array:24 [
  "pii" => "S0001731024001935"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2024.03.005"
  "estado" => "S300"
  "fechaPublicacion" => "2024-05-01"
  "aid" => "3891"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2023"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2024;115:T499-T500"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0001731023009298"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2022.10.057"
    "estado" => "S300"
    "fechaPublicacion" => "2024-05-01"
    "aid" => "3739"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2024;115:501-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
      "titulo" => "P&#225;pulas pruriginosas en clave familiar"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "501"
          "paginaFinal" => "502"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Familial Occurrence of Pruritic Papules"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 437
              "Ancho" => 1500
              "Tamanyo" => 32016
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#193;rbol geneal&#243;gico&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "G&#46; Baeza-Hern&#225;ndez, L&#46;C&#46; Araya-Uma&#241;a, C&#46; Mart&#237;nez-Mor&#225;n, D&#46; Arias-Palomo"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Baeza-Hern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "L&#46;C&#46;"
              "apellidos" => "Araya-Uma&#241;a"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Mart&#237;nez-Mor&#225;n"
            ]
            3 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Arias-Palomo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023009298?idApp=UINPBA000044"
    "url" => "/00017310/0000011500000005/v1_202405030647/S0001731023009298/v1_202405030647/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0001731023005033"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2022.07.045"
    "estado" => "S300"
    "fechaPublicacion" => "2024-05-01"
    "aid" => "3560"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2024;115:499-500"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
      "titulo" => "Garrapata complicada"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "499"
          "paginaFinal" => "500"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Complication of a Tick Bite"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0010"
          "etiqueta" => "Figura 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 552
              "Ancho" => 755
              "Tamanyo" => 153213
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46; Fern&#225;ndez de la Fuente, S&#46; Herrero Ruiz, B&#46; Echeverr&#237;a"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Fern&#225;ndez de la Fuente"
            ]
            1 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Herrero Ruiz"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Echeverr&#237;a"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023005033?idApp=UINPBA000044"
    "url" => "/00017310/0000011500000005/v1_202405030647/S0001731023005033/v1_202405030647/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:18 [
      "pii" => "S0001731023005033"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2022.07.045"
      "estado" => "S300"
      "fechaPublicacion" => "2024-05-01"
      "aid" => "3560"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2024;115:499-500"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
        "titulo" => "Garrapata complicada"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "499"
            "paginaFinal" => "500"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Complication of a Tick Bite"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:6 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 552
                "Ancho" => 755
                "Tamanyo" => 153213
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "L&#46; Fern&#225;ndez de la Fuente, S&#46; Herrero Ruiz, B&#46; Echeverr&#237;a"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Fern&#225;ndez de la Fuente"
              ]
              1 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Herrero Ruiz"
              ]
              2 => array:2 [
                "nombre" => "B&#46;"
                "apellidos" => "Echeverr&#237;a"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023005033?idApp=UINPBA000044"
      "url" => "/00017310/0000011500000005/v1_202405030647/S0001731023005033/v1_202405030647/es/main.assets"
    ]
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>"
    "titulo" => " Complication of a Tick Bite"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "T499"
        "paginaFinal" => "T500"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "L&#46; Fern&#225;ndez de la Fuente, S&#46; Herrero Ruiz, B&#46; Echeverr&#237;a"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "L&#46;"
            "apellidos" => "Fern&#225;ndez de la Fuente"
            "email" => array:1 [
              0 => "lfdelafuente@salud.madrid.org"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "S&#46;"
            "apellidos" => "Herrero Ruiz"
          ]
          2 => array:2 [
            "nombre" => "B&#46;"
            "apellidos" => "Echeverr&#237;a"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario de Fuenlabrada&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Garrapata complicada"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 350
            "Ancho" => 521
            "Tamanyo" => 67480
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Clinical history</span><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 56-year-old woman&#44; with no relevant past medical history&#44; who presented to the ER last October after finding a tick attached to her scalp &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; In the 15 days prior&#44; she had been in a rural area&#46; The tick was removed intact&#44; including the hypostome&#44; by gently pulling it out with blunt forceps&#46; Forty-eight hours later&#44; she developed an indurated lesion at the tick bite site&#44; along with low-grade fever spikes &#40;37&#46;8<span class="elsevierStyleHsp" style=""></span>&#176;C&#41;&#44; which were noted at the ER&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Upon examination&#44; the patient exhibited a necrotic eschar covered by a honey-colored crust at the tick bite site &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#44; with no perilesional erythema&#46; The patient also exhibited an ill-defined erythematous and edematous plaque extending from the tick bite site towards the lip region&#44; covering the entire forehead and periorbital region &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#46; The patient also exhibited very painful&#44; palpable&#44; bilateral&#44; and cervical lymphadenopathies of anteroposterior location&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Supplementary tests</span><p id="par0015" class="elsevierStylePara elsevierViewall">Basic blood tests were performed&#44; including a complete blood count and comprehensive profiling of blood coagulation&#44; which failed to reveal any abnormalities&#46; The liver enzyme levels&#44; however&#44; were elevated&#58; AST &#40;43 IU&#47;L&#41; and ALT &#40;53 IU&#47;L&#41;&#44; as well as the C-reactive protein &#40;CRP&#41; &#40;5&#46;37<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41;&#46; Serology for <span class="elsevierStyleItalic">Rickettsia conorii</span> and <span class="elsevierStyleItalic">Borrelia burgdorferi</span> turned out negative&#46; The removed tick was identified as a female <span class="elsevierStyleItalic">Dermacentor marginatus</span>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What is your diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Necrotic eschar and tick-borne lymphadenopathy&#44; also known as TIBOLA&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Course of the disease and treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">After the application of a 15-day daily course of doxycycline 200<span class="elsevierStyleHsp" style=""></span>mg and fusidic acid cream on the honey-colored crust&#44; the symptoms disappeared&#44; the necrotic eschar fell off&#44; and the previously altered PCR and liver enzyme levels went back to normal&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Tick bites are a relatively common reason for consultation in Spain&#44; especially in the summertime&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> There are over 800 species of ticks which feed by latching onto the skin&#44; with a preference for folds and the scalp&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In a small percentage of tick bites&#44; complications known as &#8220;tick-borne diseases&#8221; &#40;TBDs&#41; can occur&#46; There is a certain specificity between each TBD and each tick species&#46; In our setting&#44; the most common TBDs are Lyme disease&#44; transmitted by <span class="elsevierStyleItalic">Ixodes</span><span class="elsevierStyleItalic">ricinus</span>&#44; Mediterranean spotted fever&#44; transmitted by <span class="elsevierStyleItalic">Rhipicephalus sanguineus</span>&#44; and necrotic eschar and tick-borne lymphadenopathy transmitted by <span class="elsevierStyleItalic">Dermacentor marginatus</span>&#46; Less common diseases include human anaplasmosis and babesiosis&#46; Additionally&#44; sporadic cases of tularemia and Crimean-Congo fever have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Tick-borne lymphadenopathy has been described under various nomenclatures in the scientific medical literature&#44; such as TIBOLA&#44; DEBONEL &#40;dermacentor-borne necrosis erythema lymphadenopathy&#41;&#44; or SENLAT &#40;scalp eschar and neck lymphadenopathy&#41;&#46; The main causative agents of this disease are <span class="elsevierStyleItalic">Rickettsia slovaca</span>&#44; <span class="elsevierStyleItalic">Rickettsia raoultii</span>&#44; or <span class="elsevierStyleItalic">Rickettsia rioja</span>&#44; being the transmission vector ticks of the <span class="elsevierStyleItalic">Dermacentor</span> genus&#44; which are endemic to Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Unlike most tick bites&#44; these tend to occur during the autumn and winter months&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">This clinical picture should be suspected when a patient has a history of tick bites&#44; a necrotic eschar at the bite site&#44; painful lateral cervical and posterior lymphadenopathies&#44; and low-grade fever or febricula&#46; The diagnosis is primarily clinical&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Blood tests may show slightly elevated transaminase levels&#46; Some centers have tick identification methods&#44; specific serology&#44; and PCR assay detection of <span class="elsevierStyleItalic">Rickettsia slovaca</span> in the eschar itself&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Treatment should be started right away on clinical suspicion&#46; Waiting for diagnostic confirmation is ill-advised&#46; The treatment of choice is a 5-to-15-day course of doxycycline 100<span class="elsevierStyleHsp" style=""></span>mg every 12<span class="elsevierStyleHsp" style=""></span>hours&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:8 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Clinical history"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Physical examination"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Supplementary tests"
        ]
        3 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Diagnosis"
        ]
        4 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Course of the disease and treatment"
        ]
        5 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Comment"
        ]
        6 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflicts of interest"
        ]
        7 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:3 [
      0 => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 350
            "Ancho" => 521
            "Tamanyo" => 67480
          ]
        ]
      ]
      1 => array:6 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 400
            "Ancho" => 544
            "Tamanyo" => 76880
          ]
        ]
      ]
      2 => array:6 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 400
            "Ancho" => 437
            "Tamanyo" => 31256
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TIBOLA&#58; enfermedad emergente producida por picadura de garrapata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Sanantonio Valdearcos"
                            1 => "M&#46;C&#46; Otero Reigada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatr Aten Primaria"
                        "fecha" => "2015"
                        "volumen" => "17"
                        "paginaInicial" => "e193"
                        "paginaFinal" => "e195"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rickettsiosis&#44; un caso de TIBOLA"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Mart&#237;nez-Castill&#243;n"
                            1 => "D&#46;I&#46; Doste-Larrull"
                            2 => "A&#46; Sanz-Cardiel"
                            3 => "J&#46; Rodr&#237;guez-Ma&#241;as"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatr Aten Primaria"
                        "fecha" => "2016"
                        "volumen" => "18"
                        "paginaInicial" => "157"
                        "paginaFinal" => "160"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermacentor-borne Necrosis Erythema and Lymphadenopathy &#40;DEBONEL&#41;&#58; A case associated with Rickettsia rioja"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; P&#233;rez-P&#233;rez"
                            1 => "A&#46; Portillo"
                            2 => "F&#46; Allegue"
                            3 => "A&#46; Zulaica"
                            4 => "J&#46;A&#46; Oteo"
                            5 => "J&#46;L&#46; Caeiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2340/00015555-0801"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol&#46;"
                        "fecha" => "2010"
                        "volumen" => "90"
                        "paginaInicial" => "214"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20169320"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fiebre y tumefacci&#243;n cervical dolorosa tras picadura de garrapata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Campayo Losa"
                            1 => "J&#46; Almendros Vidal"
                            2 => "A&#46;L&#46; Leandro Fonseca"
                            3 => "J&#46;M&#46; Olmos Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Pediatr Integral"
                        "fecha" => "2016"
                        "volumen" => "20"
                        "paginaInicial" => "347"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of rickettsial PCR assays for the molecular diagnosis of human rickettsioses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Santib&#225;&#241;ez"
                            1 => "A&#46; Portillo"
                            2 => "P&#46; Santib&#225;&#241;ez"
                            3 => "A&#46;M&#46; Palomar"
                            4 => "J&#46;A&#46; Oteo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin&#46;"
                        "fecha" => "2013"
                        "volumen" => "31"
                        "paginaInicial" => "283"
                        "paginaFinal" => "288"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000011500000005/v1_202405030647/S0001731024001935/v1_202405030647/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6161"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Casos para el diagn&#243;stico"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011500000005/v1_202405030647/S0001731024001935/v1_202405030647/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024001935?idApp=UINPBA000044"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case for Diagnosis
Complication of a Tick Bite
Garrapata complicada
L. Fernández de la Fuente
Corresponding author
lfdelafuente@salud.madrid.org

Corresponding author.
, S. Herrero Ruiz, B. Echeverría
Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Madrid, Spain
Read
2092
Times
was read the article
496
Total PDF
1596
Total HTML
Share statistics
 array:24 [
  "pii" => "S0001731024001935"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2024.03.005"
  "estado" => "S300"
  "fechaPublicacion" => "2024-05-01"
  "aid" => "3891"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2023"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2024;115:T499-T500"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0001731023009298"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2022.10.057"
    "estado" => "S300"
    "fechaPublicacion" => "2024-05-01"
    "aid" => "3739"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2024;115:501-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
      "titulo" => "P&#225;pulas pruriginosas en clave familiar"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "501"
          "paginaFinal" => "502"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Familial Occurrence of Pruritic Papules"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 437
              "Ancho" => 1500
              "Tamanyo" => 32016
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#193;rbol geneal&#243;gico&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "G&#46; Baeza-Hern&#225;ndez, L&#46;C&#46; Araya-Uma&#241;a, C&#46; Mart&#237;nez-Mor&#225;n, D&#46; Arias-Palomo"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Baeza-Hern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "L&#46;C&#46;"
              "apellidos" => "Araya-Uma&#241;a"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Mart&#237;nez-Mor&#225;n"
            ]
            3 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Arias-Palomo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023009298?idApp=UINPBA000044"
    "url" => "/00017310/0000011500000005/v1_202405030647/S0001731023009298/v1_202405030647/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0001731023005033"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2022.07.045"
    "estado" => "S300"
    "fechaPublicacion" => "2024-05-01"
    "aid" => "3560"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2024;115:499-500"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
      "titulo" => "Garrapata complicada"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "499"
          "paginaFinal" => "500"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Complication of a Tick Bite"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0010"
          "etiqueta" => "Figura 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 552
              "Ancho" => 755
              "Tamanyo" => 153213
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46; Fern&#225;ndez de la Fuente, S&#46; Herrero Ruiz, B&#46; Echeverr&#237;a"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Fern&#225;ndez de la Fuente"
            ]
            1 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Herrero Ruiz"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Echeverr&#237;a"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023005033?idApp=UINPBA000044"
    "url" => "/00017310/0000011500000005/v1_202405030647/S0001731023005033/v1_202405030647/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:18 [
      "pii" => "S0001731023005033"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2022.07.045"
      "estado" => "S300"
      "fechaPublicacion" => "2024-05-01"
      "aid" => "3560"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2024;115:499-500"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
        "titulo" => "Garrapata complicada"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "499"
            "paginaFinal" => "500"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Complication of a Tick Bite"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:6 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 552
                "Ancho" => 755
                "Tamanyo" => 153213
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "L&#46; Fern&#225;ndez de la Fuente, S&#46; Herrero Ruiz, B&#46; Echeverr&#237;a"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Fern&#225;ndez de la Fuente"
              ]
              1 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Herrero Ruiz"
              ]
              2 => array:2 [
                "nombre" => "B&#46;"
                "apellidos" => "Echeverr&#237;a"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023005033?idApp=UINPBA000044"
      "url" => "/00017310/0000011500000005/v1_202405030647/S0001731023005033/v1_202405030647/es/main.assets"
    ]
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>"
    "titulo" => " Complication of a Tick Bite"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "T499"
        "paginaFinal" => "T500"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "L&#46; Fern&#225;ndez de la Fuente, S&#46; Herrero Ruiz, B&#46; Echeverr&#237;a"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "L&#46;"
            "apellidos" => "Fern&#225;ndez de la Fuente"
            "email" => array:1 [
              0 => "lfdelafuente@salud.madrid.org"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "S&#46;"
            "apellidos" => "Herrero Ruiz"
          ]
          2 => array:2 [
            "nombre" => "B&#46;"
            "apellidos" => "Echeverr&#237;a"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario de Fuenlabrada&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Garrapata complicada"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 350
            "Ancho" => 521
            "Tamanyo" => 67480
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Clinical history</span><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 56-year-old woman&#44; with no relevant past medical history&#44; who presented to the ER last October after finding a tick attached to her scalp &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; In the 15 days prior&#44; she had been in a rural area&#46; The tick was removed intact&#44; including the hypostome&#44; by gently pulling it out with blunt forceps&#46; Forty-eight hours later&#44; she developed an indurated lesion at the tick bite site&#44; along with low-grade fever spikes &#40;37&#46;8<span class="elsevierStyleHsp" style=""></span>&#176;C&#41;&#44; which were noted at the ER&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Upon examination&#44; the patient exhibited a necrotic eschar covered by a honey-colored crust at the tick bite site &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#44; with no perilesional erythema&#46; The patient also exhibited an ill-defined erythematous and edematous plaque extending from the tick bite site towards the lip region&#44; covering the entire forehead and periorbital region &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#46; The patient also exhibited very painful&#44; palpable&#44; bilateral&#44; and cervical lymphadenopathies of anteroposterior location&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Supplementary tests</span><p id="par0015" class="elsevierStylePara elsevierViewall">Basic blood tests were performed&#44; including a complete blood count and comprehensive profiling of blood coagulation&#44; which failed to reveal any abnormalities&#46; The liver enzyme levels&#44; however&#44; were elevated&#58; AST &#40;43 IU&#47;L&#41; and ALT &#40;53 IU&#47;L&#41;&#44; as well as the C-reactive protein &#40;CRP&#41; &#40;5&#46;37<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41;&#46; Serology for <span class="elsevierStyleItalic">Rickettsia conorii</span> and <span class="elsevierStyleItalic">Borrelia burgdorferi</span> turned out negative&#46; The removed tick was identified as a female <span class="elsevierStyleItalic">Dermacentor marginatus</span>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What is your diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Necrotic eschar and tick-borne lymphadenopathy&#44; also known as TIBOLA&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Course of the disease and treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">After the application of a 15-day daily course of doxycycline 200<span class="elsevierStyleHsp" style=""></span>mg and fusidic acid cream on the honey-colored crust&#44; the symptoms disappeared&#44; the necrotic eschar fell off&#44; and the previously altered PCR and liver enzyme levels went back to normal&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Tick bites are a relatively common reason for consultation in Spain&#44; especially in the summertime&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> There are over 800 species of ticks which feed by latching onto the skin&#44; with a preference for folds and the scalp&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In a small percentage of tick bites&#44; complications known as &#8220;tick-borne diseases&#8221; &#40;TBDs&#41; can occur&#46; There is a certain specificity between each TBD and each tick species&#46; In our setting&#44; the most common TBDs are Lyme disease&#44; transmitted by <span class="elsevierStyleItalic">Ixodes</span><span class="elsevierStyleItalic">ricinus</span>&#44; Mediterranean spotted fever&#44; transmitted by <span class="elsevierStyleItalic">Rhipicephalus sanguineus</span>&#44; and necrotic eschar and tick-borne lymphadenopathy transmitted by <span class="elsevierStyleItalic">Dermacentor marginatus</span>&#46; Less common diseases include human anaplasmosis and babesiosis&#46; Additionally&#44; sporadic cases of tularemia and Crimean-Congo fever have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Tick-borne lymphadenopathy has been described under various nomenclatures in the scientific medical literature&#44; such as TIBOLA&#44; DEBONEL &#40;dermacentor-borne necrosis erythema lymphadenopathy&#41;&#44; or SENLAT &#40;scalp eschar and neck lymphadenopathy&#41;&#46; The main causative agents of this disease are <span class="elsevierStyleItalic">Rickettsia slovaca</span>&#44; <span class="elsevierStyleItalic">Rickettsia raoultii</span>&#44; or <span class="elsevierStyleItalic">Rickettsia rioja</span>&#44; being the transmission vector ticks of the <span class="elsevierStyleItalic">Dermacentor</span> genus&#44; which are endemic to Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Unlike most tick bites&#44; these tend to occur during the autumn and winter months&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">This clinical picture should be suspected when a patient has a history of tick bites&#44; a necrotic eschar at the bite site&#44; painful lateral cervical and posterior lymphadenopathies&#44; and low-grade fever or febricula&#46; The diagnosis is primarily clinical&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Blood tests may show slightly elevated transaminase levels&#46; Some centers have tick identification methods&#44; specific serology&#44; and PCR assay detection of <span class="elsevierStyleItalic">Rickettsia slovaca</span> in the eschar itself&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Treatment should be started right away on clinical suspicion&#46; Waiting for diagnostic confirmation is ill-advised&#46; The treatment of choice is a 5-to-15-day course of doxycycline 100<span class="elsevierStyleHsp" style=""></span>mg every 12<span class="elsevierStyleHsp" style=""></span>hours&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:8 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Clinical history"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Physical examination"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Supplementary tests"
        ]
        3 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Diagnosis"
        ]
        4 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Course of the disease and treatment"
        ]
        5 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Comment"
        ]
        6 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflicts of interest"
        ]
        7 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:3 [
      0 => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 350
            "Ancho" => 521
            "Tamanyo" => 67480
          ]
        ]
      ]
      1 => array:6 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 400
            "Ancho" => 544
            "Tamanyo" => 76880
          ]
        ]
      ]
      2 => array:6 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 400
            "Ancho" => 437
            "Tamanyo" => 31256
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TIBOLA&#58; enfermedad emergente producida por picadura de garrapata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Sanantonio Valdearcos"
                            1 => "M&#46;C&#46; Otero Reigada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatr Aten Primaria"
                        "fecha" => "2015"
                        "volumen" => "17"
                        "paginaInicial" => "e193"
                        "paginaFinal" => "e195"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rickettsiosis&#44; un caso de TIBOLA"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Mart&#237;nez-Castill&#243;n"
                            1 => "D&#46;I&#46; Doste-Larrull"
                            2 => "A&#46; Sanz-Cardiel"
                            3 => "J&#46; Rodr&#237;guez-Ma&#241;as"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatr Aten Primaria"
                        "fecha" => "2016"
                        "volumen" => "18"
                        "paginaInicial" => "157"
                        "paginaFinal" => "160"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermacentor-borne Necrosis Erythema and Lymphadenopathy &#40;DEBONEL&#41;&#58; A case associated with Rickettsia rioja"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; P&#233;rez-P&#233;rez"
                            1 => "A&#46; Portillo"
                            2 => "F&#46; Allegue"
                            3 => "A&#46; Zulaica"
                            4 => "J&#46;A&#46; Oteo"
                            5 => "J&#46;L&#46; Caeiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2340/00015555-0801"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol&#46;"
                        "fecha" => "2010"
                        "volumen" => "90"
                        "paginaInicial" => "214"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20169320"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fiebre y tumefacci&#243;n cervical dolorosa tras picadura de garrapata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Campayo Losa"
                            1 => "J&#46; Almendros Vidal"
                            2 => "A&#46;L&#46; Leandro Fonseca"
                            3 => "J&#46;M&#46; Olmos Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Pediatr Integral"
                        "fecha" => "2016"
                        "volumen" => "20"
                        "paginaInicial" => "347"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of rickettsial PCR assays for the molecular diagnosis of human rickettsioses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Santib&#225;&#241;ez"
                            1 => "A&#46; Portillo"
                            2 => "P&#46; Santib&#225;&#241;ez"
                            3 => "A&#46;M&#46; Palomar"
                            4 => "J&#46;A&#46; Oteo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Enferm Infecc Microbiol Clin&#46;"
                        "fecha" => "2013"
                        "volumen" => "31"
                        "paginaInicial" => "283"
                        "paginaFinal" => "288"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000011500000005/v1_202405030647/S0001731024001935/v1_202405030647/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6161"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Casos para el diagn&#243;stico"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011500000005/v1_202405030647/S0001731024001935/v1_202405030647/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024001935?idApp=UINPBA000044"
]
Article information
ISSN: 00017310
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 22 12 34
2024 October 208 70 278
2024 September 178 45 223
2024 August 263 79 342
2024 July 228 47 275
2024 June 175 86 261
2024 May 261 58 319
2024 April 178 51 229
2024 March 83 48 131

Follow this link to access the full text of the article

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?