Case Report
Type I Cryoglobulinemia With a Fatal Outcome
Crioglobulinemia tipo I de desenlace fatal
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Vitiello, A. Abuchar, F.A. Kerdel" "autores" => array:4 [ 0 => array:4 [ "nombre" => "B." "apellidos" => "Echeverría" "email" => array:1 [ 0 => "begoecheverria2@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Vitiello" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Abuchar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "F.A." "apellidos" => "Kerdel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Instituto Valenciano de Oncología (IVO), Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de la Universidad de Miami, Florida, USA" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Crioglobulinemia tipo I de desenlace fatal" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-03-28" "fechaAceptado" => "2010-10-15" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84876" "palabras" => array:3 [ 0 => "Cryoglobulinemia" 1 => "Plasmapheresis" 2 => "Sepsis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84877" "palabras" => array:3 [ 0 => "Crioglobulinemia" 1 => "Plasmaféresis" 2 => "Sepsis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Type I cryoglobulinemia, a condition associated with lymphoproliferative disorders, is caused by monoclonal immunoglobulins that precipitate at low temperatures. It mostly involves the skin and pathology study shows no signs of vasculitis. Management is usually based on immunosuppressive drugs associated with plasmapheresis for severe disease. The use of rituximab has recently been described for resistant cases. We present an unusual case of long-standing type I cryoglobulinemia associated with a monoclonal gammopathy of uncertain significance. The patient developed extremely severe skin lesions with histological signs of vasculitis. The patient died due to the onset of noncutaneous manifestations of the cryoglobulinemia and complications of the immunosuppressive treatment.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La crioglobulinemia tipo I es un trastorno producido por inmunoglobulinas monoclonales que precipitan a bajas temperaturas. Se asocia a trastornos linfoproliferativos, su clínica es predominantemente cutánea y la anatomía patológica no muestra fenómenos de vasculitis. En su manejo se emplean habitualmente fármacos inmunosupresores junto con plasmaféresis para los casos graves. Recientemente se ha descrito el uso de rituximab para los casos resistentes. Se presenta un caso poco común de crioglobulinemia tipo I de largo tiempo de evolución asociada a una gammapatía monoclonal de significado incierto. El paciente desarrolló lesiones cutáneas de extrema gravedad con fenómenos de vasculitis en la anatomía patológica, y presentó un desenlace fatal secundariamente a la aparición de manifestaciones extracutáneas de la crioglobulinemia y a las complicaciones del tratamiento inmunosupresor.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2020 January | 0 | 5 | 5 |
| 2019 December | 0 | 14 | 14 |
| 2019 November | 0 | 4 | 4 |
| 2019 October | 0 | 5 | 5 |
| 2019 September | 0 | 1 | 1 |
| 2019 August | 0 | 7 | 7 |
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| 2019 May | 0 | 42 | 42 |
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| 2018 May | 0 | 1 | 1 |
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| 2018 February | 8 | 2 | 10 |
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| 2016 July | 23 | 7 | 30 |
| 2016 June | 7 | 0 | 7 |
| 2016 May | 4 | 8 | 12 |
| 2016 April | 6 | 0 | 6 |
| 2016 March | 3 | 0 | 3 |
| 2016 February | 5 | 1 | 6 |
| 2016 January | 11 | 2 | 13 |
| 2015 December | 12 | 0 | 12 |
| 2015 November | 5 | 0 | 5 |
| 2015 October | 6 | 4 | 10 |
| 2015 September | 4 | 1 | 5 |
| 2015 August | 9 | 2 | 11 |
| 2015 July | 19 | 9 | 28 |
| 2015 June | 22 | 3 | 25 |
| 2015 May | 57 | 17 | 74 |
| 2015 April | 41 | 20 | 61 |
| 2015 March | 26 | 18 | 44 |
| 2015 February | 34 | 9 | 43 |
| 2015 January | 30 | 7 | 37 |
| 2014 December | 25 | 7 | 32 |
| 2014 November | 25 | 9 | 34 |
| 2014 October | 28 | 15 | 43 |
| 2014 September | 32 | 10 | 42 |
| 2014 August | 37 | 17 | 54 |
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| 2014 June | 35 | 12 | 47 |
| 2014 May | 45 | 10 | 55 |
| 2014 April | 35 | 18 | 53 |
| 2014 March | 43 | 13 | 56 |
| 2014 February | 34 | 15 | 49 |
| 2014 January | 30 | 19 | 49 |
| 2013 December | 41 | 8 | 49 |
| 2013 November | 33 | 21 | 54 |
| 2013 October | 31 | 13 | 44 |
| 2013 September | 26 | 27 | 53 |
| 2013 August | 21 | 20 | 41 |
| 2013 July | 43 | 28 | 71 |
| 2013 June | 25 | 19 | 44 |
| 2013 May | 36 | 21 | 57 |
| 2013 April | 37 | 30 | 67 |
| 2013 March | 5 | 10 | 15 |
| 2013 February | 5 | 7 | 12 |
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