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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">The incidence of malignant melanoma has increased over recent decades&#46; Early diagnosis continues to be essential for effective treatment&#46; Our objective was to analyze cutaneous malignant melanomas diagnosed over a 15-year period in a tertiary hospital for trends towards earlier diagnosis and to identify subgroups with poorer prognosis&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Retrospective analysis of primary cutaneous melanomas analyzed in the pathology department of Hospital La Paz&#44; Madrid&#44; Spain&#44; between 1990 and 2004&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In total&#44; 526 melanomas were diagnosed&#46; The mean &#40;SD&#41; Breslow thickness was 2&#46;63 &#40;4&#46;84&#41; mm and the median thickness was 0&#46;98 mm &#40;range&#44; 0-65 mm&#41;&#46; The mean size &#40;widest point&#41; was 16&#46;59 &#40;12&#46;11&#41; mm&#46; The most common histological type was surface-spreading melanoma and the most common site was the trunk&#46; Melanomas detected in men were generally larger and thicker than in women &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;05&#41;&#46; Individuals aged over 60 years consulted for significantly thicker and larger tumors than younger individuals&#46; The incidence of malignant melanomas has increased steadily over the years whereas the mean Breslow thickness and size have decreased&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Diagnosis of melanoma in Spain is made increasingly earlier&#44; although locally advanced tumors are still sometimes seen in men and in individuals aged over 60 years&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">En las &#250;ltimas d&#233;cadas est&#225; aumentando la incidencia de melanoma maligno &#40;MM&#41; y el diagn&#243;stico precoz sigue siendo esencial para conseguir su curaci&#243;n&#46; Nuestro objetivo fue analizar los MM cut&#225;neos diagnosticados durante 15 a&#241;os en un hospital terciario para comprobar si existe una tendencia favorable hacia un diagn&#243;stico cada vez m&#225;s precoz e intentar identificar grupos de poblaci&#243;n con MM de peor pron&#243;stico&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis retrospectivo de los melanomas cut&#225;neos primarios analizados en el Departamento de Anatom&#237;a Patol&#243;gica del Hospital La Paz entre 1990 y 2004&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se diagnosticaron en total 526 melanomas&#46; El espesor medio de Breslow fue de 2&#44;63 mm &#40;desviaci&#243;n est&#225;ndar &#91;DE&#93; 4&#44;84&#41; y la mediana de 0&#44;98 mm &#40;0-65 mm&#41;&#59; el tama&#241;o medio &#40;di&#225;metro mayor&#41; fue de 16&#44;59 mm &#40;DE 12&#44;11&#41;&#59; el tipo histol&#243;gico m&#225;s frecuente fue el melanoma de extensi&#243;n superficial y la localizaci&#243;n m&#225;s habitual el tronco&#46; Los melanomas detectados en varones tendieron a ser m&#225;s grandes y de mayor espesor &#40;p &#61;0&#44;05&#41; que los de las mujeres&#46; Los mayores de 60 a&#241;os consultaron con tumores significativamente m&#225;s gruesos y de mayor di&#225;metro que los pacientes m&#225;s j&#243;venes&#46; A lo largo de estos a&#241;os&#44; ha aumentado progresivamente el n&#250;mero de MM&#44; pero han disminuido el Breslow medio y el tama&#241;o&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El diagn&#243;stico del melanoma en nuestro medio es cada vez m&#225;s precoz&#44; pero los varones y los mayores de 60 a&#241;os en ocasiones a&#250;n consultan con tumores localmente avanzados&#46;</p>"
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Vol. 100. Issue 6.
Pages 476-485 (August 2009)
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Vol. 100. Issue 6.
Pages 476-485 (August 2009)
Original articles
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Clinical-Pathological Features of Cutaneous Melanomas Diagnosed in a Mediterranean Tertiary Hospital Between 1990 and 2004: A Comparison Between Sexes and Age Groups and Analysis of Long-Term Outcomes
Características Clínico-Patológicas de los Melanomas Cutáneos Diagnosticados en un Hospital Terciario Mediterráneo Entre 1990 y 2004: Comparación Entre Sexos, por Grupos de Edad y Evolución a lo Largo del Tiempo
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D.M. Arranz-Sáncheza,
Corresponding author
dulcem.arranz@salud.madrid.org

Correspondence: Unidad de Dermatología, Hospital Infanta Sofía, Paseo de Europa, 34, 28702 San Sebastián de los Reyes, Madrid, Spain.
, Á. Pizarrob, J.L. Valencia-Delfac, M. Villeta-Lópezc, M.J. González-Beatod, M. Mayor-Arenalb, M. Casado-Jiménezb
a Unidad de Dermatología, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain
b Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain
c Escuela Universitaria de Estadística, Universidad Complutense de Madrid, Spain
d Departamento de Anatomía Patológica, Hospital Universitario La Paz, Madrid, Spain
This item has received
Article information
Abstract
Background

The incidence of malignant melanoma has increased over recent decades. Early diagnosis continues to be essential for effective treatment. Our objective was to analyze cutaneous malignant melanomas diagnosed over a 15-year period in a tertiary hospital for trends towards earlier diagnosis and to identify subgroups with poorer prognosis.

Material and methods

Retrospective analysis of primary cutaneous melanomas analyzed in the pathology department of Hospital La Paz, Madrid, Spain, between 1990 and 2004.

Results

In total, 526 melanomas were diagnosed. The mean (SD) Breslow thickness was 2.63 (4.84) mm and the median thickness was 0.98 mm (range, 0-65 mm). The mean size (widest point) was 16.59 (12.11) mm. The most common histological type was surface-spreading melanoma and the most common site was the trunk. Melanomas detected in men were generally larger and thicker than in women (P=.05). Individuals aged over 60 years consulted for significantly thicker and larger tumors than younger individuals. The incidence of malignant melanomas has increased steadily over the years whereas the mean Breslow thickness and size have decreased.

Conclusions

Diagnosis of melanoma in Spain is made increasingly earlier, although locally advanced tumors are still sometimes seen in men and in individuals aged over 60 years.

Key words:
melanoma
epidemiology
early diagnosis
Spain
Mediterranean population
Resumen
Introducción

En las últimas décadas está aumentando la incidencia de melanoma maligno (MM) y el diagnóstico precoz sigue siendo esencial para conseguir su curación. Nuestro objetivo fue analizar los MM cutáneos diagnosticados durante 15 años en un hospital terciario para comprobar si existe una tendencia favorable hacia un diagnóstico cada vez más precoz e intentar identificar grupos de población con MM de peor pronóstico.

Material y métodos

Análisis retrospectivo de los melanomas cutáneos primarios analizados en el Departamento de Anatomía Patológica del Hospital La Paz entre 1990 y 2004.

Resultados

Se diagnosticaron en total 526 melanomas. El espesor medio de Breslow fue de 2,63 mm (desviación estándar [DE] 4,84) y la mediana de 0,98 mm (0-65 mm); el tamaño medio (diámetro mayor) fue de 16,59 mm (DE 12,11); el tipo histológico más frecuente fue el melanoma de extensión superficial y la localización más habitual el tronco. Los melanomas detectados en varones tendieron a ser más grandes y de mayor espesor (p =0,05) que los de las mujeres. Los mayores de 60 años consultaron con tumores significativamente más gruesos y de mayor diámetro que los pacientes más jóvenes. A lo largo de estos años, ha aumentado progresivamente el número de MM, pero han disminuido el Breslow medio y el tamaño.

Conclusiones

El diagnóstico del melanoma en nuestro medio es cada vez más precoz, pero los varones y los mayores de 60 años en ocasiones aún consultan con tumores localmente avanzados.

Palabras clave:
melanoma
epidemiología
diagnóstico precoz
España
población mediterránea
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