Original article
Clinical Findings in 67 Patients With Tuberous Sclerosis
Esclerosis Tuberosa. Hallazgos Clínicos en 67 Pacientes
M. Fernández-Guarinoa,
, P. Boixedaa, M.J. Anayab, P. Beldarc, P. Jaéna
Corresponding author
montsefdez@msn.com
Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal, Crta. Colmenar Viejo km 9,100, 28034 Madrid, Spain.
Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal, Crta. Colmenar Viejo km 9,100, 28034 Madrid, Spain.
a Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain
b Servicio de Medicina Interna, Hospital Fernando Fonseca, Universidad de Lisboa, Lisboa, Portugal
c Servicio de Dermatología, Universidad de Alcalá de Henares, Hospital Universitario de Guadalajara, Guadalajara, Spain
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Colmenar Viejo km 9,100, 28034 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Esclerosis Tuberosa. Hallazgos Clínicos en 67 Pacientes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-11-12" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84544" "palabras" => array:3 [ 0 => "tuberous sclerosis" 1 => "skin manifestations" 2 => "neurological manifestations" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84543" "palabras" => array:3 [ 0 => "esclerosis tuberosa" 1 => "manifestaciones dermatológicas" 2 => "manifestaciones neurológicas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Tuberous sclerosis is an uncommon neurocutaneous syndrome characterized by the appearance of hamartomas in multiple organs. Diagnosis is based on clinical criteria.</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To report the clinical findings in a series of 67 patients with tuberous sclerosis.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">This was a descriptive and observational retrospective study of patients with tuberous sclerosis referred to our dermatology clinics between January 1994 and March 2007.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">All patients presented neurological or dermatological disorders. Other disorders, in descending frequency, were psychiatric (55.5%), renal (32.8%), cardiac (22.4%), skeletal and pulmonary (13.4%), and ophthalmological (11.9%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">We report the clinical findings in a series of patients with tuberous sclerosis. According to our literature search, this is the first such study in the Spanish population. Overall, our findings support those already published.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La esclerosis tuberosa (ET) es un síndrome neurocutáneo infrecuente caracterizado por la aparición de hamartomas en múltiples órganos. Su diagnóstico se basa en criterios clínicos.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Describir los hallazgos clínicos en una serie de 67 pacientes afectos de ET.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Llevamos a cabo un estudio retrospectivo, descriptivo y observacional de los pacientes con ET remitidos a nuestras consultas de Dermatología entre enero de 1994 y marzo de 2007.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El 100% de los pacientes presentaron alteraciones neurológicas o dermatológicas. El resto fueron, por orden: psiquiátricas (55,5%), renales (32,8%), cardíacas (22,4%), esqueléticas y pulmonares (13,4%) y oftalmológicas (11,9%).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Describimos los hallazgos clínicos en una serie de pacientes afectos de ET. Se trata, según la literatura revisada, del primer estudio de este tipo en la población española. Globalmente, nuestros datos apoyan lo hasta ahora publicado.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The cutaneous features of tuberous sclerosis: a population study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.W. Webb" 1 => "A. Clarke" 2 => "A. Fryer" 3 => "J.P. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 7 | 9 |
| 2024 October | 55 | 47 | 102 |
| 2024 September | 58 | 39 | 97 |
| 2024 August | 89 | 58 | 147 |
| 2024 July | 51 | 44 | 95 |
| 2024 June | 61 | 34 | 95 |
| 2024 May | 60 | 39 | 99 |
| 2024 April | 55 | 29 | 84 |
| 2024 March | 56 | 51 | 107 |
| 2024 February | 51 | 33 | 84 |
| 2024 January | 43 | 40 | 83 |
| 2023 December | 46 | 34 | 80 |
| 2023 November | 47 | 30 | 77 |
| 2023 October | 51 | 79 | 130 |
| 2023 September | 37 | 30 | 67 |
| 2023 August | 46 | 19 | 65 |
| 2023 July | 74 | 57 | 131 |
| 2023 June | 36 | 31 | 67 |
| 2023 May | 56 | 19 | 75 |
| 2023 April | 45 | 18 | 63 |
| 2023 March | 65 | 26 | 91 |
| 2023 February | 36 | 20 | 56 |
| 2023 January | 37 | 19 | 56 |
| 2022 December | 37 | 42 | 79 |
| 2022 November | 13 | 34 | 47 |
| 2022 October | 20 | 21 | 41 |
| 2022 September | 13 | 30 | 43 |
| 2022 August | 16 | 37 | 53 |
| 2022 July | 8 | 29 | 37 |
| 2022 June | 16 | 30 | 46 |
| 2022 May | 29 | 33 | 62 |
| 2022 April | 35 | 31 | 66 |
| 2022 March | 38 | 63 | 101 |
| 2022 February | 35 | 27 | 62 |
| 2022 January | 19 | 33 | 52 |
| 2021 December | 30 | 52 | 82 |
| 2021 November | 30 | 37 | 67 |
| 2021 October | 35 | 43 | 78 |
| 2021 September | 28 | 41 | 69 |
| 2021 August | 25 | 22 | 47 |
| 2021 July | 29 | 26 | 55 |
| 2021 June | 23 | 32 | 55 |
| 2021 May | 19 | 25 | 44 |
| 2021 April | 39 | 44 | 83 |
| 2021 March | 52 | 13 | 65 |
| 2021 February | 45 | 25 | 70 |
| 2021 January | 24 | 14 | 38 |
| 2020 December | 31 | 10 | 41 |
| 2020 November | 30 | 18 | 48 |
| 2020 October | 20 | 12 | 32 |
| 2020 September | 19 | 9 | 28 |
| 2020 August | 27 | 12 | 39 |
| 2020 July | 13 | 11 | 24 |
| 2020 June | 22 | 23 | 45 |
| 2020 May | 32 | 11 | 43 |
| 2020 April | 24 | 21 | 45 |
| 2020 March | 25 | 13 | 38 |
| 2020 February | 2 | 1 | 3 |
| 2020 January | 0 | 4 | 4 |
| 2019 December | 0 | 13 | 13 |
| 2019 November | 0 | 1 | 1 |
| 2019 September | 0 | 3 | 3 |
| 2019 July | 0 | 12 | 12 |
| 2019 June | 0 | 2 | 2 |
| 2019 May | 2 | 52 | 54 |
| 2019 April | 0 | 1 | 1 |
| 2019 March | 0 | 2 | 2 |
| 2019 February | 0 | 4 | 4 |
| 2018 June | 0 | 1 | 1 |
| 2018 February | 10 | 2 | 12 |
| 2018 January | 17 | 6 | 23 |
| 2017 December | 17 | 7 | 24 |
| 2017 November | 18 | 5 | 23 |
| 2017 October | 18 | 3 | 21 |
| 2017 September | 20 | 4 | 24 |
| 2017 August | 31 | 10 | 41 |
| 2017 July | 24 | 1 | 25 |
| 2017 June | 26 | 15 | 41 |
| 2017 May | 17 | 4 | 21 |
| 2017 April | 16 | 16 | 32 |
| 2017 March | 23 | 29 | 52 |
| 2017 February | 27 | 9 | 36 |
| 2017 January | 15 | 7 | 22 |
| 2016 December | 37 | 15 | 52 |
| 2016 November | 26 | 6 | 32 |
| 2016 October | 29 | 9 | 38 |
| 2016 September | 37 | 4 | 41 |
| 2016 August | 31 | 7 | 38 |
| 2016 July | 25 | 11 | 36 |
| 2016 June | 7 | 10 | 17 |
| 2016 May | 6 | 9 | 15 |
| 2016 April | 9 | 1 | 10 |
| 2016 March | 4 | 0 | 4 |
| 2016 February | 7 | 0 | 7 |
| 2016 January | 6 | 3 | 9 |
| 2015 December | 9 | 0 | 9 |
| 2015 November | 11 | 1 | 12 |
| 2015 October | 9 | 2 | 11 |
| 2015 September | 7 | 3 | 10 |
| 2015 August | 13 | 2 | 15 |
| 2015 July | 32 | 8 | 40 |
| 2015 June | 34 | 6 | 40 |
| 2015 May | 77 | 9 | 86 |
| 2015 April | 35 | 12 | 47 |
| 2015 March | 29 | 10 | 39 |
| 2015 February | 40 | 10 | 50 |
| 2015 January | 20 | 9 | 29 |
| 2014 December | 39 | 6 | 45 |
| 2014 November | 20 | 6 | 26 |
| 2014 October | 31 | 7 | 38 |
| 2014 September | 28 | 10 | 38 |
| 2014 August | 28 | 10 | 38 |
| 2014 July | 43 | 17 | 60 |
| 2014 June | 41 | 11 | 52 |
| 2014 May | 31 | 7 | 38 |
| 2014 April | 36 | 10 | 46 |
| 2014 March | 51 | 14 | 65 |
| 2014 February | 39 | 9 | 48 |
| 2014 January | 37 | 11 | 48 |
| 2013 December | 35 | 8 | 43 |
| 2013 November | 25 | 11 | 36 |
| 2013 October | 30 | 12 | 42 |
| 2013 September | 29 | 15 | 44 |
| 2013 August | 30 | 11 | 41 |
| 2013 July | 45 | 26 | 71 |
| 2013 June | 28 | 20 | 48 |
| 2013 May | 28 | 6 | 34 |
| 2013 April | 34 | 18 | 52 |
| 2013 March | 32 | 11 | 43 |
| 2013 February | 23 | 13 | 36 |
| 2013 January | 7 | 3 | 10 |
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