was read the article
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"tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "688" "paginaFinal" => "689" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "D. Morgado-Carrasco, H. Feola, X. Fustà-Novell, N. Martinez" "autores" => array:4 [ 0 => array:4 [ "nombre" => "D." "apellidos" => "Morgado-Carrasco" "email" => array:1 [ 0 => "morgadodaniel8@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "H." "apellidos" => "Feola" ] 2 => array:2 [ "nombre" => "X." "apellidos" => "Fustà-Novell" ] 3 => array:2 [ "nombre" => "N." "apellidos" => "Martinez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, España" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "RF-Nevi With Moderate Dysplasia Excised With Positive Surgical Margins: Should We Re-Excise?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">El concepto de nevus displásico (ND) es un tema polémico. No se ha demostrado que el ND sea una lesión precursora de melanoma cutáneo, pero diversos estudios sugieren que sería un factor de riesgo. El manejo del ND es controvertido. No hay consenso en la actitud a seguir (observación o reescisión) cuando un nevus con displasia moderada ha sido extirpado y los márgenes están afectados. En una encuesta realizada en Norteamérica, el 48% reextirparía la lesión. En el 2015, el Subcomité norteamericano de lesiones pigmentadas (Pigmented Lesion Subcommittee) sugirió que la observación podría ser una opción razonable, pero la evidencia para avalar esta recomendación era limitada<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a>.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Recientemente, Kim et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> publicaron los resultados de un estudio multicéntrico retrospectivo en 438 pacientes con nevus extirpados con displasia moderada y márgenes comprometidos (467 lesiones), estudiando el desarrollo de melanoma en estos individuos. De ellos, el 50,4% tenía biopsias previas de nevus displásicos, el 33,2% antecedentes de melanoma y el 23,8% (83/349) historia familiar de melanoma. En cuanto a la técnica de extirpación, en el 46,4% se realizó un afeitado <span class="elsevierStyleItalic">(shave),</span> en el 45,3% un <span class="elsevierStyleItalic">punch</span> y en el 7,7% una exéresis elíptica. La displasia se evaluó por un experto en forma independiente. Durante un seguimiento promedio de 6,9 años (entre 3 a 21,3 años) ningún individuo desarrolló un melanoma en el sitio del ND extirpado. Sin embargo, el 22,8% desarrolló un melanoma primario en un sitio distinto. De estos, 3 pacientes presentaron un melanoma metastásico (2 con melanoma invasivo previo a la biopsia). Entre los factores de riesgo para el desarrollo de melanoma se encontraba una mayor edad (edad media de 49,7 vs. 45,9 años; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,04), historia de melanoma previo (49% vs. 9,9%; p <<span class="elsevierStyleHsp" style=""></span>0,001) y un ND biopsiado anteriormente (33,5% vs. 13,2%; p <<span class="elsevierStyleHsp" style=""></span>0,001). No se encontró asociación con el sexo o historia familiar de melanoma. El análisis de regresión multivariante reveló que el antecedente de melanoma y de ND previo (confirmado histológicamente) estaba independientemente asociado al desarrollo de melanoma en un sitio distinto del de la biopsia del ND (<span class="elsevierStyleItalic">odds ratio</span> [OR] 11,74; IC del 95%, 5,71-24,15, p <<span class="elsevierStyleHsp" style=""></span>0,001 y OR 2,55, IC del 95%, 1,23-5,28, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,01, respectivamente), incluso después de ajustar por edad, sexo e historia familiar de melanoma.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Los resultados del estudio de Kim et al., la mayor cohorte descrita hasta la fecha, son concordantes con los hallazgos de publicaciones previas (<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>)<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> en cuanto a que la observación parece ser una opción razonable en estos casos y apoyan la hipótesis de que los ND no serían lesiones precursoras de melanoma, pero sí un marcador importante de riesgo. Debemos recordar que alrededor de un 70% de los melanomas cutáneos se desarrollan <span class="elsevierStyleItalic">de novo</span> y no sobre un nevus preexistente.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">En pacientes con nevus con displasia moderada y márgenes afectados tras la exéresis, la observación clínica puede ser una opción válida. Los pacientes con historia previa de melanoma o de 2 ND (presentando uno de estos displasia moderada) deberían ser considerados de alto riesgo y seguidos estrechamente.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1277301" "palabras" => array:5 [ 0 => "Nevus" 1 => "Nevus displásico" 2 => "Melanoma" 3 => "Márgenes afectos" 4 => "Displasia moderada" ] ] ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Tabla 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Tabla " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Autor, año \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tipo de estudio \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Número de nevus displásicos \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tipo de displasia<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tiempo de seguimiento (años) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Melanomas desarrollados sobre el nevus displásico \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Melanomas en otro sitio \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cockerell y Berson, 1985<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Retrospectivo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No descrita \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Kmetz et al., 2009<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Retrospectivo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No descrita \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6,12 (mínimo 5 años) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No evaluado \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Goodson et al., 2010<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Retrospectivo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">654 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LeveModerada \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥<span class="elsevierStyleHsp" style=""></span>2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No evaluado \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hocker et al., 2013<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Retrospectivo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">66427 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LeveModeradaSevera \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17,4 (rango, 0-29,9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No evaluado<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hiscox et al., 2017<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Retrospectivo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">147 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Moderada \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,6 (rango, 1,2-8,7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No evaluado \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Kim et al., 2018<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Retrospectivo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">467 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Moderada \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6,9 (rango, 3-21,3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 (22,8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2391705.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">En esta tabla no se han incluido estudios basados exclusivamente en el seguimiento de nevus con displasia severa.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Ningún paciente presentó un melanoma metastásico.</p>" ] ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Resumen de los estudios sobre el seguimiento de nevus displásicos extirpados con márgenes afectados</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0040" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Addressing the knowledge gap in clinical recommendations for management and complete excision of clinically atypical nevi/dysplastic nevi: Pigmented Lesion Subcommittee consensus statement" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.C. Kim" 1 => "S.M. Swetter" 2 => "C. Curiel-Lewandrowski" 3 => "J.M. Grichnik" 4 => "D. Grossman" 5 => "A.C. Halpern" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2014.2694" "Revista" => array:7 [ "tituloSerie" => "JAMA Dermatol." "fecha" => "2015" "volumen" => "151" "paginaInicial" => "212" "paginaFinal" => "218" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25409291" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1081120614002622" "estado" => "S300" "issn" => "10811206" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0045" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of subsequent cutaneous melanoma in moderately dysplastic nevi excisionally biopsied but with positive histologic margins" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.C. Kim" 1 => "E.G. Berry" 2 => "M.A. Marchetti" 3 => "S.M. Swetter" 4 => "G. Lim" 5 => "D. Grossman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JAMA Dermatol." "fecha" => "2018" "volumen" => "154" "paginaInicial" => "1401" "paginaFinal" => "1408" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0050" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrence of moderately dysplastic nevi with positive histologic margins" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Hiscox" 1 => "M.R. Hardin" 2 => "I.F. Orengo" 3 => "T. Rosen" 4 => "M. Mir" 5 => "A.H. Diwan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2017" "volumen" => "76" "paginaInicial" => "527" "paginaFinal" => "530" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0055" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A retrospective look at dysplastic nevi. What were they in 1978 and how have they fared since?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.J. Cockerell" 1 => "D.S. Berson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00000372-198501001-00017" "Revista" => array:7 [ "tituloSerie" => "Am J Dermatopathol." "fecha" => "1985" "volumen" => "7 Suppl" "paginaInicial" => "93" "paginaFinal" => "97" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3940095" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0091674914002036" "estado" => "S300" "issn" => "00916749" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0060" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of observation in the management of atypical nevi" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E.C. Kmetz" 1 => "H. Sanders" 2 => "G. Fisher" 3 => "P.G. Lang" 4 => "J.C. Maize" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/SMJ.0b013e3181904289" "Revista" => array:7 [ "tituloSerie" => "South Med J." "fecha" => "2009" "volumen" => "102" "paginaInicial" => "45" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19077745" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0091674915007757" "estado" => "S300" "issn" => "00916749" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0065" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low rates of clinical recurrence after biopsy of benign to moderately dysplastic melanocytic nevi" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.G. Goodson" 1 => "S.R. Florell" 2 => "K.M. Boucher" 3 => "D. Grossman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2009.06.080" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2010" "volumen" => "62" "paginaInicial" => "591" "paginaFinal" => "596" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20018406" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0070" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Favorable long-term outcomes in patients with histologically dysplastic nevi that approach a specimen border" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T.L. Hocker" 1 => "A. Alikhan" 2 => "N.I. Comfere" 3 => "M.S. Peters" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2012.09.031" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2013" "volumen" => "68" "paginaInicial" => "545" "paginaFinal" => "551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23127472" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00017310/0000011100000008/v1_202010020701/S0001731020302234/v1_202010020701/es/main.assets" "Apartado" => array:4 [ "identificador" => "34907" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Foro de Residentes" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011100000008/v1_202010020701/S0001731020302234/v1_202010020701/es/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731020302234?idApp=UINPBA000044" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 40 | 11 | 51 |
2024 October | 497 | 50 | 547 |
2024 September | 467 | 36 | 503 |
2024 August | 542 | 64 | 606 |
2024 July | 548 | 34 | 582 |
2024 June | 609 | 47 | 656 |
2024 May | 639 | 44 | 683 |
2024 April | 643 | 33 | 676 |
2024 March | 703 | 32 | 735 |
2024 February | 614 | 43 | 657 |
2024 January | 618 | 35 | 653 |
2023 December | 462 | 38 | 500 |
2023 November | 420 | 38 | 458 |
2023 October | 499 | 34 | 533 |
2023 September | 569 | 40 | 609 |
2023 August | 456 | 18 | 474 |
2023 July | 419 | 41 | 460 |
2023 June | 324 | 22 | 346 |
2023 May | 341 | 25 | 366 |
2023 April | 292 | 37 | 329 |
2023 March | 316 | 42 | 358 |
2023 February | 244 | 30 | 274 |
2023 January | 217 | 33 | 250 |
2022 December | 216 | 38 | 254 |
2022 November | 271 | 41 | 312 |
2022 October | 330 | 43 | 373 |
2022 September | 352 | 42 | 394 |
2022 August | 262 | 46 | 308 |
2022 July | 219 | 54 | 273 |
2022 June | 291 | 45 | 336 |
2022 May | 212 | 29 | 241 |
2022 April | 172 | 30 | 202 |
2022 March | 172 | 63 | 235 |
2022 February | 175 | 26 | 201 |
2022 January | 211 | 44 | 255 |
2021 December | 144 | 39 | 183 |
2021 November | 146 | 46 | 192 |
2021 October | 117 | 46 | 163 |
2021 September | 117 | 43 | 160 |
2021 August | 135 | 36 | 171 |
2021 July | 126 | 29 | 155 |
2021 June | 133 | 30 | 163 |
2021 May | 88 | 47 | 135 |
2021 April | 161 | 73 | 234 |
2021 March | 103 | 38 | 141 |
2021 February | 85 | 31 | 116 |
2021 January | 90 | 25 | 115 |
2020 December | 64 | 31 | 95 |
2020 November | 123 | 38 | 161 |
2020 October | 163 | 66 | 229 |
2020 September | 95 | 29 | 124 |
2020 August | 425 | 71 | 496 |
2020 July | 102 | 56 | 158 |