array:23 [
  "pii" => "S1578219009701271"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(09)70127-1"
  "estado" => "S300"
  "fechaPublicacion" => "2009-09-01"
  "aid" => "70127"
  "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
  "copyrightAnyo" => "2009"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2009;100:596-601"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2267
    "formatos" => array:3 [
      "EPUB" => 44
      "HTML" => 1591
      "PDF" => 632
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219009701283"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(09)70128-3"
    "estado" => "S300"
    "fechaPublicacion" => "2009-09-01"
    "aid" => "70128"
    "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2009;100:602-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3436
      "formatos" => array:3 [
        "EPUB" => 40
        "HTML" => 1491
        "PDF" => 1905
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Annular Plaques in the Skin Folds&#58; 4 Cases of Lichen Planus Pigmentosus-Inversus"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "602"
          "paginaFinal" => "605"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Placas Anulares en Grandes Pliegues&#58; Cuatro Casos de Liquen Plano Pigmentoso-Inverso"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Benn&#224;ssar, A&#46; Mas, M&#46; Juli&#224;, P&#46; Iranzo, J&#46; Ferrando"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Benn&#224;ssar"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mas"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Juli&#224;"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Iranzo"
            ]
            4 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Ferrando"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701283?idApp=UINPBA000044"
    "url" => "/15782190/0000010000000007/v1_201304241501/S1578219009701283/v1_201304241501/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S157821900970126X"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(09)70126-X"
    "estado" => "S300"
    "fechaPublicacion" => "2009-09-01"
    "aid" => "70126"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2009;100:586-95"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2995
      "formatos" => array:3 [
        "EPUB" => 43
        "HTML" => 1964
        "PDF" => 988
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>"
      "titulo" => "Validation of a Spanish Questionnaire to Evaluate Habits&#44; Attitudes&#44; and Understanding of Exposure to Sunlight&#58; &#8220;The Beach Questionnaire&#8221;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "586"
          "paginaFinal" => "595"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Validaci&#243;n de un Cuestionario en Espa&#241;ol Sobre Comportamientos&#44; Actitudes y Conocimientos Relacionados con la Exposici&#243;n Solar&#58; &#171;Cuestionario a pie de Playa&#187;"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; de Troya-Mart&#237;n, N&#46; Bl&#225;zquez-S&#225;nchez, F&#46; Rivas-Ruiz, I&#46; Fern&#225;ndez-Canedo, A&#46; Rup&#233;rez-Sandoval, J&#46; Pons-Palliser, E&#46; Perea-Millab"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "de Troya-Mart&#237;n"
            ]
            1 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Bl&#225;zquez-S&#225;nchez"
            ]
            2 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Rivas-Ruiz"
            ]
            3 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Fern&#225;ndez-Canedo"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Rup&#233;rez-Sandoval"
            ]
            5 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Pons-Palliser"
            ]
            6 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Perea-Millab"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821900970126X?idApp=UINPBA000044"
    "url" => "/15782190/0000010000000007/v1_201304241501/S157821900970126X/v1_201304241501/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Clinical Findings in 67 Patients With Tuberous Sclerosis"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "596"
        "paginaFinal" => "601"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46; Fern&#225;ndez-Guarino, P&#46; Boixeda, M&#46;J&#46; Anaya, P&#46; Beldar, P&#46; Ja&#233;n"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "M&#46;"
            "apellidos" => "Fern&#225;ndez-Guarino"
            "email" => array:1 [
              0 => "montsefdez&#64;msn&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Boixeda"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "M&#46;J&#46;"
            "apellidos" => "Anaya"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Beldar"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Ja&#233;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Ram&#243;n y Cajal&#44; Universidad de Alcal&#225; de Henares&#44; Madrid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital Fernando Fonseca&#44; Universidad de Lisboa&#44; Lisboa&#44; Portugal"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Universidad de Alcal&#225; de Henares&#44; Hospital Universitario de Guadalajara&#44; Guadalajara&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Servicio de Dermatolog&#237;a&#44; Hospital Ram&#243;n y Cajal&#44; Crta&#46; Colmenar Viejo km 9&#44;100&#44; 28034 Madrid&#44; Spain&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Esclerosis Tuberosa&#46; Hallazgos Cl&#237;nicos en 67 Pacientes"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2008-11-12"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec84544"
          "palabras" => array:3 [
            0 => "tuberous sclerosis"
            1 => "skin manifestations"
            2 => "neurological manifestations"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84543"
          "palabras" => array:3 [
            0 => "esclerosis tuberosa"
            1 => "manifestaciones dermatol&#243;gicas"
            2 => "manifestaciones neurol&#243;gicas"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Tuberous sclerosis is an uncommon neurocutaneous syndrome characterized by the appearance of hamartomas in multiple organs&#46; Diagnosis is based on clinical criteria&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To report the clinical findings in a series of 67 patients with tuberous sclerosis&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">This was a descriptive and observational retrospective study of patients with tuberous sclerosis referred to our dermatology clinics between January 1994 and March 2007&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">All patients presented neurological or dermatological disorders&#46; Other disorders&#44; in descending frequency&#44; were psychiatric &#40;55&#46;5&#37;&#41;&#44; renal &#40;32&#46;8&#37;&#41;&#44; cardiac &#40;22&#46;4&#37;&#41;&#44; skeletal and pulmonary &#40;13&#46;4&#37;&#41;&#44; and ophthalmological &#40;11&#46;9&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We report the clinical findings in a series of patients with tuberous sclerosis&#46; According to our literature search&#44; this is the first such study in the Spanish population&#46; Overall&#44; our findings support those already published&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La esclerosis tuberosa &#40;ET&#41; es un s&#237;ndrome neurocut&#225;neo infrecuente caracterizado por la aparici&#243;n de hamartomas en m&#250;ltiples &#243;rganos&#46; Su diagn&#243;stico se basa en criterios cl&#237;nicos&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir los hallazgos cl&#237;nicos en una serie de 67 pacientes afectos de ET&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Llevamos a cabo un estudio retrospectivo&#44; descriptivo y observacional de los pacientes con ET remitidos a nuestras consultas de Dermatolog&#237;a entre enero de 1994 y marzo de 2007&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El 100&#37; de los pacientes presentaron alteraciones neurol&#243;gicas o dermatol&#243;gicas&#46; El resto fueron&#44; por orden&#58; psiqui&#225;tricas &#40;55&#44;5&#37;&#41;&#44; renales &#40;32&#44;8&#37;&#41;&#44; card&#237;acas &#40;22&#44;4&#37;&#41;&#44; esquel&#233;ticas y pulmonares &#40;13&#44;4&#37;&#41; y oftalmol&#243;gicas &#40;11&#44;9&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Describimos los hallazgos cl&#237;nicos en una serie de pacientes afectos de ET&#46; Se trata&#44; seg&#250;n la literatura revisada&#44; del primer estudio de este tipo en la poblaci&#243;n espa&#241;ola&#46; Globalmente&#44; nuestros datos apoyan lo hasta ahora publicado&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:18 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The cutaneous features of tuberous sclerosis&#58; a population study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;W&#46; Webb"
                            1 => "A&#46; Clarke"
                            2 => "A&#46; Fryer"
                            3 => "J&#46;P&#46; Osborne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1996"
                        "volumen" => "135"
                        "paginaInicial" => "1"
                        "paginaFinal" => "5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9035700"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of diagnosis criteria of tuberous sclerosis complex in paediatric patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; J&#242;zwiak"
                            1 => "R&#46;A&#46; Schwartz"
                            2 => "C&#46;K&#46; Janninger"
                            3 => "J&#46; Bielicka-Cymerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Child Neurol"
                        "fecha" => "2000"
                        "volumen" => "15"
                        "paginaInicial" => "652"
                        "paginaFinal" => "659"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11063078"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular genetics advances in tuberous sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;P&#46; Cheadle"
                            1 => "M&#46;P&#46; Reeve"
                            2 => "J&#46;R&#46; Sampson"
                            3 => "D&#46;J&#46; Kwiatkowski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Genet"
                        "fecha" => "2000"
                        "volumen" => "107"
                        "paginaInicial" => "97"
                        "paginaFinal" => "114"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11030407"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The tuberous sclerosis complex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;B&#46; Crino"
                            1 => "K&#46;L&#46; Nathanson"
                            2 => "E&#46;P&#46; Henske"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2006"
                        "volumen" => "355"
                        "paginaInicial" => "1645"
                        "paginaFinal" => "1656"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skin lesions in children with tuberous sclerosis complex&#58; their prevalence&#44; natural course and diagnostic significance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; J&#242;zwiak"
                            1 => "R&#46;A&#46; Schwartz"
                            2 => "C&#46;K&#46; Janniger"
                            3 => "J&#46;C&#46; Michalowicz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1998"
                        "volumen" => "37"
                        "paginaInicial" => "911"
                        "paginaFinal" => "917"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9888331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and genotype studies of cardiac tumours in 154 patients with tuberous sclerosis complex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Jozwiak"
                            1 => "K&#46; Kotulsa"
                            2 => "J&#46; Kasprzyk- Obara"
                            3 => "D&#46; Domanska-Pakiela"
                            4 => "M&#46; Tomyn-Drabik"
                            5 => "P&#46; Roberts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2006-0504"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2006"
                        "volumen" => "118"
                        "paginaInicial" => "e1146"
                        "paginaFinal" => "e1151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16940165"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fetal rhabdomyoma&#58; prenatal diagnosis&#44; clinical outcome&#44; and incidence of associated tuberous sclerosis complex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;S&#46; Bader"
                            1 => "D&#46; Chitayat"
                            2 => "E&#46; Helly"
                            3 => "G&#46; Ryan"
                            4 => "J&#46;F&#46; Smallhorn"
                            5 => "A&#46; Toi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/S0022-3476(03)00494-3"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2003"
                        "volumen" => "143"
                        "paginaInicial" => "620"
                        "paginaFinal" => "624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14615733"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1552526011001014"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Behavioural and cognitive aspects of tuberous sclerosis complex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Prather"
                            1 => "P&#46; de Vries"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Child Neurol"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "666"
                        "paginaFinal" => "674"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15563012"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tuberous sclerosis and multiple tubers&#58; localizing the epileptogenic zone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;L&#46; Weiner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0013-9580.2004.04009.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Epilepsia"
                        "fecha" => "2004"
                        "volumen" => "45"
                        "paginaInicial" => "41"
                        "paginaFinal" => "42"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15281957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An epidemiological study of renal pathology in patients with tuberous sclerosis complex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46;J&#46; O&#8217;Callaghan"
                            1 => "M&#46;J&#46; Noakes"
                            2 => "C&#46;N&#46; Martyn"
                            3 => "J&#46;P&#46; Osborne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "BJU Int"
                        "fecha" => "2004"
                        "volumen" => "94"
                        "paginaInicial" => "451"
                        "paginaFinal" => "456"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary involvement in tuberous sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;P&#46; Vicente"
                            1 => "M&#46; Pons"
                            2 => "M&#46; Medina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ppul.10414"
                      "Revista" => array:7 [
                        "tituloSerie" => "Pediatr Pulmonol"
                        "fecha" => "2004"
                        "volumen" => "37"
                        "paginaInicial" => "178"
                        "paginaFinal" => "180"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14730664"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S155252601100104X"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ophthalmic manifestations of tuberous sclerosis&#58; a population-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;A&#46; Rowley"
                            1 => "F&#46;J&#46; O&#8217; Callaghan"
                            2 => "J&#46;P&#46; Osborne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Ophtalmol"
                        "fecha" => "2001"
                        "volumen" => "85"
                        "paginaInicial" => "420"
                        "paginaFinal" => "423"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Scl&#232;rose tub&#233;reuse des circonvolution c&#233;r&#233;brales&#58; idiotie et &#233;pilepsie hemipl&#233;gique"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;M&#46; Bourneville"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "1880"
                        "volumen" => "1"
                        "paginaInicial" => "81"
                        "paginaFinal" => "91"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Zur Daignostik der tuberosen sklerose"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Vogt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Z Erfrosch Behandl Judeudl Schwachsinns"
                        "fecha" => "1908"
                        "volumen" => "2"
                        "paginaInicial" => "1"
                        "paginaFinal" => "6"
                        "itemHostRev" => array:3 [
                          "pii" => "S1552526011001002"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Segmental type 2 manifestation of autosome dominant skin diseases&#46; Development of a new formal genetic concept"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Happle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hautarzt"
                        "fecha" => "2001"
                        "volumen" => "52"
                        "paginaInicial" => "283"
                        "paginaFinal" => "287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11382117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Seguimiento a largo plazo de angiofibromas tratados con l&#225;ser de CO2 en 23 pacientes con esclerosis tuberosa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Belmar"
                            1 => "P&#46; Boixeda"
                            2 => "O&#46; Baniandr&#233;s"
                            3 => "M&#46; Fern&#225;ndez-Lorente"
                            4 => "J&#46;M&#46; Ar&#225;zola"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2005"
                        "volumen" => "96"
                        "paginaInicial" => "498"
                        "paginaFinal" => "503"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cortical tuber count&#58; a biomarker indicating neurologic severity of tuberous sclerosis complex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Goodman"
                            1 => "S&#46;I&#46;I&#46; Lamm"
                            2 => "A&#46; Engel"
                            3 => "C&#46;W&#46; Shepher"
                            4 => "O&#46;W&#46; Houser"
                            5 => "M&#46;R&#46; G&#243;mez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Chile Neurol"
                        "fecha" => "1997"
                        "volumen" => "12"
                        "paginaInicial" => "85"
                        "paginaFinal" => "90"
                        "itemHostRev" => array:3 [
                          "pii" => "S1552526011000999"
                          "estado" => "S300"
                          "issn" => "15525260"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tuberous sclerosis complex&#58; advances in diagnosis&#44; genetics and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;A&#46; Schwartz"
                            1 => "G&#46; Fern&#225;ndez"
                            2 => "K&#46; Kotulska"
                            3 => "S&#46; J&#243;zwiak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2007.05.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "189"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17637444"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010000000007/v1_201304241501/S1578219009701271/v1_201304241501/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6155"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000007/v1_201304241501/S1578219009701271/v1_201304241501/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701271?idApp=UINPBA000044"
]
Share
Journal Information
Vol. 100. Issue 7.
Pages 596-601 (September 2009)
Share
Share
Download PDF
More article options
Vol. 100. Issue 7.
Pages 596-601 (September 2009)
Original article
Full text access
Clinical Findings in 67 Patients With Tuberous Sclerosis
Esclerosis Tuberosa. Hallazgos Clínicos en 67 Pacientes
Visits
6005
M. Fernández-Guarinoa,
Corresponding author
montsefdez@msn.com

Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal, Crta. Colmenar Viejo km 9,100, 28034 Madrid, Spain.
, P. Boixedaa, M.J. Anayab, P. Beldarc, P. Jaéna
a Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain
b Servicio de Medicina Interna, Hospital Fernando Fonseca, Universidad de Lisboa, Lisboa, Portugal
c Servicio de Dermatología, Universidad de Alcalá de Henares, Hospital Universitario de Guadalajara, Guadalajara, Spain
This item has received
Article information
Abstract
Background

Tuberous sclerosis is an uncommon neurocutaneous syndrome characterized by the appearance of hamartomas in multiple organs. Diagnosis is based on clinical criteria.

Objective

To report the clinical findings in a series of 67 patients with tuberous sclerosis.

Material and methods

This was a descriptive and observational retrospective study of patients with tuberous sclerosis referred to our dermatology clinics between January 1994 and March 2007.

Results

All patients presented neurological or dermatological disorders. Other disorders, in descending frequency, were psychiatric (55.5%), renal (32.8%), cardiac (22.4%), skeletal and pulmonary (13.4%), and ophthalmological (11.9%).

Conclusions

We report the clinical findings in a series of patients with tuberous sclerosis. According to our literature search, this is the first such study in the Spanish population. Overall, our findings support those already published.

Key words:
tuberous sclerosis
skin manifestations
neurological manifestations
Resumen
Introducción

La esclerosis tuberosa (ET) es un síndrome neurocutáneo infrecuente caracterizado por la aparición de hamartomas en múltiples órganos. Su diagnóstico se basa en criterios clínicos.

Objetivo

Describir los hallazgos clínicos en una serie de 67 pacientes afectos de ET.

Material y métodos

Llevamos a cabo un estudio retrospectivo, descriptivo y observacional de los pacientes con ET remitidos a nuestras consultas de Dermatología entre enero de 1994 y marzo de 2007.

Resultados

El 100% de los pacientes presentaron alteraciones neurológicas o dermatológicas. El resto fueron, por orden: psiquiátricas (55,5%), renales (32,8%), cardíacas (22,4%), esqueléticas y pulmonares (13,4%) y oftalmológicas (11,9%).

Conclusiones

Describimos los hallazgos clínicos en una serie de pacientes afectos de ET. Se trata, según la literatura revisada, del primer estudio de este tipo en la población española. Globalmente, nuestros datos apoyan lo hasta ahora publicado.

Palabras clave:
esclerosis tuberosa
manifestaciones dermatológicas
manifestaciones neurológicas
Full text is only aviable in PDF
References
[1.]
D.W. Webb, A. Clarke, A. Fryer, J.P. Osborne.
The cutaneous features of tuberous sclerosis: a population study.
Br J Dermatol, 135 (1996), pp. 1-5
[2.]
S. Jòzwiak, R.A. Schwartz, C.K. Janninger, J. Bielicka-Cymerman.
Usefulness of diagnosis criteria of tuberous sclerosis complex in paediatric patients.
J Child Neurol, 15 (2000), pp. 652-659
[3.]
J.P. Cheadle, M.P. Reeve, J.R. Sampson, D.J. Kwiatkowski.
Molecular genetics advances in tuberous sclerosis.
Hum Genet, 107 (2000), pp. 97-114
[4.]
P.B. Crino, K.L. Nathanson, E.P. Henske.
The tuberous sclerosis complex.
N Engl J Med, 355 (2006), pp. 1645-1656
[5.]
S. Jòzwiak, R.A. Schwartz, C.K. Janniger, J.C. Michalowicz.
Skin lesions in children with tuberous sclerosis complex: their prevalence, natural course and diagnostic significance.
Int J Dermatol, 37 (1998), pp. 911-917
[6.]
S. Jozwiak, K. Kotulsa, J. Kasprzyk- Obara, D. Domanska-Pakiela, M. Tomyn-Drabik, P. Roberts, et al.
Clinical and genotype studies of cardiac tumours in 154 patients with tuberous sclerosis complex.
Pediatrics, 118 (2006), pp. e1146-e1151
[7.]
R.S. Bader, D. Chitayat, E. Helly, G. Ryan, J.F. Smallhorn, A. Toi, et al.
Fetal rhabdomyoma: prenatal diagnosis, clinical outcome, and incidence of associated tuberous sclerosis complex.
J Pediatr, 143 (2003), pp. 620-624
[8.]
P. Prather, P. de Vries.
Behavioural and cognitive aspects of tuberous sclerosis complex.
J Child Neurol, 19 (2004), pp. 666-674
[9.]
H.L. Weiner.
Tuberous sclerosis and multiple tubers: localizing the epileptogenic zone.
[10.]
F.J. O’Callaghan, M.J. Noakes, C.N. Martyn, J.P. Osborne.
An epidemiological study of renal pathology in patients with tuberous sclerosis complex.
BJU Int, 94 (2004), pp. 451-456
[11.]
M.P. Vicente, M. Pons, M. Medina.
Pulmonary involvement in tuberous sclerosis.
Pediatr Pulmonol, 37 (2004), pp. 178-180
[12.]
S.A. Rowley, F.J. O’ Callaghan, J.P. Osborne.
Ophthalmic manifestations of tuberous sclerosis: a population-based study.
Br J Ophtalmol, 85 (2001), pp. 420-423
[13.]
D.M. Bourneville.
Sclèrose tubéreuse des circonvolution cérébrales: idiotie et épilepsie hemiplégique.
Arch Neurol, 1 (1880), pp. 81-91
[14.]
H. Vogt.
Zur Daignostik der tuberosen sklerose.
Z Erfrosch Behandl Judeudl Schwachsinns, 2 (1908), pp. 1-6
[15.]
R. Happle.
Segmental type 2 manifestation of autosome dominant skin diseases. Development of a new formal genetic concept.
Hautarzt, 52 (2001), pp. 283-287
[16.]
P. Belmar, P. Boixeda, O. Baniandrés, M. Fernández-Lorente, J.M. Arázola.
Seguimiento a largo plazo de angiofibromas tratados con láser de CO2 en 23 pacientes con esclerosis tuberosa.
Actas Dermosifiliogr, 96 (2005), pp. 498-503
[17.]
M. Goodman, S.I.I. Lamm, A. Engel, C.W. Shepher, O.W. Houser, M.R. Gómez.
Cortical tuber count: a biomarker indicating neurologic severity of tuberous sclerosis complex.
J Chile Neurol, 12 (1997), pp. 85-90
[18.]
R.A. Schwartz, G. Fernández, K. Kotulska, S. Józwiak.
Tuberous sclerosis complex: advances in diagnosis, genetics and management.
J Am Acad Dermatol, 57 (2007), pp. 189-202
Copyright © 2009. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
Download PDF
Idiomas
Actas Dermo-Sifiliográficas
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?