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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">La bicalutamida&#44; un antagonista no esteroideo del receptor de andr&#243;genos aprobado para el tratamiento del c&#225;ncer de pr&#243;stata&#44; se ha posicionado recientemente como una alternativa terap&#233;utica en tricolog&#237;a&#46; Se usa fuera de ficha t&#233;cnica para pacientes con una alopecia androgen&#233;tica de patr&#243;n femenino &#40;AAPF&#41;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">El mecanismo de acci&#243;n de la bicalutamida es selectivo a nivel perif&#233;rico en las c&#233;lulas foliculares de la papila d&#233;rmica&#46; Con las dosis empleadas en tricolog&#237;a&#44; no presenta actividad mineral ni glucocorticoide&#44; ni ha mostrado efectos en los niveles de testosterona&#44; estr&#243;genos o progest&#225;genos<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">No hay un consenso acerca de cu&#225;l es la dosis adecuada de bicalutamida para la AAPF&#44; aunque&#44; en cualquier caso&#44; siempre es inferior a la aprobada para el c&#225;ncer de pr&#243;stata&#46; En la serie m&#225;s numerosa&#44; la de Ismail et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#44; la dosis m&#225;s utilizada fue de 10<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a&#44; mientras que en la Fern&#225;ndez-Nieto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> fue entre 25 y 50<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a&#46; En ambos se administr&#243; generalmente combinada con otros f&#225;rmacos&#44; principalmente con minoxidil oral a dosis de 0&#44;5-1<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a&#44; y&#44; en menor medida&#44; con espironolactona<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; El tiempo transcurrido hasta la mejor&#237;a vari&#243; entre los 6 meses y los 2 a&#241;os&#44; encontr&#225;ndose una mejor&#237;a a los 6 meses de un 20&#44;2 a un 27&#44;5&#37; en la escala de Sinclair<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Dada su actividad antiandrog&#233;nica&#44; algunos estudios sugieren que su empleo a una dosis media de 14&#44;4<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a concomitante con minoxidil oral a una dosis media de 1&#44;5<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a durante m&#225;s de 3 meses&#44; podr&#237;a reducir la hipertricosis secundaria a este&#44; lo que permitir&#237;a obtener una mejor tolerancia a dosis altas de minoxidil y&#44; as&#237;&#44; optimizar el tratamiento de la AAPF<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Debido a su papel sobre la miniaturizaci&#243;n del fol&#237;culo&#44; y teniendo en cuenta el efecto anterior&#44; se utiliz&#243; con &#233;xito en una paciente con alopecia central centr&#237;fuga con una dosis de 10<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a&#44; en combinaci&#243;n con 0&#44;45<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a de minoxidil oral y un corticoide t&#243;pico<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">En los estudios publicados ha presentado un buen perfil de seguridad y tolerabilidad<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#8211;3</span></a>&#46; El efecto secundario m&#225;s referido fue la hepatotoxicidad&#44; encontr&#225;ndose hipertransaminasemia en el 2&#44;9-12&#44;5&#37;&#44; en todos los casos con un valor inferior a 3 veces el l&#237;mite superior de normalidad<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a>&#46; Este efecto ser&#237;a dosis dependiente&#44; mejorando la mayor&#237;a de los casos de forma espont&#225;nea o tras disminuir la dosis de bicalutamida&#44; sin requerir su suspensi&#243;n<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#46; Otros efectos indeseables menos frecuentes fueron alteraciones gastrointestinales&#44; edema de miembros&#44; mastalgia o migra&#241;a&#44; entre otros &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#8211;3</span></a>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">La bicalutamida est&#225; contraindicada en mujeres embarazadas y se recomienda administrarla con precauci&#243;n en mujeres con una historia personal o familiar de tumores hormono-dependientes<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Dada la evidencia actual&#44; 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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#46;<span class="elsevierStyleSup">o</span> abandonos terap&#233;uticos por efectos secundarios&#40;&#37; de abandonos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ismail et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AAPF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">316&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-10 &#91;69&#44;6&#37;&#93;-12&#44;5 &#91;2&#44;5&#37;&#93;-20 &#91;25&#37;&#93;-25 &#91;1&#37;&#125;-30 &#91;1&#46;6&#37;&#93;-50 &#91;0&#44;3&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Minoxidil oral<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;97&#44;4&#37;&#41;-Espironolactona<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&#40;54&#44;4&#37;&#41;-Monoterapia &#40;1&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2-69&#40;6&#44;21 de media&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Hipertransaminasemia &#40;2&#44;9&#37;&#41;-Edema en miembros &#40;2&#44;5&#37;&#41;-Alteraciones gastrointestinales &#40;1&#44;9&#37;&#41;-En<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1&#37; de los casos&#44; respectivamente&#58; mastalgia&#44; erupci&#243;n acneiforme&#44; astenia&#44; mialgias&#44; disminuci&#243;n de la libido&#44; alteraciones menstruales&#44; cambios de humor&#44; palpitaciones y disnea&#44; fotosensibilidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#40;4&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fern&#225;ndez-Nieto et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AAPF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-25 &#91;34&#44;1&#37;&#93;-50 &#91;65&#44;9&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Minoxidil oral 0&#44;5-1<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a &#40;75&#44;0&#37;&#41;-Dutasteride oral 0&#44;5<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a &#40;15&#44;9&#37;&#41;-Dutasteride en mesoterapia &#40;13&#44;6&#37;&#41;- Minoxidil t&#243;pico 5&#37; &#40;11&#44;4&#37;&#41;-Monoterapia &#40;6&#44;8&#37;&#41;-Finasteride oral 2&#44;5mg&#47;d&#237;a &#40;2&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2-24&#40;10&#44;5 de media&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Hipertransaminasemia &#40;11&#44;4&#37;&#41;-Efluvio &#40;6&#44;8&#37;&#41;-Alteraciones menstruales &#40;4&#44;5&#37;&#41;-Migra&#241;a &#40;2&#44;2&#37;&#41;-Hiperplasia endometrial &#40;2&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moussa et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serie de casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hipertricosis secundaria a minoxidil en AAPF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-10 &#91;57&#37;&#93;-20 &#91;40&#37;&#93;-25 &#91;3&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Minoxidil oral 0&#44;25-10<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a &#91;dosis media de 1&#44;5<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a&#93;&#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;9&#40;25&#44;92 de media&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Hipertransaminasemia &#40;6&#37;&#41;-Disestesia del cuero cabelludo &#40;3&#37;&#41;-Migra&#241;a &#40;3&#37;&#41;-Edema periocular &#40;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#40;5&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lobon et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso cl&#237;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alopecia central centr&#237;fuga&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44; con incremento a 20 &#91;100&#37;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Minoxidil oral 0&#44;45<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a y dipropionato de clobetasol 0&#44;05&#37; t&#243;pico&#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Resumen de la literatura actual acerca del empleo de bicalutamida en tricolog&#237;a</p>"
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      "titulo" => "Bibliograf&#237;a"
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              "identificador" => "bib0030"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bicalutamide&#58; A potential new oral antiandrogenic drug for female pattern hair loss"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Fernandez-Nieto"
                            1 => "D&#46; Saceda-Corralo"
                            2 => "J&#46; Jimenez-Cauhe"
                            3 => "O&#46;M&#46; Moreno-Arrones"
                            4 => "R&#46; Rodrigues-Barata"
                            5 => "A&#46; Hermosa-Gelbard"
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                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2020.04.0544"
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                        "tituloSerie" => "J Am Acad Dermatol &#91;Internet&#93;&#46;"
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                        "volumen" => "83"
                        "paginaInicial" => "e355"
                        "paginaFinal" => "e356"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32320770"
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              "identificador" => "bib0035"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety of oral bicalutamide in female pattern hair loss&#58; A retrospective review of 316 patients"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46;F&#46; Ismail"
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                            2 => "L&#46; Trindade de Carvalho"
                            3 => "B&#46; Bhoyrul"
                            4 => "D&#46; Wall"
                            5 => "R&#46; Sinclair"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2020.03.034"
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                        "tituloSerie" => "J Am Acad Dermatol &#91;Internet&#93;&#46;"
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              "identificador" => "bib0040"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bicalutamide improves minoxidil-induced hypertrichosis in female pattern hair loss&#58; A retrospective review of 35 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Moussa"
                            1 => "A&#46; Kazmi"
                            2 => "L&#46; Bokhari"
                            3 => "R&#46;D&#46; Sinclair"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2021.10.0485"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Am Acad Dermatol &#91;Internet&#93;&#46;"
                        "fecha" => "2021"
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            3 => array:3 [
              "identificador" => "bib0045"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Significant hair regrowth in a Middle Eastern woman with central centrifugal cicatricial alopecia"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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