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By learning about AI in dermatology&#44; we will be better placed to lead its development&#44; which currently is in hands of engineers who minimize the importance of correct medical diagnosis or whose focus is inappropriate&#44; thereby limiting the true value of this innovation&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The present article was written by physicians specialized in medical-surgical dermatology and venereology who have direct and indirect experience in this new field of health&#46; We will draw on this experience to highlight the most relevant aspects of IA and thus illustrate what impact AI might have on the future of dermatology&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Basic notions of artificial intelligence</span><p id="par0025" class="elsevierStylePara elsevierViewall">Medical presentations&#44; podcasts&#44; and interviews about AI will often use terms such as machine learning and neural networks&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In its essence&#44; AI is a technology developed to imitate cognitive functions of human beings<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; There are 3 basic types of AI&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The term <span class="elsevierStyleItalic">big data</span> refers to data or combinations of datasets whose size &#40;volume&#41;&#44; complexity &#40;variability&#41;&#44; and rate of growth hinder acquisition&#44; management&#44; processing&#44; or analysis by conventional means such as personal computers&#44; relational databases&#44; and conventional statistics &#40;for example&#44; SPSS&#174; software&#41;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; This type of analysis enables enormous quantities of data to be managed and generation of predictive models which are useful in clinical practice&#46; 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which consists of independent analysis of data thanks to the generation of algorithms for decision making<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a>&#46; This technology enables the identification of patterns to classify and make different predictions&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">ML works by feeding an algorithm with input data comprising past observations and constructs a model for predicting and classifying new observations unknown to the algorithm by imitating a human cognitive process &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Among the most popular ML models in the health sector are convolutional neural networks &#40;CNNs&#41;&#44; which imitate brain neuron function&#46; CNNs are formed of variable layers interconnected by weights that the algorithm calculates and adjusts through iterations &#40;repetitions&#41; in a process known as <span class="elsevierStyleItalic">gradient descent</span>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In dermatology&#44; we usually use multiple variables&#44; and so multiple neurons are needed to weave a network of connections that generate useful information&#46; When we talk of a system that bases its information on more than one layer of information&#44; we refer to deep learning &#40;DL&#41;&#46; Such networks generate excellent results provided that 2 fundamental requirements are met&#58; data &#40;both images and clinical information&#41; are available in sufficient quantity and quality &#40;big data&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Learning models for artificial intelligence</span><p id="par0065" class="elsevierStylePara elsevierViewall">AI &#40;ML&#44; DL&#41; can essentially be trained in 3 modes&#58; supervised&#44; unsupervised&#44; and by reinforcement&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In the supervised model of learning&#44; the AI algorithm is trained with a set of examples labelled by an expert in which the output results are known&#46; This is the model that we usually find in dermatological applications&#44; whose training content are images labelled with their diagnosis or selected training parameter<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a>&#46; By way of example of this supervised learning model in the field of dermatopathology&#44; in the first phase&#44; the machine is <span class="elsevierStyleItalic">taught</span> to recognize features and specific patterns&#44; and regions of interest&#44; validated in this case by a dermatopathologist &#40;for example&#44; features and patterns associated with benign melanocytic lesions and malignant ones &#91;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#93;&#41;&#46; These features and basal patterns constitute what is known as the ground truth&#46; In the second phase&#44; thanks to DL algorithms&#44; the machine is able to recognize patterns and regions of interest in lesions not previously analyzed&#44; and diagnose a lesion as a benign or malignant lesion based on these algorithms<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">The unsupervised model is based on unlabeled data in which the output structure and results are not known a priori&#46; Basically&#44; such algorithms search for grouping patterns &#40;clusters&#41; for subjects that&#44; in view of their characteristics in the different variables that define them&#44; show similarities<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46; There are few applications of this type of AI in dermatology&#44; given that in most cases algorithms are applied to images&#46; This type of model is usually used in situations in which predictions are required or in the case of needing rapid classifications for data mining<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46; An example of unsupervised learning would be the generation of classifiers for &#8216;melanoma versus nonmelanoma&#8217; by training a model that groups&#47;classifies images through patterns detected by the algorithm itself<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Artificial intelligence applied to inflammatory diseases</span><p id="par0080" class="elsevierStylePara elsevierViewall">DL algorithms have been used to classify different inflammatory skin diseases&#46; We will present some of the most relevant ones below&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Psoriasis</span><p id="par0085" class="elsevierStylePara elsevierViewall">AI-based algorithms can be useful both for making a more precise clinical assessment and for supporting the development of personalized therapeutic protocols and predictions of results<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The first IA program designed for psoriasis was that created by Guo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> in 2014&#46; Their objective was to predict the development of psoriasis by microarray gene expression profiling of 2 sets of data&#46; The binary classification achieved an overall precision of 99&#46;81&#37;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Several attempts have been made to develop an AI program that could help to assess the severity of poriasis<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;13</span></a>&#46; In the most recent models&#44; the authors used 3 different standard classifiers&#8212;support vector machines&#44; decision trees&#44; and artificial neural networks&#8212;to stratify risk and assess 3 principal attributes&#58; color&#44; texture&#44; and higher order spectra&#46; The classifier was trained with 670 psoriasis images&#46; The classifiers segmented the lesions and classified them as healthy or diseased&#46; The model achieved a precision of 99&#46;84&#37;&#44; a sensitivity of 99&#46;76&#37;&#44; and a specificity of 99&#46;99&#37;&#46; Given that the sample size was small&#44; the result could be affected by overfitting&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Other studies aimed to develop a system to stratify psoriasis severity using the Psoriasis Area and Severity Index &#40;PASI&#41;&#44; assessing the affected area<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a>&#44; scaling<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#44; induration and color<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#44; and isolated erythema<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">New studies have managed to improve the automatic detection of psoriasis lesions through use of cluster-based segmentation along with swarm intelligence techniques<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Recently&#44; and following one of the previous models&#44; the results were presented for the IMAPSORS project&#44; included within the SKIANA project&#174;&#46; Development was cofinanced by the European Commission&#46; The aim was to generate quantifiable information on the skin of patients with psoriasis using personal mobile devices&#46; The results obtained in the capacity for detecting psoriasis and in automated definition of disease severity in the form of PASI and body surface area&#44; both quantitatively and qualitatively&#44; open the door to an improvement in the definition of severity and early detection of moderate and severe forms of the disease &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>A and B&#41;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">AI programs have also been developed to assess and optimize treatment of psoriasis&#44; specifically&#44; for determining long-term response to biologic treatment&#46; The first of these studies was based on 2&#8239;ML models that studied gene expression in skin biopsies<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&#46; These models were able to predict PASI<span class="elsevierStyleInf">75</span> response after 12 weeks of treatment by assessing the early &#40;2&#8211;4 weeks&#41; expression profiling of treatment&#46; Another study undertook multiomic analysis in patients receiving etanercept&#44; and found indicators of response to treatment in gene expression and pathways associated with tumor necrosis factor and major histocompatibility complex signalling<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Although studies of gene expression profiling in biopsy samples are promising&#44; there is interest in methods that avoid the invasive nature of this technique&#46; Thus&#44; a predictive model has been developed using biochemical markers in blood<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&#46; However&#44; simpler PASI-based models were better predictors and so further study is necessary&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Another recent study used ML to predict response of patients with psoriasis to biologic treatment using basic health parameters such as age of onset of psoriasis and weight of the patient<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">AI models can also be used to discover potential off-label treatments for psoriasis and other inflammatory conditions through models that use text from scientific articles and disease classifications to identify potential drugs<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">AI programs have also been used to study comorbidities in psoriasis&#46; One of these programs identified predictors of coronary artery disease in patients with psoriasis&#59; these predictors included obesity&#44; dyslipidemia&#44; and inflammation<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a>&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Another comorbidity that affects approximately 25&#37; of patients with psoriasis is psoriatic arthritis&#46; To date&#44; there is no effective method for predicting the development of this condition&#46; An AI program has been developed based on genotypes of patients with psoriasis and psoriatic arthritis&#44; differentiating between the 2 diseases based on 200 genetic markers&#44; with an area under curve &#40;AUC&#41; of 0&#46;82&#46; This was the first study to show robust prediction of the development of psoriatic arthritis using only genetic information<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a>&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Atopic dermatitis</span><p id="par0145" class="elsevierStylePara elsevierViewall">The use of AI in atopic dermatitis can be of help both in the diagnosis and personalized treatment of the condition as well as in predicting treatment outcomes&#46; It could also be useful for helping to standardize and reduce the time taken to assess patients&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Investigation of AI in the field of atopic dermatitis is&#44; however&#44; still in its infancy&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">An ML algorithm has been designed to identify atopic dermatitis based on electronic health records<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#46; For this&#44; a natural language processor has been developed to incorporate both structured and unstructured data&#46; Using 562 electronic health records&#44; the designers achieved a positive predictive value of 84&#37; and a sensitivity of 75&#37;&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Other groups developed an artificial neural network to distinguish skin with atopic dermatitis involvement from healthy skin using imaging information<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a>&#46; However&#44; the number of samples used was low&#44; given that this was an exploratory study&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Onychomycosis</span><p id="par0165" class="elsevierStylePara elsevierViewall">A recent study compared a group of dermatologists with CNNs for the detection of onychomycosis<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a>&#46; A total of 49&#44;567 images were used to train the classifier to distinguish between nails with onychomycosis and normal nails&#46; In the validation&#44; the classifier achieved a sensitivity of 82&#46;7&#37;&#8211;96&#46;7&#37; and a specificity of 69&#46;3&#37;&#8211;96&#46;7&#37;&#46; The area under the receiver operator characteristics &#40;ROC&#41; curve was 0&#46;82&#8211;0&#46;98&#46; In this study&#44; the capacity of the classifier to differentiate healthy nails from those with onychomycosis was statistically superior to that of dermatologists&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Rosacea and acne</span><p id="par0170" class="elsevierStylePara elsevierViewall">Clinical evaluation of patients with rosacea&#44; as with other inflammatory diseases&#44; often shows high intra- and interobserver variability&#46; In this context&#44; Binol et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> developed an AI program based on CNNs to perform a quantitative and reproducible assessment of lesions&#44; after training with more than a million images&#46; These authors also defined what they called regions of anatomic interest&#44; that is&#44; facial areas highly susceptible to rosacea&#44; thereby significantly reducing false positives in identification of rosacea lesions&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Similarly&#44; digital processing of images has been used for automatic detection of acne lesions&#44; with the aim of performing a more precise and reproducible evaluation&#46; Min et al&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> developed a system that automatically counted 5 types of lesions &#40;papules&#44; nodules&#44; pustules&#44; closed comedones&#44; and open comedones&#41; and compared the results with the manual count performed by a dermatologist&#46; The lesions assessed in 25 patients found a sensitivity and specificity greater than 70&#37;&#46; Other studies have used segmentation of acne lesions&#44; breaking down the image into several homogeneous regions based on the similarity of their color<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a>&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Given that the severity of acne is the main determinant in the choice of treatment&#44; these evaluation methods based on image processing could help improve therapeutic decision-making&#46; Likewise&#44; their development could suppose a marked potential time saving for the clinician&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">In 2019&#44; Seit&#233; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> developed an AI-based smartphone application that graded and classified acne lesions &#40;comedonal&#44; inflammatory&#44; postinflammatory hyperpigmentation&#44; etc&#46;&#41;&#46; Apart from the advantages in terms of evaluation of lesions&#44; it was postulated that the use of these applications linked to geolocation could also help assess the impact of external trigger factors such as climate and pollution on the duration and severity of acne&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">In 2020&#44; Martorell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> developed an AI model for detecting acne lesions in the facial region through a smartphone application <span class="elsevierStyleItalic">SkianaCare</span>&#174;&#44; which calculates the severity for determining whether systemic treatment should complement other treatment&#44; where severity was defined by a cutoff on the global evaluation of acne &#40;GEA&#41; scale &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>A and B&#41;&#46; Thus&#44; in a series of 101 patients&#44; a precision of 97&#46;8&#37; was found in the capacity for definition of degree of severity&#46; In turn&#44; correlation between clinical manifestations and images established the need for systemic treatment&#44; mainly in the form of an oral retinoid&#44; with GEA scores greater than 3 in the facial region&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Other inflammatory diseases</span><p id="par0195" class="elsevierStylePara elsevierViewall">Other AI programs have been designed for diagnosis of different inflammatory skin diseases&#44; such as lichen planus&#44; lichenoid pityriasis&#44; and dermatomyositis from digital images<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">36&#8211;39</span></a>&#46; Huang et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> developed a classifier of multiple diseases &#40;based on assessment of 34 attributes such as erythema&#44; scaling&#44; border definition and irregularity&#41; able to differentiate between several skin diseases such as psoriasis&#44; lichen planus&#44; and seborrheic dermatitis&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">For the study of dermatomyositis&#44; in addition to assessment of skin images&#44; ultrasound images of muscle have been used to differentiate between normal muscle&#44; dermatomyositis&#44; polymyositis&#44; and inclusion-body myositis<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a>&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Application of artificial intelligence in skin cancers</span><p id="par0205" class="elsevierStylePara elsevierViewall">In the field of skin cancer&#44; of note have been some publications that cover the potential of the new&#8212;at the time&#8212;information systems&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">The first publication&#44; from 1986&#44; talked of how computers could automate diagnosis of facial tumors and issuing of recommendations<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a>&#46; Another from 1992 highlighted the use of computer imaging analyses to aid diagnoses made by professionals with less experience in the field of melanoma<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a>&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Since then&#44; and more notably in the past decade&#44; there has been an exponential increase in publications on AI to support care of patients with skin cancer&#46; This increase can be defined in 2 stages that&#44; although not perfectly differentiated&#44; give an approximate description of the development of the application of AI in skin cancer&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">In the first stage&#44; which draws on previous years&#44; there is an emphasis on theory and multiple practical attempts were made&#46; In this stage&#44; we could say that the systems based on the use of AI were honed&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">There were publications on the reliability and feasibility of the use of conventional digital macrophotographs to allow the system to distinguish between melanocytic and nonmelanocytic lesions<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a>&#46; It was also observed that the combination of clinical information and imaging helped with diagnosis of basal cell carcinoma<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a>&#46; Many other publications of the same nature highlight that through a combination of different information sources &#40;exhaustive medical history&#44; images obtained from different systems&#8230;&#41;&#44; greater precision was obtained in automated diagnosis&#46; It was even possible to see how AI could be used to determine surgical margins in intraoperative biopsies<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a>&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Automated prognostic models can also be included in this stage&#46; An example would be computational algorithms that enable prediction of metastatic progression of cutaneous melanoma based on gene expression and microRNA data<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a>&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">A second more recent stage has seen AI systems used in &#40;and outside&#41; the clinic with different functions&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">One of the most widely disseminated publications&#44; from 2017&#44; proposed using DL algorithms for classification of tumor lesions<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a>&#46; Specifically&#44; the authors compared the degree of diagnostic concordance between the automated system and a group of specialist dermatologists when distinguishing seborrheic keratosis from keratinocyte carcinomas and benign nevi from melanoma&#44; with promising results for use in support of diagnosis&#46; These algorithms could become a tool to extend the reach of dermatologists outside the clinic&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">The use of algorithms has been proposed for automated image analysis to support therapeutic decisions &#40;excision versus observation&#41; in the management of pigmented lesions<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a>&#44; or to give initial guidance to the dermatologist who subsequently would make the decision according to clinical context<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a>&#46; Of particular interest is the use of images obtained by free smartphone applications&#59; with these some authors have proposed algorithms for detecting changes in pigmented lesions that could predict progression to melanoma<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a>&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">With particular interest in pigmented and melanoma lesions&#44; one of the most prolific groups was that led by the dermatologists in Heidelberg&#44; Germany&#46; In their research&#44; they primarily use CNN-based systems&#46; In the first articles&#44; by Haenssle&#44; preliminary results superior to dermatologists were obtained for recognition of melanoma by dermoscopy in experimental conditions<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46; The group lead by Brinker has continued to highlight the excellent performance of CNN-based systems for differentiating melanomas from melanocytic nevi by dermoscopy<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">50&#44;51</span></a>&#44; combining clinical and dermoscopic images<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a>&#44; or with histopathologic images<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a>&#46; In conditions of use closer to clinical practice&#44; and including diagnosis of other types of tumor &#40;not just melanoma&#41;&#44; they have achieved results similar to those of dermatologists<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a>&#46;</p><p id="par0255" class="elsevierStylePara elsevierViewall">Other groups have achieved good results in the identification of melanomas from dermoscopic images using DL-based systems<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a>&#44; or acral melanomas using CNN-based systems<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a>&#46;</p><p id="par0260" class="elsevierStylePara elsevierViewall">These systems and approximations can be used in exploring data to generate models predictive of response to immunotherapy in cases of metastatic melanoma<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a>&#46; Some investigators are even using gene expression profiling and microRNA analyses with ML algorithms for molecular distinction between melanocytic nevi and melanoma<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a>&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">In the case of nonmelanoma skin cancer&#44; use of AI-based systems appears at present to be supported by less robust evidence<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a>&#46; In any case&#44; CNN-based systems have been successfully used in the automated detection of facial keratinocyte cancers<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> and actinic keratosis<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> from clinical photographs&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Artificial intelligence in dermatopathology</span><p id="par0270" class="elsevierStylePara elsevierViewall">Histologic diagnosis of skin lesions has a substantial subjective&#44; observer-dependent component&#46; Specially&#44; relatively nonspecific inflammatory lesions&#44; poorly differentiated skin tumors&#44; or diseases with a wide spectrum of presentations that include benign lesions through malignant ones&#44; including borderline cases&#44; can generate substantial diagnostic uncertainty&#44; with differences of opinion even among expert dermatopathologists&#46; Perhaps one of the best examples is histological diagnosis of melanocytic lesions&#58; the difference between dysplastic nevus and in situ melanoma is subtle&#44; and experienced dermatopathologists may sometimes reach different diagnoses for the same lesion<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a>&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">In dermatopathology&#44; the use of AI as a diagnostic tool started at the end of the past century&#44; with the TEGUMENT project &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a>&#46; However&#44; it is only more recently that several studies have started to support &#40;in very preliminary fashion&#41; its potential practical use as an aid for histologic diagnosis&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">AI has shown a high precision in performing several essential functions of histologic diagnosis&#44; such as mitosis count and assessment of positivity in immunohistochemical tests<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a>&#46; On the other hand&#44; DL algorithms showed a precision of almost 100&#37; in binary classification of tumor lesions&#44; and almost 80&#37; for classification of these same lesions in 4 categories &#40;basaloid&#44; squamous&#44; melanocytic&#44; and others&#41;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a>&#46;</p><p id="par0285" class="elsevierStylePara elsevierViewall">With regards the differential diagnosis between nevi and melanoma&#44; CNN-based methods have been assessed in different studies<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">63&#44;64</span></a>&#46; In 2019&#44; Hekler et al&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a> showed overall discordance of 19&#37; between a CNN-based system and an expert dermatopathologist&#44; with this percentage being similar to that between expert dermatopathologists&#46; Also in 2019&#44; Hart et al&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> reported a precision of approximately 90&#37; for binary classification of Spitz nevus and conventional nevus&#46; More recently&#44; in 2021&#44; CNN-based techniques showed a sensitivity&#44; specificity&#44; and precision approaching that of 18 expert dermatologists when assessing 50 melanocytic lesions to discriminate between nevi and melanomas<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a>&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">One of the main limitations in the use of CNN-based systems in dermatopathology is their limited classification system&#58; whereas trained dermatopathologists are able to recognize several morphologic variants and perform broad differential diagnoses&#44; current CNN-based models mainly use binary classification systems &#40;they indicate whether an image is positive or not for a diagnosis&#41; and lose precision when more categories are introduced<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a>&#46; In fact&#44; there are hardly any studies in dermatopathology of nontumor lesions&#44; where differential diagnosis is&#44; in many cases&#44; broader and more subjective&#46; Furthermore&#44; given the ground truth in the learning phase of these systems is established by one or several dermatopathologists&#44; and given that many entities lack diagnostic criteria with absolute precision&#44; this fundamental or ground truth is not completely free of subjectivity<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">Therefore&#44; although preliminary results are promising&#44; it is necessary to extend them &#40;to beyond binary systems&#41; and AI systems need to be validated before they can be used in dermatological clinical practice&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">Probably&#44; these systems could be used in the future for automating reproducible tasks&#44; such as screening&#44; making them a diagnostic aid to improve not only the daily work of the dermatopathologist&#44; but also an important tool in research and even education&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Artificial intelligence applied to cosmetics</span><p id="par0305" class="elsevierStylePara elsevierViewall">The field of cosmetic dermatology has been one of the sectors in which multiple models have been developed based on innovative solutions&#46; Currently&#44; on the market&#44; models include virtual planning for cosmetic treatment with neuromodulators and treatment with cosmetic fillers&#44; as well as use of robotics in automation of different laser treatments<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">67</span></a>&#46;</p><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Home use assistants</span><p id="par0310" class="elsevierStylePara elsevierViewall">The application of new technologies has generated multiple strategies whose end objective is to empower patients through information and generation of personalized content&#44; with the aim of facilitating decisions on skin and hair care&#46;</p><p id="par0315" class="elsevierStylePara elsevierViewall">Many companies have created intelligent questionnaires about skin and hair care that include questions about patient demographics&#44; skin and hair characteristics&#44; and desired esthetic outcomes to generate personalized recommendations&#46;</p><p id="par0320" class="elsevierStylePara elsevierViewall">Along these lines&#44; the startup known as <span class="elsevierStyleItalic">PROVEN Beauty</span>&#174;&#44; based in California&#44; used ML to offer personalized cosmetic products to consumers for skin care&#46; The algorithm uses information from a large skincare database called <span class="elsevierStyleItalic">Beauty Genome Project</span>&#44; which includes more than 8 million client opinions&#44; more than 100&#44;000 products for skincare products currently on the market&#44; 20&#44;000 ingredients&#44; and more than 4000 peer-reviewed scientific articles on skin and skincare ingredients<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">68</span></a>&#46;</p><p id="par0325" class="elsevierStylePara elsevierViewall">Augmented reality is another technology that enables personalization of routines for skin and hair care&#46; In these cases&#44; it goes one step further than questionnaire-based models by incorporating patient images in the decision-making process&#46; The company L&#39;Oreal&#174; offers 2 online web-based applications of augmented reality that are free for users&#46; The first application offers online skin analysis through the Vichy&#174; <span class="elsevierStyleItalic">Skin Consult AI&#174;</span> website&#46; This application generates a skincare and antiaging simulation with the capacity to detect&#44; quantify&#44; and predict changes in the skin<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">69</span></a>&#46; This &#8216;virtual mirror&#8217; applies computerized vision technology to simulate the result that could be obtained with beauty and cosmetic products&#46; The project was developed with the support of dermatologists to assess skin afflictions such as dyschromia&#44; dryness&#44; and wrinkles&#46; After uploading an image&#44; the system generates information for the consumer on the quality of their skin&#44; aspects to improve&#44; and personalized recommendations for a skincare regimen&#46; Aspects analyzed include infraorbital lines&#44; elasticity&#44; fine generalized lines and deep wrinkles&#44; lack of luminosity&#44; hyperpigmentation&#44; and pores&#46; However&#44; the main limitations of the system include&#58; 1&#41; bias in the recommendations based on a limited set of products&#59; 2&#41; loss of information in the analysis because lateral images are not processed&#59; 3&#41; lack of the possibility for self follow-up&#59; and 4&#41; lack of information generated by the user&#44; and so personalized recommendations that are not only based on the physical appearance of the user cannot be generated&#46;</p><p id="par0330" class="elsevierStylePara elsevierViewall">Likewise&#44; the free smartphone application denoted <span class="elsevierStyleItalic">Skin360&#174;</span>&#44; developed by Neutrogena<span class="elsevierStyleItalic">&#174;</span>&#44; uses the smartphone camera to assess the skin in search of dark marks&#44; baggy eyes&#44; wrinkles&#44; changes in texture&#44; and expression lines&#46; This assessment provides a&#8217; <span class="elsevierStyleItalic">Skin360</span> score&#44;&#8217; and makes suggestions to the user for skincare products based on these 5 parameters&#46; The patient can also check on improvements with the recommended products over the course of days&#44; weeks&#44; and months&#44; with follow-up assessments using the application&#46; In addition to this score&#44; the application also checks for lifestyle habits that may impact skin health &#40;sleep&#44; exercise&#44; stress&#44; and daily use of the product&#41;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a>&#46;</p><p id="par0335" class="elsevierStylePara elsevierViewall">In a similar vein to the above applications&#44; but led by dermatologists&#44; and with the aim of improving a patient&#8217;s skincare through cosmetic reinforcement and reducing excess discarding of products by the user due to difficulties in selecting an appropriate product&#44; in 2020&#44; Martorell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> developed the first independent application in the cosmetic industry&#44; with the support of the European Commission within the Skiana Health and AI project<span class="elsevierStyleItalic">&#174;</span> &#40;European Grants SME I 2020&#44; Grant no&#46; 885806&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0340" class="elsevierStylePara elsevierViewall">This virtual personal assistant is the first in its generation free of conflict of interest of any pharmaceutical or cosmetic company&#46; It was developed in the cloud and available for Android&#174; in the App Store and Apple&#174; in the Apple App Store under the name <span class="elsevierStyleItalic">Skiana&#174;</span>&#46; The aim&#44; through a combination of a brief intelligent questionnaire and information obtained from a facial analysis generated using AI algorithms&#44; is to improve wellbeing through healthy skin&#46; The main aims are the following&#58; 1&#41; generation of skin cancer prevention campaigns and health education through skin-healthy advice&#59; 2&#41; capture of the end user through generation of objective reports available on their mobile devices that include information on skin health&#8212;these data range from quantification of photoaging&#44; flaccidity&#44; elasticity&#44; and changes in skin texture such as quantification of acne lesions &#40;<a class="elsevierStyleCrossRefs" href="#fig0030">Figs&#46; 6 and 7</a>&#41;&#59; 3&#41; generation of patient expert in skincare&#44; providing personalized information on state of skin and training in cosmetics&#44; including information on cosmetic products&#44; in order to help improve skincare&#59; and 4&#41; positioning the dermatology and venereology specialty as a reference in the field of integral skincare&#46;</p><elsevierMultimedia ident="fig0035"></elsevierMultimedia><p id="par0345" class="elsevierStylePara elsevierViewall">The main pros and cons of the different virtual assistants are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Intelligent devices for developing personalized products</span><p id="par0350" class="elsevierStylePara elsevierViewall">The application of these technologies in the field of robotics&#44; with the development of devices able to produce personalized cosmetic products at home from the information obtained by the applications described above&#44; will be the next step in cosmetics&#44; with companies such as Procter &#38; Gamble&#174; &#40;<span class="elsevierStyleItalic">Opt&#233; Precision Skincare System</span>&#174;&#41;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a> and L&#8217;Or&#233;al&#174; &#40;<span class="elsevierStyleItalic">Perso</span>&#174;&#41;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a> being the pioneers in these types of home devices&#46;</p><p id="par0355" class="elsevierStylePara elsevierViewall">Likewise&#44; the use of these algorithms in professional supports that allow images to be taken with different light parameters such as <span class="elsevierStyleItalic">Visia&#174;</span> &#40;Canfield&#174; Inc&#46;&#41; o <span class="elsevierStyleItalic">Lifeviz&#174; micro</span> &#40;Quantificare&#174; Inc&#46;&#41; will help the cosmetics professionals to improve the skincare of their patients in their clinics<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a>&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Models to predict response by artificial intelligence</span><p id="par0360" class="elsevierStylePara elsevierViewall">The application of the DL model and generation of neural networks will help increase the effectiveness and safety of cosmetic procedures&#46;</p><p id="par0365" class="elsevierStylePara elsevierViewall">Examples along these lines include the application of DL to best define the cosmetic treatment option according to facial wrinkle depth<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">74&#8211;76</span></a>&#46; The potential for DL to predict clinical response to laser therapy has also been evaluated&#46; For example&#44; Cazzaniga et al&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">77</span></a> applied this technology to the prediction of duration of excimer laser treatment for patients with vitiligo&#44; with promising results&#46; With data from their clinical trial&#44; the model achieved an overall precision of 66&#46;46&#37; in predicting the time to repigmentation in responders&#46; Given that treatment can be slow and costly&#44; a predictive model for clinical response and duration of treatment would help both patients and healthcare providers decide whether to continue with treatment&#46; The models of clinical outcome can also be applied to other types of laser and treatment modalities for treating afflictions such as acne scars&#44; dyschromia&#44; and vascular disorders to help establish realistic expectations in interested patients&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Artificial intelligence in skin radiology and ultrasound</span><p id="par0370" class="elsevierStylePara elsevierViewall">Among the radiological imaging techniques&#44; both simple computed tomography &#40;CT&#41; and magnetic resonance &#40;MR&#41; imaging are used essentially in the context of staging or follow-up of melanoma&#46; The advantage of these techniques is that they can be readily standardized&#44; and there are large image databases for training the algorithms&#46;</p><p id="par0375" class="elsevierStylePara elsevierViewall">Techniques based on ionizing radiation&#44; such as CT in dermatology patients&#44; have been used for detecting melanoma metastasis&#46; In a study by Aissa et al&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">78</span></a>&#44; using ML techniques and vessel suppression&#44; algorithms were able to find additional metastases in 54&#46;3&#37; of cases&#46; However&#44; authors concluded that diagnosis of additional metastases would not have affected patient management&#46;</p><p id="par0380" class="elsevierStylePara elsevierViewall">Regarding the use of MR&#44; AI has been applied to the detection and diagnosis of lesions&#46; Kniepp et al&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">79</span></a> reviewed 189 brain metastases&#44; including from melanoma&#44; and using decision tree algorithms in combination with clinical data&#44; they demonstrated greater capacity to differentiate between the metastases of other tumors &#40;squamous cell carcinoma&#44; microcytic lung cancer&#41; than radiologists&#44; with an area under curve of 0&#46;82&#46; This use of radiologic imaging to infer histological diagnosis of lesions has been denoted as <span class="elsevierStyleItalic">radiomics</span>&#44; and is one step beyond image detection or segmentation&#46;</p><p id="par0385" class="elsevierStylePara elsevierViewall">Skin ultrasound is a technique that offers advantages over other imaging techniques as it is harmless&#44; fast&#44; and available at the patient&#8217;s bedside<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">79</span></a>&#46; However&#44; ultrasound has several limitations as source of data for AI&#44; the main ones being the absence of large ultrasound imaging banks suitable for training and validating algorithms and the intrinsic characteristics of ultrasound scans&#44; which means they are not as standardized as is the case with CT and MR images&#46;</p><p id="par0390" class="elsevierStylePara elsevierViewall">Nevertheless&#44; in recent years&#44; the development of AI in ultrasound has started to provide evidence regarding how it could be applied in the 3 main ultrasound issues&#44; and specifically&#44; in the case of skin ultrasound&#58; classification&#44; regression&#44; and segmentation<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">80</span></a>&#46;</p><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Classification</span><p id="par0395" class="elsevierStylePara elsevierViewall">Most classification algorithms have been applied to ultrasound diagnosis of breast or hepatic lesions<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">81&#44;82</span></a>&#46; Although there are numerous publications that have attempted to reduce the key features needed for AI-assisted diagnosis<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">83</span></a>&#44; the number of images available is usually less than 300&#44; and they have been captured in different clinics with different validation protocols&#44; and so the results are not usually comparable<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">84</span></a>&#46;</p><p id="par0400" class="elsevierStylePara elsevierViewall">From the commercial point of view&#44; some algorithms have been developed for assisted diagnosis&#44; mainly using breast and thyroid ultrasound<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">85&#8211;87</span></a>&#46; The algorithm suggests a risk of malignancy of the lesion selected by the ultrasonographer&#44; but it does not indicate a specific diagnosis for the lesion studied&#46; However&#44; these algorithms have not been validated by any regulatory agency&#46;</p><p id="par0405" class="elsevierStylePara elsevierViewall">From the point of view of skin ultrasound&#44; classification algorithms could be useful in AI-assisted diagnosis of skin lesions&#46; In a recent study by Alfageme et al&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">88</span></a>&#44; a DL-based algorithm with predetermined architecture&#44; trained with a bank of 235 ultrasound images of benign and malignant skin lesions&#44; was able to correctly classify the lesions at a similar rate to an expert human evaluator &#40;77&#46;1&#37; versus 74&#46;1&#37;&#41; who was exposed to the same image bank&#46;</p><p id="par0410" class="elsevierStylePara elsevierViewall">In the case of melanocytic lesions&#44; using ultra-high frequency ultrasound devices &#40;70&#8239;MHz probes&#41;&#44; the group led by Romanelli also reported a capacity to differentiate between melanocytic nevus with an accuracy of 76&#46;9&#37; and a sensitivity and specificity for diagnosis of melanoma of 80&#37; and 74&#37;&#44; respectively by applying DL-based algorithms<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">89</span></a>&#46;</p><p id="par0415" class="elsevierStylePara elsevierViewall">With skin ultrasound&#44; it remains to be seen what the optimum characteristics are for appropriate image banks for this application in terms of equipment&#44; resolution&#44; and similarity with inflammatory lesions&#44; which may hinder the applicability of these algorithms in clinical settings&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Regression</span><p id="par0420" class="elsevierStylePara elsevierViewall">Regression involves estimating continuous values instead of discrete classes of data&#46; DL has been applied to regression&#44; for example&#44; for estimating the orientation of muscle fibers from ultrasound images or gestational age&#46;<a class="elsevierStyleCrossRefs" href="#bib0450"><span class="elsevierStyleSup">90&#44;91</span></a> With regards skin ultrasound&#44; regression algorithms could be useful for assessing the duration of skin lesions&#44; automatic determination of ultrasound Breslow depth&#44; or in algorithms applied to the study of skin ageing and its treatment<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">92</span></a>&#46;</p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Segmentation</span><p id="par0425" class="elsevierStylePara elsevierViewall">Segmentation is the ultrasound delimitation of the structural limits of a lesion&#46; Automated ultrasound segmentation is a challenge&#44; as ultrasound images are affected by scintillation&#44; shadows&#44; and absence of limits&#44; as well as frequency compensations&#44; depth&#44; and ultrasound resolution during image acquisition<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">93</span></a>&#46;</p><p id="par0430" class="elsevierStylePara elsevierViewall">Several ultrasound segmentation approaches have been developed&#44; including methods based on intensity thresholds&#44; sets of levels&#44; and active contours<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">94</span></a>&#46; The approaches based on intensity are sensitive to noise and image quality<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">95</span></a>&#46; Active contours and sets of levels require an initialization that may impact the results&#46; Most of the conventional approaches are not totally automated&#46;</p><p id="par0435" class="elsevierStylePara elsevierViewall">ML-based segmentation methods usually involve 2 steps&#58; first&#44; a pixel classification of the target structure&#44; followed by a cleaning or softening step&#44; as pixel classification is noisy from the ultrasound point of view&#46; In recent articles&#44; several classification approaches have been investigated with specific focus on the application of several types of neural networks&#44; including DL<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">96</span></a>&#46;</p><p id="par0440" class="elsevierStylePara elsevierViewall">In skin ultrasound&#44; the segmentation algorithms could be useful for detecting lymph node metastasis or for ultrasound delimitation of skin lesions &#40;<a class="elsevierStyleCrossRef" href="#fig0040">Fig&#46; 8</a>&#41;&#46;</p><elsevierMultimedia ident="fig0040"></elsevierMultimedia></span></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Ethical and regulatory aspects of AI in dermatology</span><p id="par0445" class="elsevierStylePara elsevierViewall">We may not fully realize how unique the situation we are facing is&#44; as never before in human history have we had the capacity to compile such large volumes of data&#46;</p><p id="par0450" class="elsevierStylePara elsevierViewall">The internet of things and big data can feed the AI and ML algorithms&#46; The more complex these algorithms&#44; the greater their predictive power&#44; and so all efforts are focused on correlating a vast number of variables to achieve accurate predictions&#46; The undeniable aim is to achieve Laplace&#8217;s demon&#44; a machine able to predict any scenario in a fully deterministic fashion<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">97</span></a>&#46; For this reason&#44; AI is also being studied within the field of bioethics&#46;</p><p id="par0455" class="elsevierStylePara elsevierViewall">Of note is that the European Parliament&#44; on proposing a Letter on Robotics&#44; started listing bioethical principles as the rules to be followed for robotics engineers&#44; and compiling the ethical principles that should guide AI&#44; which have been denoted &#8220;Asilomar Principles for Artificial Intelligence&#8221;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">98</span></a>&#46;</p><p id="par0460" class="elsevierStylePara elsevierViewall">In any case&#44; the ethical framework for AI in dermatological practice should also reflect the basic principles of medical ethics&#58; autonomy&#44; benefit&#44; absence of harm&#44; and fairness&#46; But in the specific case of AI&#44; this ethical framework should also include specific sections&#44; such as transparency and accountability<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">99</span></a>&#46;</p><p id="par0465" class="elsevierStylePara elsevierViewall">The principle of autonomy refers to the fact that the patient has the right to make his or her own decisions&#46; In medical care&#44; informed consent is the mechanism by which autonomy is ensured&#44; but dermatology images not only include information in the form of pixels but also information on health &#40;at least when the image is linked to a patient&#8217;s medical history&#41;&#44; such as demographic data and institutional information&#46; When these images are used for training AI algorithms&#44; informed consents should be adapted for this purpose&#44; such that these images can continue to be used&#46;</p><p id="par0470" class="elsevierStylePara elsevierViewall">The principles of benefit and absence of harm are 2 sides of the same coin and are obvious in conventional medical care&#44; but certain contradictions may be present in the case of AI&#44; as the algorithms may benefit from stratification with many parameters&#44; improving diagnostic yield and&#44; therefore&#44; improving the patients&#8217; wellbeing&#44; but at the same time&#44; such segmentation could be used for profit&#46;</p><p id="par0475" class="elsevierStylePara elsevierViewall">The principle of fairness requires a fair distribution of medical products and services&#46; The development of AI should encourage equity&#44; removing certain discriminations and preventing certain implicit biases&#44; as will be discussed later&#46;</p><p id="par0480" class="elsevierStylePara elsevierViewall">Finally&#44; the principles of transparency and accountability may be addressed by the principle of explainability&#46; If an AI system fails or causes damage&#44; we should be in a position to determine the underlying reasons and it should be possible to perform an audit of the entire process&#46; This latter point is surely the main ethical limitation of AI&#44; as these systems are considered a type of black box in which it may be possible to understand the logical processes and mathematics behind the algorithm but not the downstream data processing&#44; such that the result is&#44; in reality&#44; unpredictable<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">100</span></a>&#46;</p><p id="par0485" class="elsevierStylePara elsevierViewall">This all ties in with the debate about accountability&#44; when the AI systems automatically trigger diagnostic or therapeutic decisions&#44; we may well ask who is accountable if the system fails<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">101</span></a>&#46; The question can be extrapolated to other fields&#44; and this debate came to the fore in March 2018 with the first fatal accident with a self-driving car in Tempe&#44; Arizona&#44; United States&#46; Was the person who was in the car responsible&#63; Or the car manufacturer&#63; Or the software developer&#63; There is no simple answer&#46; Above all&#44; it is necessary to develop regulations and legislation on the topic to ensure there are no legal grey areas&#46; When AI is applied in medicine&#44; these considerations are even more important<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">102</span></a>&#46;</p><p id="par0490" class="elsevierStylePara elsevierViewall">Another important question is whether algorithms may perpetuate human bias precisely because they work like a black box&#46; When the algorithm is trained with biased data&#44; because underrepresented populations are not included&#44; existing inequalities may be reproduced for further entrenched<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">103</span></a>&#46; If the data acquired by the algorithm are not sufficiently inclusive and balanced&#44; the system could learn to take unfair decisions &#40;this is very obvious in facial recognition systems&#44; which are more reliable with white males than black women&#41;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">104</span></a>&#46;</p><p id="par0495" class="elsevierStylePara elsevierViewall">In dermatology&#44; although there are many AI applications&#44; in the initial phases&#44; the focus has been on diagnosis of pigmented lesions&#44; above all&#44; melanoma&#46; The reality is that&#44; for the time being&#44; most AI and ML programs are learning mainly from images of people with light phototypes&#46; For example&#44; in the International Skin Imaging Collaboration&#58; Melanoma Project&#44; one of the most widely used and with open access code&#44; most of the patients have light phototypes and come from populations in the United States&#44; Europe&#44; and Australia&#46; As a result&#44; the algorithm is not very reliable for lesions on black skin&#46; Paradoxically&#44; melanoma is usually detected in more advanced phases with worse survival rates in Afro-American patients&#46; The algorithm only improves early detection in light skin types&#44; with no benefit for patients with black skin&#44; thus clearly worsening the biases already observed in society<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">104</span></a>&#46; The solution is not easy to implement but it is simple&#58; effort has to be made to train the algorithm in all skin types&#46;</p><p id="par0500" class="elsevierStylePara elsevierViewall">From the regulatory point of view&#44; several organizations have published frameworks for setting up AI applications in the field of medicine&#46; This is all rather complex&#44; starting from the fact that although legislation requires the absence of ambiguity&#44; there is currently no clear definition even for what we mean by the term artificial intelligence&#46;</p><p id="par0505" class="elsevierStylePara elsevierViewall">The second crucial point for the legislators is whether to consider the AI software used in medicine as a medical device &#40;there is a distinction between programs that analyze data to have a deeper knowledge of a disease than those that make diagnostic or therapeutic decisions in individual patients&#41;&#46; On this point&#44; we can differentiate between the European vision and that of the United States<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">105</span></a>&#46;</p><p id="par0510" class="elsevierStylePara elsevierViewall">In Europe the legislation in force is the Regulation on medical devices&#44; which was signed in May 2020 and which replaces Directive 93&#47;42&#47;EEC<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">106</span></a>&#46; As this is a regulation &#40;rather than a directive&#41;&#44; it applies directly to territories in the European Union without the need to be implemented by the different member states&#46; This regulation requires that manufacturers ensure that the devices they produce meet a series of essential requirements that will depend on the potential risks of each and that&#44; at times&#44; will need certification by an independent body&#46;</p><p id="par0515" class="elsevierStylePara elsevierViewall">In the United States&#44; the regulatory body is the US Food and Drug Administration since the end of 2016&#44; when jurisdiction over software used in the health field was transferred to this body by the 21st Century Cures Act<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">107</span></a>&#44; with a more restrictive reading in terms of introduction of unsupervised diagnostic software&#46;</p><p id="par0520" class="elsevierStylePara elsevierViewall">In addition&#44; all these tools that feed off a huge wealth of data have other implications associated with privacy and data protection&#44; as well as cybersecurity&#46; As a result of these potential threats&#44; the European Union decided to update the legislation&#44; and the General Data Protection Regulation has been in force since May 24&#44; 2018&#44; replacing the previous legislation&#46; The new legislation requires user consent&#44; and the user should be aware of the purposes&#44; with marketing of these data by third parties being explicitly excluded<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">108</span></a>&#46; In the United States&#44; computer-related security in the healthcare field is covered by the <span class="elsevierStyleItalic">Health Insurance Portability and Accountability Act</span>&#46;</p><p id="par0525" class="elsevierStylePara elsevierViewall">In 2018&#44; the European Commission established the <span class="elsevierStyleItalic">High Level Experts Group on Artificial Intelligence</span>&#44; with the aim of supporting the implementation of the European strategy for AI&#44; including drawing up recommendations for future development of norms that regulate ethical&#44; legal&#44; and social aspects of AI&#46;</p><p id="par0530" class="elsevierStylePara elsevierViewall">According to these fundamental rights and ethical principles&#44; these guidelines have 7 key requirements that any AI system should meet to be reliable&#58; 1&#41; It should not impact human autonomy&#59; 2&#41; it should be technically sound and safe&#59; 3&#41; privacy and data management should be respected&#59; 4&#41; it should be transparent&#59; 5&#41; it should be diverse&#44; with no discrimination or inequality&#59; 6&#41; it should respect the environment&#59; and 7&#41; there must be accountability<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">109</span></a>&#46;</p><p id="par0535" class="elsevierStylePara elsevierViewall">AI will play an important part in the coming years in our specialty&#44; and we need to be guided by ethical principles&#44; such as the principles of benefit and respect towards our patients&#46; We should remember that a dermatologist is not a simple interpreter of images&#44; and that our functions also include many other aspects that cannot be performed by machines&#46;</p></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conclusions</span><p id="par0540" class="elsevierStylePara elsevierViewall">We are living and will live a full-blown AI revolution in dermatology&#44; with a range of systems of differing focus and undoubted potential&#46;</p><p id="par0545" class="elsevierStylePara elsevierViewall">A recent literature review claims that neural-network based AI systems &#40;whether in their deep or convolutional modalities&#41; have a greater capacity for recognition than dermatologists<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">110</span></a>&#46; While this affirmation is open to debate and requires context&#44; it is nevertheless true that AI systems are progressively improving&#46;</p><p id="par0550" class="elsevierStylePara elsevierViewall">On the one hand&#44; conventional automated image analysis systems have been easily surpassed by neural network systems used in the past 10 years<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">111</span></a>&#46;</p><p id="par0555" class="elsevierStylePara elsevierViewall">On the other&#44; the systems are now capable of processing a huge additional amount of information to achieve a reasoning analogous to that of a dermatologist &#40;for example&#44; comparing with other pigmented lesions of the patient to avoid false suspected diagnoses in the context of a predominance of atypical nevi&#41;<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">112</span></a>&#46;</p><p id="par0560" class="elsevierStylePara elsevierViewall">After analyzing the opinion of different authors&#44; we believe that progress in these technologies needs to be progressive&#44; safe&#44; and based on the generosity of the dermatology community&#44; as publicly available databases with images and broad clinical information are essential to improve the reliability of these systems<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">113</span></a>&#46; These systems could undoubtedly be a support for other physicians if no dermatologist is available and cannot be reached on short notice&#46; Nevertheless&#44; we believe that the future will not see AI systems replacing dermatologists&#44; but rather they represent an opportunity for improving clinical practice thanks to the many advantages that these systems may offer&#46;</p><p id="par0565" class="elsevierStylePara elsevierViewall">In short&#44; the optimal situation would be a symbiosis between AI and dermatologists to improve decision-making for our patients&#44; conscious that the ideal is a combination of human intelligence with AI<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">114</span></a>&#44; maintaining a fluid relationship between physician and patient<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a>&#46; It is therefore essential to change the current tendency&#59; dermatology specialists should take the initiative in the development and orientation of the AI products focused on covering unmet needs in current medical practice&#46;</p></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflicts of interest</span><p id="par0570" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p><p id="par0575" class="elsevierStylePara elsevierViewall">Dr&#46; Antonio Martorell has received fees for participation in advisory boards and satellite symposia with the following companies&#58; AbbVie&#44; Amgen&#44; Janssen&#44; UCB&#44; Lilly&#44; Novartis&#44; LEO Pharma&#44; Sandoz&#44; and MSD&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The worldwide explosion of interest in artificial intelligence &#40;AI&#41; has created a before-and-after moment in our lives by generating great improvements in such sectors as the automotive and food production industries&#46; AI has even been called the fourth industrial revolution&#46; Machine learning through AI is helping to improve professional processes and promises to transform the health care sector as we know it in various ways&#58; 1&#41; through applications able to promote health in the general population by providing high-quality information and offering advice for different segments of the population based on prediction models&#59; 2&#41; by developing prediction models based on anonymized clinical data&#44; for preventive purposes in primary care&#59; 3&#41; by analyzing images to provide additional decision-making support for health care providers&#44; for improving specialist care at the secondary level&#59; and 4&#41; through robotics applied to processes that promote health and well-being&#46; However&#44; the medical profession harbors doubts about whether this revolution is a threat or an opportunity owing to a lack of understanding of AI technology and the methods used to validate its applications&#46; This article outlines basic aspects of AI as it is applied in dermatology and reviews the main advances achieved in the last 5 years&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">La irrupci&#243;n de la inteligencia artificial &#40;IA&#41; a nivel mundial ha supuesto un antes y un despu&#233;s en nuestras vidas&#44; generando grandes mejoras en diferentes sectores&#44; como el de la automoci&#243;n y el agroalimentario&#44; entre otros&#44; lo que ha llevado a denominarla la cuarta revoluci&#243;n industrial&#46; La AI&#44; capaz de aprender de forma automatizada y de ayudar al profesional a mejorar sus procesos&#44; promete cambiar el &#225;mbito sanitario tal y como lo conocemos mediante&#58; 1&#41; aplicaciones capaces de generar salud en la poblaci&#243;n general a partir del uso de informaci&#243;n de calidad y de segmentaci&#243;n de consejos basados en modelos de predicci&#243;n&#59; 2&#41; modelos capaces de generar algoritmos de predicci&#243;n a partir de datos anonimizados procedentes de informaci&#243;n cl&#237;nica&#44; a fin de mejorar la prevenci&#243;n primaria&#59; 3&#41; sistemas de an&#225;lisis de imagen capaces de dar a los profesionales de la salud un soporte extra en la toma de decisiones&#44; mejorando la prevenci&#243;n secundaria&#59; y 4&#41; aplicaci&#243;n de rob&#243;tica combinada en la mejora de procesos ligados al &#225;mbito de salud y bienestar&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Sin embargo&#44; la falta de conocimiento tanto en este tipo de tecnolog&#237;a&#44; como en los t&#233;rminos y la metodolog&#237;a de validaci&#243;n de la misma&#44; hace que la clase m&#233;dica dude en si esta revoluci&#243;n supone una amenaza o una oportunidad para la profesi&#243;n&#46; En el presente art&#237;culo de revisi&#243;n pretendemos introducir una serie de aspectos b&#225;sicos de la IA aplicada a la dermatolog&#237;a&#44; as&#237; como los principales avances sucedidos en este campo en los &#250;ltimos 5 a&#241;os&#46;</p></span>"
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                  \t\t\t\t">Narrow or weak&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Learning methodology focused on a single task&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Most of the AI health algorithms are developed with narrow AI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Automated diagnostic models for pneumonia from chest X-ray&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">General&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Model with AI function comparable to human abilities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Currently focused on managing uncertainty&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Predictive health models&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Super AI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Future field in which AI exceeds human ability in all fields&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">This is the AI shown in many superproductions as true AI&#44; but currently&#44; this is merely science fiction in current society&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AI oriented films&#58; <span class="elsevierStyleItalic">Terminator</span>&#44; <span class="elsevierStyleItalic">I Robot</span>&#44; etc&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Subtypes of artificial intelligence &#40;IA&#41;&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PROVEN&#174;Beauty&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vichy&#174; Skin Consult AI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Neutrogena Skin 360&#174;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Skiana&#174;Care&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intelligent questionnaire&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intelligent facial analysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Validation clinical studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">APP version available for smartphone&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Need for specific device for analysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Contact allergy screening algorithm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Independent development of cosmetic industry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes &#40;SKIANA project &#40;Grant agreement no&#46; 885806 &#91;SME Instrument&#93;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                      "doi" => "10.1016/j.annpat.2019.01.004"
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Review
Artificial intelligence in dermatology: A threat or an opportunity?
Inteligencia artificial en dermatología: ¿amenaza u oportunidad?
A. Martorella,
Corresponding author
martorelldermatologia@gmail.com

Corresponding author.
, A. Martin-Gorgojob, E. Ríos-Viñuelac, J.M. Rueda-Carneroa, F. Alfagemed, R. Tabernere
a Servicio de Dermatología, Hospital de Manises, Manises, Valencia, Spain
b Servicio de ITS/Dermatología, Sección de Especialidades Médicas, Ayuntamiento de Madrid, Madrid, Spain
c Servicio de Dermatologia, Fundación Instituto Valenciano de Oncología, Valencia, Spain
d Servicio de Dermatología, Hospital Puerta de Hierro, Madrid, Spain
e Departamento de Dermatología, Hospital Universitari Son Llàtzer, Palma de Mallorca, Spain
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Model of artificial intelligence for defining lesions in dermatopathology&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">As Marie Curie said&#44; &#8220;Nothing in life is to be feared&#44; it is only to be understood&#46; Now is the time to understand more&#44; so that we may fear less&#46;&#8221; Often&#44; when we are faced with an unknown quantity&#44; this can take on a mysterious dimension due to a lack of understanding&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In this article&#44; we aim to introduce a series of basic concepts about artificial intelligence &#40;AI&#41; applied to dermatology&#44; and we will present a range of examples of how AI can be applied in our specialty&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Our aim is to encourage all dermatologists to deepen their understanding of this new subspecialty&#46; By learning about AI in dermatology&#44; we will be better placed to lead its development&#44; which currently is in hands of engineers who minimize the importance of correct medical diagnosis or whose focus is inappropriate&#44; thereby limiting the true value of this innovation&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The present article was written by physicians specialized in medical-surgical dermatology and venereology who have direct and indirect experience in this new field of health&#46; We will draw on this experience to highlight the most relevant aspects of IA and thus illustrate what impact AI might have on the future of dermatology&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Basic notions of artificial intelligence</span><p id="par0025" class="elsevierStylePara elsevierViewall">Medical presentations&#44; podcasts&#44; and interviews about AI will often use terms such as machine learning and neural networks&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In its essence&#44; AI is a technology developed to imitate cognitive functions of human beings<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; There are 3 basic types of AI&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The term <span class="elsevierStyleItalic">big data</span> refers to data or combinations of datasets whose size &#40;volume&#41;&#44; complexity &#40;variability&#41;&#44; and rate of growth hinder acquisition&#44; management&#44; processing&#44; or analysis by conventional means such as personal computers&#44; relational databases&#44; and conventional statistics &#40;for example&#44; SPSS&#174; software&#41;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; This type of analysis enables enormous quantities of data to be managed and generation of predictive models which are useful in clinical practice&#46; An example would be predicting the profile of a patient who may be more susceptible to developing an infectious process in the surgical area with a view to taking preventive measures&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Machine learning &#40;ML&#41; is a type of AI that enables computers to learn from data&#44; without being explicitly programmed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; This technology&#44; which lies at the heart of AI and management of big data&#44; has aroused great interest in recent years&#46; In this article&#44; we will focus on ML&#44; as this is the most widely used modality in dermatology&#44; along with deep learning<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Machine learning and deep learning</span><p id="par0045" class="elsevierStylePara elsevierViewall">One of the branches of AI with greatest potential for application in medicine is ML&#44; which consists of independent analysis of data thanks to the generation of algorithms for decision making<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a>&#46; This technology enables the identification of patterns to classify and make different predictions&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">ML works by feeding an algorithm with input data comprising past observations and constructs a model for predicting and classifying new observations unknown to the algorithm by imitating a human cognitive process &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Among the most popular ML models in the health sector are convolutional neural networks &#40;CNNs&#41;&#44; which imitate brain neuron function&#46; CNNs are formed of variable layers interconnected by weights that the algorithm calculates and adjusts through iterations &#40;repetitions&#41; in a process known as <span class="elsevierStyleItalic">gradient descent</span>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In dermatology&#44; we usually use multiple variables&#44; and so multiple neurons are needed to weave a network of connections that generate useful information&#46; When we talk of a system that bases its information on more than one layer of information&#44; we refer to deep learning &#40;DL&#41;&#46; Such networks generate excellent results provided that 2 fundamental requirements are met&#58; data &#40;both images and clinical information&#41; are available in sufficient quantity and quality &#40;big data&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Learning models for artificial intelligence</span><p id="par0065" class="elsevierStylePara elsevierViewall">AI &#40;ML&#44; DL&#41; can essentially be trained in 3 modes&#58; supervised&#44; unsupervised&#44; and by reinforcement&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In the supervised model of learning&#44; the AI algorithm is trained with a set of examples labelled by an expert in which the output results are known&#46; This is the model that we usually find in dermatological applications&#44; whose training content are images labelled with their diagnosis or selected training parameter<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a>&#46; By way of example of this supervised learning model in the field of dermatopathology&#44; in the first phase&#44; the machine is <span class="elsevierStyleItalic">taught</span> to recognize features and specific patterns&#44; and regions of interest&#44; validated in this case by a dermatopathologist &#40;for example&#44; features and patterns associated with benign melanocytic lesions and malignant ones &#91;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#93;&#41;&#46; These features and basal patterns constitute what is known as the ground truth&#46; In the second phase&#44; thanks to DL algorithms&#44; the machine is able to recognize patterns and regions of interest in lesions not previously analyzed&#44; and diagnose a lesion as a benign or malignant lesion based on these algorithms<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">The unsupervised model is based on unlabeled data in which the output structure and results are not known a priori&#46; Basically&#44; such algorithms search for grouping patterns &#40;clusters&#41; for subjects that&#44; in view of their characteristics in the different variables that define them&#44; show similarities<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46; There are few applications of this type of AI in dermatology&#44; given that in most cases algorithms are applied to images&#46; This type of model is usually used in situations in which predictions are required or in the case of needing rapid classifications for data mining<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46; An example of unsupervised learning would be the generation of classifiers for &#8216;melanoma versus nonmelanoma&#8217; by training a model that groups&#47;classifies images through patterns detected by the algorithm itself<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Artificial intelligence applied to inflammatory diseases</span><p id="par0080" class="elsevierStylePara elsevierViewall">DL algorithms have been used to classify different inflammatory skin diseases&#46; We will present some of the most relevant ones below&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Psoriasis</span><p id="par0085" class="elsevierStylePara elsevierViewall">AI-based algorithms can be useful both for making a more precise clinical assessment and for supporting the development of personalized therapeutic protocols and predictions of results<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The first IA program designed for psoriasis was that created by Guo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> in 2014&#46; Their objective was to predict the development of psoriasis by microarray gene expression profiling of 2 sets of data&#46; The binary classification achieved an overall precision of 99&#46;81&#37;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Several attempts have been made to develop an AI program that could help to assess the severity of poriasis<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;13</span></a>&#46; In the most recent models&#44; the authors used 3 different standard classifiers&#8212;support vector machines&#44; decision trees&#44; and artificial neural networks&#8212;to stratify risk and assess 3 principal attributes&#58; color&#44; texture&#44; and higher order spectra&#46; The classifier was trained with 670 psoriasis images&#46; The classifiers segmented the lesions and classified them as healthy or diseased&#46; The model achieved a precision of 99&#46;84&#37;&#44; a sensitivity of 99&#46;76&#37;&#44; and a specificity of 99&#46;99&#37;&#46; Given that the sample size was small&#44; the result could be affected by overfitting&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Other studies aimed to develop a system to stratify psoriasis severity using the Psoriasis Area and Severity Index &#40;PASI&#41;&#44; assessing the affected area<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a>&#44; scaling<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#44; induration and color<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#44; and isolated erythema<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">New studies have managed to improve the automatic detection of psoriasis lesions through use of cluster-based segmentation along with swarm intelligence techniques<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Recently&#44; and following one of the previous models&#44; the results were presented for the IMAPSORS project&#44; included within the SKIANA project&#174;&#46; Development was cofinanced by the European Commission&#46; The aim was to generate quantifiable information on the skin of patients with psoriasis using personal mobile devices&#46; The results obtained in the capacity for detecting psoriasis and in automated definition of disease severity in the form of PASI and body surface area&#44; both quantitatively and qualitatively&#44; open the door to an improvement in the definition of severity and early detection of moderate and severe forms of the disease &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>A and B&#41;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">AI programs have also been developed to assess and optimize treatment of psoriasis&#44; specifically&#44; for determining long-term response to biologic treatment&#46; The first of these studies was based on 2&#8239;ML models that studied gene expression in skin biopsies<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&#46; These models were able to predict PASI<span class="elsevierStyleInf">75</span> response after 12 weeks of treatment by assessing the early &#40;2&#8211;4 weeks&#41; expression profiling of treatment&#46; Another study undertook multiomic analysis in patients receiving etanercept&#44; and found indicators of response to treatment in gene expression and pathways associated with tumor necrosis factor and major histocompatibility complex signalling<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Although studies of gene expression profiling in biopsy samples are promising&#44; there is interest in methods that avoid the invasive nature of this technique&#46; Thus&#44; a predictive model has been developed using biochemical markers in blood<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&#46; However&#44; simpler PASI-based models were better predictors and so further study is necessary&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Another recent study used ML to predict response of patients with psoriasis to biologic treatment using basic health parameters such as age of onset of psoriasis and weight of the patient<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">AI models can also be used to discover potential off-label treatments for psoriasis and other inflammatory conditions through models that use text from scientific articles and disease classifications to identify potential drugs<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">AI programs have also been used to study comorbidities in psoriasis&#46; One of these programs identified predictors of coronary artery disease in patients with psoriasis&#59; these predictors included obesity&#44; dyslipidemia&#44; and inflammation<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a>&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Another comorbidity that affects approximately 25&#37; of patients with psoriasis is psoriatic arthritis&#46; To date&#44; there is no effective method for predicting the development of this condition&#46; An AI program has been developed based on genotypes of patients with psoriasis and psoriatic arthritis&#44; differentiating between the 2 diseases based on 200 genetic markers&#44; with an area under curve &#40;AUC&#41; of 0&#46;82&#46; This was the first study to show robust prediction of the development of psoriatic arthritis using only genetic information<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a>&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Atopic dermatitis</span><p id="par0145" class="elsevierStylePara elsevierViewall">The use of AI in atopic dermatitis can be of help both in the diagnosis and personalized treatment of the condition as well as in predicting treatment outcomes&#46; It could also be useful for helping to standardize and reduce the time taken to assess patients&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Investigation of AI in the field of atopic dermatitis is&#44; however&#44; still in its infancy&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">An ML algorithm has been designed to identify atopic dermatitis based on electronic health records<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#46; For this&#44; a natural language processor has been developed to incorporate both structured and unstructured data&#46; Using 562 electronic health records&#44; the designers achieved a positive predictive value of 84&#37; and a sensitivity of 75&#37;&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Other groups developed an artificial neural network to distinguish skin with atopic dermatitis involvement from healthy skin using imaging information<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a>&#46; However&#44; the number of samples used was low&#44; given that this was an exploratory study&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Onychomycosis</span><p id="par0165" class="elsevierStylePara elsevierViewall">A recent study compared a group of dermatologists with CNNs for the detection of onychomycosis<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a>&#46; A total of 49&#44;567 images were used to train the classifier to distinguish between nails with onychomycosis and normal nails&#46; In the validation&#44; the classifier achieved a sensitivity of 82&#46;7&#37;&#8211;96&#46;7&#37; and a specificity of 69&#46;3&#37;&#8211;96&#46;7&#37;&#46; The area under the receiver operator characteristics &#40;ROC&#41; curve was 0&#46;82&#8211;0&#46;98&#46; In this study&#44; the capacity of the classifier to differentiate healthy nails from those with onychomycosis was statistically superior to that of dermatologists&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Rosacea and acne</span><p id="par0170" class="elsevierStylePara elsevierViewall">Clinical evaluation of patients with rosacea&#44; as with other inflammatory diseases&#44; often shows high intra- and interobserver variability&#46; In this context&#44; Binol et al&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> developed an AI program based on CNNs to perform a quantitative and reproducible assessment of lesions&#44; after training with more than a million images&#46; These authors also defined what they called regions of anatomic interest&#44; that is&#44; facial areas highly susceptible to rosacea&#44; thereby significantly reducing false positives in identification of rosacea lesions&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Similarly&#44; digital processing of images has been used for automatic detection of acne lesions&#44; with the aim of performing a more precise and reproducible evaluation&#46; Min et al&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> developed a system that automatically counted 5 types of lesions &#40;papules&#44; nodules&#44; pustules&#44; closed comedones&#44; and open comedones&#41; and compared the results with the manual count performed by a dermatologist&#46; The lesions assessed in 25 patients found a sensitivity and specificity greater than 70&#37;&#46; Other studies have used segmentation of acne lesions&#44; breaking down the image into several homogeneous regions based on the similarity of their color<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a>&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Given that the severity of acne is the main determinant in the choice of treatment&#44; these evaluation methods based on image processing could help improve therapeutic decision-making&#46; Likewise&#44; their development could suppose a marked potential time saving for the clinician&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">In 2019&#44; Seit&#233; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> developed an AI-based smartphone application that graded and classified acne lesions &#40;comedonal&#44; inflammatory&#44; postinflammatory hyperpigmentation&#44; etc&#46;&#41;&#46; Apart from the advantages in terms of evaluation of lesions&#44; it was postulated that the use of these applications linked to geolocation could also help assess the impact of external trigger factors such as climate and pollution on the duration and severity of acne&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">In 2020&#44; Martorell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> developed an AI model for detecting acne lesions in the facial region through a smartphone application <span class="elsevierStyleItalic">SkianaCare</span>&#174;&#44; which calculates the severity for determining whether systemic treatment should complement other treatment&#44; where severity was defined by a cutoff on the global evaluation of acne &#40;GEA&#41; scale &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>A and B&#41;&#46; Thus&#44; in a series of 101 patients&#44; a precision of 97&#46;8&#37; was found in the capacity for definition of degree of severity&#46; In turn&#44; correlation between clinical manifestations and images established the need for systemic treatment&#44; mainly in the form of an oral retinoid&#44; with GEA scores greater than 3 in the facial region&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Other inflammatory diseases</span><p id="par0195" class="elsevierStylePara elsevierViewall">Other AI programs have been designed for diagnosis of different inflammatory skin diseases&#44; such as lichen planus&#44; lichenoid pityriasis&#44; and dermatomyositis from digital images<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">36&#8211;39</span></a>&#46; Huang et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> developed a classifier of multiple diseases &#40;based on assessment of 34 attributes such as erythema&#44; scaling&#44; border definition and irregularity&#41; able to differentiate between several skin diseases such as psoriasis&#44; lichen planus&#44; and seborrheic dermatitis&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">For the study of dermatomyositis&#44; in addition to assessment of skin images&#44; ultrasound images of muscle have been used to differentiate between normal muscle&#44; dermatomyositis&#44; polymyositis&#44; and inclusion-body myositis<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a>&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Application of artificial intelligence in skin cancers</span><p id="par0205" class="elsevierStylePara elsevierViewall">In the field of skin cancer&#44; of note have been some publications that cover the potential of the new&#8212;at the time&#8212;information systems&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">The first publication&#44; from 1986&#44; talked of how computers could automate diagnosis of facial tumors and issuing of recommendations<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a>&#46; Another from 1992 highlighted the use of computer imaging analyses to aid diagnoses made by professionals with less experience in the field of melanoma<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a>&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Since then&#44; and more notably in the past decade&#44; there has been an exponential increase in publications on AI to support care of patients with skin cancer&#46; This increase can be defined in 2 stages that&#44; although not perfectly differentiated&#44; give an approximate description of the development of the application of AI in skin cancer&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">In the first stage&#44; which draws on previous years&#44; there is an emphasis on theory and multiple practical attempts were made&#46; In this stage&#44; we could say that the systems based on the use of AI were honed&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">There were publications on the reliability and feasibility of the use of conventional digital macrophotographs to allow the system to distinguish between melanocytic and nonmelanocytic lesions<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a>&#46; It was also observed that the combination of clinical information and imaging helped with diagnosis of basal cell carcinoma<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a>&#46; Many other publications of the same nature highlight that through a combination of different information sources &#40;exhaustive medical history&#44; images obtained from different systems&#8230;&#41;&#44; greater precision was obtained in automated diagnosis&#46; It was even possible to see how AI could be used to determine surgical margins in intraoperative biopsies<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a>&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Automated prognostic models can also be included in this stage&#46; An example would be computational algorithms that enable prediction of metastatic progression of cutaneous melanoma based on gene expression and microRNA data<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a>&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">A second more recent stage has seen AI systems used in &#40;and outside&#41; the clinic with different functions&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">One of the most widely disseminated publications&#44; from 2017&#44; proposed using DL algorithms for classification of tumor lesions<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a>&#46; Specifically&#44; the authors compared the degree of diagnostic concordance between the automated system and a group of specialist dermatologists when distinguishing seborrheic keratosis from keratinocyte carcinomas and benign nevi from melanoma&#44; with promising results for use in support of diagnosis&#46; These algorithms could become a tool to extend the reach of dermatologists outside the clinic&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">The use of algorithms has been proposed for automated image analysis to support therapeutic decisions &#40;excision versus observation&#41; in the management of pigmented lesions<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a>&#44; or to give initial guidance to the dermatologist who subsequently would make the decision according to clinical context<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a>&#46; Of particular interest is the use of images obtained by free smartphone applications&#59; with these some authors have proposed algorithms for detecting changes in pigmented lesions that could predict progression to melanoma<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a>&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">With particular interest in pigmented and melanoma lesions&#44; one of the most prolific groups was that led by the dermatologists in Heidelberg&#44; Germany&#46; In their research&#44; they primarily use CNN-based systems&#46; In the first articles&#44; by Haenssle&#44; preliminary results superior to dermatologists were obtained for recognition of melanoma by dermoscopy in experimental conditions<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46; The group lead by Brinker has continued to highlight the excellent performance of CNN-based systems for differentiating melanomas from melanocytic nevi by dermoscopy<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">50&#44;51</span></a>&#44; combining clinical and dermoscopic images<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a>&#44; or with histopathologic images<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a>&#46; In conditions of use closer to clinical practice&#44; and including diagnosis of other types of tumor &#40;not just melanoma&#41;&#44; they have achieved results similar to those of dermatologists<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a>&#46;</p><p id="par0255" class="elsevierStylePara elsevierViewall">Other groups have achieved good results in the identification of melanomas from dermoscopic images using DL-based systems<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a>&#44; or acral melanomas using CNN-based systems<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a>&#46;</p><p id="par0260" class="elsevierStylePara elsevierViewall">These systems and approximations can be used in exploring data to generate models predictive of response to immunotherapy in cases of metastatic melanoma<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a>&#46; Some investigators are even using gene expression profiling and microRNA analyses with ML algorithms for molecular distinction between melanocytic nevi and melanoma<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a>&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">In the case of nonmelanoma skin cancer&#44; use of AI-based systems appears at present to be supported by less robust evidence<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a>&#46; In any case&#44; CNN-based systems have been successfully used in the automated detection of facial keratinocyte cancers<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> and actinic keratosis<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> from clinical photographs&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Artificial intelligence in dermatopathology</span><p id="par0270" class="elsevierStylePara elsevierViewall">Histologic diagnosis of skin lesions has a substantial subjective&#44; observer-dependent component&#46; Specially&#44; relatively nonspecific inflammatory lesions&#44; poorly differentiated skin tumors&#44; or diseases with a wide spectrum of presentations that include benign lesions through malignant ones&#44; including borderline cases&#44; can generate substantial diagnostic uncertainty&#44; with differences of opinion even among expert dermatopathologists&#46; Perhaps one of the best examples is histological diagnosis of melanocytic lesions&#58; the difference between dysplastic nevus and in situ melanoma is subtle&#44; and experienced dermatopathologists may sometimes reach different diagnoses for the same lesion<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a>&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">In dermatopathology&#44; the use of AI as a diagnostic tool started at the end of the past century&#44; with the TEGUMENT project &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a>&#46; However&#44; it is only more recently that several studies have started to support &#40;in very preliminary fashion&#41; its potential practical use as an aid for histologic diagnosis&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">AI has shown a high precision in performing several essential functions of histologic diagnosis&#44; such as mitosis count and assessment of positivity in immunohistochemical tests<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a>&#46; On the other hand&#44; DL algorithms showed a precision of almost 100&#37; in binary classification of tumor lesions&#44; and almost 80&#37; for classification of these same lesions in 4 categories &#40;basaloid&#44; squamous&#44; melanocytic&#44; and others&#41;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a>&#46;</p><p id="par0285" class="elsevierStylePara elsevierViewall">With regards the differential diagnosis between nevi and melanoma&#44; CNN-based methods have been assessed in different studies<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">63&#44;64</span></a>&#46; In 2019&#44; Hekler et al&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a> showed overall discordance of 19&#37; between a CNN-based system and an expert dermatopathologist&#44; with this percentage being similar to that between expert dermatopathologists&#46; Also in 2019&#44; Hart et al&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> reported a precision of approximately 90&#37; for binary classification of Spitz nevus and conventional nevus&#46; More recently&#44; in 2021&#44; CNN-based techniques showed a sensitivity&#44; specificity&#44; and precision approaching that of 18 expert dermatologists when assessing 50 melanocytic lesions to discriminate between nevi and melanomas<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a>&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">One of the main limitations in the use of CNN-based systems in dermatopathology is their limited classification system&#58; whereas trained dermatopathologists are able to recognize several morphologic variants and perform broad differential diagnoses&#44; current CNN-based models mainly use binary classification systems &#40;they indicate whether an image is positive or not for a diagnosis&#41; and lose precision when more categories are introduced<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a>&#46; In fact&#44; there are hardly any studies in dermatopathology of nontumor lesions&#44; where differential diagnosis is&#44; in many cases&#44; broader and more subjective&#46; Furthermore&#44; given the ground truth in the learning phase of these systems is established by one or several dermatopathologists&#44; and given that many entities lack diagnostic criteria with absolute precision&#44; this fundamental or ground truth is not completely free of subjectivity<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">Therefore&#44; although preliminary results are promising&#44; it is necessary to extend them &#40;to beyond binary systems&#41; and AI systems need to be validated before they can be used in dermatological clinical practice&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">Probably&#44; these systems could be used in the future for automating reproducible tasks&#44; such as screening&#44; making them a diagnostic aid to improve not only the daily work of the dermatopathologist&#44; but also an important tool in research and even education&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Artificial intelligence applied to cosmetics</span><p id="par0305" class="elsevierStylePara elsevierViewall">The field of cosmetic dermatology has been one of the sectors in which multiple models have been developed based on innovative solutions&#46; Currently&#44; on the market&#44; models include virtual planning for cosmetic treatment with neuromodulators and treatment with cosmetic fillers&#44; as well as use of robotics in automation of different laser treatments<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">67</span></a>&#46;</p><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Home use assistants</span><p id="par0310" class="elsevierStylePara elsevierViewall">The application of new technologies has generated multiple strategies whose end objective is to empower patients through information and generation of personalized content&#44; with the aim of facilitating decisions on skin and hair care&#46;</p><p id="par0315" class="elsevierStylePara elsevierViewall">Many companies have created intelligent questionnaires about skin and hair care that include questions about patient demographics&#44; skin and hair characteristics&#44; and desired esthetic outcomes to generate personalized recommendations&#46;</p><p id="par0320" class="elsevierStylePara elsevierViewall">Along these lines&#44; the startup known as <span class="elsevierStyleItalic">PROVEN Beauty</span>&#174;&#44; based in California&#44; used ML to offer personalized cosmetic products to consumers for skin care&#46; The algorithm uses information from a large skincare database called <span class="elsevierStyleItalic">Beauty Genome Project</span>&#44; which includes more than 8 million client opinions&#44; more than 100&#44;000 products for skincare products currently on the market&#44; 20&#44;000 ingredients&#44; and more than 4000 peer-reviewed scientific articles on skin and skincare ingredients<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">68</span></a>&#46;</p><p id="par0325" class="elsevierStylePara elsevierViewall">Augmented reality is another technology that enables personalization of routines for skin and hair care&#46; In these cases&#44; it goes one step further than questionnaire-based models by incorporating patient images in the decision-making process&#46; The company L&#39;Oreal&#174; offers 2 online web-based applications of augmented reality that are free for users&#46; The first application offers online skin analysis through the Vichy&#174; <span class="elsevierStyleItalic">Skin Consult AI&#174;</span> website&#46; This application generates a skincare and antiaging simulation with the capacity to detect&#44; quantify&#44; and predict changes in the skin<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">69</span></a>&#46; This &#8216;virtual mirror&#8217; applies computerized vision technology to simulate the result that could be obtained with beauty and cosmetic products&#46; The project was developed with the support of dermatologists to assess skin afflictions such as dyschromia&#44; dryness&#44; and wrinkles&#46; After uploading an image&#44; the system generates information for the consumer on the quality of their skin&#44; aspects to improve&#44; and personalized recommendations for a skincare regimen&#46; Aspects analyzed include infraorbital lines&#44; elasticity&#44; fine generalized lines and deep wrinkles&#44; lack of luminosity&#44; hyperpigmentation&#44; and pores&#46; However&#44; the main limitations of the system include&#58; 1&#41; bias in the recommendations based on a limited set of products&#59; 2&#41; loss of information in the analysis because lateral images are not processed&#59; 3&#41; lack of the possibility for self follow-up&#59; and 4&#41; lack of information generated by the user&#44; and so personalized recommendations that are not only based on the physical appearance of the user cannot be generated&#46;</p><p id="par0330" class="elsevierStylePara elsevierViewall">Likewise&#44; the free smartphone application denoted <span class="elsevierStyleItalic">Skin360&#174;</span>&#44; developed by Neutrogena<span class="elsevierStyleItalic">&#174;</span>&#44; uses the smartphone camera to assess the skin in search of dark marks&#44; baggy eyes&#44; wrinkles&#44; changes in texture&#44; and expression lines&#46; This assessment provides a&#8217; <span class="elsevierStyleItalic">Skin360</span> score&#44;&#8217; and makes suggestions to the user for skincare products based on these 5 parameters&#46; The patient can also check on improvements with the recommended products over the course of days&#44; weeks&#44; and months&#44; with follow-up assessments using the application&#46; In addition to this score&#44; the application also checks for lifestyle habits that may impact skin health &#40;sleep&#44; exercise&#44; stress&#44; and daily use of the product&#41;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a>&#46;</p><p id="par0335" class="elsevierStylePara elsevierViewall">In a similar vein to the above applications&#44; but led by dermatologists&#44; and with the aim of improving a patient&#8217;s skincare through cosmetic reinforcement and reducing excess discarding of products by the user due to difficulties in selecting an appropriate product&#44; in 2020&#44; Martorell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> developed the first independent application in the cosmetic industry&#44; with the support of the European Commission within the Skiana Health and AI project<span class="elsevierStyleItalic">&#174;</span> &#40;European Grants SME I 2020&#44; Grant no&#46; 885806&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0340" class="elsevierStylePara elsevierViewall">This virtual personal assistant is the first in its generation free of conflict of interest of any pharmaceutical or cosmetic company&#46; It was developed in the cloud and available for Android&#174; in the App Store and Apple&#174; in the Apple App Store under the name <span class="elsevierStyleItalic">Skiana&#174;</span>&#46; The aim&#44; through a combination of a brief intelligent questionnaire and information obtained from a facial analysis generated using AI algorithms&#44; is to improve wellbeing through healthy skin&#46; The main aims are the following&#58; 1&#41; generation of skin cancer prevention campaigns and health education through skin-healthy advice&#59; 2&#41; capture of the end user through generation of objective reports available on their mobile devices that include information on skin health&#8212;these data range from quantification of photoaging&#44; flaccidity&#44; elasticity&#44; and changes in skin texture such as quantification of acne lesions &#40;<a class="elsevierStyleCrossRefs" href="#fig0030">Figs&#46; 6 and 7</a>&#41;&#59; 3&#41; generation of patient expert in skincare&#44; providing personalized information on state of skin and training in cosmetics&#44; including information on cosmetic products&#44; in order to help improve skincare&#59; and 4&#41; positioning the dermatology and venereology specialty as a reference in the field of integral skincare&#46;</p><elsevierMultimedia ident="fig0035"></elsevierMultimedia><p id="par0345" class="elsevierStylePara elsevierViewall">The main pros and cons of the different virtual assistants are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Intelligent devices for developing personalized products</span><p id="par0350" class="elsevierStylePara elsevierViewall">The application of these technologies in the field of robotics&#44; with the development of devices able to produce personalized cosmetic products at home from the information obtained by the applications described above&#44; will be the next step in cosmetics&#44; with companies such as Procter &#38; Gamble&#174; &#40;<span class="elsevierStyleItalic">Opt&#233; Precision Skincare System</span>&#174;&#41;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a> and L&#8217;Or&#233;al&#174; &#40;<span class="elsevierStyleItalic">Perso</span>&#174;&#41;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a> being the pioneers in these types of home devices&#46;</p><p id="par0355" class="elsevierStylePara elsevierViewall">Likewise&#44; the use of these algorithms in professional supports that allow images to be taken with different light parameters such as <span class="elsevierStyleItalic">Visia&#174;</span> &#40;Canfield&#174; Inc&#46;&#41; o <span class="elsevierStyleItalic">Lifeviz&#174; micro</span> &#40;Quantificare&#174; Inc&#46;&#41; will help the cosmetics professionals to improve the skincare of their patients in their clinics<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a>&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Models to predict response by artificial intelligence</span><p id="par0360" class="elsevierStylePara elsevierViewall">The application of the DL model and generation of neural networks will help increase the effectiveness and safety of cosmetic procedures&#46;</p><p id="par0365" class="elsevierStylePara elsevierViewall">Examples along these lines include the application of DL to best define the cosmetic treatment option according to facial wrinkle depth<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">74&#8211;76</span></a>&#46; The potential for DL to predict clinical response to laser therapy has also been evaluated&#46; For example&#44; Cazzaniga et al&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">77</span></a> applied this technology to the prediction of duration of excimer laser treatment for patients with vitiligo&#44; with promising results&#46; With data from their clinical trial&#44; the model achieved an overall precision of 66&#46;46&#37; in predicting the time to repigmentation in responders&#46; Given that treatment can be slow and costly&#44; a predictive model for clinical response and duration of treatment would help both patients and healthcare providers decide whether to continue with treatment&#46; The models of clinical outcome can also be applied to other types of laser and treatment modalities for treating afflictions such as acne scars&#44; dyschromia&#44; and vascular disorders to help establish realistic expectations in interested patients&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Artificial intelligence in skin radiology and ultrasound</span><p id="par0370" class="elsevierStylePara elsevierViewall">Among the radiological imaging techniques&#44; both simple computed tomography &#40;CT&#41; and magnetic resonance &#40;MR&#41; imaging are used essentially in the context of staging or follow-up of melanoma&#46; The advantage of these techniques is that they can be readily standardized&#44; and there are large image databases for training the algorithms&#46;</p><p id="par0375" class="elsevierStylePara elsevierViewall">Techniques based on ionizing radiation&#44; such as CT in dermatology patients&#44; have been used for detecting melanoma metastasis&#46; In a study by Aissa et al&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">78</span></a>&#44; using ML techniques and vessel suppression&#44; algorithms were able to find additional metastases in 54&#46;3&#37; of cases&#46; However&#44; authors concluded that diagnosis of additional metastases would not have affected patient management&#46;</p><p id="par0380" class="elsevierStylePara elsevierViewall">Regarding the use of MR&#44; AI has been applied to the detection and diagnosis of lesions&#46; Kniepp et al&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">79</span></a> reviewed 189 brain metastases&#44; including from melanoma&#44; and using decision tree algorithms in combination with clinical data&#44; they demonstrated greater capacity to differentiate between the metastases of other tumors &#40;squamous cell carcinoma&#44; microcytic lung cancer&#41; than radiologists&#44; with an area under curve of 0&#46;82&#46; This use of radiologic imaging to infer histological diagnosis of lesions has been denoted as <span class="elsevierStyleItalic">radiomics</span>&#44; and is one step beyond image detection or segmentation&#46;</p><p id="par0385" class="elsevierStylePara elsevierViewall">Skin ultrasound is a technique that offers advantages over other imaging techniques as it is harmless&#44; fast&#44; and available at the patient&#8217;s bedside<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">79</span></a>&#46; However&#44; ultrasound has several limitations as source of data for AI&#44; the main ones being the absence of large ultrasound imaging banks suitable for training and validating algorithms and the intrinsic characteristics of ultrasound scans&#44; which means they are not as standardized as is the case with CT and MR images&#46;</p><p id="par0390" class="elsevierStylePara elsevierViewall">Nevertheless&#44; in recent years&#44; the development of AI in ultrasound has started to provide evidence regarding how it could be applied in the 3 main ultrasound issues&#44; and specifically&#44; in the case of skin ultrasound&#58; classification&#44; regression&#44; and segmentation<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">80</span></a>&#46;</p><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Classification</span><p id="par0395" class="elsevierStylePara elsevierViewall">Most classification algorithms have been applied to ultrasound diagnosis of breast or hepatic lesions<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">81&#44;82</span></a>&#46; Although there are numerous publications that have attempted to reduce the key features needed for AI-assisted diagnosis<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">83</span></a>&#44; the number of images available is usually less than 300&#44; and they have been captured in different clinics with different validation protocols&#44; and so the results are not usually comparable<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">84</span></a>&#46;</p><p id="par0400" class="elsevierStylePara elsevierViewall">From the commercial point of view&#44; some algorithms have been developed for assisted diagnosis&#44; mainly using breast and thyroid ultrasound<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">85&#8211;87</span></a>&#46; The algorithm suggests a risk of malignancy of the lesion selected by the ultrasonographer&#44; but it does not indicate a specific diagnosis for the lesion studied&#46; However&#44; these algorithms have not been validated by any regulatory agency&#46;</p><p id="par0405" class="elsevierStylePara elsevierViewall">From the point of view of skin ultrasound&#44; classification algorithms could be useful in AI-assisted diagnosis of skin lesions&#46; In a recent study by Alfageme et al&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">88</span></a>&#44; a DL-based algorithm with predetermined architecture&#44; trained with a bank of 235 ultrasound images of benign and malignant skin lesions&#44; was able to correctly classify the lesions at a similar rate to an expert human evaluator &#40;77&#46;1&#37; versus 74&#46;1&#37;&#41; who was exposed to the same image bank&#46;</p><p id="par0410" class="elsevierStylePara elsevierViewall">In the case of melanocytic lesions&#44; using ultra-high frequency ultrasound devices &#40;70&#8239;MHz probes&#41;&#44; the group led by Romanelli also reported a capacity to differentiate between melanocytic nevus with an accuracy of 76&#46;9&#37; and a sensitivity and specificity for diagnosis of melanoma of 80&#37; and 74&#37;&#44; respectively by applying DL-based algorithms<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">89</span></a>&#46;</p><p id="par0415" class="elsevierStylePara elsevierViewall">With skin ultrasound&#44; it remains to be seen what the optimum characteristics are for appropriate image banks for this application in terms of equipment&#44; resolution&#44; and similarity with inflammatory lesions&#44; which may hinder the applicability of these algorithms in clinical settings&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Regression</span><p id="par0420" class="elsevierStylePara elsevierViewall">Regression involves estimating continuous values instead of discrete classes of data&#46; DL has been applied to regression&#44; for example&#44; for estimating the orientation of muscle fibers from ultrasound images or gestational age&#46;<a class="elsevierStyleCrossRefs" href="#bib0450"><span class="elsevierStyleSup">90&#44;91</span></a> With regards skin ultrasound&#44; regression algorithms could be useful for assessing the duration of skin lesions&#44; automatic determination of ultrasound Breslow depth&#44; or in algorithms applied to the study of skin ageing and its treatment<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">92</span></a>&#46;</p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Segmentation</span><p id="par0425" class="elsevierStylePara elsevierViewall">Segmentation is the ultrasound delimitation of the structural limits of a lesion&#46; Automated ultrasound segmentation is a challenge&#44; as ultrasound images are affected by scintillation&#44; shadows&#44; and absence of limits&#44; as well as frequency compensations&#44; depth&#44; and ultrasound resolution during image acquisition<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">93</span></a>&#46;</p><p id="par0430" class="elsevierStylePara elsevierViewall">Several ultrasound segmentation approaches have been developed&#44; including methods based on intensity thresholds&#44; sets of levels&#44; and active contours<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">94</span></a>&#46; The approaches based on intensity are sensitive to noise and image quality<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">95</span></a>&#46; Active contours and sets of levels require an initialization that may impact the results&#46; Most of the conventional approaches are not totally automated&#46;</p><p id="par0435" class="elsevierStylePara elsevierViewall">ML-based segmentation methods usually involve 2 steps&#58; first&#44; a pixel classification of the target structure&#44; followed by a cleaning or softening step&#44; as pixel classification is noisy from the ultrasound point of view&#46; In recent articles&#44; several classification approaches have been investigated with specific focus on the application of several types of neural networks&#44; including DL<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">96</span></a>&#46;</p><p id="par0440" class="elsevierStylePara elsevierViewall">In skin ultrasound&#44; the segmentation algorithms could be useful for detecting lymph node metastasis or for ultrasound delimitation of skin lesions &#40;<a class="elsevierStyleCrossRef" href="#fig0040">Fig&#46; 8</a>&#41;&#46;</p><elsevierMultimedia ident="fig0040"></elsevierMultimedia></span></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Ethical and regulatory aspects of AI in dermatology</span><p id="par0445" class="elsevierStylePara elsevierViewall">We may not fully realize how unique the situation we are facing is&#44; as never before in human history have we had the capacity to compile such large volumes of data&#46;</p><p id="par0450" class="elsevierStylePara elsevierViewall">The internet of things and big data can feed the AI and ML algorithms&#46; The more complex these algorithms&#44; the greater their predictive power&#44; and so all efforts are focused on correlating a vast number of variables to achieve accurate predictions&#46; The undeniable aim is to achieve Laplace&#8217;s demon&#44; a machine able to predict any scenario in a fully deterministic fashion<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">97</span></a>&#46; For this reason&#44; AI is also being studied within the field of bioethics&#46;</p><p id="par0455" class="elsevierStylePara elsevierViewall">Of note is that the European Parliament&#44; on proposing a Letter on Robotics&#44; started listing bioethical principles as the rules to be followed for robotics engineers&#44; and compiling the ethical principles that should guide AI&#44; which have been denoted &#8220;Asilomar Principles for Artificial Intelligence&#8221;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">98</span></a>&#46;</p><p id="par0460" class="elsevierStylePara elsevierViewall">In any case&#44; the ethical framework for AI in dermatological practice should also reflect the basic principles of medical ethics&#58; autonomy&#44; benefit&#44; absence of harm&#44; and fairness&#46; But in the specific case of AI&#44; this ethical framework should also include specific sections&#44; such as transparency and accountability<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">99</span></a>&#46;</p><p id="par0465" class="elsevierStylePara elsevierViewall">The principle of autonomy refers to the fact that the patient has the right to make his or her own decisions&#46; In medical care&#44; informed consent is the mechanism by which autonomy is ensured&#44; but dermatology images not only include information in the form of pixels but also information on health &#40;at least when the image is linked to a patient&#8217;s medical history&#41;&#44; such as demographic data and institutional information&#46; When these images are used for training AI algorithms&#44; informed consents should be adapted for this purpose&#44; such that these images can continue to be used&#46;</p><p id="par0470" class="elsevierStylePara elsevierViewall">The principles of benefit and absence of harm are 2 sides of the same coin and are obvious in conventional medical care&#44; but certain contradictions may be present in the case of AI&#44; as the algorithms may benefit from stratification with many parameters&#44; improving diagnostic yield and&#44; therefore&#44; improving the patients&#8217; wellbeing&#44; but at the same time&#44; such segmentation could be used for profit&#46;</p><p id="par0475" class="elsevierStylePara elsevierViewall">The principle of fairness requires a fair distribution of medical products and services&#46; The development of AI should encourage equity&#44; removing certain discriminations and preventing certain implicit biases&#44; as will be discussed later&#46;</p><p id="par0480" class="elsevierStylePara elsevierViewall">Finally&#44; the principles of transparency and accountability may be addressed by the principle of explainability&#46; If an AI system fails or causes damage&#44; we should be in a position to determine the underlying reasons and it should be possible to perform an audit of the entire process&#46; This latter point is surely the main ethical limitation of AI&#44; as these systems are considered a type of black box in which it may be possible to understand the logical processes and mathematics behind the algorithm but not the downstream data processing&#44; such that the result is&#44; in reality&#44; unpredictable<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">100</span></a>&#46;</p><p id="par0485" class="elsevierStylePara elsevierViewall">This all ties in with the debate about accountability&#44; when the AI systems automatically trigger diagnostic or therapeutic decisions&#44; we may well ask who is accountable if the system fails<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">101</span></a>&#46; The question can be extrapolated to other fields&#44; and this debate came to the fore in March 2018 with the first fatal accident with a self-driving car in Tempe&#44; Arizona&#44; United States&#46; Was the person who was in the car responsible&#63; Or the car manufacturer&#63; Or the software developer&#63; There is no simple answer&#46; Above all&#44; it is necessary to develop regulations and legislation on the topic to ensure there are no legal grey areas&#46; When AI is applied in medicine&#44; these considerations are even more important<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">102</span></a>&#46;</p><p id="par0490" class="elsevierStylePara elsevierViewall">Another important question is whether algorithms may perpetuate human bias precisely because they work like a black box&#46; When the algorithm is trained with biased data&#44; because underrepresented populations are not included&#44; existing inequalities may be reproduced for further entrenched<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">103</span></a>&#46; If the data acquired by the algorithm are not sufficiently inclusive and balanced&#44; the system could learn to take unfair decisions &#40;this is very obvious in facial recognition systems&#44; which are more reliable with white males than black women&#41;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">104</span></a>&#46;</p><p id="par0495" class="elsevierStylePara elsevierViewall">In dermatology&#44; although there are many AI applications&#44; in the initial phases&#44; the focus has been on diagnosis of pigmented lesions&#44; above all&#44; melanoma&#46; The reality is that&#44; for the time being&#44; most AI and ML programs are learning mainly from images of people with light phototypes&#46; For example&#44; in the International Skin Imaging Collaboration&#58; Melanoma Project&#44; one of the most widely used and with open access code&#44; most of the patients have light phototypes and come from populations in the United States&#44; Europe&#44; and Australia&#46; As a result&#44; the algorithm is not very reliable for lesions on black skin&#46; Paradoxically&#44; melanoma is usually detected in more advanced phases with worse survival rates in Afro-American patients&#46; The algorithm only improves early detection in light skin types&#44; with no benefit for patients with black skin&#44; thus clearly worsening the biases already observed in society<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">104</span></a>&#46; The solution is not easy to implement but it is simple&#58; effort has to be made to train the algorithm in all skin types&#46;</p><p id="par0500" class="elsevierStylePara elsevierViewall">From the regulatory point of view&#44; several organizations have published frameworks for setting up AI applications in the field of medicine&#46; This is all rather complex&#44; starting from the fact that although legislation requires the absence of ambiguity&#44; there is currently no clear definition even for what we mean by the term artificial intelligence&#46;</p><p id="par0505" class="elsevierStylePara elsevierViewall">The second crucial point for the legislators is whether to consider the AI software used in medicine as a medical device &#40;there is a distinction between programs that analyze data to have a deeper knowledge of a disease than those that make diagnostic or therapeutic decisions in individual patients&#41;&#46; On this point&#44; we can differentiate between the European vision and that of the United States<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">105</span></a>&#46;</p><p id="par0510" class="elsevierStylePara elsevierViewall">In Europe the legislation in force is the Regulation on medical devices&#44; which was signed in May 2020 and which replaces Directive 93&#47;42&#47;EEC<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">106</span></a>&#46; As this is a regulation &#40;rather than a directive&#41;&#44; it applies directly to territories in the European Union without the need to be implemented by the different member states&#46; This regulation requires that manufacturers ensure that the devices they produce meet a series of essential requirements that will depend on the potential risks of each and that&#44; at times&#44; will need certification by an independent body&#46;</p><p id="par0515" class="elsevierStylePara elsevierViewall">In the United States&#44; the regulatory body is the US Food and Drug Administration since the end of 2016&#44; when jurisdiction over software used in the health field was transferred to this body by the 21st Century Cures Act<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">107</span></a>&#44; with a more restrictive reading in terms of introduction of unsupervised diagnostic software&#46;</p><p id="par0520" class="elsevierStylePara elsevierViewall">In addition&#44; all these tools that feed off a huge wealth of data have other implications associated with privacy and data protection&#44; as well as cybersecurity&#46; As a result of these potential threats&#44; the European Union decided to update the legislation&#44; and the General Data Protection Regulation has been in force since May 24&#44; 2018&#44; replacing the previous legislation&#46; The new legislation requires user consent&#44; and the user should be aware of the purposes&#44; with marketing of these data by third parties being explicitly excluded<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">108</span></a>&#46; In the United States&#44; computer-related security in the healthcare field is covered by the <span class="elsevierStyleItalic">Health Insurance Portability and Accountability Act</span>&#46;</p><p id="par0525" class="elsevierStylePara elsevierViewall">In 2018&#44; the European Commission established the <span class="elsevierStyleItalic">High Level Experts Group on Artificial Intelligence</span>&#44; with the aim of supporting the implementation of the European strategy for AI&#44; including drawing up recommendations for future development of norms that regulate ethical&#44; legal&#44; and social aspects of AI&#46;</p><p id="par0530" class="elsevierStylePara elsevierViewall">According to these fundamental rights and ethical principles&#44; these guidelines have 7 key requirements that any AI system should meet to be reliable&#58; 1&#41; It should not impact human autonomy&#59; 2&#41; it should be technically sound and safe&#59; 3&#41; privacy and data management should be respected&#59; 4&#41; it should be transparent&#59; 5&#41; it should be diverse&#44; with no discrimination or inequality&#59; 6&#41; it should respect the environment&#59; and 7&#41; there must be accountability<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">109</span></a>&#46;</p><p id="par0535" class="elsevierStylePara elsevierViewall">AI will play an important part in the coming years in our specialty&#44; and we need to be guided by ethical principles&#44; such as the principles of benefit and respect towards our patients&#46; We should remember that a dermatologist is not a simple interpreter of images&#44; and that our functions also include many other aspects that cannot be performed by machines&#46;</p></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conclusions</span><p id="par0540" class="elsevierStylePara elsevierViewall">We are living and will live a full-blown AI revolution in dermatology&#44; with a range of systems of differing focus and undoubted potential&#46;</p><p id="par0545" class="elsevierStylePara elsevierViewall">A recent literature review claims that neural-network based AI systems &#40;whether in their deep or convolutional modalities&#41; have a greater capacity for recognition than dermatologists<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">110</span></a>&#46; While this affirmation is open to debate and requires context&#44; it is nevertheless true that AI systems are progressively improving&#46;</p><p id="par0550" class="elsevierStylePara elsevierViewall">On the one hand&#44; conventional automated image analysis systems have been easily surpassed by neural network systems used in the past 10 years<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">111</span></a>&#46;</p><p id="par0555" class="elsevierStylePara elsevierViewall">On the other&#44; the systems are now capable of processing a huge additional amount of information to achieve a reasoning analogous to that of a dermatologist &#40;for example&#44; comparing with other pigmented lesions of the patient to avoid false suspected diagnoses in the context of a predominance of atypical nevi&#41;<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">112</span></a>&#46;</p><p id="par0560" class="elsevierStylePara elsevierViewall">After analyzing the opinion of different authors&#44; we believe that progress in these technologies needs to be progressive&#44; safe&#44; and based on the generosity of the dermatology community&#44; as publicly available databases with images and broad clinical information are essential to improve the reliability of these systems<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">113</span></a>&#46; These systems could undoubtedly be a support for other physicians if no dermatologist is available and cannot be reached on short notice&#46; Nevertheless&#44; we believe that the future will not see AI systems replacing dermatologists&#44; but rather they represent an opportunity for improving clinical practice thanks to the many advantages that these systems may offer&#46;</p><p id="par0565" class="elsevierStylePara elsevierViewall">In short&#44; the optimal situation would be a symbiosis between AI and dermatologists to improve decision-making for our patients&#44; conscious that the ideal is a combination of human intelligence with AI<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">114</span></a>&#44; maintaining a fluid relationship between physician and patient<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a>&#46; It is therefore essential to change the current tendency&#59; dermatology specialists should take the initiative in the development and orientation of the AI products focused on covering unmet needs in current medical practice&#46;</p></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflicts of interest</span><p id="par0570" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p><p id="par0575" class="elsevierStylePara elsevierViewall">Dr&#46; Antonio Martorell has received fees for participation in advisory boards and satellite symposia with the following companies&#58; AbbVie&#44; Amgen&#44; Janssen&#44; UCB&#44; Lilly&#44; Novartis&#44; LEO Pharma&#44; Sandoz&#44; and MSD&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The worldwide explosion of interest in artificial intelligence &#40;AI&#41; has created a before-and-after moment in our lives by generating great improvements in such sectors as the automotive and food production industries&#46; AI has even been called the fourth industrial revolution&#46; Machine learning through AI is helping to improve professional processes and promises to transform the health care sector as we know it in various ways&#58; 1&#41; through applications able to promote health in the general population by providing high-quality information and offering advice for different segments of the population based on prediction models&#59; 2&#41; by developing prediction models based on anonymized clinical data&#44; for preventive purposes in primary care&#59; 3&#41; by analyzing images to provide additional decision-making support for health care providers&#44; for improving specialist care at the secondary level&#59; and 4&#41; through robotics applied to processes that promote health and well-being&#46; However&#44; the medical profession harbors doubts about whether this revolution is a threat or an opportunity owing to a lack of understanding of AI technology and the methods used to validate its applications&#46; This article outlines basic aspects of AI as it is applied in dermatology and reviews the main advances achieved in the last 5 years&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">La irrupci&#243;n de la inteligencia artificial &#40;IA&#41; a nivel mundial ha supuesto un antes y un despu&#233;s en nuestras vidas&#44; generando grandes mejoras en diferentes sectores&#44; como el de la automoci&#243;n y el agroalimentario&#44; entre otros&#44; lo que ha llevado a denominarla la cuarta revoluci&#243;n industrial&#46; La AI&#44; capaz de aprender de forma automatizada y de ayudar al profesional a mejorar sus procesos&#44; promete cambiar el &#225;mbito sanitario tal y como lo conocemos mediante&#58; 1&#41; aplicaciones capaces de generar salud en la poblaci&#243;n general a partir del uso de informaci&#243;n de calidad y de segmentaci&#243;n de consejos basados en modelos de predicci&#243;n&#59; 2&#41; modelos capaces de generar algoritmos de predicci&#243;n a partir de datos anonimizados procedentes de informaci&#243;n cl&#237;nica&#44; a fin de mejorar la prevenci&#243;n primaria&#59; 3&#41; sistemas de an&#225;lisis de imagen capaces de dar a los profesionales de la salud un soporte extra en la toma de decisiones&#44; mejorando la prevenci&#243;n secundaria&#59; y 4&#41; aplicaci&#243;n de rob&#243;tica combinada en la mejora de procesos ligados al &#225;mbito de salud y bienestar&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Sin embargo&#44; la falta de conocimiento tanto en este tipo de tecnolog&#237;a&#44; como en los t&#233;rminos y la metodolog&#237;a de validaci&#243;n de la misma&#44; hace que la clase m&#233;dica dude en si esta revoluci&#243;n supone una amenaza o una oportunidad para la profesi&#243;n&#46; En el presente art&#237;culo de revisi&#243;n pretendemos introducir una serie de aspectos b&#225;sicos de la IA aplicada a la dermatolog&#237;a&#44; as&#237; como los principales avances sucedidos en este campo en los &#250;ltimos 5 a&#241;os&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Martorell A&#44; Martin-Gorgojo A&#44; R&#237;os-Vi&#241;uela E&#44; Rueda-Carnero JM&#44; Alfageme F&#44; Taberner R&#46; Inteligencia artificial en dermatolog&#237;a&#58; &#191;amenaza u oportunidad&#63; Actas Dermosifiliogr&#46; 2022&#59;113&#58;30&#8211;46&#46;</p>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Detection of psoriasis with the SkianaPsors system A&#44; clinical expression of psoriasis B&#44; automated detection of psoriasis&#46;</p>"
        ]
      ]
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        "identificador" => "fig0030"
        "etiqueta" => "Figure 6"
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        "mostrarFloat" => true
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        "figura" => array:1 [
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">SkianaCare&#174; smartphone application&#58; acne classifier&#46; A&#46; Example of male with mild acne B&#44; example of female with moderate acne&#46;</p>"
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      6 => array:8 [
        "identificador" => "fig0035"
        "etiqueta" => "Figure 7"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">SkianaCare&#174; smartphone application&#58; automated assessment of skin photoaging&#46; A and B&#44; example of 2 women of the same age with different severity of photoaging&#46;</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "fig0040"
        "etiqueta" => "Figure 8"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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          0 => array:3 [
            "identificador" => "at0040"
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            "rol" => "short"
          ]
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        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Artificial intelligence applied to radiology&#46; Example of the utility of the learning technology to differentiate ultrasound structures&#46;</p>"
        ]
      ]
      8 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0045"
            "detalle" => "Table "
            "rol" => "short"
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        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Type of AI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Definition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Application&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Examples&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Narrow or weak&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Learning methodology focused on a single task&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Most of the AI health algorithms are developed with narrow AI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Automated diagnostic models for pneumonia from chest X-ray&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">General&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Model with AI function comparable to human abilities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Currently focused on managing uncertainty&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Predictive health models&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Super AI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Future field in which AI exceeds human ability in all fields&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">This is the AI shown in many superproductions as true AI&#44; but currently&#44; this is merely science fiction in current society&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AI oriented films&#58; <span class="elsevierStyleItalic">Terminator</span>&#44; <span class="elsevierStyleItalic">I Robot</span>&#44; etc&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Subtypes of artificial intelligence &#40;IA&#41;&#46;</p>"
        ]
      ]
      9 => array:8 [
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        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0050"
            "detalle" => "Table "
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        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PROVEN&#174;Beauty&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vichy&#174; Skin Consult AI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Neutrogena Skin 360&#174;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Skiana&#174;Care&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intelligent questionnaire&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intelligent facial analysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Validation clinical studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">APP version available for smartphone&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Need for specific device for analysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Contact allergy screening algorithm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Independent development of cosmetic industry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes &#40;SKIANA project &#40;Grant agreement no&#46; 885806 &#91;SME Instrument&#93;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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Idiomas
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