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Por lo tanto&#44; en el presente estudio nos preguntamos&#44; cu&#225;l ser&#225; la real eficacia del uso de inyecciones de PRP como monoterapia en varones diagnosticados con AGA&#46; As&#237; mismo&#44; buscamos determinar si existe una correlaci&#243;n entre la respuesta favorable a dicho tratamiento con la edad de los pacientes y con el tipo y el tiempo de evoluci&#243;n de la AGA&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Materiales y m&#233;todos</span><p id="par0010" class="elsevierStylePara elsevierViewall">Para responder a nuestro interrogante&#44; se dise&#241;&#243; un estudio de &#171;antes&#47;despu&#233;s&#187;&#44; donde se incluyeron 30 pacientes con diagn&#243;stico de AGA&#44; menores de 45 a&#241;os y sin antecedentes conocidos de neoplasias malignas&#44; s&#237;ndrome de inmunodeficiencia adquirida&#44; hepatitis B&#44; hepatitis C o susceptibilidad a desarrollar cicatriz queloide&#46; Adem&#225;s&#44; ninguno de los pacientes recib&#237;a de manera cr&#243;nica medicaci&#243;n antiinflamatoria no esteroidea&#44; ni presentaban lesiones dermatol&#243;gicas activas en las &#225;reas afectadas por la AGA&#46; Nuestra cohorte de pacientes estuvo comprendida por todos los patrones de alopecia descritos por Norwood&#44; excepto el VI&#44; el VII y el Va&#46; As&#237; mismo&#44; ninguno de los pacientes hab&#237;a recibido alg&#250;n tratamiento capilar al menos durante los 3 meses previos al estudio y finalmente&#44; el recuento basal de plaquetas de los pacientes deb&#237;a superar las 140000 plaquetas por microlitro &#40;&#956;L&#41;&#46; Despu&#233;s de obtener el consentimiento informado por escrito&#44; de acuerdo con el Comit&#233; &#201;tico de la Universidad de Tishreen&#44; se realiz&#243; un an&#225;lisis del recuento sangu&#237;neo completo&#44; de las enzimas hep&#225;ticas&#44; de la velocidad de sedimentaci&#243;n globular&#44; del ant&#237;geno de superficie de la hepatitis B y de los anticuerpos contra el virus de la hepatitis C&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Cada paciente fue inspeccionado en b&#250;squeda del &#225;rea de menor densidad capilar&#46; Se demarc&#243; 1<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleSup">2</span> y se recort&#243; el cabello que se encontraba en esta &#225;rea&#46; Para delimitar el cm<span class="elsevierStyleSup">2</span> se utiliz&#243; una cinta m&#233;trica graduada en cm y se midi&#243; la distancia longitudinal desde el extremo correspondiente de la ceja o la ra&#237;z nasal&#46; Luego se ampli&#243; la imagen de dicha zona utilizando un dermatoscopio &#40;Heine mini 3000&#174; LED Dermatoscope&#44; Alemania&#41; y se realiz&#243; una fotograf&#237;a antes de cada inyecci&#243;n&#46; Esta fotograf&#237;a fue transferida al programa de Microsoft &#40;Paint&#59; versi&#243;n&#58; 6&#46;1&#41; la que posteriormente fue amplificada para facilitar el conteo manual por 3 observadores&#46; Para evitar duplicar el conteo de los fol&#237;culos&#44; se colocaba un punto rojo en cada cabello inmediatamente despu&#233;s de haberlo contado&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Preparaci&#243;n del PRP</span><p id="par0020" class="elsevierStylePara elsevierViewall">El PRP se prepar&#243; de manera est&#233;ril&#44; extrayendo 18<span class="elsevierStyleHsp" style=""></span>ml de sangre perif&#233;rica y luego estos ml se dividieron en dos mitades&#46; Cada mitad &#40;9<span class="elsevierStyleHsp" style=""></span>ml de sangre&#41; fue transferida a un tubo que conten&#237;a 1<span class="elsevierStyleHsp" style=""></span>ml de citrato de sodio al 3&#44;8&#37; y luego se centrifug&#243; a 800 revoluciones por minuto &#40;rpm&#41; durante 15 min &#40;Scilogex DM0412&#44; Nueva York&#44; Estados Unidos&#41;&#46; Seis<span class="elsevierStyleHsp" style=""></span>ml de la capa de sobrenadante&#44; que conten&#237;a 2&#44;25 veces la concentraci&#243;n basal de las plaquetas&#44; se extrajeron usando una aguja de calibre de 20 y se colocaron en 6 jeringuillas de insulina&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Las inyecciones intrad&#233;rmicas del PRP en las &#225;reas afectadas del cuero cabelludo se realizaron con los pacientes en posici&#243;n sentada&#46; Se dej&#243; un &#225;rea de 1<span class="elsevierStyleHsp" style=""></span>cm entre cada aplicaci&#243;n&#46; No fue necesario utilizar anestesia local&#46; En total se realizaron tres sesiones con 1 mes de intervalo entre cada aplicaci&#243;n&#46; Se valor&#243; a los pacientes utilizando un dermatoscopio antes de cada inyecci&#243;n&#44; as&#237; como a los 2 y 6 meses despu&#233;s de la primera inyecci&#243;n&#44; midiendo la densidad capilar de manera manual&#59; es decir&#44; se contaron las unidades foliculares en el 1<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleSup">2</span> fijado anteriormente&#46; La respuesta al tratamiento se consider&#243; positiva si la densidad capilar hab&#237;a aumentado en m&#225;s de 10 cabellos&#47;cm<span class="elsevierStyleSup">2</span> tras dos meses&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se seleccionaron 32 varones diagnosticados de AGA entre septiembre del 2017 y diciembre del 2018&#46; Se excluyeron dos pacientes&#59; uno por la ingesta de diclofenaco s&#243;dico &#40;AINE&#41; durante el per&#237;odo de estudio y el otro porque se detectaron anticuerpos s&#233;ricos contra el virus de la hepatitis C&#46; Finalmente&#44; un total de 30 pacientes fueron incluidos en este estudio&#46; La cohorte de nuestro estudio estuvo conformada por pacientes con edades comprendidas entre los 17 y los 42 a&#241;os &#40;media 26&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;7&#41;&#46; Los pacientes con un patr&#243;n de tipo III y III vertex&#44; seg&#250;n la clasificaci&#243;n de Norwood&#44; fueron los m&#225;s frecuentes &#40;8 pacientes cada uno&#59; es decir&#44; 26&#44;7&#37;&#41;&#46; Veintiocho pacientes &#40;93&#44;3&#37;&#41; ten&#237;an antecedentes familiares de AGA&#46; Se observ&#243; que la densidad capilar se increment&#243; en un 19&#44;17&#37; al finalizar los 2 meses de haber aplicado el PRP &#40;172&#44;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>59&#44;04 pelos&#47;cm<span class="elsevierStyleSup">2</span> antes del tratamiento a 206&#44;06<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>70&#44;77 pelos&#47;cm<span class="elsevierStyleSup">2</span> tras 2 meses&#41;&#46; Este aumento fue significativo y se mantuvo a los 6 meses despu&#233;s de haber realizado el tratamiento &#40;media 205&#44;53<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>68&#44;20 cabellos&#47;cm<span class="elsevierStyleSup">2</span>&#44; prueba de Friedman&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41; &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">figs&#46; 1-2</a>&#41;&#46; Como efectos secundarios directos durante cada inyecci&#243;n se observ&#243; un sangrado m&#237;nimo y un dolor considerado tolerable por los pacientes&#59; as&#237; mismo&#44; despu&#233;s de cada sesi&#243;n&#44; algunos pacientes refirieron un dolor de cabeza que tambi&#233;n fue bien tolerado y que desaparec&#237;a en un corto tiempo&#44; incluso sin la necesidad de administrar acetaminof&#233;n&#46; En nuestra cohorte&#44; el incremento en la densidad capilar del 10 al 20&#37; fue el resultado que se objetiv&#243; con mayor frecuencia 33&#44;3&#37; &#40;10&#47;30&#41;&#46; Adem&#225;s&#44; en el 6&#44;7&#37; &#40;2&#47;30&#41; de los pacientes se evidenci&#243; un aumento de m&#225;s del 50&#37; en la densidad capilar&#46; Sin embargo&#44; en el 13&#44;3&#37; &#40;4&#47;30&#41; a los 6 meses despu&#233;s de haber realizado las inyecciones de PRP se demostr&#243; una disminuci&#243;n en la densidad capilar &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Adem&#225;s&#44; observamos una correspondencia entre la eficacia de la aplicaci&#243;n del PRP y el tipo de AGA &#40;prueba exacta de Fisher&#44; valor de p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41;&#46; El patr&#243;n con menor respuesta fue el de tipo III vertex &#40;solo el 37&#44;5&#37; de los pacientes respondieron positivamente&#41;&#46; Sin embargo&#44; la tasa de eficacia fue del 100&#37; para los tipos I&#44; III y IV&#59; 83&#44;33&#37; para el tipo II y 75&#37; para el tipo V&#46; No hubo correlaci&#243;n entre una respuesta favorable y la edad del paciente &#40;prueba exacta de Fisher&#44; valor de p&#58; 0&#44;5&#41; o la duraci&#243;n de la AGA &#40;prueba exacta de Fisher&#44; valor de p&#58; 0&#44;7&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discusi&#243;n</span><p id="par0035" class="elsevierStylePara elsevierViewall">En estudios previos se ha afirmado que el PRP es una alternativa &#250;til en el tratamiento de la AGA<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">2-4&#44;6</span></a>&#59; sin embargo&#44; por el contrario&#44; existen reportes que cuestionan su eficacia<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a>&#46; En el presente estudio&#44; objetivamos que el PRP mejor&#243; la densidad capilar en un 19&#44;17&#37; de los varones con AGA a los 2 meses de aplicaci&#243;n y que esta mejor&#237;a se mantuvo tambi&#233;n a los 4 meses&#46; Nuestros datos concuerdan con el estudio presentado por Ho et al&#46; &#40;2018&#41;&#44; en el que se utilizaron inyecciones de PRP en combinaci&#243;n con otros tratamientos capilares<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a>&#44; mientras que en este estudio se aplic&#243; el PRP en monoterapia&#46; En el estudio de Alves y Grimalt &#40;2016&#41;&#44; el incremento medio en la densidad capilar a los 6 meses del tratamiento fue del 7&#44;6&#37;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a>&#44; mientras que nosotros observamos un aumento del 19&#44;17&#37;&#46; Esta discrepancia podr&#237;a atribuirse en parte&#44; a la inclusi&#243;n de pacientes de ambos sexos en el dise&#241;o del estudio de Alves y Grimalt&#44; mientras que nuestro estudio se restringi&#243; &#250;nicamente a pacientes del sexo masculino&#46; Puig et al&#46; &#40;2016&#41; no evidenciaron una mejor&#237;a significativa tras el uso del PRP en las pacientes del sexo femenino diagnosticadas con AGA<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a>&#46; Sin embargo&#44; sus datos no han descartado que dicho tratamiento pueda ser efectivo en los pacientes de sexo masculino&#46; Tras la aplicaci&#243;n de las inyecciones de PRP&#44; tanto los pacientes como los m&#233;dicos buscan un incremento de la densidad capilar en m&#225;s del 50&#37;&#46; Esto ocurri&#243; &#250;nicamente en el 6&#44;7&#37; de nuestros pacientes&#59; mientras que en la mayor&#237;a de los casos el incremento de la densidad capilar fue solo de entre el 10 y el 20&#37; &#40;33&#44;3&#37; de los pacientes&#41;&#46; En consecuencia&#44; confirmamos que la eficacia del tratamiento con PRP variar&#225; considerablemente entre los pacientes&#44; hecho a tener cuenta en la pr&#225;ctica cl&#237;nica&#46; La variaci&#243;n de la eficacia del PRP depender&#225; de las diferencias en su preparaci&#243;n y en su aplicaci&#243;n&#46; Sin embargo&#44; hasta el momento actual&#44; no existe ning&#250;n protocolo est&#225;ndar para su realizaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a>&#46; Finalmente&#44; el 13&#44;3&#37; de nuestra cohorte demostr&#243; una disminuci&#243;n en la densidad capilar despu&#233;s de la terapia con el PRP&#46; Estos datos se podr&#237;an explicar debido a la progresi&#243;n de la AGA&#44; la cual no se controlar&#225; &#250;nicamente mediante las inyecciones del PRP&#46; Adem&#225;s&#44; nuestros resultados han demostrado la existencia de una correlaci&#243;n entre la eficacia de las inyecciones de PRP y el patr&#243;n de la AGA&#46; Sin embargo&#44; un an&#225;lisis estad&#237;stico m&#225;s exhaustivo ser&#225; necesario antes de confirmar dicha conclusi&#243;n&#46; Hasta donde sabemos&#44; no existen estudios previos acerca de la correlaci&#243;n entre la respuesta al tratamiento con el PRP y la edad del paciente o el tiempo de duraci&#243;n de la alopecia&#46; En el presente estudio se pudo objetivar que la eficacia del uso del PRP ser&#225; independiente de la edad y la duraci&#243;n de la alopecia&#46; Sin embargo&#44; creemos que existe la necesidad de realizar un estudio con una cohorte m&#225;s amplia que posibilite confirmar estos hallazgos&#46; Las limitaciones del presente estudio son el peque&#241;o tama&#241;o de la muestra&#44; el corto per&#237;odo de seguimiento y la falta de datos acerca del di&#225;metro del fol&#237;culo debido a la falta de equipos suficientes en nuestras cl&#237;nicas&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusi&#243;n</span><p id="par0040" class="elsevierStylePara elsevierViewall">Las inyecciones de PRP tendr&#225;n un efecto favorable sobre la densidad capilar en los pacientes de sexo masculino diagnosticados de una AGA&#44; presentando efectos secundarios m&#237;nimos a corto plazo&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicto de intereses</span><p id="par0045" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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    "fechaAceptado" => "2019-11-04"
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          "palabras" => array:4 [
            0 => "Alopecia androgen&#233;tica"
            1 => "Dermatoscopio"
            2 => "Densidad capilar"
            3 => "Plasma rico en plaquetas"
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            0 => "Androgenetic alopecia"
            1 => "Dermatoscope"
            2 => "Hair density"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Antecedentes y objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El plasma rico en plaquetas es una fuente de factores de crecimiento utilizada recientemente en el tratamiento de la alopecia androgen&#233;tica &#40;AGA&#41;&#59; sin embargo&#44; la eficacia de este tratamiento sigue siendo controversial&#46; Los objetivos del presente estudio son evaluar la eficacia del plasma rico en plaquetas en el incremento de la densidad capilar en varones con AGA&#44; as&#237; como&#44; determinar si existe una correlaci&#243;n entre la respuesta favorable a dicho tratamiento&#44; con la edad del paciente&#44; con el tipo de AGA y con el tiempo de evoluci&#243;n de esta&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Materiales y m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se dise&#241;&#243; un estudio de &#171;antes&#47;despu&#233;s&#187; y se incluyeron 30 varones&#46; Estos pacientes no hab&#237;an recibido ning&#250;n tratamiento para la AGA al menos en los 3 meses previos al estudio&#46; Cada paciente recibi&#243; 3 inyecciones en intervalos de un mes&#46; La densidad capilar de cada sujeto se midi&#243; manualmente mediante un dermatoscopio antes de la primera intervenci&#243;n y tambi&#233;n a los 2 y 6 meses&#46; Para determinar la eficacia del tratamiento se realiz&#243; un an&#225;lisis comparativo&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La densidad capilar se increment&#243; en un 19&#44;17&#37; despu&#233;s de la intervenci&#243;n &#40;172&#44;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>59&#44;04 cabellos&#47;cm<span class="elsevierStyleSup">2</span> antes del tratamiento a 205&#44;53<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>68&#44;20 cabellos&#47;cm<span class="elsevierStyleSup">2</span> despu&#233;s de los 6 meses&#41;&#59; los efectos secundarios fueron m&#237;nimos en el seguimiento a corto plazo&#46; El patr&#243;n de alopecia de tipo vertex III fue el patr&#243;n que present&#243; una menor respuesta&#46; No se objetiv&#243; ninguna correlaci&#243;n entre la respuesta favorable al tratamiento y la edad del paciente o la duraci&#243;n de la AGA&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Las inyecciones de plasma rico en plaquetas en pacientes varones con AGA tendr&#225;n un efecto favorable sobre la densidad capilar&#46;</p></span>"
        "secciones" => array:4 [
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          1 => array:2 [
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            "titulo" => "Materiales y m&#233;todos"
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          2 => array:2 [
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Background and aims</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Platelet rich plasma is a source of growth factors recently introduced to treat androgenetic alopecia &#40;AGA&#41; with conflicting results&#46; Our aims are to assess the efficacy of platelet rich plasma in increasing hair density in males with AGA&#44; and to investigate a correlation between positive response and each of patient&#39;s age and type and duration of AGA&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Materials &#38; methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">This before and after study included 30 males with no history of hair treatments for at least 3 months prior to our study&#46; Each patient received 3 injections at one-month intervals&#46; Scalp hair density of each subject was measured manually by a dermatoscope before and following 2 and 6 months of the first intervention&#46; Data were compared to evaluate efficacy&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Hair density was increased by 19&#46;17&#37; following our intervention &#40;172&#46;46<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>59&#46;04 hairs&#47;cm<span class="elsevierStyleSup">2</span> before treatment to 205&#46;53<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>68&#46;20 hairs&#47;cm<span class="elsevierStyleSup">2</span> after 6 months&#41; with minimal short-term side effects&#46; Type III vertex was the least responsive pattern and no correlation was observed between positive response and either patient&#39;s age or duration of AGA&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusion</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Platelet rich plasma injections for men with AGA has a positive effect on hair density&#46;</p></span>"
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Despu&#233;s de 6 meses&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III vertex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">175&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">229&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">177&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III vertex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">177&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">155&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">243&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">136&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">160&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">193&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">III&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">166&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">213&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">220&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">V&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">V&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">138&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">202&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">207&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">152&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III vertex&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">V&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">145&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">160&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">151&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">265&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">273&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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          "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas basales y valores de la densidad capilar en 30 pacientes varones con alopecia androgen&#233;tica tratados con 3 sesiones de plasma rico en plaquetas con 1 mes de intervalo</p>"
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