unilateral angiokeratomas of Fordyce in whom we detected higher cortisol levels in the scrotal circulation than in the systemic circulation&#46; Studies with a larger number of patients are required to determine whether retrograde blood flow with high concentrations of suprarenal hormones could play a role in the etiology and pathogenesis of these angiokeratomas&#46;</p></span>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Piqu&#233;-Duran E&#44; et al&#46; Angioqueratoma de Fordyce unilateral&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;163&#8211;4&#46;</p>"
      ]
    ]
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      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical appearance of the lesions&#44; which affect only the left half of the scrotum&#46; The right side is unaffected&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
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            "imagen" => "gr2.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histological appearance of a lesion&#44; showing a pedunculated papule with grossly dilated blood vessels&#46; Signs of thrombosis and recanalization can be seen&#46; Acanthosis and hyperkeratosis are present in the epidermis&#46; Some vessels appear to be included within the epidermis&#46; Hematoxylin-eosin&#44; original magnification &#215;40&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; Nd&#58;YAG&#44; neodymium&#58;yttrium aluminum garnet&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Reference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Age&#44; y&#47;Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Duration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Side Affected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Varicocele&#47;Examinations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#47;Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subclinical&#47;Diagnosed by echo-Doppler&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carbon dioxide laser and Nd&#58;YAG laser&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#47;Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&#47;Physical examination&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Electrocautery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Present case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#47;Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grade 2 varicocele&#47;Ultrasound&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Shaving of the larger lesions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cases of Unilateral Angiokeratomas of Fordyce&#46;</p>"
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    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Angiokeratoma of the vulva"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                          ]
                        ]
                      ]
                    ]
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                            1 => "M&#46; Huesmann"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "P&#46; Agger"
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                          ]
                        ]
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                  ]
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                            0 => "R&#46; Orvieto"
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                          ]
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                          "etal" => false
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Article information
ISSN: 15782190
Original language: English
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