Case for diagnosis
Sessile Nodule on the Gingival Mucosa
Nódulo sésil en mucosa gingival
Read
9720
Timeswas read the article
2398
Total PDF
7322
Total HTML
Share statistics
array:24 [ "pii" => "S1578219012001746" "issn" => "15782190" "doi" => "10.1016/j.adengl.2012.06.008" "estado" => "S300" "fechaPublicacion" => "2012-06-01" "aid" => "530" "copyright" => "Elsevier España, S.L. and AEDV" "copyrightAnyo" => "2011" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2012;103:433-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4225 "formatos" => array:3 [ "EPUB" => 47 "HTML" => 3392 "PDF" => 786 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0001731011005230" "issn" => "00017310" "doi" => "10.1016/j.ad.2011.08.011" "estado" => "S300" "fechaPublicacion" => "2012-06-01" "aid" => "530" "copyright" => "Elsevier España, S.L. y AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2012;103:433-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6791 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 4814 "PDF" => 1974 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagnóstico</span>" "titulo" => "Nódulo sésil en mucosa gingival" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "433" "paginaFinal" => "434" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Sessile Nodule on the Gingival Mucosa" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 998 "Ancho" => 792 "Tamanyo" => 89302 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Català, M. Alegre, A. Alomar, P. Domingo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Català" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Alegre" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Alomar" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Domingo" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219012001746" "doi" => "10.1016/j.adengl.2012.06.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001746?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011005230?idApp=UINPBA000044" "url" => "/00017310/0000010300000005/v1_201304241408/S0001731011005230/v1_201304241408/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219012001758" "issn" => "15782190" "doi" => "10.1016/j.adengl.2012.06.009" "estado" => "S300" "fechaPublicacion" => "2012-06-01" "aid" => "531" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Actas Dermosifiliogr. 2012;103:435-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6835 "formatos" => array:3 [ "EPUB" => 52 "HTML" => 4920 "PDF" => 1863 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>" "titulo" => "Umbilicated Papules on the Dorsum of Hands" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "435" "paginaFinal" => "436" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pápulas umbilicadas en dorso de manos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 528 "Ancho" => 666 "Tamanyo" => 75376 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.I. Sánchez-Moya, R. Juarez-Tosina, D. García Almagro" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A.I." "apellidos" => "Sánchez-Moya" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Juarez-Tosina" ] 2 => array:2 [ "nombre" => "D." "apellidos" => "García Almagro" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731011005242" "doi" => "10.1016/j.ad.2011.09.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011005242?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001758?idApp=UINPBA000044" "url" => "/15782190/0000010300000005/v1_201304241308/S1578219012001758/v1_201304241308/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219012001692" "issn" => "15782190" "doi" => "10.1016/j.adengl.2012.06.003" "estado" => "S300" "fechaPublicacion" => "2012-06-01" "aid" => "449" "copyright" => "Elsevier España, S.L. and AEDV" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2012;103:427-31" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6660 "formatos" => array:3 [ "EPUB" => 60 "HTML" => 5757 "PDF" => 843 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Splenic Marginal Zone B-Cell Lymphoma with Epidermotropic Skin Involvement" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "427" "paginaFinal" => "431" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Linfoma B esplénico de la zona marginal con afectación cutánea epidermotropa" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 759 "Ancho" => 950 "Tamanyo" => 123369 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Infiltrated plaques and nodules.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Gómez-de la Fuente, L.B. Villalón, L. Calzado-Villarreal, F. Pinedo-Moraleda, J.L. López-Estebaranz" "autores" => array:5 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Gómez-de la Fuente" ] 1 => array:2 [ "nombre" => "L.B." "apellidos" => "Villalón" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Calzado-Villarreal" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Pinedo-Moraleda" ] 4 => array:2 [ "nombre" => "J.L." "apellidos" => "López-Estebaranz" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731011003243" "doi" => "10.1016/j.ad.2011.06.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011003243?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001692?idApp=UINPBA000044" "url" => "/15782190/0000010300000005/v1_201304241308/S1578219012001692/v1_201304241308/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case for diagnosis</span>" "titulo" => "Sessile Nodule on the Gingival Mucosa" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "433" "paginaFinal" => "434" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Català, M. Alegre, A. Alomar, P. Domingo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Català" "email" => array:1 [ 0 => "acatala@santpau.cat" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Alegre" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Alomar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "P." "apellidos" => "Domingo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Enfermedades Infecciosas, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nódulo sésil en mucosa gingival" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 599 "Ancho" => 475 "Tamanyo" => 71313 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 33-year-old white man recently diagnosed with human immunodeficiency virus (HIV) and under treatment with highly-active antiretroviral therapy (HAART), consisting of darunavir, ritonavir, and tenofovir/emtricitabine, for the last 3 months. He was referred with a 2-week history of a single asymptomatic lesion in the mouth that caused occasional bleeding and discomfort when eating.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Examination revealed a sessile, exophytic nodule with a fleshy appearance and smooth surface; it measured 8<span class="elsevierStyleHsp" style=""></span>mm in diameter and was located on the inner surface of the lower gum (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The general assessment of the patient confirmed the absence of palpable locoregional lymph nodes or associated skin or mucosal lesions.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">The lesion was removed by shave excision, followed by coagulation of the base. Histologic examination by hematoxylin-eosin staining revealed a diffuse dermal proliferation of spindle cells that penetrated between the collagen bundles, along with the formation of blood-filled vascular spaces (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Several preexisting blood vessels were also observed protruding towards the newly formed vessels (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Immunohistochemistry was positive for herpes virus type 8 (HHV-8).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis?</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Oral Kaposi sarcoma.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Course</span><p id="par0030" class="elsevierStylePara elsevierViewall">Screening studies excluded visceral involvement. The lesion was completely removed by shave excision at the first visit and required no additional treatment.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Kaposi sarcoma is the most commonly diagnosed tumor in patients with acquired immunodeficiency syndrome and accounts for 90% of all cancers in this group.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The oral cavity is a common site of epidemic Kaposi sarcoma and it is estimated that 71% of HIV-positive patients with Kaposi sarcoma present lesions in this location. In 22% of cases the tumor initially presents in the mouth.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The most common clinical manifestations are dark red to violaceous macules and ulcerated nodular lesions, mainly located on the palate.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Favorable conditions created by HIV infection include a predominance of T<span class="elsevierStyleInf">H</span>1 cytokines, such as interferon-gamma, tumor necrosis factor alpha, and interleukins 1 and 6, all of which are known to induce Kaposi sarcoma.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The introduction of HAART promotes the healing of Kaposi sarcoma lesions and prevents the appearance of others, mainly due to the reduction of the HIV and HHV-8 load<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> and a decrease in antiangiogenic and antiinflammatory factors. However, after starting treatment with HAART, patients may also experience inflammatory immune reconstitution syndrome, a paradoxical reaction, with exacerbation of opportunistic infections in the context of immunological recovery.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The example we present is the result of the combination of both factors: immune response to a preexisting opportunistic HHV-8 infection and the inflammatory component of inflammatory immune reconstitution syndrome (reflected by the rapid growth and pedunculated form of the tumor).</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Medical History" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Physical Examination" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Histopathology" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Diagnosis" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Clinical Course" ] 5 => array:2 [ "identificador" => "sec0030" "titulo" => "Discussion" ] 6 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Catalá A, et al. Nódulo sésil en mucosa gingival. Actas Dermosifiliogr.2012;103:433-4.</p>" ] ] "multimedia" => array:3 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 599 "Ancho" => 475 "Tamanyo" => 71313 ] ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 788 "Ancho" => 665 "Tamanyo" => 276181 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin-eosin, original magnification ×5.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 501 "Ancho" => 665 "Tamanyo" => 147724 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin-eosin, original magnification ×20.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalencia y características de las dermatosis relacionadas con la infección por VIH en la actualidad" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Blanes" 1 => "I. Belinchón" 2 => "E. Merino" 3 => "J. Portilla" 4 => "J. Sánchez-Payad" 5 => "I. Betlloch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2010" "volumen" => "101" "paginaInicial" => "702" "paginaFinal" => "709" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20965013" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outlook in oral and cutaneous Kaposi's sarcoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Rohrmus" 1 => "E.M. Thoma-Greber" 2 => "J.R. Bogner" 3 => "M. Röcken" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(00)03503-0" "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "2000" "volumen" => "356" "paginaInicial" => "2160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11191549" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoma de Kaposi asociado a corticoterapia sistémica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. González-Sixto" 1 => "A. Conde" 2 => "E. May" 3 => "R. Pardavila" 4 => "C. de la Torre" 5 => "M. Cruces" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2007" "volumen" => "98" "paginaInicial" => "553" "paginaFinal" => "555" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17919431" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoma de Kaposi asociado al tratamiento con infliximab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Martinez" 1 => "L.J. Perez" 2 => "E. Escario" 3 => "P.A. Ribera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2010" "volumen" => "101" "paginaInicial" => "462" "paginaFinal" => "464" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20525496" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Insights into pathogenic events of HIV associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Feller" 1 => "J. Lemmer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1750-9378-3-1" "Revista" => array:5 [ "tituloSerie" => "Infect Agent Cancer" "fecha" => "2008" "volumen" => "3" "paginaInicial" => "1" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18208585" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010300000005/v1_201304241308/S1578219012001746/v1_201304241308/en/main.assets" "Apartado" => array:4 [ "identificador" => "6171" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Cases for Diagnosis" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010300000005/v1_201304241308/S1578219012001746/v1_201304241308/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012001746?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 17 | 12 | 29 |
| 2024 October | 127 | 33 | 160 |
| 2024 September | 128 | 19 | 147 |
| 2024 August | 141 | 60 | 201 |
| 2024 July | 115 | 34 | 149 |
| 2024 June | 106 | 27 | 133 |
| 2024 May | 117 | 26 | 143 |
| 2024 April | 91 | 24 | 115 |
| 2024 March | 79 | 27 | 106 |
| 2024 February | 72 | 29 | 101 |
| 2024 January | 60 | 31 | 91 |
| 2023 December | 77 | 13 | 90 |
| 2023 November | 73 | 30 | 103 |
| 2023 October | 58 | 20 | 78 |
| 2023 September | 60 | 29 | 89 |
| 2023 August | 41 | 13 | 54 |
| 2023 July | 40 | 30 | 70 |
| 2023 June | 48 | 21 | 69 |
| 2023 May | 54 | 28 | 82 |
| 2023 April | 44 | 27 | 71 |
| 2023 March | 47 | 22 | 69 |
| 2023 February | 51 | 19 | 70 |
| 2023 January | 41 | 28 | 69 |
| 2022 December | 59 | 40 | 99 |
| 2022 November | 41 | 21 | 62 |
| 2022 October | 25 | 20 | 45 |
| 2022 September | 33 | 44 | 77 |
| 2022 August | 26 | 42 | 68 |
| 2022 July | 19 | 33 | 52 |
| 2022 June | 31 | 17 | 48 |
| 2022 May | 62 | 40 | 102 |
| 2022 April | 114 | 41 | 155 |
| 2022 March | 70 | 66 | 136 |
| 2022 February | 59 | 25 | 84 |
| 2022 January | 99 | 35 | 134 |
| 2021 December | 72 | 29 | 101 |
| 2021 November | 63 | 34 | 97 |
| 2021 October | 112 | 48 | 160 |
| 2021 September | 58 | 37 | 95 |
| 2021 August | 80 | 23 | 103 |
| 2021 July | 84 | 25 | 109 |
| 2021 June | 53 | 28 | 81 |
| 2021 May | 82 | 41 | 123 |
| 2021 April | 215 | 80 | 295 |
| 2021 March | 153 | 23 | 176 |
| 2021 February | 97 | 27 | 124 |
| 2021 January | 57 | 19 | 76 |
| 2020 December | 81 | 17 | 98 |
| 2020 November | 39 | 24 | 63 |
| 2020 October | 72 | 20 | 92 |
| 2020 September | 47 | 11 | 58 |
| 2020 August | 36 | 15 | 51 |
| 2020 July | 40 | 11 | 51 |
| 2020 June | 41 | 23 | 64 |
| 2020 May | 36 | 13 | 49 |
| 2020 April | 44 | 18 | 62 |
| 2020 March | 39 | 20 | 59 |
| 2020 February | 4 | 0 | 4 |
| 2020 January | 4 | 2 | 6 |
| 2019 December | 8 | 2 | 10 |
| 2019 November | 4 | 3 | 7 |
| 2019 October | 0 | 1 | 1 |
| 2019 September | 7 | 2 | 9 |
| 2019 August | 4 | 5 | 9 |
| 2019 July | 4 | 8 | 12 |
| 2019 June | 6 | 16 | 22 |
| 2019 May | 4 | 20 | 24 |
| 2019 April | 4 | 10 | 14 |
| 2019 March | 2 | 14 | 16 |
| 2019 February | 2 | 1 | 3 |
| 2019 January | 2 | 3 | 5 |
| 2018 November | 3 | 0 | 3 |
| 2018 October | 5 | 0 | 5 |
| 2018 September | 3 | 0 | 3 |
| 2018 June | 0 | 1 | 1 |
| 2018 May | 0 | 3 | 3 |
| 2018 April | 0 | 2 | 2 |
| 2018 March | 17 | 1 | 18 |
| 2018 February | 77 | 4 | 81 |
| 2018 January | 60 | 11 | 71 |
| 2017 December | 108 | 9 | 117 |
| 2017 November | 46 | 9 | 55 |
| 2017 October | 59 | 7 | 66 |
| 2017 September | 46 | 21 | 67 |
| 2017 August | 58 | 24 | 82 |
| 2017 July | 44 | 9 | 53 |
| 2017 June | 75 | 27 | 102 |
| 2017 May | 53 | 10 | 63 |
| 2017 April | 49 | 15 | 64 |
| 2017 March | 28 | 45 | 73 |
| 2017 February | 50 | 6 | 56 |
| 2017 January | 42 | 19 | 61 |
| 2016 December | 57 | 6 | 63 |
| 2016 November | 97 | 22 | 119 |
| 2016 October | 104 | 26 | 130 |
| 2016 September | 101 | 13 | 114 |
| 2016 August | 88 | 12 | 100 |
| 2016 July | 56 | 16 | 72 |
| 2016 June | 16 | 0 | 16 |
| 2016 May | 6 | 15 | 21 |
| 2016 April | 4 | 0 | 4 |
| 2016 March | 6 | 2 | 8 |
| 2016 February | 9 | 7 | 16 |
| 2016 January | 4 | 0 | 4 |
| 2015 December | 9 | 2 | 11 |
| 2015 November | 18 | 6 | 24 |
| 2015 October | 15 | 0 | 15 |
| 2015 September | 5 | 9 | 14 |
| 2015 August | 8 | 4 | 12 |
| 2015 July | 137 | 13 | 150 |
| 2015 June | 79 | 6 | 85 |
| 2015 May | 94 | 7 | 101 |
| 2015 April | 94 | 13 | 107 |
| 2015 March | 102 | 10 | 112 |
| 2015 February | 110 | 8 | 118 |
| 2015 January | 103 | 22 | 125 |
| 2014 December | 87 | 12 | 99 |
| 2014 November | 81 | 18 | 99 |
| 2014 October | 109 | 19 | 128 |
| 2014 September | 87 | 15 | 102 |
| 2014 August | 89 | 19 | 108 |
| 2014 July | 108 | 24 | 132 |
| 2014 June | 113 | 13 | 126 |
| 2014 May | 47 | 6 | 53 |
| 2014 April | 45 | 4 | 49 |
| 2014 March | 53 | 7 | 60 |
| 2014 February | 50 | 9 | 59 |
| 2014 January | 35 | 4 | 39 |
| 2013 December | 41 | 7 | 48 |
| 2013 November | 38 | 9 | 47 |
| 2013 October | 25 | 5 | 30 |
| 2013 September | 30 | 4 | 34 |
| 2013 August | 18 | 5 | 23 |
| 2013 July | 5 | 17 | 22 |
| 2013 June | 8 | 12 | 20 |
| 2013 May | 12 | 11 | 23 |
| 2013 April | 19 | 8 | 27 |
| 2013 March | 16 | 7 | 23 |
| 2013 February | 28 | 3 | 31 |
| 2013 January | 37 | 7 | 44 |
| 2012 December | 13 | 7 | 20 |
| 2012 November | 0 | 3 | 3 |
| 2012 August | 2 | 2 | 4 |
Show all
