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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Alopecia areata is an autoimmune inflammatory disease affecting the hair follicles&#46; Researchers are currently interested in whether the presence of bacterial pathogens and&#47;or a history of immunization can trigger an autoimmune response in patients who are genetically predisposed&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">This study aimed to determine whether there is an association between the development of alopecia areata and throat carriage of bacterial pathogens or a history of immunization&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Sixty-five men and women with alopecia areata and 65 control patients with other skin diseases were studied at the Dr Ladislao de la Pascua Dermatology Clinic between September 2008 and February 2009&#46; The patients ranged in age from 18 to 59 years&#46; Patients with scalp diseases were excluded from the control group&#46; In all cases&#44; the patient was questioned about immunizations received in the previous 6 months&#44; and a throat swab was cultured&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A history of immunization &#40;odds ratio &#91;OR&#93;&#44; 3&#46;3&#59; 1&#46;6&#37; confidence interval &#91;CI&#93;&#44; 1&#46;6-6&#46;7&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41;&#44; the presence of bacterial pathogens in the oropharynx &#40;OR&#44; 2&#46;6&#59; 95&#37; CI&#44; 1&#46;1-6&#46;2&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;033&#41;&#44; and being a carrier of Streptococcus pyogenes &#40;OR&#44; 2&#46;1&#59; 95&#37; CI&#44; 1&#46;7-2&#46;5&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;042&#41; were risk factors for alopecia areata&#46; <span class="elsevierStyleItalic">Klebsiella pneumoniae&#44; S pyogenes&#44; Pseudomonas aeruginosa&#44; Streptococcus pneumoniae&#44; Serratia marcescens</span> and <span class="elsevierStyleItalic">Escherichia coli</span> were isolated from cultures&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">This is the first study to show an association between alopecia areata and throat carriage of bacterial pathogens or history of immunization&#44; as risk factors for development of the disease&#46; Given the characteristics of our study population&#44; the association appears valid for patients with less than 25&#37; hair loss and a course of disease under 1 year&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La alopecia areata es una enfermedad inflamatoria autoinmune que afecta al pelo&#46; Actualmente se estudia si las bacterias pat&#243;genas y las inmunizaciones son inductores de la respuesta autoinmune en pacientes con susceptibilidad gen&#233;tica&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio fue determinar si las bacterias pat&#243;genas en la faringe y el antecedente de haber recibido inmunizaciones est&#225;n asociados a la enfermedad&#46;</p> <span class="elsevierStyleSectionTitle">Materiales y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">En el Centro Dermatol&#243;gico &#171;Dr&#46; Ladislao de la Pascua&#187;&#44; desde septiembre de 2008 a febrero de 2009&#44; se estudiaron 65 pacientes con alopecia areata y 65 controles con otras dermatosis&#44; excluyendo las del cuero cabelludo&#46; Se incluyeron pacientes de 18 a 59 a&#241;os de edad y de ambos sexos&#46; A todos se les interrog&#243; sobre inmunizaciones recibidas 6 meses antes y se les realiz&#243; un cultivo de exudado far&#237;ngeo&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Haber recibido inmunizaciones&#44; la presencia de bacterias pat&#243;genas en la faringe y ser portador de <span class="elsevierStyleItalic">S&#46; pyogenes</span> se comportaron como factores de riesgo para la alopecia areata&#44; con una raz&#243;n de probabilidades de 3&#44;3 &#40;IC 95&#37; 1&#44;6-6&#44;7&#59; p &#61; 0&#44;001&#41;&#44; 2&#44;6 &#40;IC 95&#37;&#58; 1&#44;1-6&#44;2&#59; p &#61; 0&#44;033&#41; y 2&#44;1 &#40;IC 95&#37; 1&#44;7-2&#44;5&#59; p &#61; 0&#44;042&#41;&#44; respectivamente&#46; Las bacterias aisladas fueron <span class="elsevierStyleItalic">Klebiella penumoniae&#44; Streptococcus pyogenes&#44; Pseudomonas aeruginosa&#44; Streptococcus pneumoniae&#44; Serratia marcescens</span> y <span class="elsevierStyleItalic">Escherichia coli</span>&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Este es el primer estudio que apoya los hallazgos de estado de portador de bacterias pat&#243;genas en la faringe y la aplicaci&#243;n de inmunizaciones como factores de riesgo para desarrollar alopecia areata&#46; Por las caracter&#237;sticas de nuestra poblaci&#243;n&#44; esta asociaci&#243;n es v&#225;lida para los pacientes con menos del 25&#37; de p&#233;rdida de pelo y con una evoluci&#243;n inferior a un a&#241;o&#46;</p>"
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                      "titulo" => "Is alopecia areata an autoimmune disease&#63;"
                      "autores" => array:1 [
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                          "autores" => array:1 [
                            0 => "V&#46;A&#46; Randall"
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                        "tituloSerie" => "Lancet"
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                        "volumen" => "9297"
                        "paginaInicial" => "1922"
                        "paginaFinal" => "1924"
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                          "autores" => array:2 [
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                        "tituloSerie" => "Autoimmunity Rev"
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                        "paginaInicial" => "64"
                        "paginaFinal" => "69"
                      ]
                    ]
                  ]
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                      "titulo" => "Incidence of alopecia areata in Olmsted County&#44; Minnesota&#44; 1975 through 1989"
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                          "autores" => array:4 [
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                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1995"
                        "volumen" => "70"
                        "paginaInicial" => "628"
                        "paginaFinal" => "633"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7791384"
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                            2 => "R&#46;S&#46; Kalish"
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1172/JCI31942"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2007"
                        "volumen" => "117"
                        "paginaInicial" => "2019"
                        "paginaFinal" => "2027"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17671634"
                            "web" => "Medline"
                          ]
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                      "titulo" => "The genetic basis of alopecia areata&#58; HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol Symposium Proc"
                        "fecha" => "1999"
                        "volumen" => "4"
                        "paginaInicial" => "216"
                        "paginaFinal" => "219"
                      ]
                    ]
                  ]
                ]
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                        ]
                      ]
                    ]
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                        "paginaInicial" => "625"
                        "paginaFinal" => "632"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10554427"
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                          "autores" => array:2 [
                            0 => "M&#46; Samarkos"
                            1 => "G&#46; Vaiopoulos"
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                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Drug Targets Inflamm Allergy"
                        "fecha" => "2005"
                        "volumen" => "4"
                        "paginaInicial" => "99"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15720242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular mimicry&#58; Structural camouflage of proteins and nucleic acids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;A&#46; Tsonis"
                            1 => "B&#46; Dwivedi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bbamcr.2007.11.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochim Biophys Acta"
                        "fecha" => "2008"
                        "volumen" => "1783"
                        "paginaInicial" => "177"
                        "paginaFinal" => "187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18068679"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanisms for the induction of autoimmunity by infectious agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46;W&#46; Wucherpfennig"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI14235"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2001"
                        "volumen" => "108"
                        "paginaInicial" => "1097"
                        "paginaFinal" => "1104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11602615"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata and cytomegalovirus infection in twins&#58; Genes versus environment&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Jackow"
                            1 => "D&#46; Pharm"
                            2 => "N&#46; Buffer"
                            3 => "M&#46; Hordinsky"
                            4 => "J&#46; Nelson"
                            5 => "J&#46; Tarrand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1998"
                        "volumen" => "38"
                        "paginaInicial" => "418"
                        "paginaFinal" => "425"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9520023"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Murine cytomegalovirus is not associated with alopecia areata in C3H&#47;HeJ mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;J&#46; McElwee"
                            1 => "D&#46; Boggess"
                            2 => "B&#46; Burgett"
                            3 => "R&#46; Bates"
                            4 => "H&#46;G&#46; Bedigan"
                            5 => "J&#46;P&#46; Sundberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1747.1998.00207.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1998"
                        "volumen" => "110"
                        "paginaInicial" => "986"
                        "paginaFinal" => "987"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9620311"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of cytomegalovirus replication in alopecia areata pathogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Ofidani"
                            1 => "P&#46; Amerio"
                            2 => "M&#46;L&#46; Bernardino"
                            3 => "C&#46; Feliciani"
                            4 => "G&#46; Bossi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Med Surg"
                        "fecha" => "2000"
                        "volumen" => "4"
                        "paginaInicial" => "63"
                        "paginaFinal" => "65"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11179926"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Onset of alopecia areata alter Epstein-Barr virus infectious mononucleosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;A&#46; Rodr&#237;guez"
                            1 => "M&#46; Duvic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2008.02.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2008"
                        "volumen" => "59"
                        "paginaInicial" => "137"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18329131"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "There is no relationship between hepatitis C virus and alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Z&#46; Jadali"
                            1 => "O&#46; Mansouri"
                            2 => "F&#46; Jadali"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2006"
                        "volumen" => "16"
                        "paginaInicial" => "94"
                        "paginaFinal" => "95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16491522"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "No increased prevalence of Helicobacter pylori in patients with alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Rigopoulos"
                            1 => "A&#46; Katsambas"
                            2 => "A&#46; Karalexis"
                            3 => "G&#46; Papatheodorou"
                            4 => "T&#46; Rokkas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2002"
                        "volumen" => "46"
                        "paginaInicial" => "141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11756964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bacterial superantigens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Proft"
                            1 => "J&#46;D&#46; Fraser"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "2003"
                        "volumen" => "133"
                        "paginaInicial" => "299"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12930353"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalencia de portaci&#243;n asintom&#225;tica del estreptococo beta hemol&#237;tico del grupo A"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;M&#46; Giannelli"
                            1 => "G&#46;R&#46; Posse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Argent Pediatr"
                        "fecha" => "2007"
                        "volumen" => "105"
                        "paginaInicial" => "221"
                        "paginaFinal" => "224"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic pharyngeal carriage of group A streptococci"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;R&#46; Tanz"
                            1 => "S&#46;T&#46; Shulman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.inf.0000255328.19808.be"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Infect Dis J"
                        "fecha" => "2007"
                        "volumen" => "26"
                        "paginaInicial" => "175"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17259882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharyngeal carriage of group A streptococci in school children in Chennai"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;A&#46; Lloyd"
                            1 => "S&#46;E&#46; Jacob"
                            2 => "T&#46; Menon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Med Res"
                        "fecha" => "2006"
                        "volumen" => "124"
                        "paginaInicial" => "195"
                        "paginaFinal" => "198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17015934"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis and treatment of streptococcal pharyngitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46;A&#46; Choby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Fam Physician"
                        "fecha" => "2009"
                        "volumen" => "79"
                        "paginaInicial" => "383"
                        "paginaFinal" => "390"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19275067"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defining and dealing with carriers of group A streptococci"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;E&#46; Pichichero"
                            1 => "J&#46;R&#46; Casey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Contemporary Pediatr"
                        "fecha" => "2003"
                        "volumen" => "20"
                        "paginaInicial" => "46"
                        "paginaFinal" => "56"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Flora normal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;F&#46; Brooks"
                            1 => "J&#46;S&#46; Butel"
                            2 => "S&#46;A&#46; Morse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Microbiolog&#237;a m&#233;dica de Jawetz&#44; Melnick y Adelberg"
                        "paginaInicial" => "218"
                        "paginaFinal" => "219"
                        "edicion" => "16 ed&#46;"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vacunaci&#243;n en el adulto"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;A&#46; G&#243;mez-Samano"
                            1 => "R&#46;A&#46; Bourlon-Cu&#233;llar"
                            2 => "M&#46;T&#46; Bourlon"
                            3 => "O&#46;F&#46; Coronel-Ayala"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Int Mex"
                        "fecha" => "2007"
                        "volumen" => "23"
                        "paginaInicial" => "408"
                        "paginaFinal" => "414"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata investigational assessment guidelines-Part II"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;A&#46; Olsen"
                            1 => "M&#46;K&#46; Hordinsky"
                            2 => "V&#46;H&#46; Price"
                            3 => "J&#46;L&#46; Roberts"
                            4 => "J&#46; Shapiro"
                            5 => "D&#46; Canfield"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2003.09.032"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2004"
                        "volumen" => "51"
                        "paginaInicial" => "440"
                        "paginaFinal" => "447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15337988"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multivariate analysis in alopecia areata&#58; risk factors and validity of clinical forms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;J&#46; Garc&#237;a-Hern&#225;ndez"
                            1 => "A&#46; Rodr&#237;guez-Pichardo"
                            2 => "F&#46; Camacho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1999"
                        "volumen" => "135"
                        "paginaInicial" => "998"
                        "paginaFinal" => "999"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10456364"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A clinical study of alopecia areata in Mexico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;A&#46; Guzm&#225;n-S&#225;nchez"
                            1 => "G&#46;D&#46; Villanueva-Qintero"
                            2 => "N&#46;A&#46; Alfaro"
                            3 => "A&#46; McMichel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4632.2007.03378.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "46"
                        "paginaInicial" => "1310"
                        "paginaFinal" => "1312"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18173533"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Profile of alopecia areata in northern India"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46;K&#46; Sharma"
                            1 => "G&#46; Dawn"
                            2 => "B&#46; Kumar"
                          ]
                        ]
                      ]
                    ]
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                        "paginaFinal" => "441"
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                        "link" => array:1 [
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                            "web" => "Medline"
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                        ]
                      ]
                    ]
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                        "paginaFinal" => "1178"
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                        "link" => array:1 [
                          0 => array:2 [
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                      "titulo" => "Recombinant human hepatitis B vaccine initiating alopecia areata&#58; testing the hypothesis using the C3H&#47;HeJ mouse model"
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Original article
Immunization and Bacterial Pathogens in the Oropharynx as Risk Factors for Alopecia Areata
Inmunizaciones y bacterias patógenas en la faringe como factores de riesgo para alopecia areata
M.A. Morales-Sánchez
Corresponding author
marthams@prodigy.net.mx

Corresponding author.
, M.A. Domínguez-Gómez, F. Jurado-Santa Cruz, M.L. Peralta-Pedrero
Centro Dermatológico Dr. Ladislao de la Pascua, Mexico City, Mexico
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Alopecia areata is an autoimmune inflammatory disease affecting the hair follicles&#46; Researchers are currently interested in whether the presence of bacterial pathogens and&#47;or a history of immunization can trigger an autoimmune response in patients who are genetically predisposed&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">This study aimed to determine whether there is an association between the development of alopecia areata and throat carriage of bacterial pathogens or a history of immunization&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Sixty-five men and women with alopecia areata and 65 control patients with other skin diseases were studied at the Dr Ladislao de la Pascua Dermatology Clinic between September 2008 and February 2009&#46; The patients ranged in age from 18 to 59 years&#46; Patients with scalp diseases were excluded from the control group&#46; In all cases&#44; the patient was questioned about immunizations received in the previous 6 months&#44; and a throat swab was cultured&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A history of immunization &#40;odds ratio &#91;OR&#93;&#44; 3&#46;3&#59; 1&#46;6&#37; confidence interval &#91;CI&#93;&#44; 1&#46;6-6&#46;7&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;001&#41;&#44; the presence of bacterial pathogens in the oropharynx &#40;OR&#44; 2&#46;6&#59; 95&#37; CI&#44; 1&#46;1-6&#46;2&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;033&#41;&#44; and being a carrier of Streptococcus pyogenes &#40;OR&#44; 2&#46;1&#59; 95&#37; CI&#44; 1&#46;7-2&#46;5&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;042&#41; were risk factors for alopecia areata&#46; <span class="elsevierStyleItalic">Klebsiella pneumoniae&#44; S pyogenes&#44; Pseudomonas aeruginosa&#44; Streptococcus pneumoniae&#44; Serratia marcescens</span> and <span class="elsevierStyleItalic">Escherichia coli</span> were isolated from cultures&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">This is the first study to show an association between alopecia areata and throat carriage of bacterial pathogens or history of immunization&#44; as risk factors for development of the disease&#46; Given the characteristics of our study population&#44; the association appears valid for patients with less than 25&#37; hair loss and a course of disease under 1 year&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La alopecia areata es una enfermedad inflamatoria autoinmune que afecta al pelo&#46; Actualmente se estudia si las bacterias pat&#243;genas y las inmunizaciones son inductores de la respuesta autoinmune en pacientes con susceptibilidad gen&#233;tica&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio fue determinar si las bacterias pat&#243;genas en la faringe y el antecedente de haber recibido inmunizaciones est&#225;n asociados a la enfermedad&#46;</p> <span class="elsevierStyleSectionTitle">Materiales y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">En el Centro Dermatol&#243;gico &#171;Dr&#46; Ladislao de la Pascua&#187;&#44; desde septiembre de 2008 a febrero de 2009&#44; se estudiaron 65 pacientes con alopecia areata y 65 controles con otras dermatosis&#44; excluyendo las del cuero cabelludo&#46; Se incluyeron pacientes de 18 a 59 a&#241;os de edad y de ambos sexos&#46; A todos se les interrog&#243; sobre inmunizaciones recibidas 6 meses antes y se les realiz&#243; un cultivo de exudado far&#237;ngeo&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Haber recibido inmunizaciones&#44; la presencia de bacterias pat&#243;genas en la faringe y ser portador de <span class="elsevierStyleItalic">S&#46; pyogenes</span> se comportaron como factores de riesgo para la alopecia areata&#44; con una raz&#243;n de probabilidades de 3&#44;3 &#40;IC 95&#37; 1&#44;6-6&#44;7&#59; p &#61; 0&#44;001&#41;&#44; 2&#44;6 &#40;IC 95&#37;&#58; 1&#44;1-6&#44;2&#59; p &#61; 0&#44;033&#41; y 2&#44;1 &#40;IC 95&#37; 1&#44;7-2&#44;5&#59; p &#61; 0&#44;042&#41;&#44; respectivamente&#46; Las bacterias aisladas fueron <span class="elsevierStyleItalic">Klebiella penumoniae&#44; Streptococcus pyogenes&#44; Pseudomonas aeruginosa&#44; Streptococcus pneumoniae&#44; Serratia marcescens</span> y <span class="elsevierStyleItalic">Escherichia coli</span>&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Este es el primer estudio que apoya los hallazgos de estado de portador de bacterias pat&#243;genas en la faringe y la aplicaci&#243;n de inmunizaciones como factores de riesgo para desarrollar alopecia areata&#46; Por las caracter&#237;sticas de nuestra poblaci&#243;n&#44; esta asociaci&#243;n es v&#225;lida para los pacientes con menos del 25&#37; de p&#233;rdida de pelo y con una evoluci&#243;n inferior a un a&#241;o&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:35 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is alopecia areata an autoimmune disease&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V&#46;A&#46; Randall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2001"
                        "volumen" => "9297"
                        "paginaInicial" => "1922"
                        "paginaFinal" => "1924"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata&#58; a tissue specific autoimmune disease of the hair follicle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Gilhar"
                            1 => "R&#46;S&#46; Kalish"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Autoimmunity Rev"
                        "fecha" => "2006"
                        "volumen" => "5"
                        "paginaInicial" => "64"
                        "paginaFinal" => "69"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence of alopecia areata in Olmsted County&#44; Minnesota&#44; 1975 through 1989"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;H&#46; Safavi"
                            1 => "S&#46;A&#46; Muller"
                            2 => "A&#46;N&#46; Moshell"
                            3 => "R&#46;J&#46; Melton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0025-6196(11)63913-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1995"
                        "volumen" => "70"
                        "paginaInicial" => "628"
                        "paginaFinal" => "633"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7791384"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lymphocytes&#44; neuropeptides&#44; and genes involved in alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Gilhar"
                            1 => "R&#46; Paus"
                            2 => "R&#46;S&#46; Kalish"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI31942"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2007"
                        "volumen" => "117"
                        "paginaInicial" => "2019"
                        "paginaFinal" => "2027"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17671634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The genetic basis of alopecia areata&#58; HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;W&#46; Colombe"
                            1 => "C&#46;D&#46; Lou"
                            2 => "V&#46;H&#46; Price"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol Symposium Proc"
                        "fecha" => "1999"
                        "volumen" => "4"
                        "paginaInicial" => "216"
                        "paginaFinal" => "219"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata&#44; stress and psychiatric disorders&#58; a review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;J&#46; Garc&#237;a-Hern&#225;ndez"
                            1 => "S&#46; Ruiz-Doblado"
                            2 => "A&#46; Rodr&#237;guez-Pichardo"
                            3 => "F&#46; Camacho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol"
                        "fecha" => "1999"
                        "volumen" => "26"
                        "paginaInicial" => "625"
                        "paginaFinal" => "632"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10554427"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of infections in the pathogenesis of autoimmune diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Samarkos"
                            1 => "G&#46; Vaiopoulos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Drug Targets Inflamm Allergy"
                        "fecha" => "2005"
                        "volumen" => "4"
                        "paginaInicial" => "99"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15720242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular mimicry&#58; Structural camouflage of proteins and nucleic acids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;A&#46; Tsonis"
                            1 => "B&#46; Dwivedi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bbamcr.2007.11.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochim Biophys Acta"
                        "fecha" => "2008"
                        "volumen" => "1783"
                        "paginaInicial" => "177"
                        "paginaFinal" => "187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18068679"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanisms for the induction of autoimmunity by infectious agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46;W&#46; Wucherpfennig"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI14235"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2001"
                        "volumen" => "108"
                        "paginaInicial" => "1097"
                        "paginaFinal" => "1104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11602615"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata and cytomegalovirus infection in twins&#58; Genes versus environment&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Jackow"
                            1 => "D&#46; Pharm"
                            2 => "N&#46; Buffer"
                            3 => "M&#46; Hordinsky"
                            4 => "J&#46; Nelson"
                            5 => "J&#46; Tarrand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1998"
                        "volumen" => "38"
                        "paginaInicial" => "418"
                        "paginaFinal" => "425"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9520023"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Murine cytomegalovirus is not associated with alopecia areata in C3H&#47;HeJ mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;J&#46; McElwee"
                            1 => "D&#46; Boggess"
                            2 => "B&#46; Burgett"
                            3 => "R&#46; Bates"
                            4 => "H&#46;G&#46; Bedigan"
                            5 => "J&#46;P&#46; Sundberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1747.1998.00207.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1998"
                        "volumen" => "110"
                        "paginaInicial" => "986"
                        "paginaFinal" => "987"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9620311"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of cytomegalovirus replication in alopecia areata pathogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Ofidani"
                            1 => "P&#46; Amerio"
                            2 => "M&#46;L&#46; Bernardino"
                            3 => "C&#46; Feliciani"
                            4 => "G&#46; Bossi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Med Surg"
                        "fecha" => "2000"
                        "volumen" => "4"
                        "paginaInicial" => "63"
                        "paginaFinal" => "65"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11179926"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Onset of alopecia areata alter Epstein-Barr virus infectious mononucleosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;A&#46; Rodr&#237;guez"
                            1 => "M&#46; Duvic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2008.02.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2008"
                        "volumen" => "59"
                        "paginaInicial" => "137"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18329131"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "There is no relationship between hepatitis C virus and alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Z&#46; Jadali"
                            1 => "O&#46; Mansouri"
                            2 => "F&#46; Jadali"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2006"
                        "volumen" => "16"
                        "paginaInicial" => "94"
                        "paginaFinal" => "95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16491522"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "No increased prevalence of Helicobacter pylori in patients with alopecia areata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Rigopoulos"
                            1 => "A&#46; Katsambas"
                            2 => "A&#46; Karalexis"
                            3 => "G&#46; Papatheodorou"
                            4 => "T&#46; Rokkas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2002"
                        "volumen" => "46"
                        "paginaInicial" => "141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11756964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bacterial superantigens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Proft"
                            1 => "J&#46;D&#46; Fraser"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "2003"
                        "volumen" => "133"
                        "paginaInicial" => "299"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12930353"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalencia de portaci&#243;n asintom&#225;tica del estreptococo beta hemol&#237;tico del grupo A"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;M&#46; Giannelli"
                            1 => "G&#46;R&#46; Posse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Argent Pediatr"
                        "fecha" => "2007"
                        "volumen" => "105"
                        "paginaInicial" => "221"
                        "paginaFinal" => "224"
                      ]
                    ]
                  ]
                ]
              ]
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            17 => array:3 [
              "identificador" => "bib18"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic pharyngeal carriage of group A streptococci"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;R&#46; Tanz"
                            1 => "S&#46;T&#46; Shulman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.inf.0000255328.19808.be"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Infect Dis J"
                        "fecha" => "2007"
                        "volumen" => "26"
                        "paginaInicial" => "175"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17259882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharyngeal carriage of group A streptococci in school children in Chennai"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;A&#46; Lloyd"
                            1 => "S&#46;E&#46; Jacob"
                            2 => "T&#46; Menon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Med Res"
                        "fecha" => "2006"
                        "volumen" => "124"
                        "paginaInicial" => "195"
                        "paginaFinal" => "198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17015934"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Diagnosis and treatment of streptococcal pharyngitis"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46;A&#46; Choby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Fam Physician"
                        "fecha" => "2009"
                        "volumen" => "79"
                        "paginaInicial" => "383"
                        "paginaFinal" => "390"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19275067"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defining and dealing with carriers of group A streptococci"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;E&#46; Pichichero"
                            1 => "J&#46;R&#46; Casey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Contemporary Pediatr"
                        "fecha" => "2003"
                        "volumen" => "20"
                        "paginaInicial" => "46"
                        "paginaFinal" => "56"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Flora normal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;F&#46; Brooks"
                            1 => "J&#46;S&#46; Butel"
                            2 => "S&#46;A&#46; Morse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Microbiolog&#237;a m&#233;dica de Jawetz&#44; Melnick y Adelberg"
                        "paginaInicial" => "218"
                        "paginaFinal" => "219"
                        "edicion" => "16 ed&#46;"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vacunaci&#243;n en el adulto"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;A&#46; G&#243;mez-Samano"
                            1 => "R&#46;A&#46; Bourlon-Cu&#233;llar"
                            2 => "M&#46;T&#46; Bourlon"
                            3 => "O&#46;F&#46; Coronel-Ayala"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Int Mex"
                        "fecha" => "2007"
                        "volumen" => "23"
                        "paginaInicial" => "408"
                        "paginaFinal" => "414"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata investigational assessment guidelines-Part II"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;A&#46; Olsen"
                            1 => "M&#46;K&#46; Hordinsky"
                            2 => "V&#46;H&#46; Price"
                            3 => "J&#46;L&#46; Roberts"
                            4 => "J&#46; Shapiro"
                            5 => "D&#46; Canfield"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2003.09.032"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2004"
                        "volumen" => "51"
                        "paginaInicial" => "440"
                        "paginaFinal" => "447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15337988"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multivariate analysis in alopecia areata&#58; risk factors and validity of clinical forms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;J&#46; Garc&#237;a-Hern&#225;ndez"
                            1 => "A&#46; Rodr&#237;guez-Pichardo"
                            2 => "F&#46; Camacho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1999"
                        "volumen" => "135"
                        "paginaInicial" => "998"
                        "paginaFinal" => "999"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10456364"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A clinical study of alopecia areata in Mexico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;A&#46; Guzm&#225;n-S&#225;nchez"
                            1 => "G&#46;D&#46; Villanueva-Qintero"
                            2 => "N&#46;A&#46; Alfaro"
                            3 => "A&#46; McMichel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4632.2007.03378.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "46"
                        "paginaInicial" => "1310"
                        "paginaFinal" => "1312"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18173533"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Profile of alopecia areata in northern India"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46;K&#46; Sharma"
                            1 => "G&#46; Dawn"
                            2 => "B&#46; Kumar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1996"
                        "volumen" => "35"
                        "paginaInicial" => "22"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8838924"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alopecia areata&#58; a long term follow-up study of 191 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Tosti"
                            1 => "S&#46; Bellavista"
                            2 => "M&#46; Iorizzo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2006.05.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2006"
                        "volumen" => "55"
                        "paginaInicial" => "438"
                        "paginaFinal" => "441"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16908349"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
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              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Magn&#250;sd&#243;ttir BT&#44; J&#243;nsson JS&#44; Kristinsson KG&#46; Algengi <span class="elsevierStyleItalic">Streptococcus pyogenes</span> og methisill&#237;n &#243;n&#230;mra <span class="elsevierStyleItalic">Staphylococcus aureus</span> &#237; h&#225;lsi heilbrig&#240;ra barna &#237; Gar&#240;ab&#230; Laeknabladid&#46; 2008&#59; 94&#58;447-51&#46;"
                ]
              ]
            ]
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              "identificador" => "bib30"
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                    0 => array:2 [
                      "titulo" => "Chronic plaque psoriasis&#58; streptococcus pyogenes throat carriage rate and therapeutic response to oral antibiotics in comparison with oral methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46; Raza"
                            1 => "M&#46; Usman"
                            2 => "A&#46; Hameed"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "12.2007/JCPSP.717720"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Coll Physicians Surg Pak"
                        "fecha" => "2007"
                        "volumen" => "17"
                        "paginaInicial" => "717"
                        "paginaFinal" => "720"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18182134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hair loss after routine immunizations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;P&#46; Wise"
                            1 => "K&#46;P&#46; Kiminyo"
                            2 => "M&#46;E&#46; Salive"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1997"
                        "volumen" => "278"
                        "paginaInicial" => "1176"
                        "paginaFinal" => "1178"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9326478"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vaccination as an additional player in the mosaic of autoimmunity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Schoenfeld"
                            1 => "A&#46; Aharon-Maor"
                            2 => "Y&#46; Sherer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2000"
                        "volumen" => "18"
                        "paginaInicial" => "181"
                        "paginaFinal" => "184"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10812488"
                            "web" => "Medline"
                          ]
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                    ]
                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Vaccination and autoimmunity-&#8220;vaccinosis&#8221;&#58; a dangerous liaison&#63;"
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                        0 => array:2 [
                          "etal" => false
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                            1 => "A&#46; Aron-Maor"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Autoimmunity"
                        "fecha" => "2000"
                        "volumen" => "14"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "titulo" => "A case-control study of serious autoimmune adverse events following hepatitis B immunization"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;A&#46; Geier"
                            1 => "M&#46;R&#46; Geier"
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                    ]
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                    0 => array:1 [
                      "Revista" => array:6 [
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                        "volumen" => "38"
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                        "paginaFinal" => "301"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16206512"
                            "web" => "Medline"
                          ]
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                ]
              ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recombinant human hepatitis B vaccine initiating alopecia areata&#58; testing the hypothesis using the C3H&#47;HeJ mouse model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;P&#46; Sundberg"
                            1 => "K&#46;A&#46; Silva"
                            2 => "W&#46; Zhang"
                            3 => "B&#46;A&#46; Sundberg"
                            4 => "K&#46; Edwards"
                            5 => "L&#46;E&#46; King"
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                    ]
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                  "host" => array:1 [
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                      "Revista" => array:5 [
                        "tituloSerie" => "ESVD ACVD"
                        "fecha" => "2009"
                        "volumen" => "20"
                        "paginaInicial" => "99"
                        "paginaFinal" => "104"
                      ]
                    ]
                  ]
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Article information
ISSN: 15782190
Original language: English
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2022 April 32 25 57
2022 March 17 51 68
2022 February 28 24 52
2022 January 18 31 49
2021 December 18 43 61
2021 November 26 44 70
2021 October 23 56 79
2021 September 22 49 71
2021 August 11 28 39
2021 July 15 33 48
2021 June 17 23 40
2021 May 16 28 44
2021 April 34 48 82
2021 March 41 24 65
2021 February 63 32 95
2021 January 40 23 63
2020 December 23 13 36
2020 November 18 28 46
2020 October 21 16 37
2020 September 15 10 25
2020 August 20 17 37
2020 July 16 18 34
2020 June 18 20 38
2020 May 16 15 31
2020 April 9 20 29
2020 March 18 24 42
2020 February 0 1 1
2020 January 0 4 4
2019 December 0 6 6
2019 November 0 5 5
2019 October 0 13 13
2019 September 0 5 5
2019 August 0 6 6
2019 July 0 13 13
2019 June 0 3 3
2019 May 0 39 39
2019 April 0 9 9
2019 March 0 6 6
2019 February 0 3 3
2018 June 0 1 1
2018 May 0 7 7
2018 April 0 3 3
2018 March 1 2 3
2018 February 13 3 16
2018 January 11 3 14
2017 December 18 12 30
2017 November 17 6 23
2017 October 23 6 29
2017 September 28 8 36
2017 August 38 8 46
2017 July 25 2 27
2017 June 37 20 57
2017 May 44 18 62
2017 April 44 22 66
2017 March 49 33 82
2017 February 26 6 32
2017 January 15 9 24
2016 December 24 14 38
2016 November 17 17 34
2016 October 29 34 63
2016 September 34 8 42
2016 August 35 9 44
2016 July 24 6 30
2016 June 10 8 18
2016 May 8 10 18
2016 April 7 7 14
2016 March 4 5 9
2016 February 6 1 7
2016 January 5 2 7
2015 December 15 1 16
2015 November 3 1 4
2015 October 7 1 8
2015 September 4 4 8
2015 August 24 2 26
2015 July 34 3 37
2015 June 30 9 39
2015 May 57 15 72
2015 April 38 10 48
2015 March 69 12 81
2015 February 23 13 36
2015 January 29 12 41
2014 December 26 18 44
2014 November 21 23 44
2014 October 27 34 61
2014 September 24 19 43
2014 August 27 13 40
2014 July 36 20 56
2014 June 38 12 50
2014 May 40 10 50
2014 April 40 7 47
2014 March 50 19 69
2014 February 42 20 62
2014 January 33 13 46
2013 December 29 10 39
2013 November 28 19 47
2013 October 25 15 40
2013 September 40 22 62
2013 August 30 17 47
2013 July 35 23 58
2013 June 36 26 62
2013 May 25 25 50
2013 April 31 28 59
2013 March 35 21 56
2013 February 17 14 31
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Idiomas
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?