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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La Dermatitis Al&#233;rgica de Contacto &#40;DAC&#41; es un problema frecuente y con una importante repercusi&#243;n personal&#44; social y econ&#243;mica&#44; que exige el desarrollo de programas de investigaci&#243;n cl&#237;nica y epidemiol&#243;gica<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a>&#46; La <span class="elsevierStyleItalic">European Surveillance System on Contact Allergies</span> &#40;ESSCA&#41; es un proyecto activo de la <span class="elsevierStyleItalic">European Society of Contact Dermatitis</span> &#40;ESCD&#41; cuyo objetivo es el estudio epidemiol&#243;gico de la DAC a nivel europeo<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">2</span></a>&#46; En Espa&#241;a&#44; estos datos son recogidos en el Registro Espa&#241;ol de Dermatitis de Contacto &#40;REIDAC&#41;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a>&#44; en el seno del Grupo Espa&#241;ol de Investigaci&#243;n en Dermatitis de Contacto y Alergia Cut&#225;nea &#40;GEIDAC&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Las pruebas epicut&#225;neas son el m&#233;todo fundamental para detectar la sensibilizaci&#243;n a al&#233;rgenos de contacto y una herramienta necesaria para la confirmaci&#243;n diagn&#243;stica de la DAC&#46; El estudio de cualquier paciente con sospecha de DAC debe incluir una bater&#237;a est&#225;ndar nacional o internacional de pruebas epicut&#225;neas y&#44; opcionalmente&#44; una o m&#225;s bater&#237;as espec&#237;ficas ampliadas con los productos propios<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Cl&#225;sicamente&#44; se considera que un al&#233;rgeno debe incluirse en una bater&#237;a est&#225;ndar o &#171;basal&#187; si presenta una frecuencia de sensibilizaci&#243;n mayor del 0&#44;5-1&#37; en las pruebas epicut&#225;neas de pacientes no seleccionados&#46; Adem&#225;s de este criterio&#44; tambi&#233;n se consideran otros&#44; como que sea especialmente importante para un grupo de pacientes o &#225;mbito de exposici&#243;n&#44; o que se trate de un al&#233;rgeno emergente en la literatura dermatol&#243;gica o frecuente en pa&#237;ses colindantes<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a>&#46; Aunque la inclusi&#243;n tambi&#233;n deber&#237;a guiarse por el hecho de tener una relevancia presente&#44; la variabilidad en la apreciaci&#243;n de esa relevancia origina que este par&#225;metro solo se utilice en casos particulares<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a>&#46; Como una medida de eficiencia en la realizaci&#243;n de pruebas epicut&#225;neas&#44; recientemente se ha descrito como criterio el &#171;n&#250;mero de pacientes parcheados necesario para conseguir un paciente con relevancia presente&#187;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">La bater&#237;a est&#225;ndar espa&#241;ola es una bater&#237;a din&#225;mica que se actualiza peri&#243;dicamente por los miembros del GEIDAC<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a>&#46; Para determinar qu&#233; al&#233;rgenos permanecen&#44; se a&#241;aden o eliminan en cada actualizaci&#243;n&#44; adem&#225;s de considerar lo comentado anteriormente&#44; se analiza de forma prospectiva la frecuencia de sensibilizaci&#243;n de los al&#233;rgenos de la propia bater&#237;a y de otros posibles al&#233;rgenos candidatos&#46; La &#250;ltima actualizaci&#243;n se realiz&#243; en 2016<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Por otro lado&#44; la &#250;ltima actualizaci&#243;n de la bater&#237;a basal europea tuvo lugar en 2019 y supuso la inclusi&#243;n del prop&#243;leo&#44; el 2-hidroextil-metacrilato &#40;HEMA&#41; y la mezcla de ca&#237;nas III<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">8</span></a>&#44; proponi&#233;ndose revisar nuevamente la serie europea en 2021 con un grupo de al&#233;rgenos emergentes<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">8&#44;9</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">El objetivo de nuestro trabajo es analizar la frecuencia de sensibilizaci&#243;n y la relevancia de estos al&#233;rgenos para valorar si debieran ser incluidos en la bater&#237;a est&#225;ndar espa&#241;ola y europea&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todos</span><p id="par0035" class="elsevierStylePara elsevierViewall">Desarrollamos un estudio observacional transversal de manera prospectiva de los enfermos sucesivos a los que se les realizaron pruebas epicut&#225;neas de contacto en los centros asociados al REIDAC&#44; desde el 1 de enero de 2019 al 31 de diciembre de 2020&#44; estudiando los al&#233;rgenos a las concentraciones descritas en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; Las pruebas epicut&#225;neas fueron realizadas seg&#250;n la gu&#237;a ESCD con dos lecturas&#44; consider&#225;ndose positivas las pruebas con &#40;&#43;&#41;&#44; &#40;&#43;&#43;&#41; o &#40;&#43;&#43;&#43;&#41;&#46; Las relevancias se consideraron presentes seg&#250;n los datos de la historia cl&#237;nica<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a><span class="elsevierStyleItalic">&#46;</span> Los al&#233;rgenos analizados se obtuvieron de las marcas comerciales Chemotechnique&#174; &#40;Chemotechnique MB Diagnostics AB&#44; Vellinge&#44; Sweden&#41; y allergEAZE&#174; &#40;SmartPractice&#44; Calgary&#44; Canada&#41;&#44; seg&#250;n la disponibilidad en cada centro&#46; Algunos de los centros parchearon el bronopol&#44; la diazolidinil urea y la imidazolidinil con el True Test&#174; &#40;SmartPractice Denmark ApS&#46; Herredsvejen 2&#46; 3400 Hiller&#248;d&#46; Dinamarca&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Todos los centros participantes en el estudio pertenecen al GEIDAC e incluyen sistem&#225;ticamente los resultados de todas las pruebas epicut&#225;neas realizadas en su pr&#225;ctica cl&#237;nica habitual&#46; Idealmente&#44; el volcado de los datos se realiza el d&#237;a de la &#250;ltima lectura&#44; obteni&#233;ndose los datos epidemiol&#243;gicos en tiempo real&#46; El estudio ha sido aprobado por el comit&#233; de &#233;tica del Hospital Universitario Insular de Gran Canaria y&#44; en su caso&#44; por los del resto de los centros&#46; Para garantizar la normativa de privacidad de los datos&#44; &#233;stos son anonimizados en origen&#46; Los datos cl&#237;nicos son los mismos y de las mismas categor&#237;as que los establecidos en el <span class="elsevierStyleItalic">minimal data sheet</span> de la ESSCA<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">2&#44;11</span></a>&#44; lo que permite su exportaci&#243;n a otras bases de datos con id&#233;nticas categor&#237;as&#46; Para la recogida de datos se utiliza la plataforma OpenClinica &#40;OpenClinica LLC and collaborators&#44; Waltham&#44; MA&#44; USA&#41;&#44; y para el an&#225;lisis de los datos se utiliza el paquete estad&#237;stico Stata 16 &#40;StataCorp&#46; 2019&#46; Stata Statistical Software&#58; Release 16&#46; College Station&#44; TX&#58; StataCorp LLC&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">La estructura de la base de datos es modular&#44; lo cual permite realizar estudios epidemiol&#243;gicos prospectivos&#44; en los que se recogen datos espec&#237;ficos durante un periodo de tiempo acotado&#46; Para el presente estudio&#44; dentro de la estructura original en OpenClinica se a&#241;adieron los al&#233;rgenos de la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> a la bater&#237;a est&#225;ndar espa&#241;ola&#44; origin&#225;ndose una &#171;bater&#237;a espa&#241;ola extendida&#187;&#46; Los datos epidemiol&#243;gicos y resultados de las pruebas epicut&#225;neas se registraron seg&#250;n el m&#233;todo estandarizado en el REIDAC&#46; Adem&#225;s de las positividades y relevancias presentes&#44; se recogieron los datos necesarios para obtener el &#237;ndice <span class="elsevierStyleItalic">Male&#44; Occupational dermatitis&#44; Atopic dermatitis&#44; Hand dermatitis&#44; Leg dermatitis&#44; Facial dermatitis&#44; Age &#62; 40 years</span> &#40;MOAHLFA&#41;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a>&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0050" class="elsevierStylePara elsevierViewall">El n&#250;mero total de pacientes incluidos en el REIDAC durante el periodo de estudio fue de 4&#46;654&#46; Debido a las dificultades por la crisis de la pandemia del coronavirus &#40;COVID-19&#41;&#44; solo se pudieron estudiar con la bater&#237;a espa&#241;ola extendida 1&#46;890 pacientes &#40;40&#44;6&#37;&#41; de 14 centros hospitalarios&#46; Los datos del bronopol&#44; diazolidinil urea e imidazolidinil urea se obtuvieron de los parcheados en vaselina y True Test procedentes de 19 centros &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; La <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> describe el &#237;ndice MOAHLFA de la poblaci&#243;n del estudio&#46; Los datos globales de sensibilizaci&#243;n y relevancia pueden verse en la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Los al&#233;rgenos que mostraron una frecuencia de sensibilizaci&#243;n mayor del 1&#37; fueron&#58; hidroper&#243;xido de linalool &#40;4&#44;4&#37; parcheado al 1&#37; vs&#46; 3&#44;4&#37; parcheado al 0&#44;5&#37;&#41;&#44; HEMA &#40;3&#44;7&#37;&#41;&#44; benzisotiazolinona &#40;3&#44;5&#37;&#41;&#44; hidroper&#243;xido de limoneno &#40;3&#44;2&#37; parcheado al 0&#44;3&#37; vs&#46; 1&#44;4&#37; parcheado al 0&#44;2&#37;&#41;&#44; mezcla textil &#40;3&#44;1&#37;&#41;&#44; metabisulfito s&#243;dico &#40;1&#44;9&#37;&#41; y prop&#243;leo &#40;1&#44;4&#37;&#41;&#46; Los al&#233;rgenos que mostraron una frecuencia de relevancia mayor del 1&#37; fueron&#58; hidroper&#243;xido de linalool &#40;2&#44;7&#37; parcheado al 1&#37; vs&#46; 2&#44;1&#37; parcheado al 0&#44;3&#37;&#41;&#44; HEMA &#40;2&#44;5&#37;&#41; e hidroper&#243;xido de limoneno &#40;2&#37; parcheado al 0&#44;3&#37; vs&#46; 0&#44;9&#37; parcheado al 0&#44;2&#37;&#41;&#46; Dos al&#233;rgenos mostraron una frecuencia de relevancia de entre el 0&#44;9 y el 1&#37;&#58; benzisotiazolinona &#40;0&#44;96&#37;&#41; y mezcla textil &#40;0&#44;9&#37;&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Los al&#233;rgenos que asociaron un n&#250;mero de pacientes parcheados necesario para conseguir un paciente con relevancia presente menor de 100 fueron&#58; hidroper&#243;xido de linalool &#40;36 parcheado al 1&#37;&#41;&#44; HEMA &#40;39&#41; e hidroper&#243;xido de limoneno &#40;49&#41;&#46; Dos al&#233;rgenos asociaron un n&#250;mero de pacientes parcheados necesario para conseguir un paciente con relevancia presente de entre 100 y 110&#58; benzisotiazolinona &#40;101&#41; y mezcla textil &#40;108&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discusi&#243;n</span><p id="par0065" class="elsevierStylePara elsevierViewall">Nuestros resultados indican que&#44; por su frecuencia de sensibilizaci&#243;n&#44; deber&#237;a considerarse la inclusi&#243;n de siete nuevos al&#233;rgenos en la bater&#237;a est&#225;ndar espa&#241;ola&#58; hidroper&#243;xido de linalool&#44; hidroper&#243;xido de limoneno&#44; HEMA&#44; benzisotiazolinona&#44; mezcla textil&#44; prop&#243;leo y metabisulfito s&#243;dico&#46; Esta recomendaci&#243;n viene reforzada por el hecho de que todos ellos&#44; con excepci&#243;n del prop&#243;leo y el metabisulfito s&#243;dico&#44; asociaron una alta relevancia presente y un bajo n&#250;mero de parches necesarios para detectar una relevancia presente&#46; Hay que destacar que los hidroper&#243;xidos de linalool y limoneno deber&#237;an incluirse a sus concentraciones mayores &#40;1&#37; y 0&#44;3&#37; respectivamente&#41;&#44; dada la mayor frecuencia de sensibilizaci&#243;n y relevancia&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">El <span class="elsevierStyleBold">linalool</span> y <span class="elsevierStyleBold">limoneno</span> son fragancias terp&#233;nicas muy utilizadas&#46; Los hidroper&#243;xidos que se originan a partir de estas mol&#233;culas con la exposici&#243;n ambiental son los haptenos que tienen capacidad de sensibilizaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a>&#46; En nuestro estudio&#44; hemos encontrado altas frecuencias de sensibilizaci&#243;n y relevancia&#44; mayores cuando ambos al&#233;rgenos se parchean a su concentraci&#243;n m&#225;s alta &#40;1 y 0&#44;3&#37;&#44; respectivamente&#41;&#46; Hallazgos similares han sido documentados en diversas cohortes europeas<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">13&#8211;15</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">El <span class="elsevierStyleBold">2-hidroxietil-metacrilato</span> &#40;HEMA&#41; ha demostrado ser muy efectivo como marcador de la sensibilizaci&#243;n a acrilatos<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">16</span></a>&#46; El HEMA fue a&#241;adido a la bater&#237;a est&#225;ndar europea en la &#250;ltima actualizaci&#243;n de 2019<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">8</span></a>&#46; En nuestra serie&#44; hemos encontrado una frecuencia de sensibilizaci&#243;n y relevancia muy altas&#44; hallazgos en consonancia con los documentados en otros estudios con grandes cohortes en Reino Unido<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">17</span></a> e Italia<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">La <span class="elsevierStyleBold">benzisotiazolinona</span> &#40;BIT&#41; y <span class="elsevierStyleBold">octilisotiazolinona</span> &#40;OIT&#41; son derivados de las isotiazolinonas con acci&#243;n microbicida que est&#225;n siendo estudiados en el contexto de la epidemia de sensibilizaci&#243;n a metilisotiazolinona &#40;MIT&#41;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">8</span></a>&#46; En nuestro estudio&#44; solo la BIT asoci&#243; un alto porcentaje de sensibilizaci&#243;n y relevancia&#46; Un estudio de Geier et al&#46; en una cohorte alemana multic&#233;ntrica document&#243; una prevalencia de sensibilizaci&#243;n a MIT&#44; BIT y OIT del 4&#44;6&#37;&#44; 1&#44;6&#37; y 1&#37;&#44; respectivamente<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">19</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">La <span class="elsevierStyleBold">mezcla textil</span> incluye un conjunto de ocho colorantes <span class="elsevierStyleItalic">disperse</span> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Este al&#233;rgeno fue incluido en la bater&#237;a basal europea en 2015<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a>&#46; Dadas las altas frecuencias de sensibilizaci&#243;n y relevancia que hemos encontrado&#44; nuestro estudio justificar&#237;a su inclusi&#243;n tambi&#233;n en la espa&#241;ola&#44; quedando por dilucidar el porcentaje de casos que corresponden a una verdadera sensibilizaci&#243;n al <span class="elsevierStyleItalic">Disperse Orange</span> 3 o una reacci&#243;n cruzada a para-fenilendiamina<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">21</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">El <span class="elsevierStyleBold">metabisulfito</span><span class="elsevierStyleBold">s&#243;dico</span> y otros sulfitos son utilizados por su capacidad microbiost&#225;tica y antioxidante en cosm&#233;ticos&#44; medicamentos y alimentos&#46; Aunque la frecuencia de sensibilizaci&#243;n a metabisulfito s&#243;dico es alta en la mayor&#237;a de los estudios epidemiol&#243;gicos&#44; su relevancia es dif&#237;cil de determinar por ser un conservante ubicuo y poder generar reacciones irritativas o dudosas en las pruebas epicut&#225;neas<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">22</span></a>&#46; En nuestra cohorte encontramos una alta frecuencia de sensibilizaci&#243;n y una baja relevancia presente&#46; No obstante&#44; algunos trabajos han evidenciado una alta relevancia si se lleva a cabo una anamnesis cuidadosa<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">22&#44;23</span></a>&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">El <span class="elsevierStyleBold">prop&#243;leo</span> es un componente estructural de las colmenas de las abejas cada vez m&#225;s utilizado en biocosm&#233;ticos&#46; Fue a&#241;adido a la bater&#237;a est&#225;ndar europea en la actualizaci&#243;n de 2019<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">8</span></a>&#46; En nuestro grupo existi&#243; una alta frecuencia de sensibilizaci&#243;n&#44; pero escasa relevancia&#46; Un estudio multic&#233;ntrico en Reino Unido document&#243; una frecuencia de sensibilizaci&#243;n cercana al 2&#37;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">24</span></a>&#46; Es necesario tener en cuenta la posibilidad de sensibilizaci&#243;n concomitante con componentes del <span class="elsevierStyleItalic">Myroxylon pereirae</span> &#40;b&#225;lsamo del Per&#250;&#41;&#44; la colofonia y la mezcla de fragancias I<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">25</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">El <span class="elsevierStyleBold">bronopol</span> es un liberador de formaldeh&#237;do &#40;FA&#41; que se emplea como conservante en numerosos productos&#46; Algunos estudios epidemiol&#243;gicos han observado frecuencias de sensibilizaci&#243;n de en torno al 1&#37; en Europa<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">26&#44;27</span></a>&#44; y en la &#250;ltima d&#233;cada se ha observado una disminuci&#243;n progresiva de la sensibilizaci&#243;n en Norteam&#233;rica<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">28</span></a>&#46; Su relevancia actual es objeto de debate&#46; En nuestro estudio&#44; encontramos una moderada frecuencia de positivos con baja relevancia presente&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">La <span class="elsevierStyleBold">mezcla de compuestas II</span> incluye seis al&#233;rgenos de la familia de plantas <span class="elsevierStyleItalic">Compositae</span> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#44; que es el principal responsable de la DAC por plantas en Europa<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">29</span></a>&#46; Las lactonas sesquiterp&#233;nicas son la principal fuente de sensibilizaci&#243;n&#46; La mezcla de lactonas sesquiterp&#233;nicas forma parte de las bater&#237;as est&#225;ndar europea y espa&#241;ola&#44; y su parcheo simult&#225;neo con la mezcla de compuestas II ha mostrado aumentar notablemente la sensibilidad para detectar DAC por <span class="elsevierStyleItalic">Compositae</span> en Dinamarca<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">29</span></a>&#46; En nuestro grupo&#44; hallamos bajas frecuencias de sensibilizaci&#243;n y relevancia presente&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">El <span class="elsevierStyleBold">decil</span><span class="elsevierStyleBold">gluc&#243;sido</span> y <span class="elsevierStyleBold">lauril</span><span class="elsevierStyleBold">gluc&#243;sido</span> son alquil gluc&#243;sidos empleados como surfactantes en muchos compuestos&#46; En Norteam&#233;rica se ha observado un aumento lentamente progresivo de la frecuencia de sensibilizaci&#243;n en a&#241;os pasados&#44; hasta un 2&#37; en 2016<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">28</span></a>&#46; La prevalencia en el Reino Unido e Irlanda es del 1&#44;5&#37;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">30&#44;31</span></a>&#46; En nuestro trabajo&#44; la frecuencia de sensibilizaci&#243;n y relevancia fueron bajas&#44; probablemente por un uso menos extendido de estos surfactantes en los cosm&#233;ticos&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">La <span class="elsevierStyleBold">diazolidinil</span><span class="elsevierStyleBold">urea</span> &#40;Germal II&#44; DIAZ&#41; y la <span class="elsevierStyleBold">imidazolidinil</span><span class="elsevierStyleBold">urea</span> &#40;Germal 115&#44; IMID&#41; son liberadores de FA ubicuamente usados como conservantes&#44; incluidos en la bater&#237;a est&#225;ndar espa&#241;ola en 2016<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">4</span></a>&#46; Algunos trabajos europeos han mostrado frecuencias de sensibilizaci&#243;n del 0&#44;5-1&#44;5&#37;<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">26&#44;27</span></a>&#44; y su relevancia actual es desconocida&#46; En nuestro estudio hemos encontrado una baja frecuencia de sensibilizaci&#243;n y relevancia presente&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Nuestro trabajo muestra la factibilidad de organizar la informaci&#243;n en dermatitis de contacto en un registro multic&#233;ntrico adaptado a Internet&#44; lo cual garantiza una estandarizaci&#243;n completa de los datos&#44; permitiendo realizar una vigilancia epidemiol&#243;gica en tiempo real<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Nuestro estudio tiene dos limitaciones fundamentales&#46; La crisis de la COVID-19 conllev&#243; dificultades para conseguir algunos al&#233;rgenos y una importante disminuci&#243;n de la participaci&#243;n de los centros del REIDAC durante el a&#241;o 2020&#46; Otra limitaci&#243;n es la valoraci&#243;n subjetiva de la relevancia de las pruebas epicut&#225;neas&#44; siendo &#233;sta una limitaci&#243;n inherente a la mayor&#237;a de los estudios epidemiol&#243;gicos en DAC<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a>&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusiones</span><p id="par0130" class="elsevierStylePara elsevierViewall">Dado que el n&#250;mero de al&#233;rgenos en la bater&#237;a est&#225;ndar es limitado&#44; y en sus actualizaciones se debe valorar la inclusi&#243;n de al&#233;rgenos nuevos y eliminar los obsoletos&#44; nuestro trabajo aporta datos epidemiol&#243;gicos que sustentan estas posibles modificaciones&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Asimismo&#44; ponemos de manifiesto la utilidad de organizar la informaci&#243;n en dermatitis de contacto mediante un registro multic&#233;ntrico basado en Internet&#44; a partir del cual se pueden desarrollar&#44; de forma pr&#225;ctica y flexible&#44; estudios que contribuyen a la actualizaci&#243;n epidemiol&#243;gica en este campo&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Financiaci&#243;n</span><p id="par0140" class="elsevierStylePara elsevierViewall">El REIDAC ha recibido financiaci&#243;n de Sanofi&#44; GlaxoSmithKline y Novartis en forma de donaciones no condicionadas&#46; Los laboratorios financiadores no han participado en el dise&#241;o&#44; an&#225;lisis ni revisi&#243;n del art&#237;culo&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicto de intereses</span><p id="par0145" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes y objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La actualizaci&#243;n de las series est&#225;ndar de pruebas epicut&#225;neas debe basarse en datos objetivos de frecuencia de sensibilizaci&#243;n de los al&#233;rgenos que componen cada bater&#237;a&#46; La &#250;ltima renovaci&#243;n de la bater&#237;a est&#225;ndar espa&#241;ola se realiz&#243; en 2016 y de la europea en 2019&#44; quedando pendiente valorar la inclusi&#243;n de al&#233;rgenos emergentes&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Desarrollamos un estudio observacional&#44; prospectivo y multic&#233;ntrico de los pacientes consecutivos del registro del Grupo Espa&#241;ol de Investigaci&#243;n en Dermatitis y Alergia Cut&#225;nea sometidos a pruebas epicut&#225;neas con hidroper&#243;xido de linalool&#44; hidroper&#243;xido de limoneno&#44; 2-hidroxi-etil-metacrilato&#44; benzisotiazolinona&#44; octilisotiazolinona&#44; mezcla textil&#44; metabisulfito s&#243;dico&#44; prop&#243;leo&#44; bronopol&#44; mezcla de compuestas II&#44; diazolidinil urea&#44; imidazolidinil urea&#44; decil gluc&#243;sido y lauril gluc&#243;sido&#44; durante los a&#241;os 2019 y 2020&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se analiz&#243; una muestra de 4&#46;654 pacientes estudiados con diazolidinil urea&#44; imidazolidinil urea y bronopol&#44; y de 1&#46;890 pacientes con el resto de los al&#233;rgenos&#46; El &#237;ndice MOAHLFA fue&#58; M 30&#37;&#44; O 18&#37;&#44; A 15&#37;&#44; H 29&#37;&#44; L 6&#44;5&#37;&#44; F 23&#37;&#44; A 68&#37;&#46; Siete al&#233;rgenos mostraron una frecuencia de sensibilizaci&#243;n mayor del 1&#37;&#58; hidroper&#243;xido de linalool&#44; 2-hidroxi-etil-metacrilato&#44; benzisotiazolinona&#44; hidroper&#243;xido de limoneno&#44; mezcla textil&#44; metabisulfito s&#243;dico y prop&#243;leo&#46; Tres al&#233;rgenos mostraron una frecuencia de relevancia presente superior al 1&#37;&#58; hidroper&#243;xido de linalool&#44; 2-hidroxi-etil-metacrilato e hidroper&#243;xido de limoneno&#59; para benzisotiazolinona y mezcla textil&#44; esta frecuencia fue de entre el 0&#44;9 y el 1&#37;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nuestros resultados indican que deber&#237;a valorarse la inclusi&#243;n de siete nuevos al&#233;rgenos en la bater&#237;a est&#225;ndar espa&#241;ola&#46; Estos resultados podr&#237;an contribuir a la pr&#243;xima actualizaci&#243;n de la bater&#237;a basal europea&#46;</p></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Standard patch test series must be updated using objective data on allergen sensitization&#46; The Spanish standard series was last updated in 2016 and the European series in 2019&#44; and the inclusion of several emerging allergens needs to be evaluated&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We conducted a prospective&#44; observational&#44; multicenter study of consecutive patients from the registry of the Spanish Contact Dermatitis and Skin Allergy Research Group &#40;GEIDAC&#41; who were patch tested in 2019 and 2020 with linalool hydroperoxide&#44; limonene hydroperoxide&#44; 2-hydroxyethyl-methacrylate&#44; benzisothiazolinone&#44; octylisothiazolinone&#44; textile dye mix &#40;TDM&#41;&#44; sodium metabisulfite&#44; propolis&#44; bronopol&#44; Compositae mix II&#44; diazolidinyl urea&#44; imidazolidinyl urea&#44; decyl glucoside&#44; and lauryl glucoside&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We analyzed data for 4654 patients tested with diazolidinyl urea&#44; imidazolidinyl urea&#44; and bronopol&#44; and 1890 tested with the other allergens&#46; The values for the MOAHLFA index components were 30&#37; for male&#44; 18&#37; for occupational dermatitis&#44; 15&#37; for atopic dermatitis&#44; 29&#37; for hand&#44; 6&#46;5&#37; for leg&#44; 23&#37; for face&#44; and 68&#37; for age &#62;&#160;40 years&#46; Sensitization rates above 1&#37; were observed for 7 allergens&#58; linalool hydroperoxide&#44; 2-hydroxyethyl-methacrylate&#44; benzisothiazolinone&#44; limonene hydroperoxide&#44; TDM&#44; sodium metabisulfite&#44; and propolis&#46; Three allergens had a current relevance rate of over 1&#37;&#58; linalool hydroperoxide&#44; 2-hydroxyethyl-methacrylat&#44; and limonene hydroperoxide&#46; Benzisothiazolinone and TDM had a relevance rate of between 0&#46;9&#37; and 1&#37;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Our results indicate that 7 new allergens should be considered when extending the Spanish standard patch test series&#46; The data from our series could be helpful for guiding the next extension of the European baseline series&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
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                  <table border="0" frame="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleBold">Al&#233;rgenos incluidos en la bater&#237;a est&#225;ndar europea candidatos para la espa&#241;ola</span></th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">2-hidroxi-etil-metacrilato &#40;HEMA&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">2&#37; Vas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Mezcla textil&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&#44;6&#37; Vas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">1&#46;</span> Disperse Blue 35 1&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">2&#46;</span> Disperse Orange 1 1&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">3&#46;</span> Disperse Orange 3 1&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">4&#46;</span> Disperse Red 1 1&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">5&#46;</span> Disperse Red 17 1&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">6&#46;</span> Disperse Yellow 3 1&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">7&#46;</span> Disperse Blue 106 0&#44;3&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">8&#46;</span> Disperse Blue 124 0&#44;3&#37;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Prop&#243;leo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Al&#233;rgenos incluidos en la bater&#237;a est&#225;ndar espa&#241;ola candidatos para la europea</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diazolidinil urea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Imidazolidinil urea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diazolidinil urea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">True Test 550<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;cm<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Imidazolidinil urea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">True Test 600<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;cm<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Al&#233;rgenos candidatos para las bater&#237;as est&#225;ndar europea y espa&#241;ola</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hidroper&#243;xido de linalool&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hidroperoxido de linalool&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5 Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hidroper&#243;xido de limoneno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;3&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hidroper&#243;xido de limoneno&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Benzisotiazolinona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Octilisotiazolinona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Metabisulfito s&#243;dico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2-bromo-2-nitropropano-1&#44;3-diol &#40;bronopol&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2-bromo-2-nitropropano-1&#44;3-diol &#40;bronopol&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">True Test 250<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;cm<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mezcla de compuestas II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;5&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">1&#46;</span> Anthemis nobilis extract 0&#44;6&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">2&#46;</span> Chamomilla recutita extract 0&#44;6&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">3&#46;</span> Achillea millefolium extract 0&#44;5&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">4&#46;</span> Tanacetum vulgare extract 0&#44;5&#37;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">5&#46;</span> Arnica montana extract 0&#44;25&#37; <span class="elsevierStyleBold">6&#46;</span> Parthenolide 0&#44;05&#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Decil gluc&#243;sido&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lauril gluc&#243;sido&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#37; Vas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2708751.png"
              ]
            ]
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        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Lista de al&#233;rgenos analizados</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hospital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ciudad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes parcheados con la bater&#237;a est&#225;ndar espa&#241;ola<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes parcheados con la bater&#237;a espa&#241;ola extendida<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CHU Toledo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Toledo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">296&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">295&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HU Germans&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Badalona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">347&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">272&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HU Guadalajara&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Guadalajara&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">259&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">237&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HU Infanta Sof&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">285&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">213&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CHUS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Santiago de Compostela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">211&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">209&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CHUIMI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Las Palmas de Gran Canaria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">236&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">174&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HGU Morales Meseguer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Murcia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">211&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">167&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HU Princesa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">207&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HU Santa Creu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Barcelona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">246&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HU Fuenlabrada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">230&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HU Araba&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vitoria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">323&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HU 12 de Octubre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">194&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HF Jim&#233;nez D&#237;az&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">180&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CAU Le&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Le&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">221&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HGU Valencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Valencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">376&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">H Arnau Vilanova&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Valencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">364&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HG Alicante&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alicante&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">274&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HU La Fe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Valencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">160&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CH Navarra&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pamplona&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Total</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">4&#46;654</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">1&#46;898</span>&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes parcheados con la bater&#237;a est&#225;ndar espa&#241;ola<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a> &#40;n&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Positivos &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes parcheados con la bater&#237;a espa&#241;ola extendida<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">b</span></a> &#40;n&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Positivos &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Males</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;381&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">410 &#40;29&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">575&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">174 &#40;30&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Occupational</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">O&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">835&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">149 &#40;17&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">339&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61 &#40;17&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Atopy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">763&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">125 &#40;16&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">293&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;15&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hand</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">H&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;399&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">421 &#40;30&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">558&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">164 &#40;29&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Leg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">257&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;6&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Face</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;180&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">300 &#40;25&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col">Pacientes parcheados &#40;n&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">3&#44;13</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Prop&#243;leo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;885&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleBold">1&#44;38</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;94&#37; - 2&#44;02&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Al&#233;rgenos incluidos en la est&#225;ndar espa&#241;ola candidatos para la europea</span></span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diazolidinil urea&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Imidazolidinil urea&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;609&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Al&#233;rgenos candidatos para las bater&#237;as est&#225;ndar europea y espa&#241;ola</span></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hidroper&#243;xido de linalool &#40;1&#37; vas&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hidroper&#243;xido de linalool &#40;0&#44;3&#37; vas&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hidroper&#243;xido de limoneno &#40;0&#44;3&#37; vas&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hidroper&#243;xido de limoneno &#40;0&#44;2&#37; vas&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Benzisotiazolinona&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Octil-isotiazolinona&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Metabisulfito s&#243;dico&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2-bromo-2-nitropropano-1&#44;3-diol &#40;bronopol&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">856&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mezcla de compuestas II&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;642&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;20&#37; - 0&#44;89&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;12&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Decil gluc&#243;sido&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;80&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;32&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lauril gluc&#243;sido&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;874&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;32&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;14&#37; - 0&#44;71&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diazolidinyl urea&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;46&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;27&#37; - 0&#44;77&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;20&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Imidazolidinyl urea&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;25&#37; - 0&#44;73&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bronopol&nbsp;\t\t\t\t\t\t\n
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          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Frecuencias de sensibilizaci&#243;n y relevancia de los al&#233;rgenos estudiados</p>"
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                0 => array:2 [
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                    0 => array:2 [
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                        0 => array:2 [
                          "etal" => true
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                            2 => "V&#46; Fern&#225;ndez-Redondo"
                            3 => "J&#46;M&#46; Fern&#225;ndez-Vozmediano"
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                      "doi" => "10.1016/j.ad.2010.10.003"
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                  "referenciaCompleta" => "Uter W&#46; European Surveillance System on Contact Allergies&#46; Data Centre&#46; https&#58;&#47;&#47;www&#46;essca-dc&#46;org&#47; &#91;Consultado 21 Abr 2021&#93;&#46;"
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                    0 => array:2 [
                      "titulo" => "Actualizaci&#243;n de la serie est&#225;ndar espa&#241;ola de pruebas al&#233;rgicas de contacto por el Grupo Espa&#241;ol de Investigaci&#243;n en Dermatitis de Contacto y Alergia Cut&#225;nea &#40;GEIDAC&#41; para 2016"
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                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2016.04.009"
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                      "titulo" => "Thoughts on sensitizers in a standard patch test series&#46; The European Society of Contact Dermatitis"
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                            4 => "I&#46;R&#46; White"
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                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0536.1999.tb06154.x"
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                        "tituloSerie" => "Contact Dermatitis&#46;"
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                        "volumen" => "41"
                        "paginaInicial" => "241"
                        "paginaFinal" => "250"
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