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Supervivencia específica desde el diagnóstico del tumor primario. Curvas de supervivencia para cada tipo de recidiva cutánea desde el momento del diagnóstico del tumor primario hasta la muerte por melanoma. (Kaplan-Meier p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,044). b. Supervivencia específica desde la recidiva cutánea. Curvas de supervivencia para cada tipo de recidiva desde el momento del diagnóstico de la recidiva cutánea hasta la muerte por melanoma (Kaplan-Meier p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Marcoval, J.R. Ferreres, R.M. Penín, J.M. Piulats, J.M. Caminal, À. Fabra" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Marcoval" ] 1 => array:2 [ "nombre" => "J.R." "apellidos" => "Ferreres" ] 2 => array:2 [ "nombre" => "R.M." 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"apellidos" => "Fabra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Oncología, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Oftalmología, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Laboratori d’Oncologia Molecular, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Análisis descriptivo de los patrones de recidiva cutánea en los pacientes con melanoma" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3646 "Ancho" => 2687 "Tamanyo" => 354006 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A, Specific survival after diagnosis of the primary tumor. Survival curves for each type of cutaneous recurrence from the diagnosis of the primary tumor until death from melanoma (Kaplan-Meier, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.044). B, Specific survival from the time of the cutaneous recurrence. Survival curves for each type of relapse from diagnosis of cutaneous relapse until death from melanoma (Kaplan-Meier, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.001).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">During the last few decades, the incidence of cutaneous melanoma has increased more than that of any other malignant neoplasm.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> Interest from the scientific community and the number of publications on melanoma have increased in parallel. Yet, few clinical studies have analyzed cutaneous recurrence patterns in malignant melanoma.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4–7</span></a> Some studies have included cutaneous metastases in multivariate models, such as the recent study of the American Joint Committee on Cancer (AJCC), in which the presence of regional and distant cutaneous metastases were independent prognostic factors, although the authors did not specifically analyze the cutaneous recurrence pattern or its correlation with other parameters.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Our objective was to analyze the prognostic significance of the cutaneous recurrence pattern in malignant melanoma and its association with other clinicopathologic characteristics.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Material and Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">The study population comprised all patients with malignant cutaneous melanoma (stage I, II, or III) at diagnosis who were disease-free after their initial treatment at Hospital de Bellvitge, Barcelona, Spain between 1988 and 2008 and had a minimum 2 years of follow-up. The institution is a tertiary-level teaching hospital that provides health care to approximately 1 million people. Patients with stage IV melanoma at diagnosis and patients with melanoma of unknown origin were excluded.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Melanomas in situ were removed with a 5-mm margin, melanomas in the vertical growth phase with a maximum depth of < 1<span class="elsevierStyleHsp" style=""></span>mm (Breslow depth) were removed with a 1-cm margin, melanomas measuring 1.01<span class="elsevierStyleHsp" style=""></span>mm to 2<span class="elsevierStyleHsp" style=""></span>mm were removed with 2-cm margins, and melanomas > 2<span class="elsevierStyleHsp" style=""></span>mm deep were removed with 3-cm margins. Until 2000, regional nodes were removed when primary tumors presented a Breslow depth > 1.5<span class="elsevierStyleHsp" style=""></span>mm and were located on the extremities. When the location was the trunk or head, this approach was used only when the primary tumor lay adjacent to the lymph drainage area corresponding to the primary tumor. From 2000 onward, sentinel node biopsy was applied in all melanomas with a Breslow depth > 1<span class="elsevierStyleHsp" style=""></span>mm, and regional nodes were removed in cases of invasion of the sentinel node by the melanoma.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Clinical follow-up was at the dermatology department every 4 months during the first 2 years after diagnosis and every 6 months until 5 years after diagnosis. Follow-up in the case of melanomas with a Breslow depth <1<span class="elsevierStyleHsp" style=""></span>mm was for 5 years; patients were then referred to their area dermatologist for lifetime yearly checkups. Follow-up in the case of melanomas with a Breslow depth > 1<span class="elsevierStyleHsp" style=""></span>mm was for 10 years at the dermatology department; patients were then referred to their area dermatologist for lifetime yearly checkups.</p><p id="par0030" class="elsevierStylePara elsevierViewall">During the first 2 years of follow-up, blood chemistry (including lactate dehydrogenase) was assessed at each visit and a yearly radiograph was taken. Additional tests were performed depending on clinical and laboratory findings.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Retrospective data retrieved from the clinical histories were entered into a digital database to which only the authors of the present article had access. The data collected included sex, age at diagnosis, site of the primary tumor, date of diagnosis, date of cutaneous recurrence, date of most recent checkup, and, where applicable, date of death due to melanoma. The clinical type of recurrence was evaluated in each case according to the following criteria: local recurrence in the presence of invasion of the skin adjacent to the scar left by excision of the primary tumor, with margins considered acceptable according to our protocol; and regional metastasis or regional recurrence when the lesions were restricted to the area drained by a regional lymph node station of the primary tumor (satellitosis in lesions limited to 5<span class="elsevierStyleHsp" style=""></span>cm from the scar left by excision of the primary tumor and in-transit metastasis when at a greater distance). Finally, lesions outside the area drained by a regional lymph node of the primary tumor were classed as distant cutaneous metastasis. The histopathology data collected were clinicopathologic type, maximum Breslow depth, Clark level, and presence of ulceration.</p><p id="par0040" class="elsevierStylePara elsevierViewall">As for statistical analysis, quantitative variables were compared using analysis of variance, and qualitative variables were compared using contingency tables. Given the limited number of cases, the χ<span class="elsevierStyleSup">2</span> test could not be applied in many cases, and we were only able to estimate the existence of correlations. Survival curves were analyzed using the Kaplan-Meier method. The log-rank test was used to detect significant differences between the survival curves. The statistical analysis was performed using SPSS 13.0 for Windows. Statistical significance was set at <span class="elsevierStyleItalic">P<span class="elsevierStyleHsp" style=""></span></span><<span class="elsevierStyleHsp" style=""></span>.05. The low number of cases prevented us from performing a multivariate analysis.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">A total of 1080 patients with cutaneous malignant melanoma who were disease-free after the initial treatment completed the minimum 2 years of follow-up. Cutaneous recurrence of melanoma was detected in 85 (7.87%) patients. In 71 (83.53%), cutaneous recurrence was the first evidence of recurrence of melanoma after the initial treatment. This group comprised 27 men and 44 women (mean age, 60.68 years). The first recurrence was local in 32 patients, regional cutaneous metastasis in 32, and distant cutaneous metastasis in 7.</p><p id="par0050" class="elsevierStylePara elsevierViewall">For each type of recurrence, <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the following data: sex, mean age, site of the primary tumor, mean maximum Breslow depth, presence or absence of ulceration, clinicopathologic type, and number of patients who died of the melanoma in each category, as well as mean disease-free survival, mean cause-specific survival after cutaneous recurrence, and mean cause-specific survival after diagnosis of melanoma.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The association between recurrence patterns and qualitative variables was compared using contingency tables; although statistical tests could not be applied, a marked tendency was observed towards an association between the cutaneous recurrence pattern and the site of the primary tumor and, to a lesser extent, sex. Certain clinicopathological types of melanoma also tended to be associated with specific cutaneous recurrence patterns (lentigo maligna melanoma with local recurrence) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><p id="par0060" class="elsevierStylePara elsevierViewall">Analysis of variance revealed significant differences in age between the 3 categories of cutaneous recurrence (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.037), but not in Breslow depth (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Analysis of variance did not reveal significant differences for disease-free survival, cause-specific survival after cutaneous recurrence, and cause-specific survival after diagnosis of the primary tumor (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><p id="par0065" class="elsevierStylePara elsevierViewall">However, Kaplan-Meier survival curves for each type of recurrence revealed significant differences in survival time since the diagnosis of melanoma (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.044) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A) and in survival time since the diagnosis of cutaneous recurrence (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.001) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Patients with local and regional recurrence were treated with surgery where possible. When there were several lesions or when lesions reappeared after excision, patients were treated with radiotherapy. Two patients with regional cutaneous recurrence of multiple small lesions were treated with topical imiquimod; however, response was partial, and the patients were subsequently treated with radiotherapy. In patients with distant cutaneous metastasis, lesions were excised if there were few of them. However, as most patients developed visceral metastasis after a few months, they received chemotherapy (with dacarbazine in most cases).</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">According to the literature, cutaneous metastasis is relatively common in the natural history of melanoma, occurring in 2% to 20% of cases depending on the series.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,7,9,10</span></a> However, little is known about the risk factors involved in the development of different patterns of cutaneous recurrence (local, regional metastasis, or distant metastasis) or their prognostic significance.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Some studies distinguish between local, regional, and distant recurrence, although others do not distinguish between local and regional recurrence or focus solely on one of the two. In addition, the conclusions are not consistent.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4–6</span></a> According to some studies, patients with different cutaneous recurrence patterns do not present significant differences in survival.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In contrast, the prognostic significance of cutaneous metastasis was recently analyzed in an AJCC multivariate study by Balch et al,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> in which regional metastases were category N2c and distant cutaneous metastases were category M1a and, therefore, have prognostic significance. However, the study was wide-ranging and did not analyze the prognostic significance of local recurrence or the correlation between the cutaneous recurrence pattern and other parameters.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Discrepancies can also be found with respect to the number of patients in whom cutaneous recurrence is the first sign of progression of melanoma. For example, in a recent study, cutaneous recurrence was the first sign of tumor progression in only 56.3%.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> However, in our study, when melanoma spread to the skin, it was often the first sign of melanoma recurrence (83.53%).</p><p id="par0085" class="elsevierStylePara elsevierViewall">Savoia et al<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> recently found that the cutaneous recurrence pattern was closely related to the site of the primary tumor. We also found that the site of the primary tumor affected the pattern of cutaneous dissemination (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). In fact, patients with melanoma on the lower extremities and on the head only developed local and regional cutaneous recurrence. Patients with melanoma on the trunk presented local, regional, and distant recurrence with a similar frequency, whereas cutaneous relapses were exceptional in tumors located on the upper extremities (only 3 cases) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). It is noteworthy that most distant cutaneous metastases occurred in melanomas on the trunk (6 of the 7 patients with distant cutaneous metastases had a primary tumor on the trunk) and that 20 of the 32 patients with regional cutaneous metastases had a primary tumor on the lower extremities. The reason why regional metastases are usually observed on the lower limbs is unknown. According to the literature, locoregional metastases are favored by embolization of dermal lymph vessels between the primary tumor and regional lymph nodes. In addition, a correlation has been detected between lymphatic invasion and subsequent locoregional recurrence.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Some authors consider that lymphatic stasis after node removal is an additional risk factor and argue that most of their patients with regional metastasis have the primary tumor on the lower limbs, where lymphedema is common after node removal.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> However, lymphedema can also appear on the arms after axillary node removal, and, in our study, we only observed 1 case of regional cutaneous metastasis on the arms, thus contradicting the above argument.</p><p id="par0090" class="elsevierStylePara elsevierViewall">The analysis of the association between the cutaneous recurrence pattern and the other variables studied highlights that local and regional recurrence were more common in women, possibly because of a greater frequency of primary tumors on the lower limbs among women (83% of our patients with melanoma on the lower limbs were women). It is also noteworthy that the mean age of our patients with distant metastasis was significantly lower (47.86 years) than that of patients with local recurrence (60.47 years) and regional recurrence (63.69 years). We found that the cutaneous recurrence pattern was not related to Breslow depth, as we did not detect significant differences between the 3 patterns. Nor did we detect significant differences between the cutaneous recurrence patterns for the remaining clinicopathologic characteristics analyzed (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><p id="par0095" class="elsevierStylePara elsevierViewall">As for survival, our patients with local recurrence of melanoma in situ progressed favorably with local surgery. Of the remaining patients with local recurrence of invasive melanoma, 11 of 30 died of melanoma. In the group with regional cutaneous recurrence, 17 of 32 died. Six of 7 patients with distant cutaneous metastasis died. Although analysis of variance revealed no significant differences, patients with local recurrence and patients with regional recurrence had a shorter recurrence-free period once the primary tumor was removed (40.45 and 45.88 months, respectively), compared with cases of distant cutaneous metastasis (69.43 months) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). However, once the first cutaneous recurrence developed, time to death from melanoma was longer for patients with local and regional recurrence (38.00 and 24.00 months, respectively) than for patients with distant cutaneous metastasis (13.17 months) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). Kaplan-Meier analysis revealed that survival was significantly impacted by the cutaneous recurrence pattern: significant differences were observed for cause-specific survival after diagnosis of the primary tumor and cause-specific survival after diagnosis of the cutaneous recurrence (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A and B). These results are consistent with the prognostic value observed for distant and regional cutaneous relapse in the study by Balch et al,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> on which the current prognostic classification of the AJCC is based.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Our results suggest that differences in prognosis between the various types of cutaneous relapse should be taken into account in clinical management and in the choice of possible therapeutic options. Given the relatively favorable prognosis of patients with local or regional cutaneous recurrence, first-choice approaches were local but barely aggressive treatments such as surgery, radiotherapy, perfusion, and electrochemotherapy, whereas patients with distant cutaneous metastasis and a short period until development of visceral metastasis (only 13.17 months) could benefit from more aggressive systemic treatment.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,12</span></a> Follow-up of the latter group should be more meticulous owing to the frequent and rapid onset of visceral metastasis.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Our study is limited by its retrospective design and the small sample size, which prevented us from performing a multivariate analysis. Consequently, confounders could be present. The χ<span class="elsevierStyleSup">2</span> test could not be applied in many cases, and we were only able to estimate the existence of correlations.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Our results suggest that the cutaneous recurrence pattern has prognostic significance and that it depends on the location of the primary tumor, given that most local and regional recurrences occur in melanomas located on the lower limbs and head.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of Interest</span><p id="par0115" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres95511" "titulo" => array:5 [ 0 => "Abstract" 1 => "Background and objectives" 2 => "Material and methods" 3 => "Results" 4 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec82669" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres95510" "titulo" => array:5 [ 0 => "Resumen" 1 => "Introducción" 2 => "Material y métodos" 3 => "Resultados" 4 => "Conclusiones" ] ] 3 => array:2 [ "identificador" => "xpalclavsec82670" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and Methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of Interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-10-06" "fechaAceptado" => "2011-04-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec82669" "palabras" => array:5 [ 0 => "Melanoma" 1 => "Metastasis" 2 => "Cutaneous metastases" 3 => "Skin" 4 => "Prognosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82670" "palabras" => array:5 [ 0 => "Melanoma" 1 => "Metástasis" 2 => "Metástasis cutáneas" 3 => "Piel" 4 => "Pronóstico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Few studies have addressed cutaneous recurrence of melanoma. The aim of this retrospective study was to analyze the characteristics and prognostic significance of the different patterns of cutaneous recurrence.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patients diagnosed with melanoma between 1988 and 2008 at Hospital de Bellvitge, Barcelona, Spain and for whom data were available for at least 2 years of follow-up were included in the study. Local recurrence was defined as melanoma invasion of the skin adjacent to the scar left by excision of the primary tumor, regional metastasis or recurrence as metastasis restricted to the area drained by a regional lymph node station, and distant cutaneous metastasis as metastasis occurring outside this area. The relationship between cutaneous recurrence pattern and age, sex, primary tumor site, tumor subtype, Breslow depth, and ulceration was assessed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Eighty-five out of 1,080 patients (7.87%) had cutaneous recurrence. In 71 of those patients (83.53%; 27 men and 44 women; mean age, 60.68 years), this was the first indication of melanoma recurrence. Thirty-two patients had local recurrence, 32 regional metastasis, and 7 distant metastasis. Significant differences were observed in survival time from diagnosis of the primary tumor (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.044) and from diagnosis of cutaneous recurrence (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>.001) according to the type of recurrence.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Our results suggest that the pattern of cutaneous recurrence is prognostically significant and related to the site of the primary tumor given that the majority of local and regional recurrences occurred in primary tumors located on the lower limbs and head.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Existen pocos estudios sobre recidiva cutánea en el melanoma. Nuestro objetivo fue analizar retrospectivamente las características y el significado pronóstico de los distintos patrones de recidiva cutánea del melanoma.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con melanoma diagnosticados entre 1988-2008 en el Hospital de Bellvitge de Barcelona, con más de dos años de seguimiento, fueron incluidos en el estudio. Se consideró recidiva local a la infiltración cutánea por melanoma en continuidad con la cicatriz de exéresis del tumor primario, metástasis o recidiva regional cuando las lesiones se mantenían en el territorio de drenaje linfático regional y metástasis cutánea a distancia cuando se localizaron fuera de este territorio. Se analizó la relación del patrón de recidiva cutánea con edad, sexo, localización del tumor primario, tipo clinicopatológico, profundidad máxima de invasión y ulceración.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Ochenta y cinco de 1.080 pacientes desarrollaron recidiva cutánea (7,87%). En 71 de 85 pacientes (83,53%) la recidiva cutánea fue la primera evidencia de recidiva (27 varones y 44 mujeres; edad media: 60,68 años). Treinta y dos pacientes presentaron recidiva local, 32 regional y 7 a distancia. Las curvas de supervivencia mostraron diferencias significativas en tiempo de supervivencia específica desde el diagnóstico del melanoma primario (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,044) y desde el diagnóstico de la recidiva cutánea (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Nuestros resultados sugieren que el patrón de recidiva cutánea tiene significado pronóstico y que está relacionado con la localización del tumor primario, puesto que la mayoría de recidivas locales y regionales se producen en las extremidades inferiores y en la cabeza.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Marcoval J, et al. Análisis descriptivo de los patrones de recidiva cutánea en los pacientes con melanoma. Actas Dermosifiliogr. 2011;102:791-796.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3646 "Ancho" => 2687 "Tamanyo" => 354006 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A, Specific survival after diagnosis of the primary tumor. Survival curves for each type of cutaneous recurrence from the diagnosis of the primary tumor until death from melanoma (Kaplan-Meier, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.044). B, Specific survival from the time of the cutaneous recurrence. Survival curves for each type of relapse from diagnosis of cutaneous relapse until death from melanoma (Kaplan-Meier, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.001).</p>" ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Local (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Regional (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Distant (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Sex 27 men/44 women</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 men/ 19 women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 men/ 22 women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 men/3 women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Mean age, 60.68 y</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60.47 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63.69 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.86 y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.037 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Location</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Head 13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Trunk 22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Arms 3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Legs 33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Mean Breslow depth, 4.00 mm</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.16 mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.84 mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.13 mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.950 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Ulceration, 12 yes/59 no</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 yes/25 no \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 yes/27 no \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 yes/ 7 no \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Clinicopathologic type</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lentigo maligna melanoma, 5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Superficial spreading melanoma, 31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Acral lentiginous melanoma, 14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nodular melanoma, 11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mucosal melanoma, 2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nonevaluable, 8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Death from melanoma, 34/71</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11/32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17/32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6/7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Survival time, mo</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Disease-free survival, 45.83<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">69.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.374 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Specific survival since recurrence, 26.27<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.244 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Specific survival since diagnosis, 61.88<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">78.67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.572 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab181920.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara">Time in months from diagnosis of the primary tumor until diagnosis of the cutaneous recurrence (71 patients).</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara">Survival time in months from diagnosis of recurrence until death from melanoma (34 patients).</p>" ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara">Time in months from diagnosis of the primary tumor until death from melanoma (34 patients).</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Clinicopathological Variables Analyzed in Patients With Cutaneous Recurrence as the First Evidence of Recurrence of Melanoma After 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 5 | 5 | 10 |
2024 October | 82 | 34 | 116 |
2024 September | 92 | 22 | 114 |
2024 August | 125 | 65 | 190 |
2024 July | 108 | 29 | 137 |
2024 June | 100 | 30 | 130 |
2024 May | 76 | 31 | 107 |
2024 April | 69 | 28 | 97 |
2024 March | 72 | 36 | 108 |
2024 February | 61 | 34 | 95 |
2024 January | 51 | 30 | 81 |
2023 December | 50 | 24 | 74 |
2023 November | 63 | 24 | 87 |
2023 October | 61 | 30 | 91 |
2023 September | 57 | 35 | 92 |
2023 August | 26 | 12 | 38 |
2023 July | 49 | 33 | 82 |
2023 June | 38 | 30 | 68 |
2023 May | 49 | 27 | 76 |
2023 April | 53 | 24 | 77 |
2023 March | 57 | 23 | 80 |
2023 February | 49 | 23 | 72 |
2023 January | 40 | 24 | 64 |
2022 December | 62 | 46 | 108 |
2022 November | 33 | 28 | 61 |
2022 October | 33 | 29 | 62 |
2022 September | 22 | 34 | 56 |
2022 August | 28 | 37 | 65 |
2022 July | 19 | 33 | 52 |
2022 June | 26 | 18 | 44 |
2022 May | 45 | 37 | 82 |
2022 April | 54 | 56 | 110 |
2022 March | 61 | 63 | 124 |
2022 February | 49 | 40 | 89 |
2022 January | 54 | 34 | 88 |
2021 December | 43 | 48 | 91 |
2021 November | 60 | 39 | 99 |
2021 October | 73 | 51 | 124 |
2021 September | 37 | 35 | 72 |
2021 August | 36 | 45 | 81 |
2021 July | 29 | 22 | 51 |
2021 June | 28 | 37 | 65 |
2021 May | 66 | 53 | 119 |
2021 April | 81 | 37 | 118 |
2021 March | 62 | 28 | 90 |
2021 February | 50 | 40 | 90 |
2021 January | 34 | 26 | 60 |
2020 December | 29 | 19 | 48 |
2020 November | 28 | 30 | 58 |
2020 October | 16 | 10 | 26 |
2020 September | 37 | 12 | 49 |
2020 August | 26 | 22 | 48 |
2020 July | 42 | 16 | 58 |
2020 June | 38 | 22 | 60 |
2020 May | 31 | 23 | 54 |
2020 April | 32 | 16 | 48 |
2020 March | 26 | 21 | 47 |
2020 February | 10 | 8 | 18 |
2020 January | 0 | 4 | 4 |
2019 December | 6 | 9 | 15 |
2019 November | 4 | 1 | 5 |
2019 September | 4 | 0 | 4 |
2019 August | 4 | 4 | 8 |
2019 July | 7 | 6 | 13 |
2019 June | 4 | 13 | 17 |
2019 May | 6 | 16 | 22 |
2019 April | 4 | 8 | 12 |
2019 March | 0 | 10 | 10 |
2019 February | 4 | 2 | 6 |
2019 January | 1 | 0 | 1 |
2018 December | 0 | 2 | 2 |
2018 November | 4 | 1 | 5 |
2018 October | 4 | 2 | 6 |
2018 September | 3 | 0 | 3 |
2018 March | 2 | 0 | 2 |
2018 February | 29 | 2 | 31 |
2018 January | 48 | 7 | 55 |
2017 December | 42 | 6 | 48 |
2017 November | 46 | 9 | 55 |
2017 October | 39 | 6 | 45 |
2017 September | 33 | 12 | 45 |
2017 August | 60 | 14 | 74 |
2017 July | 51 | 4 | 55 |
2017 June | 63 | 28 | 91 |
2017 May | 50 | 12 | 62 |
2017 April | 59 | 27 | 86 |
2017 March | 42 | 20 | 62 |
2017 February | 33 | 15 | 48 |
2017 January | 17 | 10 | 27 |
2016 December | 43 | 7 | 50 |
2016 November | 55 | 6 | 61 |
2016 October | 62 | 14 | 76 |
2016 September | 48 | 9 | 57 |
2016 August | 55 | 13 | 68 |
2016 July | 52 | 11 | 63 |
2016 June | 12 | 7 | 19 |
2016 May | 5 | 15 | 20 |
2016 April | 6 | 16 | 22 |
2016 March | 5 | 8 | 13 |
2016 February | 5 | 13 | 18 |
2016 January | 6 | 8 | 14 |
2015 December | 9 | 8 | 17 |
2015 November | 9 | 13 | 22 |
2015 October | 10 | 13 | 23 |
2015 September | 13 | 3 | 16 |
2015 August | 15 | 1 | 16 |
2015 July | 63 | 6 | 69 |
2015 June | 59 | 4 | 63 |
2015 May | 85 | 14 | 99 |
2015 April | 55 | 9 | 64 |
2015 March | 65 | 6 | 71 |
2015 February | 40 | 6 | 46 |
2015 January | 44 | 9 | 53 |
2014 December | 54 | 10 | 64 |
2014 November | 35 | 15 | 50 |
2014 October | 52 | 11 | 63 |
2014 September | 34 | 10 | 44 |
2014 August | 48 | 16 | 64 |
2014 July | 60 | 18 | 78 |
2014 June | 69 | 11 | 80 |
2014 May | 74 | 14 | 88 |
2014 April | 47 | 8 | 55 |
2014 March | 83 | 25 | 108 |
2014 February | 59 | 14 | 73 |
2014 January | 73 | 14 | 87 |
2013 December | 65 | 12 | 77 |
2013 November | 16 | 19 | 35 |
2013 October | 13 | 8 | 21 |
2013 September | 13 | 4 | 17 |
2013 August | 13 | 15 | 28 |
2013 July | 10 | 20 | 30 |
2013 June | 14 | 25 | 39 |
2013 May | 15 | 24 | 39 |
2013 April | 8 | 23 | 31 |
2013 March | 21 | 13 | 34 |
2013 February | 32 | 5 | 37 |
2013 January | 25 | 3 | 28 |
2012 December | 12 | 4 | 16 |