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Comentarios Editoriales
Sífilis precoz: nuevas aproximaciones diagnósticas para un escenario cambiante
Early Syphilis: New Diagnostic Approaches in a Changing Scenario
T. Toledo-Pastrana
Unidad de Gestión Clínica de Dermatología, Servicio de Dermatología, Hospital Universitario Virgen Macarena, Sevilla, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">La s&#237;filis afecta a millones de personas anualmente&#44; con una incidencia creciente en la &#250;ltima d&#233;cada&#44; a&#241;o tras a&#241;o&#46; Tradicionalmente el algoritmo diagn&#243;stico de la s&#237;filis comenzaba con la realizaci&#243;n de las pruebas no trepon&#233;micas &#40;RPR y VRDL&#41; y&#44; en caso de positividad&#44; se solicitaban las trepon&#233;micas como confirmaci&#243;n &#40;TPHA&#44; FTA-ABS y TPPA&#41;&#46; En los &#250;ltimos a&#241;os se han desarrollado pruebas trepon&#233;micas automatizadas &#40;EIA y CLIA&#41; con alta sensibilidad&#44; mayor rapidez de realizaci&#243;n e independientes de observador&#46; Esto obliga a considerarlas como herramientas de cribado o <span class="elsevierStyleItalic">screening</span> especialmente &#250;tiles&#44; ya que adem&#225;s son de bajo coste&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Estos cambios han provocado que el algoritmo diagn&#243;stico tradicional de la s&#237;filis &#40;pruebas no trepon&#233;micas primero&#44; trepon&#233;micas despu&#233;s&#41; est&#233; siendo reemplazado por otros que dan papel protagonista a las pruebas trepon&#233;micas automatizadas&#44; como as&#237; ha propuesto el European Centre for Disease Prevention and Control &#40;ECDP&#41; en su &#250;ltima revisi&#243;n&#58; comenzar con la realizaci&#243;n de una prueba trepon&#233;mica automatizada &#40;EIA y CLIA&#41;&#44; y posteriormente realizar una prueba no trepon&#233;mica cuantitativa &#40;RPR&#41;&#46; En el caso de que la prueba no trepon&#233;mica sea negativa se realiza una segunda prueba trepon&#233;mica &#8212;automatizada o no&#8212; distinta a la utilizada previamente como prueba de <span class="elsevierStyleItalic">screening</span><a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Las nuevas t&#233;cnicas automatizadas permiten&#44; adem&#225;s&#44; la medici&#243;n de anticuerpos espec&#237;ficos frente a <span class="elsevierStyleItalic">T&#46; pallidum</span> tipo IgM o IgG&#44; lo que resulta de especial inter&#233;s para monitorizar la respuesta terap&#233;utica&#44; ya que IgM baja r&#225;pidamente tras un tratamiento adecuado&#44; especialmente en el seguimiento de respuesta en pacientes con coinfecci&#243;n VIH<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Resulta fundamental conocer como dermat&#243;logos los notables avances en las pruebas diagn&#243;sticas y los cambios planteados para el algoritmo diagn&#243;stico de la s&#237;filis&#46; El trabajo de Garc&#237;a-Legaz Mart&#237;nez et al&#46; realizan una exposici&#243;n de c&#243;mo estos nuevos planteamientos diagn&#243;sticos son de extrema utilidad en la pr&#225;ctica cl&#237;nica habitual<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a>&#46; Es nuestra obligaci&#243;n mantenernos actualizados en este campo&#44; no solo por ser la venereolog&#237;a parte fundamental de nuestra especialidad&#44; sino para evitar interpretaciones equ&#237;vocas en las pruebas solicitadas o errores en el diagn&#243;stico y seguimiento de nuestros pacientes&#46;</p></span>"
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Article information
ISSN: 00017310
Original language: Spanish
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