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Comparative Analysis of the Expression of Cell Adhesion Molecules in Cutaneous T-Cell Lymphomas (Mycosis Fungoides/Sézary Syndrome) and Inflammatory Skin Diseases
Análisis comparativo de la expresión de moléculas de adhesión celular en linfomas cutáneos (micosis fungoide/síndrome de Sézary) y dermatosis inflamatorias mediadas por células T
Hospital Clinic de Barcelona, Servicio de Dermatología, Barcelona, Spain
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Revisión de la literatura" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.B. Cervini, V. Tosi, S.H. Kim, M. Bocian, G. Chantada, C. Nousari, O.G. Carballo, A.M. Pierini" "autores" => array:8 [ 0 => array:2 [ "nombre" => "A.B." "apellidos" => "Cervini" ] 1 => array:2 [ "nombre" => "V." "apellidos" => "Tosi" ] 2 => array:2 [ "nombre" => "S.H." "apellidos" => "Kim" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Bocian" ] 4 => array:2 [ "nombre" => "G." "apellidos" => "Chantada" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Nousari" ] 6 => array:2 [ "nombre" => "O.G." "apellidos" => "Carballo" ] 7 => array:2 [ "nombre" => "A.M." "apellidos" => "Pierini" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707356?idApp=UINPBA000044" "url" => "/15782190/0000010100000010/v1_201304241533/S1578219010707356/v1_201304241533/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219010707332" "issn" => "15782190" "doi" => "10.1016/S1578-2190(10)70733-2" "estado" => "S300" "fechaPublicacion" => "2010-12-01" "aid" => "70733" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2010;101:858-65" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2130 "formatos" => array:3 [ "EPUB" => 37 "HTML" => 1353 "PDF" => 740 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Treatment of Moderate-to-Severe Psoriasis in Clinical Practice: A Survey of Spanish Dermatologists" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "858" "paginaFinal" => "865" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Realidad terapéutica de la psoriasis moderada-grave en España. Encuesta de opinión" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Moreno-Ramírez, E. Fonseca, P. Herranz, M. Ara" "autores" => array:4 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Moreno-Ramírez" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Fonseca" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Herranz" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Ara" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707332?idApp=UINPBA000044" "url" => "/15782190/0000010100000010/v1_201304241533/S1578219010707332/v1_201304241533/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Comparative Analysis of the Expression of Cell Adhesion Molecules in Cutaneous T-Cell Lymphomas (Mycosis Fungoides/Sézary Syndrome) and Inflammatory Skin Diseases" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "866" "paginaFinal" => "877" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. López-Lerma, M.T. Estrach" "autores" => array:2 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "López-Lerma" "email" => array:1 [ 0 => "ilopez@aedv.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M.T." "apellidos" => "Estrach" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Hospital Clinic de Barcelona, Servicio de Dermatología, Barcelona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Análisis comparativo de la expresión de moléculas de adhesión celular en linfomas cutáneos (micosis fungoide/síndrome de Sézary) y dermatosis inflamatorias mediadas por células T" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-12-29" "fechaAceptado" => "2010-04-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84827" "palabras" => array:4 [ 0 => "Cutaneous T-cell lymphoma" 1 => "Mycosis fungoides" 2 => "Cell adhesion molecules" 3 => "Sézary syndrome" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84826" "palabras" => array:4 [ 0 => "Linfoma cutáneo de células T" 1 => "Micosis fungoide" 2 => "Moléculas de adhesión celular" 3 => "Síndrome de Sézary" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cell adhesion molecules play a pivotal role in the establishment of T-cell populations in the skin. In this study, we quantify the expression of cell adhesion molecules in patients with cutaneous T-cell lymphoma (CTCL) and compare it with the expression found in other skin diseases.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Frozen material was obtained from 42 patients in 5 different groups: early CTCL, comprising patients with patch- and plaque-stage mycosis fungoides (n=11); advanced CTCL (n=7), comprising patients with mycosis fungoides (n=3) and Sézary syndrome (n=4); inflammatory skin disease (n=12), comprising patients with psoriasis (n=9) and atopic dermatitis (n=3); chronic skin diseases with persistent plaques that do not fulfil the histological criteria for mycosis fungoides (pre-CTCL) (n=8); and healthy volunteers (n=4). Expression of the following cell adhesion molecules was analyzed: lymphocyte function-associated antigen 1, intercellular adhesion molecule 1 (ICAM-1), ICAM-3, cutaneous lymphocyte-associated antigen, E-selectin, very late antigen 4, vascular cell adhesion molecule 1, αEβ7 integrin, and E-cadherin.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The immunohistochemical analyses used here revealed statistically significant differences between CTCL and other skin diseases but not between early and advanced CTCL. The expression of αEβ7 integrin and ICAM-3 in the epidermis per high-power field (400× magnification) allowed the different groups to be distinguished from each other, except for advanced CTCL and pre-CTCL. There were statistically significant differences between advanced CTCL and pre-CTCL in terms of the expression of E-selectin at 400× magnification and the expression of ICAM-1 in a honeycomb pattern in epidermal keratinocytes.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The expression of cell adhesion molecules involved in the adhesion and migration of lymphocytes in the skin does not differ significantly between initial and advanced stages of CTCL.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Las moléculas de adhesión celular (MAC) desempeñan un papel fundamental en la localización de los linfocitos T en la piel. El presente estudio cuantifica la expresión de MAC en pacientes con linfoma cutáneo de células T (LCCT) y lo compara con la observada en otras dermatosis.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se dispuso de material congelado de 42 pacientes distribuidos en 5 grupos: LCCT iniciales, micosis fungoide en fase de mácula y placa (11 pacientes); LCCT avanzados (n = 7): micosis fungoide y síndrome de Sézary; enfermedades cutáneas inflamatorias (n = 12): psoriasis y dermatitis atópica; dermatosis crónicas persistentes en placas que no cumplen criterios histológicos de micosis fungoide (pre-LCCT) (n = 8) y pacientes sanos (n = 4). Se ha estudiado la expresión de los antígenos LFA-1, ICAM-1, ICAM-3, CLA, selectina E, VLA-4, VCAM-1, αE β7 y cadherina E.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los parámetros de inmunotinción valorados no han permitido demostrar diferencias estadísticamente significativas entre los grupos LCCT inicial y avanzado, pero sí con respecto a otras dermatosis. La expresión de CD103 e ICAM-3 por campo epidérmico de 400× puede emplearse como variable para distinguir entre los distintos subgrupos estudiados, salvo en el caso de la comparación entre LCCT y pre-LCCT. Estos dos últimos grupos presentan diferencias estadísticamente significativas en la observación de la expresión de selectina E a 400× y la determinación del patrón en forma de panal de ICAM-1 en los queratinocitos epidérmicos.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La expresión de MAC que participan en los fenómenos de adhesión y trasmigración de los linfocitos en la piel no difiere significativamente entre las fases inicial y avanzada de los LCCT.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Structure and function of cell adhesion molecules" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Petruzzelli" 1 => "M. Takami" 2 => "D. Humes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1999" "volumen" => "106" "paginaInicial" => "467" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10225251" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.P. Schön" 1 => "T.M. Zollner" 2 => "W.H. Boehncke" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.2003.12563.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2003" "volumen" => "121" "paginaInicial" => "951" "paginaFinal" => "962" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14708592" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelial-leukocyte adhesion molecules in human disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.P. Bevilacqua" 1 => "R.M. Nelson" 2 => "G. Mannori" 3 => "O. Cecconi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.med.45.1.361" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Med" "fecha" => "1994" "volumen" => "45" "paginaInicial" => "361" "paginaFinal" => "378" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7515220" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.A. Springer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "1994" "volumen" => "76" "paginaInicial" => "301" "paginaFinal" => "314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7507411" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory skin diseases, T cells and immune surveilance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Robert" 1 => "T.S. Kupper" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Eng J Med" "fecha" => "1999" "volumen" => "341" "paginaInicial" => "1817" "paginaFinal" => "1828" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.C. Fuhlbrigge" 1 => "J.D. Kieffer" 2 => "D. Armerding" 3 => "T.S. Kupper" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/40166" "Revista" => array:7 [ "tituloSerie" => "Nature" "fecha" => "1997" "volumen" => "389" "paginaInicial" => "978" "paginaFinal" => "981" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9353122" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510711023339" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CLA(+) T cells in cutaneous diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.F. Santamaria-Babí" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2004" "volumen" => "14" "paginaInicial" => "13" "paginaFinal" => "18" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14965789" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cell adhesion receptors in lymphoma dissemination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Drillenburg" 1 => "S.T. Pals" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2000" "volumen" => "95" "paginaInicial" => "1900" "paginaFinal" => "1910" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10706853" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "WHO-EORTC classification for cutaneous lymphomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Willemze" 1 => "E.S. Jaffe" 2 => "G. Burg" 3 => "L. Cerroni" 4 => "E. Berti" 5 => "S.H. Swerdlow" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2004-09-3502" "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2005" "volumen" => "105" "paginaInicial" => "3768" "paginaFinal" => "3785" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15692063" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Defining early mycosis fungoides" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Pimpinelli" 1 => "E.A. Olsen" 2 => "M. Santucci" 3 => "E. Vonderheid" 4 => "A.C. Haeffner" 5 => "S. Stevens" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2005.08.057" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2005" "volumen" => "53" "paginaInicial" => "1053" "paginaFinal" => "1063" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16310068" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.R. De Fougerolles" 1 => "T.A. Springer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1992" "volumen" => "175" "paginaInicial" => "185" "paginaFinal" => "190" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1730916" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Ríos L, Baranda L, Fernández-Herrera JM. Expresión de una nueva molécula de adhesión celular ICAM-3 en dermatosis cutáneas. Premio isdin 1992/1993 “Prof. Joaquín Piñol Aguadé” otorgado por la Academia Española de Dermatología y Sifiliografía." ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of ICAM-3/CD50 in normal and diseased skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Montazeri" 1 => "J. Kanitakis" 2 => "G. Zambruno" 3 => "D. Bourchany" 4 => "D. Schmitt" 5 => "A. Claudy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1995" "volumen" => "133" "paginaInicial" => "377" "paginaFinal" => "384" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8546991" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intercellular adhesion molecule-3 on endothelial cells. Expression in tumors but not in inflammatory responses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. Patey" 1 => "R. Vazeux" 2 => "D. Canioni" 3 => "T. Potter" 4 => "W.M. Gallatin" 5 => "N. Brousse" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Pathol" "fecha" => "1996" "volumen" => "148" "paginaInicial" => "465" "paginaFinal" => "472" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8579109" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of intercellular adhesion molecule 3 (CDw50) on endothelial cells in cutaneous lymphomas. A comparative study between nodal and cutaneous lymphomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.N. Dommann" 1 => "C.C. Dommann-Scherrer" 2 => "T. Ziegler" 3 => "J. Meyer" 4 => "R.M. Trüeb" 5 => "T. Kündig" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "1997" "volumen" => "19" "paginaInicial" => "391" "paginaFinal" => "395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9261475" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal and inflamed skin: modulation by recombinant gamma interferon and tumor necrosis factor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.E.M. Griffiths" 1 => "J.J. Voorhees" 2 => "B.J. Nickoloff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1989" "volumen" => "20" "paginaInicial" => "617" "paginaFinal" => "629" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2497153" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Markedly diminished epidermal keratinocyte expression of intercellular adhesion molecule-1 (ICAM-1) in Sézary syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B.J. Nickoloff" 1 => "C.E. Griffiths" 2 => "O. Baadsgaard" 3 => "J.J. Voorhees" 4 => "C.A. Hanson" 5 => "K.D. Cooper" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1989" "volumen" => "261" "paginaInicial" => "2217" "paginaFinal" => "2221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2467016" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio de la expresión de la integrina aEb (CD103) y de los antígenos CD54 (ICAM-1) y CD11a (LFA-1) en lesiones precoces y avazadas de linfoma cutáneo de células T (micosis fungoide/ síndrome de Sézary)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.M. Pujol" 1 => "J. Sole" 2 => "J. Miralles" 3 => "J.M. Moragas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifilogr" "fecha" => "1998" "volumen" => "89" "paginaInicial" => "19" "paginaFinal" => "28" "itemHostRev" => array:3 [ "pii" => "S0016510709026091" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative analysis of histological and immunohistological features in mycosis fungoides and Sézary syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Kamarashev" 1 => "G. Burg" 2 => "W. Kempf" 3 => "M. Hess Schmid" 4 => "R. Dummer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1998" "volumen" => "25" "paginaInicial" => "407" "paginaFinal" => "412" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9826165" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of adhesion molecules in cutaneous inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.J. Walsh" 1 => "G.F. Murphy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1992" "volumen" => "19" "paginaInicial" => "161" "paginaFinal" => "167" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1401341" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510708029519" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of LFA-1 in non-Hodgkin's lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.J. Medeiros" 1 => "L.M. Weiss" 2 => "L.J. Picker" 3 => "C. Clayberger" 4 => "S.J. Horning" 5 => "A.M. Krensky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "1989" "volumen" => "63" "paginaInicial" => "255" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2642732" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510710019929" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selectins and their ligand: Current concepts and controversies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.S. Kansas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "1996" "volumen" => "88" "paginaInicial" => "3259" "paginaFinal" => "3287" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8896391" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of cutaneous lymphocyte-associated antigen on human CD4(+) and CD8(+) Th2 cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Akdis" 1 => "S. Klunker" 2 => "M. Schliz" 3 => "K. Blaser" 4 => "C.A. Akdis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1521-4141(2000012)30:12<3533::AID-IMMU3533>3.0.CO;2-5" "Revista" => array:6 [ "tituloSerie" => "Eur J Immunol" "fecha" => "2000" "volumen" => "30" "paginaInicial" => "3533" "paginaFinal" => "3541" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11093173" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vascular and non-vascular expression of INCAM-110" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.E. Rice" 1 => "J.M. Munro" 2 => "C. Corless" 3 => "M.P. Bevilacqua" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Pathol" "fecha" => "1991" "volumen" => "138" "paginaInicial" => "385" "paginaFinal" => "393" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1704191" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of circulating adhesion molecules in erythrodermic skin disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.W. Groves" 1 => "P. Kapahi" 2 => "J.N. Barker" 3 => "D.O. Haskard" 4 => "D.M. MacDonald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1995" "volumen" => "32" "paginaInicial" => "32" "paginaFinal" => "36" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7529777" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of monoclonal antibody HML-1-defined alpha E beta 7 integrin in cutaneous T cell lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I. Simonitsch" 1 => "B. Volc-Platzer" 2 => "I. Mosberger" 3 => "T. Radaszkiewicz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Pathol" "fecha" => "1994" "volumen" => "145" "paginaInicial" => "1148" "paginaFinal" => "1158" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7977645" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms of binding of cutaneous lymphocyte-associated antigen-positive and alphaebeta7-positive lymphocytes to oral and skin keratinocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.W. Brown" 1 => "J. Furness" 2 => "P.M. Speight" 3 => "G.J. Thomas" 4 => "J. Li" 5 => "M.H. Thornhill" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Immunology" "fecha" => "1999" "volumen" => "98" "paginaInicial" => "9" "paginaFinal" => "15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10469228" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510708028277" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preferential expression of αEβ7 integrin (CD103) on CD8+ T cells in the psoriatic epidermis: regulation by interleukins 4 and 12 and transforming growth factor-β" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Y. Teraki" 1 => "T. Shiohara" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2002" "volumen" => "147" "paginaInicial" => "1118" "paginaFinal" => "1126" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12452860" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of αEβ7 integrin (CD 103) and E-cadherin in epidermotropism in cutaneous T-cell lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.B. Dietz" 1 => "D. Whitaker-Menezes" 2 => "S.R. Lessin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1996" "volumen" => "23" "paginaInicial" => "312" "paginaFinal" => "318" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8864917" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510710020894" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Roles of E- and P-cadherin in the human skin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Furukawa" 1 => "K. Fujii" 2 => "Y. Horiguchi" 3 => "N. Matsuyoshi" 4 => "M. Fujita" 5 => "K. Toda" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1097-0029(19970815)38:4<343::AID-JEMT2>3.0.CO;2-K" "Revista" => array:6 [ "tituloSerie" => "Microsc Res Tech" "fecha" => "1997" "volumen" => "38" "paginaInicial" => "343" "paginaFinal" => "352" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9297684" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000010/v1_201304241533/S1578219010707344/v1_201304241533/en/main.assets" "Apartado" => array:4 [ "identificador" => "6256" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000010/v1_201304241533/S1578219010707344/v1_201304241533/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707344?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
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| 2023 September | 40 | 23 | 63 |
| 2023 August | 17 | 18 | 35 |
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| 2023 May | 30 | 22 | 52 |
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| 2021 March | 49 | 14 | 63 |
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| 2020 December | 21 | 12 | 33 |
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| 2020 October | 13 | 10 | 23 |
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| 2020 April | 20 | 15 | 35 |
| 2020 March | 17 | 24 | 41 |
| 2020 February | 2 | 2 | 4 |
| 2020 January | 0 | 7 | 7 |
| 2019 December | 0 | 9 | 9 |
| 2019 November | 0 | 4 | 4 |
| 2019 October | 1 | 1 | 2 |
| 2019 September | 0 | 8 | 8 |
| 2019 July | 0 | 13 | 13 |
| 2019 June | 0 | 19 | 19 |
| 2019 May | 0 | 58 | 58 |
| 2019 April | 0 | 10 | 10 |
| 2019 March | 0 | 11 | 11 |
| 2018 February | 6 | 3 | 9 |
| 2018 January | 10 | 6 | 16 |
| 2017 December | 12 | 6 | 18 |
| 2017 November | 13 | 2 | 15 |
| 2017 October | 12 | 6 | 18 |
| 2017 September | 11 | 4 | 15 |
| 2017 August | 24 | 4 | 28 |
| 2017 July | 17 | 4 | 21 |
| 2017 June | 25 | 11 | 36 |
| 2017 May | 15 | 4 | 19 |
| 2017 April | 19 | 7 | 26 |
| 2017 March | 23 | 6 | 29 |
| 2017 February | 18 | 5 | 23 |
| 2017 January | 15 | 9 | 24 |
| 2016 December | 22 | 7 | 29 |
| 2016 November | 20 | 3 | 23 |
| 2016 October | 16 | 15 | 31 |
| 2016 September | 22 | 3 | 25 |
| 2016 August | 28 | 8 | 36 |
| 2016 July | 28 | 4 | 32 |
| 2016 June | 17 | 5 | 22 |
| 2016 May | 4 | 0 | 4 |
| 2016 April | 6 | 0 | 6 |
| 2016 March | 4 | 0 | 4 |
| 2016 February | 9 | 3 | 12 |
| 2016 January | 6 | 3 | 9 |
| 2015 December | 14 | 1 | 15 |
| 2015 November | 13 | 0 | 13 |
| 2015 October | 7 | 5 | 12 |
| 2015 September | 12 | 2 | 14 |
| 2015 August | 16 | 3 | 19 |
| 2015 July | 25 | 1 | 26 |
| 2015 June | 31 | 8 | 39 |
| 2015 May | 78 | 10 | 88 |
| 2015 April | 32 | 9 | 41 |
| 2015 March | 19 | 10 | 29 |
| 2015 February | 13 | 6 | 19 |
| 2015 January | 13 | 11 | 24 |
| 2014 December | 30 | 7 | 37 |
| 2014 November | 13 | 5 | 18 |
| 2014 October | 19 | 9 | 28 |
| 2014 September | 18 | 14 | 32 |
| 2014 August | 20 | 19 | 39 |
| 2014 July | 27 | 16 | 43 |
| 2014 June | 27 | 14 | 41 |
| 2014 May | 26 | 17 | 43 |
| 2014 April | 24 | 9 | 33 |
| 2014 March | 33 | 12 | 45 |
| 2014 February | 21 | 22 | 43 |
| 2014 January | 28 | 15 | 43 |
| 2013 December | 31 | 15 | 46 |
| 2013 November | 25 | 12 | 37 |
| 2013 October | 24 | 20 | 44 |
| 2013 September | 25 | 22 | 47 |
| 2013 August | 18 | 21 | 39 |
| 2013 July | 24 | 28 | 52 |
| 2013 June | 27 | 16 | 43 |
| 2013 May | 24 | 16 | 40 |
| 2013 April | 19 | 15 | 34 |
| 2013 March | 24 | 23 | 47 |
| 2013 February | 10 | 11 | 21 |
| 2013 January | 2 | 2 | 4 |
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