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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cell adhesion molecules play a pivotal role in the establishment of T-cell populations in the skin&#46; In this study&#44; we quantify the expression of cell adhesion molecules in patients with cutaneous T-cell lymphoma &#40;CTCL&#41; and compare it with the expression found in other skin diseases&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Frozen material was obtained from 42 patients in 5 different groups&#58; early CTCL&#44; comprising patients with patch- and plaque-stage mycosis fungoides &#40;n&#61;11&#41;&#59; advanced CTCL &#40;n&#61;7&#41;&#44; comprising patients with mycosis fungoides &#40;n&#61;3&#41; and S&#233;zary syndrome &#40;n&#61;4&#41;&#59; inflammatory skin disease &#40;n&#61;12&#41;&#44; comprising patients with psoriasis &#40;n&#61;9&#41; and atopic dermatitis &#40;n&#61;3&#41;&#59; chronic skin diseases with persistent plaques that do not fulfil the histological criteria for mycosis fungoides &#40;pre-CTCL&#41; &#40;n&#61;8&#41;&#59; and healthy volunteers &#40;n&#61;4&#41;&#46; Expression of the following cell adhesion molecules was analyzed&#58; lymphocyte function-associated antigen 1&#44; intercellular adhesion molecule 1 &#40;ICAM-1&#41;&#44; ICAM-3&#44; cutaneous lymphocyte-associated antigen&#44; E-selectin&#44; very late antigen 4&#44; vascular cell adhesion molecule 1&#44; &#945;E&#946;7 integrin&#44; and E-cadherin&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The immunohistochemical analyses used here revealed statistically significant differences between CTCL and other skin diseases but not between early and advanced CTCL&#46; The expression of &#945;E&#946;7 integrin and ICAM-3 in the epidermis per high-power field &#40;400&#215; magnification&#41; allowed the different groups to be distinguished from each other&#44; except for advanced CTCL and pre-CTCL&#46; There were statistically significant differences between advanced CTCL and pre-CTCL in terms of the expression of E-selectin at 400&#215; magnification and the expression of ICAM-1 in a honeycomb pattern in epidermal keratinocytes&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The expression of cell adhesion molecules involved in the adhesion and migration of lymphocytes in the skin does not differ significantly between initial and advanced stages of CTCL&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Las mol&#233;culas de adhesi&#243;n celular &#40;MAC&#41; desempe&#241;an un papel fundamental en la localizaci&#243;n de los linfocitos T en la piel&#46; El presente estudio cuantifica la expresi&#243;n de MAC en pacientes con linfoma cut&#225;neo de c&#233;lulas T &#40;LCCT&#41; y lo compara con la observada en otras dermatosis&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se dispuso de material congelado de 42 pacientes distribuidos en 5 grupos&#58; LCCT iniciales&#44; micosis fungoide en fase de m&#225;cula y placa &#40;11 pacientes&#41;&#59; LCCT avanzados &#40;n &#61; 7&#41;&#58; micosis fungoide y s&#237;ndrome de S&#233;zary&#59; enfermedades cut&#225;neas inflamatorias &#40;n &#61; 12&#41;&#58; psoriasis y dermatitis at&#243;pica&#59; dermatosis cr&#243;nicas persistentes en placas que no cumplen criterios histol&#243;gicos de micosis fungoide &#40;pre-LCCT&#41; &#40;n &#61; 8&#41; y pacientes sanos &#40;n &#61; 4&#41;&#46; Se ha estudiado la expresi&#243;n de los ant&#237;genos LFA-1&#44; ICAM-1&#44; ICAM-3&#44; CLA&#44; selectina E&#44; VLA-4&#44; VCAM-1&#44; &#945;E &#946;7 y cadherina E&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los par&#225;metros de inmunotinci&#243;n valorados no han permitido demostrar diferencias estad&#237;sticamente significativas entre los grupos LCCT inicial y avanzado&#44; pero s&#237; con respecto a otras dermatosis&#46; La expresi&#243;n de CD103 e ICAM-3 por campo epid&#233;rmico de 400&#215; puede emplearse como variable para distinguir entre los distintos subgrupos estudiados&#44; salvo en el caso de la comparaci&#243;n entre LCCT y pre-LCCT&#46; Estos dos &#250;ltimos grupos presentan diferencias estad&#237;sticamente significativas en la observaci&#243;n de la expresi&#243;n de selectina E a 400&#215; y la determinaci&#243;n del patr&#243;n en forma de panal de ICAM-1 en los queratinocitos epid&#233;rmicos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La expresi&#243;n de MAC que participan en los fen&#243;menos de adhesi&#243;n y trasmigraci&#243;n de los linfocitos en la piel no difiere significativamente entre las fases inicial y avanzada de los LCCT&#46;</p>"
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Journal Information
Vol. 101. Issue 10.
Pages 866-877 (December 2010)
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Vol. 101. Issue 10.
Pages 866-877 (December 2010)
Original article
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Comparative Analysis of the Expression of Cell Adhesion Molecules in Cutaneous T-Cell Lymphomas (Mycosis Fungoides/Sézary Syndrome) and Inflammatory Skin Diseases
Análisis comparativo de la expresión de moléculas de adhesión celular en linfomas cutáneos (micosis fungoide/síndrome de Sézary) y dermatosis inflamatorias mediadas por células T
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I. López-Lerma
Corresponding author
ilopez@aedv.es

Corresponding author.
, M.T. Estrach
Hospital Clinic de Barcelona, Servicio de Dermatología, Barcelona, Spain
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Article information
Abstract
Introduction

Cell adhesion molecules play a pivotal role in the establishment of T-cell populations in the skin. In this study, we quantify the expression of cell adhesion molecules in patients with cutaneous T-cell lymphoma (CTCL) and compare it with the expression found in other skin diseases.

Material and methods

Frozen material was obtained from 42 patients in 5 different groups: early CTCL, comprising patients with patch- and plaque-stage mycosis fungoides (n=11); advanced CTCL (n=7), comprising patients with mycosis fungoides (n=3) and Sézary syndrome (n=4); inflammatory skin disease (n=12), comprising patients with psoriasis (n=9) and atopic dermatitis (n=3); chronic skin diseases with persistent plaques that do not fulfil the histological criteria for mycosis fungoides (pre-CTCL) (n=8); and healthy volunteers (n=4). Expression of the following cell adhesion molecules was analyzed: lymphocyte function-associated antigen 1, intercellular adhesion molecule 1 (ICAM-1), ICAM-3, cutaneous lymphocyte-associated antigen, E-selectin, very late antigen 4, vascular cell adhesion molecule 1, αEβ7 integrin, and E-cadherin.

Results

The immunohistochemical analyses used here revealed statistically significant differences between CTCL and other skin diseases but not between early and advanced CTCL. The expression of αEβ7 integrin and ICAM-3 in the epidermis per high-power field (400× magnification) allowed the different groups to be distinguished from each other, except for advanced CTCL and pre-CTCL. There were statistically significant differences between advanced CTCL and pre-CTCL in terms of the expression of E-selectin at 400× magnification and the expression of ICAM-1 in a honeycomb pattern in epidermal keratinocytes.

Conclusions

The expression of cell adhesion molecules involved in the adhesion and migration of lymphocytes in the skin does not differ significantly between initial and advanced stages of CTCL.

Key words:
Cutaneous T-cell lymphoma
Mycosis fungoides
Cell adhesion molecules
Sézary syndrome
Resumen
Introducción y objetivos

Las moléculas de adhesión celular (MAC) desempeñan un papel fundamental en la localización de los linfocitos T en la piel. El presente estudio cuantifica la expresión de MAC en pacientes con linfoma cutáneo de células T (LCCT) y lo compara con la observada en otras dermatosis.

Material y métodos

Se dispuso de material congelado de 42 pacientes distribuidos en 5 grupos: LCCT iniciales, micosis fungoide en fase de mácula y placa (11 pacientes); LCCT avanzados (n = 7): micosis fungoide y síndrome de Sézary; enfermedades cutáneas inflamatorias (n = 12): psoriasis y dermatitis atópica; dermatosis crónicas persistentes en placas que no cumplen criterios histológicos de micosis fungoide (pre-LCCT) (n = 8) y pacientes sanos (n = 4). Se ha estudiado la expresión de los antígenos LFA-1, ICAM-1, ICAM-3, CLA, selectina E, VLA-4, VCAM-1, αE β7 y cadherina E.

Resultados

Los parámetros de inmunotinción valorados no han permitido demostrar diferencias estadísticamente significativas entre los grupos LCCT inicial y avanzado, pero sí con respecto a otras dermatosis. La expresión de CD103 e ICAM-3 por campo epidérmico de 400× puede emplearse como variable para distinguir entre los distintos subgrupos estudiados, salvo en el caso de la comparación entre LCCT y pre-LCCT. Estos dos últimos grupos presentan diferencias estadísticamente significativas en la observación de la expresión de selectina E a 400× y la determinación del patrón en forma de panal de ICAM-1 en los queratinocitos epidérmicos.

Conclusión

La expresión de MAC que participan en los fenómenos de adhesión y trasmigración de los linfocitos en la piel no difiere significativamente entre las fases inicial y avanzada de los LCCT.

Palabras clave:
Linfoma cutáneo de células T
Micosis fungoide
Moléculas de adhesión celular
Síndrome de Sézary
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Copyright © 2010. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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