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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">La psoriasis es una enfermedad inflamatoria cr&#243;nica sobre la que act&#250;an m&#250;ltiples factores asociados con el estilo de vida&#46; En los &#250;ltimos a&#241;os&#44; varios trabajos han puesto de manifiesto la capacidad de determinados alimentos y patrones diet&#233;ticos para modular distintos marcadores relacionados con la inflamaci&#243;n sist&#233;mica<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a>&#44; componente importante de la psoriasis moderada-grave y estrechamente ligado a sus comorbilidades&#46; En un metaan&#225;lisis de ensayos cl&#237;nicos&#44; la reducci&#243;n de peso a trav&#233;s de la dieta se asoci&#243; con una disminuci&#243;n significativa de la gravedad de la enfermedad<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a>&#46; Si bien estas mejor&#237;as podr&#237;an ser atribuidas a la reducci&#243;n de la inflamaci&#243;n sist&#233;mica asociada a la obesidad&#44; los resultados de los estudios incluidos mostraban gran heterogeneidad&#44; sugiriendo la participaci&#243;n de otros factores m&#225;s all&#225; de la p&#233;rdida de peso en el beneficio observado&#46; La composici&#243;n de la dieta&#44; como coment&#225;bamos&#44; podr&#237;a ser uno de ellos<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; La dieta mediterr&#225;nea &#40;DM&#41; es una gran fuente de mol&#233;culas antioxidantes y antiinflamatorias&#44; habi&#233;ndose asociado a una disminuci&#243;n del riesgo de enfermedades cardiovasculares e inflamatorias cr&#243;nicas<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a>&#46; Con base en lo mencionado&#44; varios grupos han abordado los potenciales beneficios que la DM podr&#237;a presentar en pacientes con psoriasis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">En un estudio transversal publicado en 2015 por Barrea et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> un porcentaje significativamente mayor de pacientes con psoriasis mostraron una adherencia baja a la DM con respecto a los controles &#40;30&#44;6 vs&#46; 4&#44;8&#37;&#44; p &#60; 0&#44;001&#41;&#46; La adherencia a la dieta se correlacion&#243; negativamente con la gravedad de la enfermedad medida con el &#237;ndice PASI&#46; En el an&#225;lisis de regresi&#243;n m&#250;ltiple&#44; el consumo de aceite de oliva fue uno de los principales predictores del mismo&#44; con un coeficiente de determinaci&#243;n &#40;r<span class="elsevierStyleSup">2</span>&#41; de 0&#44;548 &#40;p &#60; 0&#44;001&#41;&#46; El mayor estudio al respecto es un estudio transversal publicado en 2018 en JAMA Dermatology<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> el cual incluy&#243; a 35&#46;735 sujetos procedentes de la cohorte NutriNet-Sant&#233;&#46; De los sujetos estudiados&#44; 3&#46;557 presentaban psoriasis&#44; clasificada como grave en 878 pacientes&#46; En el an&#225;lisis multivariante&#44; tras ajustar por variables como la edad&#44; el sexo&#44; el peso y factores de riesgo cardiovascular&#44; el porcentaje de pacientes con formas graves de la enfermedad fue significativamente menor entre los grupos de mayor adherencia a la dieta&#46; Por otra parte&#44; Castaldo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> evaluaron el efecto de cuatro semanas de dieta cetog&#233;nica muy baja en calor&#237;as seguida de seis semanas de DM hipocal&#243;rica en un grupo de pacientes con psoriasis sin tratamiento sist&#233;mico y con sobrepeso&#47;obesidad&#46; Obtuvieron reducciones significativas del peso y mejor&#237;as en el PASI y en la calidad de vida de estos enfermos&#46; Llamativamente&#44; no encontraron una correlaci&#243;n lineal entre la bajada de peso y el PASI&#44; sugiriendo un efecto antiinflamatorio de los cuerpos cet&#243;nicos y de otros componentes diet&#233;ticos en el beneficio observado&#46; Finalmente&#44; un trabajo reciente encontr&#243; una correlaci&#243;n inversa e independiente del peso entre la actividad de la artritis psori&#225;sica y la adherencia a la DM&#44; abriendo camino a un potencial beneficio de este patr&#243;n diet&#233;tico tambi&#233;n en este cuadro<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a>&#46; La <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> ofrece un resumen de los art&#237;culos que abordan el tema de la revisi&#243;n&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Como conclusi&#243;n&#44; la evidencia disponible se&#241;ala que la DM podr&#237;a asociarse a formas menos graves de psoriasis y&#47;o artritis psori&#225;sica&#46; Teniendo en cuenta que la menor gravedad fue independiente del &#237;ndice de masa corporal en varios estudios<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">4&#8211;7</span></a>&#44; es posible que el beneficio de este patr&#243;n diet&#233;tico vaya m&#225;s all&#225; de la p&#233;rdida de peso&#46; No obstante&#44; en los pr&#243;ximos a&#241;os ser&#225;n necesarios m&#225;s estudios longitudinales y con dise&#241;o experimental para consolidar estos hallazgos y para definir de una manera precisa el papel que la DM debe jugar en el tratamiento de esta enfermedad&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Financiaci&#243;n</span><p id="par0020" class="elsevierStylePara elsevierViewall">Este trabajo no ha recibido ning&#250;n tipo de financiaci&#243;n&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicto de intereses</span><p id="par0025" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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                  \t\t\t\t">-Observacional&#44; transversal&#46;-Adherencia evaluada con cuestionario PREDIMED&#58; &#60; 6 baja adherencia&#59; 6-9 adherencia moderada&#59; &#62; 9 alta adherencia&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- 62 pacientes psori&#225;sicos sin tratamiento sist&#233;mico previo&#46;- 62 controles pareados por edad&#44; sexo e IMC&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Porcentaje significativamente mayor de pacientes con psoriasis mostraron una adherencia baja con respecto a los controles &#40;30&#44;6 vs&#46; 4&#44;8&#37;&#44; p &#60; 0&#44;001&#41;&#46;-Correlaci&#243;n negativa entre puntuaci&#243;n en PREDIMED y PASI &#40;r &#61; -0&#44;576&#44; p &#60; 0&#44;01&#41;&#46;- Uso de EVOO factor predictivo independiente de PASI entre &#237;tems del PREDIMED &#40;r<span class="elsevierStyleSup">2</span> &#61; 0&#44;548&#44; &#946; &#61; &#8722;0&#44;741&#44; t &#61; &#8722;7&#46;636&#44; p &#60; 0&#44;001&#41;&#46;- Consumo de pescado factor predictivo independiente de PCR &#40;r2 &#61; 0&#44;139&#44; &#946; &#61; &#8722;0&#44;372&#44; t &#61; &#8722;2&#46;922&#44; p &#61; 0&#44;005&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Phan et al&#46;&#44; 2018<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Francia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Observacional&#44; transversal&#46;-Adherencia evaluada con cuestionario MEDI-LITE &#40;puntuaci&#243;n 0 a 18-adherencia total-&#41;&#59; 3 terciles&#58; primero 0-7&#59; segundo 8-9&#59; tercero &#62; 10&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-35&#46;735 sujetos procedentes de la cohorte NutriNet-Sant&#233;&#46;-3&#46;557 pacientes con psoriasis-878 psoriasis grave &#40;24&#44;7&#37;&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-An&#225;lisis univariante&#58; Porcentaje de pacientes con psoriasis grave fue mayor en el tercil 1 &#40;Psoriasis grave 45&#44;5&#37;&#44; psoriasis no grave 36&#44;6&#37;&#44; no psoriasis 35&#44;6&#37;&#44; p &#60; 0&#44;001&#41;&#46;-An&#225;lisis multivariante<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&#58;&#8226; Tercil 2&#44; OR &#40;IC 95&#37;&#41; para psoriasis grave&#58; 0&#44;74 &#40;0&#44;61-0&#44;90&#41;&#46;&#8226; Tercil 3&#44; OR &#40;IC 95&#37;&#41; para psoriasis grave&#58; 0&#44;74 &#40;0&#44;60-0&#44;91&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Molina-Leyva et al&#46;&#44; 2019<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Espa&#241;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Observacional&#44; transversal&#46;-Adherencia evaluada con cuestionario PREDIMED&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 pacientes con psoriasis en tratamiento sist&#233;mico&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-PASI menor en pacientes con mayor adherencia a DM&#46; Baja adherencia&#58; 7 &#40;IC 95&#37; 3&#44;6-8&#44;20&#41;&#59; Moderada adherencia&#58; 3&#44;4 &#40;IC 95&#37; 1&#44;05-9&#44;45&#41;&#59; Alta adherencia&#58; 0&#44;8 &#40;IC 95&#37; 0&#44;00-2&#44;57&#41; &#40;p &#61; 0&#44;007&#41;- PCR menor en grupo con mayor adherencia a DM &#40;3&#44;20 &#177;2&#44;73 vs&#46; 2&#44;54 &#177; 3&#44;84 vs&#46; 1&#44;12 &#177; 1&#44;23&#44; p &#61; 0&#44;05&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Korovesi et al&#46;&#44; 2019<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Observacional&#44; transversal&#46;-Adherencia evaluada con MedDietScore&#46;&#8804; 21&#58; baja adherencia&#59; 21-35&#58; adherencia moderada&#59; &#8805; 35&#58; alta adherencia&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-69 pacientes con psoriasis sin tratamiento sist&#233;mico previo&#46;-69 controles pareados por edad&#44; sexo&#44; IMC y fecha de inclusi&#243;n&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Adherencia a la DM se asoci&#243; de manera inversa con el riesgo de presentar psoriasis&#8224; &#40;OR 0&#44;34&#44; IC 95&#37;&#58; 0&#44;13-0&#44;92&#44; p &#61; 0&#44;03&#41;&#46;-MedDietScore se correlacion&#243; de manera negativa con el PASI &#40;r &#61; -0&#44;39&#44; p &#61; 0&#44;001&#41;&#46;-PASI inversamente asociado con consumo de legumbres&#44; pescado y AOVE &#40;p &#60; 0&#44;05&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Castaldo et al&#46;&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Italia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Ensayo cl&#237;nico abierto&#44; 1 brazo&#46;-Intervenci&#243;n&#58; 4 primeras semanas dieta cetog&#233;nica&#44; seguidas de 6 semanas de DM hipocal&#243;rica&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 pacientes con psoriasis en placas estable y sobrepeso&#44; sin f&#225;rmacos sist&#233;micos previos&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Reducci&#243;n PASI media de -10&#44;6 &#40;IC 95&#37; -12&#44;8 a -8&#44;4&#59; p &#60; 0&#44;001&#41;&#46;-PASI50 en el 97&#44;3&#37; y PASI75 en el 64&#44;9&#37;&#46;-Reducci&#243;n de peso media de -9&#46;5&#37; &#40;IC 95&#37; -10&#46;5 a -8&#46;4&#59; p&#60;0&#44;001&#41; y -12&#46;0&#37; &#40;IC 95&#37; -13&#44;7 a -10&#44;4&#59; p &#60; 0&#44;001&#41; al final del periodo cetog&#233;nico y del periodo con dieta mediterr&#225;nea&#44; respectivamente&#46;-Reducci&#243;n de DLQI media -13&#44;4 IC 95&#37; -17&#46;0 a -9&#44;7&#59; p &#60; 0&#44;001&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso et al&#46;&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Italia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Observacional&#44; transversal&#44; multic&#233;ntrico&#46;-Adherencia evaluada con cuestionario PREDIMED&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-211 pacientes con artritis psori&#225;sica&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Relaci&#243;n inversa entre DAPSA y puntuaci&#243;n en PREDIMED &#40;B &#61; &#8722;3&#44;291&#59; IC 95&#37; &#8211;5&#44;884 a &#8211; 0&#44;698&#59; p &#61; 0&#44;013&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Ajustando por edad&#44; sexo&#44; IMC&#44; tabaquismo&#44; actividad f&#237;sica&#44; nivel educacional&#44; historia basal de enfermedad cardiovascular&#44; diabetes&#44; HTA e hipertrigliceridemia&#46;</p>"
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            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Ajustado por sexo&#44; IMC y tratamiento previo con f&#225;rmacos modificadores de la enfermedad&#46;</p> <p class="elsevierStyleNotepara" id="npar0015">&#8224;Ajustado por edad&#44; el sexo e IMC&#46;</p> <p class="elsevierStyleNotepara" id="npar0020">DAPSA&#58; <span class="elsevierStyleItalic">Disease Activity in PSoriasis Arthritis</span>&#59; DLQI&#58; <span class="elsevierStyleItalic">Dermatology Life Quality Index</span>&#59; DM&#58; Dieta medieterr&#225;nea&#59; IC&#58; Intervalo de confianza&#59; IMC&#58; &#205;ndice de masa corporal&#59; PASI&#58; <span class="elsevierStyleItalic">Psoriasis Area and Severity Index</span>&#59; PASI50&#58; Reducci&#243;n de 50&#37; del PASI basal&#59; PASI75&#58; Reducci&#243;n de 75&#37; del PASI basal&#59; PCR&#58; Prote&#237;na C-reactiva&#59; PREDIMED&#58; PRevenci&#243;n con DIeta MEDiterr&#225;nea&#59; EVOO&#58; <span class="elsevierStyleItalic">extra-virgin olive oil</span>&#46;</p>"
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        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudios que eval&#250;an el efecto de la dieta mediterr&#225;nea en la psoriasis y&#47;o artritis psori&#225;sica</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
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        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Environmental Risk Factors in Psoriasis&#58; The Point of View of the Nutritionist"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Barrea"
                            1 => "F&#46; Nappi"
                            2 => "C&#46; Di Somma"
                            3 => "M&#46;C&#46; Savanelli"
                            4 => "A&#46; Falco"
                            5 => "A&#46; Balato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3390/ijerph13070743"
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Environ Res Public Health&#46;"
                        "fecha" => "2016"
                        "volumen" => "13"
                        "paginaInicial" => "743"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27455297"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
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              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of lifestyle weight loss intervention on disease severity in patients with psoriasis&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Upala"
                            1 => "A&#46; Sanguankeo"
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                        ]
                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ijo.2015.64"
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes &#40;Lond&#41;&#46;"
                        "fecha" => "2015"
                        "volumen" => "39"
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            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nutrition and psoriasis&#58; is there any association between the severity of the disease and adherence to the Mediterranean diet&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Barrea"
                            1 => "N&#46; Balato"
                            2 => "C&#46; Di Somma"
                            3 => "P&#46;E&#46; Macchia"
                            4 => "M&#46; Napolitano"
                            5 => "M&#46;C&#46; Savanelli"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12967-014-0372-1"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Transl Med&#46;"
                        "fecha" => "2015"
                        "volumen" => "13"
                        "paginaInicial" => "18"
                        "link" => array:1 [
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                        ]
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                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association Between Mediterranean Anti-inflammatory Dietary Profile and Severity of Psoriasis&#58; Results From the NutriNet-Sant&#233; Cohort"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Phan"
                            1 => "M&#46; Touvier"
                            2 => "E&#46; Kesse-Guyot"
                            3 => "M&#46; Adjibade"
                            4 => "S&#46; Hercberg"
                            5 => "P&#46; Wolkenstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2018.2127"
                      "Revista" => array:5 [
                        "tituloSerie" => "JAMA Dermatol&#46;"
                        "fecha" => "2018"
                        "volumen" => "154"
                        "paginaInicial" => "1017"
                        "paginaFinal" => "1024"
                      ]
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                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aggressive weight-loss program with a ketogenic induction phase for the treatment of chronic plaque psoriasis&#58; A proof-of-concept&#44; single-arm&#44; open-label clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Castaldo"
                            1 => "L&#46; Rastrelli"
                            2 => "G&#46; Galdo"
                            3 => "P&#46; Molettieri"
                            4 => "F&#46; Rotondi Aufiero"
                            5 => "E&#46; Cereda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.nut.2020.110757"
                      "Revista" => array:5 [
                        "tituloSerie" => "Nutrition&#46;"
                        "fecha" => "2020"
                        "volumen" => "74"
                        "paginaInicial" => "110757"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32222582"
                            "web" => "Medline"
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                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
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Foro de Residentes
FR – El papel de la dieta mediterránea en el tratamiento de la psoriasis
RF – Role of the Mediterranean Diet in the Treatment of Psoriasis
E. Berna-Rico
Corresponding author
emilioberna2a@gmail.com

Autor para correspondencia.
, D. Fernandez-Nieto, A. Gonzalez-Cantero
Servicio de Dermatología, Hospital Universitario Ramon y Cajal. Instituto de Investigación Sanitaria del Hospital Ramon y Cajal (IRYCIS), Madrid, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">La psoriasis es una enfermedad inflamatoria cr&#243;nica sobre la que act&#250;an m&#250;ltiples factores asociados con el estilo de vida&#46; En los &#250;ltimos a&#241;os&#44; varios trabajos han puesto de manifiesto la capacidad de determinados alimentos y patrones diet&#233;ticos para modular distintos marcadores relacionados con la inflamaci&#243;n sist&#233;mica<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a>&#44; componente importante de la psoriasis moderada-grave y estrechamente ligado a sus comorbilidades&#46; En un metaan&#225;lisis de ensayos cl&#237;nicos&#44; la reducci&#243;n de peso a trav&#233;s de la dieta se asoci&#243; con una disminuci&#243;n significativa de la gravedad de la enfermedad<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a>&#46; Si bien estas mejor&#237;as podr&#237;an ser atribuidas a la reducci&#243;n de la inflamaci&#243;n sist&#233;mica asociada a la obesidad&#44; los resultados de los estudios incluidos mostraban gran heterogeneidad&#44; sugiriendo la participaci&#243;n de otros factores m&#225;s all&#225; de la p&#233;rdida de peso en el beneficio observado&#46; La composici&#243;n de la dieta&#44; como coment&#225;bamos&#44; podr&#237;a ser uno de ellos<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; La dieta mediterr&#225;nea &#40;DM&#41; es una gran fuente de mol&#233;culas antioxidantes y antiinflamatorias&#44; habi&#233;ndose asociado a una disminuci&#243;n del riesgo de enfermedades cardiovasculares e inflamatorias cr&#243;nicas<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a>&#46; Con base en lo mencionado&#44; varios grupos han abordado los potenciales beneficios que la DM podr&#237;a presentar en pacientes con psoriasis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">En un estudio transversal publicado en 2015 por Barrea et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> un porcentaje significativamente mayor de pacientes con psoriasis mostraron una adherencia baja a la DM con respecto a los controles &#40;30&#44;6 vs&#46; 4&#44;8&#37;&#44; p &#60; 0&#44;001&#41;&#46; La adherencia a la dieta se correlacion&#243; negativamente con la gravedad de la enfermedad medida con el &#237;ndice PASI&#46; En el an&#225;lisis de regresi&#243;n m&#250;ltiple&#44; el consumo de aceite de oliva fue uno de los principales predictores del mismo&#44; con un coeficiente de determinaci&#243;n &#40;r<span class="elsevierStyleSup">2</span>&#41; de 0&#44;548 &#40;p &#60; 0&#44;001&#41;&#46; El mayor estudio al respecto es un estudio transversal publicado en 2018 en JAMA Dermatology<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> el cual incluy&#243; a 35&#46;735 sujetos procedentes de la cohorte NutriNet-Sant&#233;&#46; De los sujetos estudiados&#44; 3&#46;557 presentaban psoriasis&#44; clasificada como grave en 878 pacientes&#46; En el an&#225;lisis multivariante&#44; tras ajustar por variables como la edad&#44; el sexo&#44; el peso y factores de riesgo cardiovascular&#44; el porcentaje de pacientes con formas graves de la enfermedad fue significativamente menor entre los grupos de mayor adherencia a la dieta&#46; Por otra parte&#44; Castaldo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> evaluaron el efecto de cuatro semanas de dieta cetog&#233;nica muy baja en calor&#237;as seguida de seis semanas de DM hipocal&#243;rica en un grupo de pacientes con psoriasis sin tratamiento sist&#233;mico y con sobrepeso&#47;obesidad&#46; Obtuvieron reducciones significativas del peso y mejor&#237;as en el PASI y en la calidad de vida de estos enfermos&#46; Llamativamente&#44; no encontraron una correlaci&#243;n lineal entre la bajada de peso y el PASI&#44; sugiriendo un efecto antiinflamatorio de los cuerpos cet&#243;nicos y de otros componentes diet&#233;ticos en el beneficio observado&#46; Finalmente&#44; un trabajo reciente encontr&#243; una correlaci&#243;n inversa e independiente del peso entre la actividad de la artritis psori&#225;sica y la adherencia a la DM&#44; abriendo camino a un potencial beneficio de este patr&#243;n diet&#233;tico tambi&#233;n en este cuadro<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a>&#46; La <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> ofrece un resumen de los art&#237;culos que abordan el tema de la revisi&#243;n&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Como conclusi&#243;n&#44; la evidencia disponible se&#241;ala que la DM podr&#237;a asociarse a formas menos graves de psoriasis y&#47;o artritis psori&#225;sica&#46; Teniendo en cuenta que la menor gravedad fue independiente del &#237;ndice de masa corporal en varios estudios<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">4&#8211;7</span></a>&#44; es posible que el beneficio de este patr&#243;n diet&#233;tico vaya m&#225;s all&#225; de la p&#233;rdida de peso&#46; No obstante&#44; en los pr&#243;ximos a&#241;os ser&#225;n necesarios m&#225;s estudios longitudinales y con dise&#241;o experimental para consolidar estos hallazgos y para definir de una manera precisa el papel que la DM debe jugar en el tratamiento de esta enfermedad&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Financiaci&#243;n</span><p id="par0020" class="elsevierStylePara elsevierViewall">Este trabajo no ha recibido ning&#250;n tipo de financiaci&#243;n&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicto de intereses</span><p id="par0025" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Autor&#44; A&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pa&#237;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dise&#241;o del estudio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Poblaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Resultados principales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Barrea et al&#46;&#44; 2015<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Italia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Observacional&#44; transversal&#46;-Adherencia evaluada con cuestionario PREDIMED&#58; &#60; 6 baja adherencia&#59; 6-9 adherencia moderada&#59; &#62; 9 alta adherencia&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- 62 pacientes psori&#225;sicos sin tratamiento sist&#233;mico previo&#46;- 62 controles pareados por edad&#44; sexo e IMC&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Porcentaje significativamente mayor de pacientes con psoriasis mostraron una adherencia baja con respecto a los controles &#40;30&#44;6 vs&#46; 4&#44;8&#37;&#44; p &#60; 0&#44;001&#41;&#46;-Correlaci&#243;n negativa entre puntuaci&#243;n en PREDIMED y PASI &#40;r &#61; -0&#44;576&#44; p &#60; 0&#44;01&#41;&#46;- Uso de EVOO factor predictivo independiente de PASI entre &#237;tems del PREDIMED &#40;r<span class="elsevierStyleSup">2</span> &#61; 0&#44;548&#44; &#946; &#61; &#8722;0&#44;741&#44; t &#61; &#8722;7&#46;636&#44; p &#60; 0&#44;001&#41;&#46;- Consumo de pescado factor predictivo independiente de PCR &#40;r2 &#61; 0&#44;139&#44; &#946; &#61; &#8722;0&#44;372&#44; t &#61; &#8722;2&#46;922&#44; p &#61; 0&#44;005&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Phan et al&#46;&#44; 2018<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Francia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Observacional&#44; transversal&#46;-Adherencia evaluada con cuestionario MEDI-LITE &#40;puntuaci&#243;n 0 a 18-adherencia total-&#41;&#59; 3 terciles&#58; primero 0-7&#59; segundo 8-9&#59; tercero &#62; 10&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-35&#46;735 sujetos procedentes de la cohorte NutriNet-Sant&#233;&#46;-3&#46;557 pacientes con psoriasis-878 psoriasis grave &#40;24&#44;7&#37;&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-An&#225;lisis univariante&#58; Porcentaje de pacientes con psoriasis grave fue mayor en el tercil 1 &#40;Psoriasis grave 45&#44;5&#37;&#44; psoriasis no grave 36&#44;6&#37;&#44; no psoriasis 35&#44;6&#37;&#44; p &#60; 0&#44;001&#41;&#46;-An&#225;lisis multivariante<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&#58;&#8226; Tercil 2&#44; OR &#40;IC 95&#37;&#41; para psoriasis grave&#58; 0&#44;74 &#40;0&#44;61-0&#44;90&#41;&#46;&#8226; Tercil 3&#44; OR &#40;IC 95&#37;&#41; para psoriasis grave&#58; 0&#44;74 &#40;0&#44;60-0&#44;91&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Molina-Leyva et al&#46;&#44; 2019<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Espa&#241;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Observacional&#44; transversal&#46;-Adherencia evaluada con cuestionario PREDIMED&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 pacientes con psoriasis en tratamiento sist&#233;mico&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-PASI menor en pacientes con mayor adherencia a DM&#46; Baja adherencia&#58; 7 &#40;IC 95&#37; 3&#44;6-8&#44;20&#41;&#59; Moderada adherencia&#58; 3&#44;4 &#40;IC 95&#37; 1&#44;05-9&#44;45&#41;&#59; Alta adherencia&#58; 0&#44;8 &#40;IC 95&#37; 0&#44;00-2&#44;57&#41; &#40;p &#61; 0&#44;007&#41;- PCR menor en grupo con mayor adherencia a DM &#40;3&#44;20 &#177;2&#44;73 vs&#46; 2&#44;54 &#177; 3&#44;84 vs&#46; 1&#44;12 &#177; 1&#44;23&#44; p &#61; 0&#44;05&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Korovesi et al&#46;&#44; 2019<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Grecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Observacional&#44; transversal&#46;-Adherencia evaluada con MedDietScore&#46;&#8804; 21&#58; baja adherencia&#59; 21-35&#58; adherencia moderada&#59; &#8805; 35&#58; alta adherencia&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-69 pacientes con psoriasis sin tratamiento sist&#233;mico previo&#46;-69 controles pareados por edad&#44; sexo&#44; IMC y fecha de inclusi&#243;n&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Adherencia a la DM se asoci&#243; de manera inversa con el riesgo de presentar psoriasis&#8224; &#40;OR 0&#44;34&#44; IC 95&#37;&#58; 0&#44;13-0&#44;92&#44; p &#61; 0&#44;03&#41;&#46;-MedDietScore se correlacion&#243; de manera negativa con el PASI &#40;r &#61; -0&#44;39&#44; p &#61; 0&#44;001&#41;&#46;-PASI inversamente asociado con consumo de legumbres&#44; pescado y AOVE &#40;p &#60; 0&#44;05&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Castaldo et al&#46;&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Italia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Ensayo cl&#237;nico abierto&#44; 1 brazo&#46;-Intervenci&#243;n&#58; 4 primeras semanas dieta cetog&#233;nica&#44; seguidas de 6 semanas de DM hipocal&#243;rica&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 pacientes con psoriasis en placas estable y sobrepeso&#44; sin f&#225;rmacos sist&#233;micos previos&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Reducci&#243;n PASI media de -10&#44;6 &#40;IC 95&#37; -12&#44;8 a -8&#44;4&#59; p &#60; 0&#44;001&#41;&#46;-PASI50 en el 97&#44;3&#37; y PASI75 en el 64&#44;9&#37;&#46;-Reducci&#243;n de peso media de -9&#46;5&#37; &#40;IC 95&#37; -10&#46;5 a -8&#46;4&#59; p&#60;0&#44;001&#41; y -12&#46;0&#37; &#40;IC 95&#37; -13&#44;7 a -10&#44;4&#59; p &#60; 0&#44;001&#41; al final del periodo cetog&#233;nico y del periodo con dieta mediterr&#225;nea&#44; respectivamente&#46;-Reducci&#243;n de DLQI media -13&#44;4 IC 95&#37; -17&#46;0 a -9&#44;7&#59; p &#60; 0&#44;001&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso et al&#46;&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Italia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Observacional&#44; transversal&#44; multic&#233;ntrico&#46;-Adherencia evaluada con cuestionario PREDIMED&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-211 pacientes con artritis psori&#225;sica&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Relaci&#243;n inversa entre DAPSA y puntuaci&#243;n en PREDIMED &#40;B &#61; &#8722;3&#44;291&#59; IC 95&#37; &#8211;5&#44;884 a &#8211; 0&#44;698&#59; p &#61; 0&#44;013&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&#46;&nbsp;\t\t\t\t\t\t\n
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Article information
ISSN: 00017310
Original language: Spanish
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