Original articles
Clinical-Pathological Features of Cutaneous Melanomas Diagnosed in a Mediterranean Tertiary Hospital Between 1990 and 2004: A Comparison Between Sexes and Age Groups and Analysis of Long-Term Outcomes
Características Clínico-Patológicas de los Melanomas Cutáneos Diagnosticados en un Hospital Terciario Mediterráneo Entre 1990 y 2004: Comparación Entre Sexos, por Grupos de Edad y Evolución a lo Largo del Tiempo
D.M. Arranz-Sáncheza,
, Á. Pizarrob, J.L. Valencia-Delfac, M. Villeta-Lópezc, M.J. González-Beatod, M. Mayor-Arenalb, M. Casado-Jiménezb
Corresponding author
dulcem.arranz@salud.madrid.org
Correspondence: Unidad de Dermatología, Hospital Infanta Sofía, Paseo de Europa, 34, 28702 San Sebastián de los Reyes, Madrid, Spain.
Correspondence: Unidad de Dermatología, Hospital Infanta Sofía, Paseo de Europa, 34, 28702 San Sebastián de los Reyes, Madrid, Spain.
a Unidad de Dermatología, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain
b Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain
c Escuela Universitaria de Estadística, Universidad Complutense de Madrid, Spain
d Departamento de Anatomía Patológica, Hospital Universitario La Paz, Madrid, Spain
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"apellidos" => "Arranz-Sánchez" "email" => array:1 [ 0 => "dulcem.arranz@salud.madrid.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Á." "apellidos" => "Pizarro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "J.L." "apellidos" => "Valencia-Delfa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Villeta-López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "M.J." 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"apellidos" => "Casado-Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Unidad de Dermatología, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Escuela Universitaria de Estadística, Universidad Complutense de Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Unidad de Dermatología, Hospital Infanta Sofía, Paseo de Europa, 34, 28702 San Sebastián de los Reyes, Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Características Clínico-Patológicas de los Melanomas Cutáneos Diagnosticados en un Hospital Terciario Mediterráneo Entre 1990 y 2004: Comparación Entre Sexos, por Grupos de Edad y Evolución a lo Largo del Tiempo" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-10-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84500" "palabras" => array:5 [ 0 => "melanoma" 1 => "epidemiology" 2 => "early diagnosis" 3 => "Spain" 4 => "Mediterranean population" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84499" "palabras" => array:5 [ 0 => "melanoma" 1 => "epidemiología" 2 => "diagnóstico precoz" 3 => "España" 4 => "población mediterránea" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">The incidence of malignant melanoma has increased over recent decades. Early diagnosis continues to be essential for effective treatment. Our objective was to analyze cutaneous malignant melanomas diagnosed over a 15-year period in a tertiary hospital for trends towards earlier diagnosis and to identify subgroups with poorer prognosis.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Retrospective analysis of primary cutaneous melanomas analyzed in the pathology department of Hospital La Paz, Madrid, Spain, between 1990 and 2004.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In total, 526 melanomas were diagnosed. The mean (SD) Breslow thickness was 2.63 (4.84) mm and the median thickness was 0.98 mm (range, 0-65 mm). The mean size (widest point) was 16.59 (12.11) mm. The most common histological type was surface-spreading melanoma and the most common site was the trunk. Melanomas detected in men were generally larger and thicker than in women (<span class="elsevierStyleItalic">P</span>=.05). Individuals aged over 60 years consulted for significantly thicker and larger tumors than younger individuals. The incidence of malignant melanomas has increased steadily over the years whereas the mean Breslow thickness and size have decreased.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Diagnosis of melanoma in Spain is made increasingly earlier, although locally advanced tumors are still sometimes seen in men and in individuals aged over 60 years.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">En las últimas décadas está aumentando la incidencia de melanoma maligno (MM) y el diagnóstico precoz sigue siendo esencial para conseguir su curación. Nuestro objetivo fue analizar los MM cutáneos diagnosticados durante 15 años en un hospital terciario para comprobar si existe una tendencia favorable hacia un diagnóstico cada vez más precoz e intentar identificar grupos de población con MM de peor pronóstico.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Análisis retrospectivo de los melanomas cutáneos primarios analizados en el Departamento de Anatomía Patológica del Hospital La Paz entre 1990 y 2004.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se diagnosticaron en total 526 melanomas. El espesor medio de Breslow fue de 2,63 mm (desviación estándar [DE] 4,84) y la mediana de 0,98 mm (0-65 mm); el tamaño medio (diámetro mayor) fue de 16,59 mm (DE 12,11); el tipo histológico más frecuente fue el melanoma de extensión superficial y la localización más habitual el tronco. Los melanomas detectados en varones tendieron a ser más grandes y de mayor espesor (p =0,05) que los de las mujeres. Los mayores de 60 años consultaron con tumores significativamente más gruesos y de mayor diámetro que los pacientes más jóvenes. A lo largo de estos años, ha aumentado progresivamente el número de MM, pero han disminuido el Breslow medio y el tamaño.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El diagnóstico del melanoma en nuestro medio es cada vez más precoz, pero los varones y los mayores de 60 años en ocasiones aún consultan con tumores localmente avanzados.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:33 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 2 | 7 |
| 2024 October | 63 | 33 | 96 |
| 2024 September | 50 | 14 | 64 |
| 2024 August | 77 | 48 | 125 |
| 2024 July | 59 | 32 | 91 |
| 2024 June | 62 | 41 | 103 |
| 2024 May | 49 | 25 | 74 |
| 2024 April | 60 | 38 | 98 |
| 2024 March | 49 | 29 | 78 |
| 2024 February | 61 | 38 | 99 |
| 2024 January | 51 | 39 | 90 |
| 2023 December | 36 | 36 | 72 |
| 2023 November | 56 | 45 | 101 |
| 2023 October | 38 | 26 | 64 |
| 2023 September | 40 | 23 | 63 |
| 2023 August | 27 | 24 | 51 |
| 2023 July | 45 | 60 | 105 |
| 2023 June | 47 | 26 | 73 |
| 2023 May | 42 | 19 | 61 |
| 2023 April | 24 | 21 | 45 |
| 2023 March | 30 | 28 | 58 |
| 2023 February | 21 | 19 | 40 |
| 2023 January | 33 | 27 | 60 |
| 2022 December | 40 | 47 | 87 |
| 2022 November | 22 | 34 | 56 |
| 2022 October | 23 | 28 | 51 |
| 2022 September | 21 | 53 | 74 |
| 2022 August | 23 | 35 | 58 |
| 2022 July | 18 | 27 | 45 |
| 2022 June | 12 | 26 | 38 |
| 2022 May | 21 | 47 | 68 |
| 2022 April | 29 | 38 | 67 |
| 2022 March | 39 | 58 | 97 |
| 2022 February | 22 | 27 | 49 |
| 2022 January | 29 | 46 | 75 |
| 2021 December | 30 | 42 | 72 |
| 2021 November | 19 | 52 | 71 |
| 2021 October | 29 | 45 | 74 |
| 2021 September | 19 | 38 | 57 |
| 2021 August | 14 | 20 | 34 |
| 2021 July | 18 | 27 | 45 |
| 2021 June | 12 | 22 | 34 |
| 2021 May | 14 | 21 | 35 |
| 2021 April | 26 | 27 | 53 |
| 2021 March | 37 | 9 | 46 |
| 2021 February | 31 | 22 | 53 |
| 2021 January | 20 | 9 | 29 |
| 2020 December | 26 | 10 | 36 |
| 2020 November | 20 | 22 | 42 |
| 2020 October | 7 | 8 | 15 |
| 2020 September | 20 | 14 | 34 |
| 2020 August | 20 | 15 | 35 |
| 2020 July | 20 | 5 | 25 |
| 2020 June | 16 | 21 | 37 |
| 2020 May | 24 | 12 | 36 |
| 2020 April | 16 | 14 | 30 |
| 2020 March | 18 | 13 | 31 |
| 2020 February | 1 | 7 | 8 |
| 2019 December | 0 | 7 | 7 |
| 2019 November | 0 | 1 | 1 |
| 2019 September | 0 | 2 | 2 |
| 2019 August | 0 | 1 | 1 |
| 2019 June | 0 | 1 | 1 |
| 2019 May | 0 | 35 | 35 |
| 2019 April | 0 | 1 | 1 |
| 2019 March | 0 | 2 | 2 |
| 2019 February | 0 | 5 | 5 |
| 2018 December | 0 | 2 | 2 |
| 2018 October | 0 | 2 | 2 |
| 2018 February | 29 | 2 | 31 |
| 2018 January | 27 | 4 | 31 |
| 2017 December | 33 | 7 | 40 |
| 2017 November | 16 | 2 | 18 |
| 2017 October | 13 | 5 | 18 |
| 2017 September | 19 | 1 | 20 |
| 2017 August | 26 | 6 | 32 |
| 2017 July | 23 | 3 | 26 |
| 2017 June | 30 | 13 | 43 |
| 2017 May | 26 | 6 | 32 |
| 2017 April | 22 | 7 | 29 |
| 2017 March | 26 | 8 | 34 |
| 2017 February | 26 | 6 | 32 |
| 2017 January | 11 | 5 | 16 |
| 2016 December | 42 | 8 | 50 |
| 2016 November | 30 | 12 | 42 |
| 2016 October | 24 | 18 | 42 |
| 2016 September | 33 | 1 | 34 |
| 2016 August | 28 | 2 | 30 |
| 2016 July | 29 | 0 | 29 |
| 2016 June | 13 | 6 | 19 |
| 2016 May | 10 | 1 | 11 |
| 2016 April | 11 | 6 | 17 |
| 2016 March | 7 | 7 | 14 |
| 2016 February | 8 | 8 | 16 |
| 2016 January | 7 | 10 | 17 |
| 2015 December | 6 | 5 | 11 |
| 2015 November | 12 | 9 | 21 |
| 2015 October | 6 | 3 | 9 |
| 2015 September | 7 | 2 | 9 |
| 2015 August | 17 | 6 | 23 |
| 2015 July | 38 | 3 | 41 |
| 2015 June | 32 | 12 | 44 |
| 2015 May | 83 | 15 | 98 |
| 2015 April | 30 | 13 | 43 |
| 2015 March | 21 | 17 | 38 |
| 2015 February | 54 | 15 | 69 |
| 2015 January | 27 | 26 | 53 |
| 2014 December | 32 | 5 | 37 |
| 2014 November | 13 | 6 | 19 |
| 2014 October | 27 | 8 | 35 |
| 2014 September | 21 | 8 | 29 |
| 2014 August | 29 | 17 | 46 |
| 2014 July | 37 | 16 | 53 |
| 2014 June | 34 | 10 | 44 |
| 2014 May | 31 | 9 | 40 |
| 2014 April | 39 | 15 | 54 |
| 2014 March | 37 | 15 | 52 |
| 2014 February | 47 | 6 | 53 |
| 2014 January | 32 | 11 | 43 |
| 2013 December | 33 | 12 | 45 |
| 2013 November | 28 | 12 | 40 |
| 2013 October | 29 | 15 | 44 |
| 2013 September | 35 | 15 | 50 |
| 2013 August | 24 | 14 | 38 |
| 2013 July | 45 | 40 | 85 |
| 2013 June | 25 | 13 | 38 |
| 2013 May | 21 | 13 | 34 |
| 2013 April | 19 | 15 | 34 |
| 2013 March | 31 | 17 | 48 |
| 2013 February | 28 | 8 | 36 |
| 2013 January | 7 | 3 | 10 |
Show all
