Original articles
Clear Cells in Cutaneous Squamous Cell Carcinoma
Las Células Claras en el Carcinoma Espinocelular Cutáneo
R. Corbalán-Véleza,
, J.A. Ruiz-Maciab, C. Brufauc, J.M. López-Lozanod, E. Martínez-Barbae, F.J. Carapetod
Corresponding author
raulcorb@gmail.com
Correspondence: Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Ctra. Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain.
Correspondence: Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Ctra. Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain.
a Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca Murcia, Spain
b Servicio de Anatomía Patológica, Hospital Vega Baja, Orihuela, Alicante, Spain
c Servicio de Dermatología, Hospital General Reina Sofía, Murcia, Spain
d Servicio de Medicina Preventiva, Hospital Vega Baja, Orihuela, Alicante, Spain
e Servicio de Anatomía Patológica, Hospital Universitario Virgen de la Arrixaca Murcia, Spain
Read
7817
Timeswas read the article
4015
Total PDF
3802
Total HTML
Share statistics
array:23 [ "pii" => "S157821900970068X" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70068-X" "estado" => "S300" "fechaPublicacion" => "2009-05-01" "aid" => "70068" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:307-16" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3044 "formatos" => array:3 [ "EPUB" => 42 "HTML" => 1499 "PDF" => 1503 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219009700691" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70069-1" "estado" => "S300" "fechaPublicacion" => "2009-05-01" "aid" => "70069" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2009;100:317-20" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3281 "formatos" => array:3 [ "EPUB" => 33 "HTML" => 1934 "PDF" => 1314 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case reports</span>" "titulo" => "Allergic Contact Dermatitis to Diethylthiourea in a Neoprene Wader" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "317" "paginaFinal" => "320" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatitis Alérgica de Contacto a Dietitiourea por un Traje de Pesca de Neopreno" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.C. Martínez-González, J.J. Goday-Buján, M. Almagro, E. Fonseca" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M.C." "apellidos" => "Martínez-González" ] 1 => array:2 [ "nombre" => "J.J." "apellidos" => "Goday-Buján" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Almagro" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Fonseca" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700691?idApp=UINPBA000044" "url" => "/15782190/0000010000000004/v1_201304241454/S1578219009700691/v1_201304241454/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219009700678" "issn" => "15782190" "doi" => "10.1016/S1578-2190(09)70067-8" "estado" => "S300" "fechaPublicacion" => "2009-05-01" "aid" => "70067" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2009;100:298-306" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2266 "formatos" => array:3 [ "EPUB" => 34 "HTML" => 1429 "PDF" => 803 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Validity of a Telephone Survey for Determining the Prevalence of Atopic Dermatitis and its Seasonal Variation in Spain" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "298" "paginaFinal" => "306" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Validez de una Encuesta Telefónica para Determinar la Prevalencia y la Estacionalidad de la Dermatitis Atópica en España" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. García-Díez, Ll. Puig, J. Ortiz, A. Blanco" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "García-Díez" ] 1 => array:2 [ "nombre" => "Ll." "apellidos" => "Puig" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Ortiz" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Blanco" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009700678?idApp=UINPBA000044" "url" => "/15782190/0000010000000004/v1_201304241454/S1578219009700678/v1_201304241454/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Clear Cells in Cutaneous Squamous Cell Carcinoma" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "307" "paginaFinal" => "316" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R. Corbalán-Vélez, J.A. Ruiz-Macia, C. Brufau, J.M. López-Lozano, E. Martínez-Barba, F.J. Carapeto" "autores" => array:6 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "Corbalán-Vélez" "email" => array:1 [ 0 => "raulcorb@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "J.A." "apellidos" => "Ruiz-Macia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Brufau" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "J.M." "apellidos" => "López-Lozano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] 4 => array:3 [ "nombre" => "E." "apellidos" => "Martínez-Barba" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] ] ] 5 => array:3 [ "nombre" => "F.J." "apellidos" => "Carapeto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca Murcia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Vega Baja, Orihuela, Alicante, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Reina Sofía, Murcia, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Medicina Preventiva, Hospital Vega Baja, Orihuela, Alicante, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] 4 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario Virgen de la Arrixaca Murcia, Spain" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Universitario Virgen de la Arrixaca, Ctra. Murcia-Cartagena, s/n, 30120 El Palmar, Murcia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Las Células Claras en el Carcinoma Espinocelular Cutáneo" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-07-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84456" "palabras" => array:4 [ 0 => "clear cells" 1 => "squamous cell carcinoma" 2 => "skin" 3 => "dermatopathology" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84455" "palabras" => array:4 [ 0 => "células claras" 1 => "carcinoma espinocelular" 2 => "piel" 3 => "dermatopatología" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Although few cases of squamous cell carcinoma (SCC) with clear cells have been published, we believe that these cells are often present in SCC.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We studied 249 SCCs, analyzing a number of clinical and histological variables. Various immunohistochemical techniques (immunoperoxidase method) were used to determine whether adnexal differentiation was present.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">There were 96 SCCs with a proportion of clear cells of over 25%. Advanced or established SCCs and SCCs associated with Bowen disease contained a larger proportion of clear cells. We defined 2 histological patterns: a) clear cells around the keratin pearls of SCCs arising from pre-existing actinic keratosis and with indirect signs of human papilloma virus infection in hair follicles; and b) clear cells that simulate adnexal differentiation in lesions arising on pre-existing Bowen disease lesions. There were also 19 carcinomas with true adnexal differentiation.</p> <span class="elsevierStyleSectionTitle">Discussion</span><p class="elsevierStyleSimplePara elsevierViewall">Clear cells are frequently observed in SCC, though large numbers of clear cells are present only in certain SCCs. The appearance of clear cells in SCCs is progressive and they are only present in more advanced SCC. The presence of clear cells is suggestive of adnexal differentiation; however, in the majority of cases, their presence is due to infiltration of normal adnexal structures by the cells of pagetoid Bowen disease. True adnexal differentiation exists only in a small percentage of cases (7.6% in our study). The histological pattern described as clear cells around keratin pearls practically rules out this differentiation.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Se han publicado pocos casos de carcinoma espinocelular (CE) de células claras, aunque creemos que es frecuente observar células claras en los CE.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos estudiado 249 CE. Analizamos distintas variables clínicas e histológicas. Hemos usado diversas técnicas de inmunohistoquímica (método de inmunoperoxidasa) para valorar si existía diferenciación anexial.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Observamos 96 CE con más de un 25% de células claras. Existe más cantidad de células claras en los CE desarrollados o «no incipientes» y en los derivados de enfermedad de Bowen (EB). Describimos dos patrones histológicos: a) células claras alrededor de las perlas córneas del CE, que se asocia a la existencia de queratosis actínica como lesión previa y a signos indirectos de virus del papiloma humano (VPH) en infundíbulos pilosos, y b) células claras que simulan diferenciación anexial, relacionado con EB como lesión previa. También hemos encontrado 19 carcinomas con verdadera diferenciación anexial.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Es frecuente observar células claras en los CE, aunque solo algunos presentan una gran cantidad. El desarrollo de células claras en los CE sería progresivo y solo aparecería en los CE más desarrollados. Cuando se observan células claras en los CE, se tiende a pensar que existe diferenciación anexial, sin embargo, en la mayoría de casos se trataría solo de EB de células claras que infiltra estructuras anexiales normales. En un pequeño porcentaje de casos (7,6% en nuestro estudio) sí existe verdadera diferenciación anexial. Por otra parte, el patrón histológico descrito como células claras alrededor de perlas córneas prácticamente nos descartaría dicha diferenciación.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">This study was awarded the 2007-2008 August C. Stiefel Research Prize.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clear cell carcinoma of the skin: a variant of the squamous cell carcinoma that simulates sebaceous carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Kuo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "1980" "volumen" => "4" "paginaInicial" => "573" "paginaFinal" => "583" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6163367" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clear-cell carcinoma: an ultrastructural study of 57 tumors from various sites" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.J. Kwon" 1 => "J.Y. Ro" 2 => "B. Mackay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ultrastruct Pathol" "fecha" => "1996" "volumen" => "20" "paginaInicial" => "519" "paginaFinal" => "527" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8940759" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clear-cell tumors of the skin: a histopathologic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Civatte" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1984" "volumen" => "11" "paginaInicial" => "165" "paginaFinal" => "175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6090516" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clear cell tumors of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Suster" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Diagn Pathol" "fecha" => "1996" "volumen" => "13" "paginaInicial" => "40" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8834514" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clear cell squamous cell carcinoma. A histologic, immunohistologic, and ultrastructural study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Requena" 1 => "M. Sánchez" 2 => "I. Requena" 3 => "V. Alegre" 4 => "E. Sánchez-Yus" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dermatol SurgOncol" "fecha" => "1991" "volumen" => "17" "paginaInicial" => "656" "paginaFinal" => "660" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemical staining for androgen receptors. A sensitive marker of sebaceous differentiation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I.B. Bayer-Garner" 1 => "V. Givens" 2 => "B. Smoller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "1999" "volumen" => "21" "paginaInicial" => "426" "paginaFinal" => "431" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10535570" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An immunohistochemical study of BCA-225 in various skin cancers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Ansai" 1 => "Y. Hozumi" 2 => "S. Kondo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Dermatol" "fecha" => "1994" "volumen" => "21" "paginaInicial" => "20" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8157817" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Penile clear cell carcinoma. A report of 5 cases of a distinct entity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Liegl" 1 => "S. Regauer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2004" "volumen" => "28" "paginaInicial" => "1513" "paginaFinal" => "1517" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15489656" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clear cell basal cell epithelioma: light and electron microscopic study of an unusual variant" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.A. Barnadas" 1 => "R.G. Freeman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1988" "volumen" => "15" "paginaInicial" => "1" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3351059" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clear cell basal cell carcinoma: An unusual degenerative variant" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.J. Barr" 1 => "K.S. Alpern" 2 => "D.J. Santa-Cruz" 3 => "D.F. Fretzin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1993" "volumen" => "20" "paginaInicial" => "308" "paginaFinal" => "316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8227606" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clear cell carcinoma of the skin: a tricholemmal carcinoma?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.Y. Lee" 1 => "C.K. Tang" 2 => "Y.S. Leung" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1989" "volumen" => "16" "paginaInicial" => "31" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2466065" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Viral diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Weedon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Skin Pathology" "paginaInicial" => "583" "paginaFinal" => "603" "serieFecha" => "1998" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basaloid and warty carcinomas of the vulva. Distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.J. Kurman" 1 => "T. Toki" 2 => "M.H. Schiffman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "1993" "volumen" => "17" "paginaInicial" => "133" "paginaFinal" => "145" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8380681" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Common and plantar warts with trichilemmal keratinization-like keratinizing process: a possible existence of pseudo-trichilemmal keratinization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Kimura" 1 => "T. Komatsu" 2 => "K. Ohyama" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1982" "volumen" => "9" "paginaInicial" => "391" "paginaFinal" => "395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6186709" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infectious diseases of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W. Grayson" 1 => "E. Calonje" 2 => "PhH. McKee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Pathology of the skin with clinical correlations" "paginaInicial" => "838" "paginaFinal" => "850" "edicion" => "3rd ed." "serieFecha" => "2005" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neoplasias anexiales" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.H. McCalmont" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "J.L.BologniaJ.L.JorizzoR.P.RapiniT.D.HornJ.M.MascaroA.J.Manzini" "paginaInicial" => "1733" "paginaFinal" => "1755" "serieVolumen" => "Vol. II" "serieTitulo" => "Dermatología" "serieFecha" => "2004" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumours of the skin appendages" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.M. McKie" 1 => "E. Calonje" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "editores" => "T.BurnsS.BreathnachN.CoxC.Griffiths" "edicion" => "7th ed." "serieVolumen" => "Vol. II" "serieTitulo" => "Rook's Textbook of Dermatology" "serieFecha" => "2004" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Dermirkesen" 1 => "N. Hoede" 2 => "R. Moll" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JCutan Pathol" "fecha" => "1995" "volumen" => "22" "paginaInicial" => "518" "paginaFinal" => "535" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CD34 in human hair follicle" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Poblet" 1 => "F. Jiménez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.2003.12550_2.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2003" "volumen" => "121" "paginaInicial" => "1220" "paginaFinal" => "1221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14708630" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemical comparison of p16 expression in actinic keratoses and squamous cell carcinomas of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Hodges" 1 => "B.R. Smoller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.MP.0000032536.48264.D1" "Revista" => array:6 [ "tituloSerie" => "Mod Pathol" "fecha" => "2002" "volumen" => "15" "paginaInicial" => "1121" "paginaFinal" => "1125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12429789" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "¿Qué es una odds ratio?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Martínez González" 1 => "J. Irala Estevez" 2 => "F. Guillén Grima" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin" "fecha" => "1999" "volumen" => "112" "paginaInicial" => "416" "paginaFinal" => "422" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous sebaceous neoplasms with a focal glandular pattern (seboapocrine lesions): a clinicopathological study of three cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.V. Kazakov" 1 => "E. Calonje" 2 => "A. Rütten" 3 => "K. Glatz" 4 => "M. Michal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DAD.0b013e31806f6a4d" "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2007" "volumen" => "29" "paginaInicial" => "359" "paginaFinal" => "364" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17667168" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Squamous cell carcinoma. A population-based incidence study in Rochester, Minn" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T.Y. Chuang" 1 => "N.A. Popescu" 2 => "W.P. Su" 3 => "C.G. Chute" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1990" "volumen" => "126" "paginaInicial" => "185" "paginaFinal" => "188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2301956" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Health effects of sunlight exposure in the United States" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Engel" 1 => "M.L. Johnson" 2 => "S.G. Haynes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1988" "volumen" => "124" "paginaInicial" => "72" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3257372" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinomas espinocelulares" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Yáñez-Díaz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Tumores Cutáneos" "paginaInicial" => "97" "paginaFinal" => "116" "serieFecha" => "1999" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The majority of cutaneous squamous cell carcinomas arise in actinic keratoses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Czarnecki" 1 => "C.J. Meehan" 2 => "F. Bruce" 3 => "G. Culjak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10227-001-0041-x" "Revista" => array:6 [ "tituloSerie" => "J Cutan Med Surg" "fecha" => "2002" "volumen" => "6" "paginaInicial" => "207" "paginaFinal" => "209" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11951126" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequency of prior actinic keratosis in cutaneous squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.A. Mittelbronn" 1 => "D.L. Mullins" 2 => "F.A. Ramos-Caro" 3 => "F.P. Flowers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "1998" "volumen" => "37" "paginaInicial" => "677" "paginaFinal" => "681" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9762818" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The multicentre south European study “Helios” II: different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Rosso" 1 => "R. Zanetti" 2 => "C. Martínez" 3 => "M.J. Torno" 4 => "S. Schraub" 5 => "H. Sancho-Garnier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br JCancer" "fecha" => "1996" "volumen" => "73" "paginaInicial" => "1447" "paginaFinal" => "1454" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiología e inmunopatogenia del cáncer cutáneo no melanoma. El papel iniciador y promotor del VPH" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V.G. Villarrubia" 1 => "L.A. Costa" 2 => "M. Pérez" 3 => "S. Vidal" 4 => "P. Jaén" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Piel" "fecha" => "2001" "volumen" => "16" "paginaInicial" => "428" "paginaFinal" => "438" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma espinocelular cutáneo y papilomavirus (VPH)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Corbalán Vélez" 1 => "J.A. Ruiz Macia" 2 => "C. Brufau" 3 => "F.J. Carapeto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliograf" "fecha" => "2007" "volumen" => "98" "paginaInicial" => "583" "paginaFinal" => "593" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Precáncer epitelial cutáneo-mucoso" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Brufau Redondo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Tumores Cutáneos" "paginaInicial" => "97" "paginaFinal" => "116" "serieFecha" => "1999" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomaviruses and nonmelanoma skin cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.A. Harwood" 1 => "C.M. Proby" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Infect Dis" "fecha" => "2002" "volumen" => "15" "paginaInicial" => "101" "paginaFinal" => "114" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11964909" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased prevalence of human papillomavirus in hairs plucked from patients with psoriasis treated with psoralen-UV-A" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Wolf" 1 => "H. Seidl" 2 => "B. Bäck" 3 => "B. Binder" 4 => "G. Höfler" 5 => "F. Quehenberger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.140.3.317" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2004" "volumen" => "140" "paginaInicial" => "317" "paginaFinal" => "324" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15023775" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p16INK4a expression in actinic keratosis and Bowen's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.E. Salama" 1 => "M.N. Mahmood" 2 => "H.S. Qureshi" 3 => "C. Ma" 4 => "R.J. Zarbo" 5 => "A.H. Oramsby" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2003" "volumen" => "149" "paginaInicial" => "1006" "paginaFinal" => "1012" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14632806" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Robson" 1 => "J. Greene" 2 => "N. Ansari" 3 => "B. Kim" 4 => "P.T. Seed" 5 => "P.H. McKee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2001" "volumen" => "25" "paginaInicial" => "710" "paginaFinal" => "720" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11395548" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma sebáceo extraocular de presentación atípica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.A. Martín-Díaz" 1 => "M. Mayor" 2 => "C. Rubio" 3 => "N. Hernández-Cano" 4 => "M.J. González-Beato" 5 => "M. Casado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2004" "volumen" => "95" "paginaInicial" => "586" "paginaFinal" => "589" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Highly aggressive extraocular sebaceous carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Moreno" 1 => "W.K. Jacyk" 2 => "M.J. Judd" 3 => "L. Requena" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2001" "volumen" => "23" "paginaInicial" => "450" "paginaFinal" => "455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11801779" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tricholemmal carcinoma: clinicopathologic study of 10 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.E. Swanson" 1 => "A.J. Marrogi" 2 => "D.J. Williams" 3 => "D.L. Cherwitz" 4 => "M.R. Wick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1992" "volumen" => "19" "paginaInicial" => "100" "paginaFinal" => "109" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1597565" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010000000004/v1_201304241454/S157821900970068X/v1_201304241454/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000004/v1_201304241454/S157821900970068X/v1_201304241454/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821900970068X?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 0 | 3 | 3 |
| 2024 October | 82 | 74 | 156 |
| 2024 September | 80 | 63 | 143 |
| 2024 August | 97 | 72 | 169 |
| 2024 July | 72 | 57 | 129 |
| 2024 June | 85 | 54 | 139 |
| 2024 May | 67 | 54 | 121 |
| 2024 April | 75 | 48 | 123 |
| 2024 March | 61 | 50 | 111 |
| 2024 February | 58 | 58 | 116 |
| 2024 January | 70 | 94 | 164 |
| 2023 December | 53 | 62 | 115 |
| 2023 November | 54 | 50 | 104 |
| 2023 October | 45 | 54 | 99 |
| 2023 September | 46 | 48 | 94 |
| 2023 August | 41 | 41 | 82 |
| 2023 July | 39 | 85 | 124 |
| 2023 June | 55 | 57 | 112 |
| 2023 May | 57 | 54 | 111 |
| 2023 April | 35 | 45 | 80 |
| 2023 March | 37 | 33 | 70 |
| 2023 February | 21 | 39 | 60 |
| 2023 January | 24 | 32 | 56 |
| 2022 December | 31 | 51 | 82 |
| 2022 November | 19 | 53 | 72 |
| 2022 October | 23 | 39 | 62 |
| 2022 September | 19 | 50 | 69 |
| 2022 August | 22 | 49 | 71 |
| 2022 July | 17 | 35 | 52 |
| 2022 June | 25 | 29 | 54 |
| 2022 May | 25 | 57 | 82 |
| 2022 April | 52 | 51 | 103 |
| 2022 March | 37 | 69 | 106 |
| 2022 February | 19 | 33 | 52 |
| 2022 January | 42 | 40 | 82 |
| 2021 December | 29 | 44 | 73 |
| 2021 November | 42 | 51 | 93 |
| 2021 October | 55 | 50 | 105 |
| 2021 September | 42 | 46 | 88 |
| 2021 August | 28 | 30 | 58 |
| 2021 July | 29 | 39 | 68 |
| 2021 June | 32 | 32 | 64 |
| 2021 May | 25 | 40 | 65 |
| 2021 April | 44 | 68 | 112 |
| 2021 March | 55 | 43 | 98 |
| 2021 February | 56 | 39 | 95 |
| 2021 January | 25 | 22 | 47 |
| 2020 December | 36 | 22 | 58 |
| 2020 November | 23 | 21 | 44 |
| 2020 October | 17 | 30 | 47 |
| 2020 September | 20 | 21 | 41 |
| 2020 August | 26 | 32 | 58 |
| 2020 July | 15 | 6 | 21 |
| 2020 June | 18 | 28 | 46 |
| 2020 May | 29 | 20 | 49 |
| 2020 April | 24 | 17 | 41 |
| 2020 March | 44 | 21 | 65 |
| 2020 February | 4 | 8 | 12 |
| 2020 January | 0 | 3 | 3 |
| 2019 December | 0 | 11 | 11 |
| 2019 November | 0 | 6 | 6 |
| 2019 October | 0 | 4 | 4 |
| 2019 September | 0 | 6 | 6 |
| 2019 August | 0 | 4 | 4 |
| 2019 July | 0 | 15 | 15 |
| 2019 June | 0 | 32 | 32 |
| 2019 May | 1 | 90 | 91 |
| 2019 April | 0 | 53 | 53 |
| 2019 March | 0 | 9 | 9 |
| 2019 February | 0 | 22 | 22 |
| 2019 January | 0 | 15 | 15 |
| 2018 December | 0 | 4 | 4 |
| 2018 November | 0 | 6 | 6 |
| 2018 September | 0 | 7 | 7 |
| 2018 August | 0 | 27 | 27 |
| 2018 July | 0 | 12 | 12 |
| 2018 June | 0 | 15 | 15 |
| 2018 May | 0 | 14 | 14 |
| 2018 April | 0 | 27 | 27 |
| 2018 March | 0 | 24 | 24 |
| 2018 February | 11 | 9 | 20 |
| 2018 January | 14 | 24 | 38 |
| 2017 December | 14 | 21 | 35 |
| 2017 November | 13 | 36 | 49 |
| 2017 October | 12 | 23 | 35 |
| 2017 September | 9 | 17 | 26 |
| 2017 August | 22 | 21 | 43 |
| 2017 July | 23 | 21 | 44 |
| 2017 June | 28 | 34 | 62 |
| 2017 May | 25 | 36 | 61 |
| 2017 April | 24 | 19 | 43 |
| 2017 March | 14 | 34 | 48 |
| 2017 February | 13 | 30 | 43 |
| 2017 January | 9 | 10 | 19 |
| 2016 December | 29 | 14 | 43 |
| 2016 November | 27 | 12 | 39 |
| 2016 October | 31 | 16 | 47 |
| 2016 September | 41 | 19 | 60 |
| 2016 August | 23 | 6 | 29 |
| 2016 July | 19 | 5 | 24 |
| 2016 June | 9 | 8 | 17 |
| 2016 May | 6 | 7 | 13 |
| 2016 April | 6 | 4 | 10 |
| 2016 March | 4 | 1 | 5 |
| 2016 February | 8 | 8 | 16 |
| 2016 January | 10 | 8 | 18 |
| 2015 December | 6 | 6 | 12 |
| 2015 November | 11 | 8 | 19 |
| 2015 October | 9 | 12 | 21 |
| 2015 September | 9 | 4 | 13 |
| 2015 August | 17 | 2 | 19 |
| 2015 July | 39 | 15 | 54 |
| 2015 June | 37 | 10 | 47 |
| 2015 May | 48 | 22 | 70 |
| 2015 April | 37 | 24 | 61 |
| 2015 March | 29 | 26 | 55 |
| 2015 February | 18 | 21 | 39 |
| 2015 January | 20 | 30 | 50 |
| 2014 December | 29 | 25 | 54 |
| 2014 November | 14 | 18 | 32 |
| 2014 October | 27 | 28 | 55 |
| 2014 September | 33 | 21 | 54 |
| 2014 August | 28 | 19 | 47 |
| 2014 July | 44 | 27 | 71 |
| 2014 June | 46 | 15 | 61 |
| 2014 May | 47 | 17 | 64 |
| 2014 April | 54 | 9 | 63 |
| 2014 March | 51 | 22 | 73 |
| 2014 February | 44 | 13 | 57 |
| 2014 January | 33 | 22 | 55 |
| 2013 December | 45 | 13 | 58 |
| 2013 November | 30 | 25 | 55 |
| 2013 October | 23 | 22 | 45 |
| 2013 September | 27 | 18 | 45 |
| 2013 August | 25 | 20 | 45 |
| 2013 July | 41 | 31 | 72 |
| 2013 June | 26 | 21 | 47 |
| 2013 May | 20 | 18 | 38 |
| 2013 April | 18 | 23 | 41 |
| 2013 March | 29 | 23 | 52 |
| 2013 February | 32 | 20 | 52 |
| 2013 January | 8 | 3 | 11 |
Show all
