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in particular dipeptidyl peptidase-IV &#40;DPP-4&#41; inhibitors&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Several observations support a pathogenic role of eosinophils in BP&#46; Dermal inflammatory infiltrate rich in eosinophils is a prominent histological feature and peripheral blood eosinophilia has been documented in 50&#8211;60&#37; of BP patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">6&#44;7</span></a> Moreover&#44; peripheral blood and cutaneous eosinophil levels have been correlated with disease severity&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">7&#44;8</span></a> Eosinophils seem to be key effector cells in BP initiation and progression&#46; In fact&#44; eosinophil skin infiltration is an early event and precedes blister formation&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">9</span></a> Eosinophils degranulation and release of extracellular eosinophil traps and granule proteins promote lesion formation&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">10&#44;11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Although increasing evidence of contribution of eosinophils for BP pathogenesis accumulate&#44; the influence of circulating and dermal infiltrate eosinophil levels on the phenotype of BP remains poorly understood&#46; The main objective of this study was to evaluate the association between peripheral blood and cutaneous eosinophil levels and the clinical and immunological characteristics of the disease&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">A retrospective cohort study was conducted on all patients diagnosed with BP between January 1st&#44; 2011 and December 31st&#44; 2020&#44; at a tertiary referral centre&#46; The study was approved by the Local Ethics Committee&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The diagnosis of BP was established according to the following criteria&#58; &#40;1&#41; suggestive clinical and histopathological picture&#59; &#40;2&#41; linear deposits of IgG and&#47;or C3 along the dermal&#8211;epidermal junction by direct immunofluorescence &#40;DIF&#41; microscopy of a perilesional skin biopsy&#59; and &#40;3&#41; the presence of circulating IgG autoantibodies against BP180 and&#47;or BP230&#44; as identified by BP180 NC16A&#47;BP230 enzyme-linked immunosorbent assay &#40;ELISA&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We excluded all patients with an alternative cause for peripheral blood and tissue eosinophilia&#44; including atopic dermatitis&#44; asthma&#44; allergic rhinitis&#44; parasitic infection and lymphoma&#46; All patients treated with drugs that affect eosinophil counts in the moment of BP diagnosis&#44; including systemic steroids and immunosuppressants&#44; were also excluded&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Peripheral blood eosinophil counts prior to the administration of any treatment were reviewed&#46; Peripheral blood eosinophil counts were classified as normal if below 500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L&#44; high if between 500 and 1500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L and very high if above 1500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L&#46; The levels of peripheral blood anti-BP180 NC16A and anti-BP230 IgG autoantibodies were measured by ELISA &#40;Euroimmun&#44; L&#369;beck&#44; Germany&#41;&#46; Seropositivity was determined based on the cut-off values proposed by the manufacturer &#40;i&#46;e&#46;&#44; 20<span class="elsevierStyleHsp" style=""></span>U&#47;ml&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Haematoxylin and eosin &#40;H&#38;E&#41;-stained lesional skin specimens were reviewed in terms of eosinophil levels by three Dermatopathologists &#40;MAG&#44; PEL&#44; LSA&#41;&#46; In each sample&#44; representative hot spots with the highest density of eosinophils were identified in the dermal inflammatory infiltrate&#46; 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All reported <span class="elsevierStyleItalic">P</span> values are two-tailed&#44; with a <span class="elsevierStyleItalic">P</span> value of 0&#46;05 indicating statistical significance&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Descriptive characteristics and comorbidities of the study population</span><p id="par0050" class="elsevierStylePara elsevierViewall">The study cohort included 233 patients with BP&#44; of whom 123 &#40;52&#46;8&#37;&#41; were males&#46; The mean age &#40;SD&#41; at diagnosis was 79&#46;3 &#40;9&#46;3&#41; years and the median age was 81&#46;0 &#40;range 51&#46;0&#8211;101&#46;0&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Overall&#44; 113 patients &#40;48&#46;5&#37;&#41; had type-2 diabetes mellitus at the onset of BP&#46; Seventy-two patients &#40;30&#46;9&#37;&#41; developed BP while being treated with DPP-4 inhibitors&#46; The most commonly prescribed DDP-4 inhibitor was vildagliptin &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>36&#59; 50&#46;0&#37;&#41;&#44; followed by linagliptin &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#59; 33&#46;3&#37;&#41; and sitagliptin &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#59; 16&#46;7&#37;&#41;&#46; The median latency time between the DPP-4 inhibitor introduction and the onset of BP was 18&#46;0 months &#40;range 4&#46;0&#8211;96&#46;0 months&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Ninety-three patients &#40;39&#46;9&#37;&#41; had concomitant neurologic disease&#46; The most common associated neurologic disease was dementia &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#59; 20&#46;6&#37;&#41;&#44; followed by cerebrovascular disease &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31&#59; 13&#46;3&#37;&#41;&#44; Parkinson disease &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#59; 6&#46;9&#37;&#41; and epilepsy &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#59; 3&#46;9&#37;&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Descriptive characteristics of the patients are detailed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Association between peripheral blood and cutaneous eosinophil levels and features of BP</span><p id="par0070" class="elsevierStylePara elsevierViewall">The mean peripheral blood eosinophil count was 956&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>408&#46;6<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L&#46; At the dermal hot spot area&#44; the mean number of eosinophils was 30&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;0&#46; Dermal infiltrate eosinophil number were directedly correlated with peripheral blood eosinophil counts &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;234&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41;&#46; The relationship between peripheral blood and dermal infiltrate eosinophil counts and demographic&#44; clinical&#44; and immunological characteristics of BP patients is detailed in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Dermal infiltrate eosinophil counts were significantly higher in patients with BP accompanying neurological disease &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;032&#41;&#46; In contrast&#44; patients treated with DPP-4 inhibitors had significantly lower counts of eosinophils both at the peripheral blood and at the dermal hot spot area &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;008&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;013&#44; respectively&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">With respect to the anatomical distribution of lesions&#44; presenting a disseminated form of BP &#40;i&#46;e&#46; BSA<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50&#37;&#41; was significantly more frequent in the group with high peripheral blood eosinophil counts &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;028&#41;&#46; Moreover&#44; hands and feet involvement were also more frequent in this group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;029&#41;&#46; Mucosal involvement was significantly associated with lower eosinophil count in the dermal infiltrate hot spot area &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The levels of anti-BP180 NC16A IgG antibodies were directly correlated both with peripheral blood and with dermal infiltrate eosinophil counts &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;356&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#59; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;197&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;43&#44; respectively&#41;&#46; The mean level of anti-BP180 NC16A IgG antibodies was significantly higher in the group with high peripheral blood eosinophil counts &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; No correlation was found with anti-BP230 IgG antibodies&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Requiring inpatient care was significantly associated with higher baseline peripheral blood eosinophil count &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;025&#41;&#46; Moreover&#44; relapsing was also more frequent among patients with higher peripheral blood eosinophil counts at presentation &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;020&#41;&#46; Most relapses occurred within the first six months of the study &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>56&#47;68&#59; 82&#46;4&#37;&#41;&#46; Among the 68 patients who experienced a relapse of BP&#44; 19 had high and 12 very high peripheral blood eosinophil counts at relapse &#40;27&#46;9&#37; and 16&#46;6&#37;&#44; respectively&#41;&#46; In these patients&#44; peripheral blood eosinophil counts at baseline and at relapse were significantly correlated &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;82&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Most patients who relapsed and had high baseline peripheral blood eosinophil count also presented peripheral blood eosinophilia at relapse &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>22&#47;31&#59; 71&#46;0&#37;&#41;&#46; In contrast&#44; only two patients with non-elevated baseline peripheral blood eosinophil count subsequently presented peripheral blood eosinophilia at relapse &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#47;37&#59; 5&#46;4&#37;&#41;&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0095" class="elsevierStylePara elsevierViewall">The current study revealed that peripheral blood and cutaneous eosinophil levels are associated with BP severity and with treatment outcomes&#46; Peripheral blood eosinophilia was associated with extensive disease and with hand and feet involvement&#46; Moreover&#44; it predicted a higher risk of requiring inpatient care and relapsing&#46; Peripheral blood and tissue eosinophil levels were associated with high titles of BP180 NC16A IgG antibodies&#46; Eosinophil-poor inflammatory infiltrates predicted an increased prevalence of mucosal involvement&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Previous studies had provided inconclusive conclusions on the influence of peripheral blood eosinophil levels on clinical and immunological features of BP&#46; Peripheral blood eosinophil levels were recently shown to be positively correlated with peripheral blood levels of both IgG and IgE anti-BP180 and with disease severity&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">7&#44;12</span></a> Kridin reported that patients with BP and eosinophilia had a higher rate of palmoplantar involvement and extensive disease&#46; In contrast&#44; patients with normal eosinophil counts tended to had atypical clinical features including higher mucosal and head&#47;neck involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">7</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Although an inflammatory infiltrate rich in eosinophil is a well-known feature of BP&#44; the relation between tissue eosinophil levels and the presentation of BP is yet to be established&#46; Izumi et al&#46; showed that patients who presented with an inflammatory phenotype with erythema and urticarial plaques had an increased seropositivity of BP180 NC16A IgG and a higher number of infiltrating eosinophils in lesional skin sections&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">13</span></a> Moreover&#44; tissue eosinophil levels have been recently correlated with disease severity&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">8</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The current study supports the association of peripheral blood eosinophilia and high dermal eosinophil counts with BP severity&#46; Likewise&#44; we found an association between disseminated forms of disease and high titles of BP180 NC16A IgG&#44; which are well-known to parallel BP activity&#46; In contrast&#44; we found a significant association between mucosal involvement and lower dermal eosinophil levels in concordance with a recent study reporting a higher prevalence of mucosal involvement in patients with a cell-poor inflammatory infiltrate&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">14</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">We observed that patients with high peripheral blood eosinophil levels have an increased risk of requiring inpatient care and relapsing after successful disease control&#46; In contrast&#44; dermal infiltrate eosinophil levels were not associated with treatment outcomes&#46; Therefore&#44; high peripheral blood eosinophil levels may signify a more recalcitrant clinical presentation necessitating more aggressive management&#46; Notably&#44; almost half of the patients who experienced a relapse had high or very high peripheral blood eosinophil levels at the time of relapse&#46; Moreover&#44; we found a strong and significant correlation between peripheral blood eosinophil counts at baseline and at relapse&#46; Our present results suggest that peripheral blood eosinophil levels may be a biomarker of BP relapse&#46; Most cases of clinical relapse of BP occur in the first six months of follow-up&#46; Therefore&#44; monitoring peripheral blood eosinophil counts in this period may allow early detection of relapse&#44; particularly in patients with high baseline peripheral blood eosinophil counts&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Our study disclosed a significant association between the comorbidities of BP patients and both peripheral blood and dermal infiltrate eosinophil levels&#46; Similar to previous studies&#44; diabetic patients treated with DPP-4 inhibitors had lower circulating and dermal infiltrate eosinophil counts&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">15&#8211;17</span></a> In contrast&#44; we found that BP patients with accompanying neurologic disease likely present high circulating eosinophil levels and an eosinophil-rich inflammatory infiltrate&#46; While the association of neurologic diseases in BP with high levels of peripheral blood eosinophils had been previously reported&#44; its association with high dermal eosinophil levels was only identified in a recently published study&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">8&#44;18</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">A pivotal contribution of eosinophils in BP pathogenesis has long been suggested as increasing evidence of its biological actions accumulate&#46; Increased expression of eotaxin-1 and Interleukin &#40;IL&#41; -5&#44; two key mediators in the recruitment and activation of eosinophils&#44; has been demonstrated in peripheral blood and blister fluid of BP patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">19&#44;20</span></a> Following activation&#44; in the presence of BP autoantibodies&#44; eosinophils directly contribute to BP blister formation&#46; Eosinophils degranulate and release granular proteins&#44; such as eosinophil cationic protein&#44; eosinophil extracellular traps and matrix metalloproteinase that directly contribute to BP antigens degradation and dermal&#8211;epidermal junction cleavage&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">10&#44;11</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Eosinophils may be a target for new therapeutics in BP&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">21</span></a> In fact&#44; the increasing number of cases of successful treatment of BP with omalizumab supports this strategy&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">22&#44;23</span></a> Other potential emerging drugs for BP treatment include bertilimumab&#44; a fully human monoclonal antibody targeting eotaxin-1&#44; and anti-IL5 monoclonal antibodies&#44; such as mepolizumab and benzalizumab&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">15&#44;24&#44;25</span></a> Determination of peripheral blood and dermal eosinophil levels may have a role in patient selection for these treatments&#46; Although clearly promising&#44; further studies are necessary to evaluate the efficacy and safety of eosinophil-directed therapies in the management of BP&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">The main limitation of the current study is its retrospective design&#46; Disease severity evaluation was limited by the lack of data on standardised BPADI index for each patient&#46; Besides&#44; eosinophil tissue levels were evaluated on a single lesional punch biopsy&#46; However&#44; biopsies from all patients were obtained from the most inflammatory skin lesion and count was performed by three Dermatopathologists&#46; Selection of more severe and recalcitrant cases may have arisen as the study was carried out in a tertiary referral centre setting&#46; Nevertheless&#44; our study sheds light on a topic that has not been fully investigated so far&#46; Moreover&#44; it provides novel insight regarding the relation between BP clinical and immunological characteristics and peripheral blood and dermal infiltrate eosinophil levels&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion&#44; circulating and cutaneous eosinophils levels may be useful biomarkers for disease activity and treatment outcomes in BP&#46; Monitoring peripheral blood eosinophil counts may allow early detection of relapse&#46; In addition&#44; inhibition of eosinophil activity may be a strategy for new therapeutics in BP&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interests</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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    "fechaRecibido" => "2022-01-08"
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            0 => "Bullous dermatosis"
            1 => "Bullous pemphigoid"
            2 => "Eosinophilia"
            3 => "Eosinophils"
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            0 => "Dermatosis ampollosa"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and aims</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A dermal inflammatory infiltrate rich in eosinophils is a prominent histological feature of bullous pemphigoid &#40;BP&#41; and peripheral blood eosinophilia has been documented in 50&#8211;60&#37; of BP patients&#46; Nevertheless&#44; the impact of circulating and dermal infiltrate eosinophil levels on BP remains poorly understood&#46; The main objective of this work was to investigate the association of peripheral blood and dermal infiltrate eosinophil levels with clinical and immunological characteristics of the disease&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Retrospective cohort study including all patients diagnosed with BP between 2011 and 2020&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The study cohort included 233 patients with BP&#46; The mean baseline peripheral blood eosinophil count was 956&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>408&#46;6<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L and the mean number of tissue eosinophils at the dermal hot spot area was 30&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;0&#46; Patients with disseminated presentation &#40;i&#46;e&#46; BSA<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50&#37;&#41; had significantly higher peripheral blood eosinophil counts &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;028&#41;&#46; Mucosal involvement was significantly associated with lower dermal eosinophil count &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Requiring inpatient care and relapsing were significantly associated with high peripheral blood eosinophil count &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;025&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;020&#44; respectively&#41;&#46; Among the 68 patients who experienced a relapse&#44; 31 had peripheral blood eosinophilia &#40;i&#46;e&#46; &#62;500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L&#41; at relapse &#40;44&#46;2&#37;&#41;&#46; Peripheral blood eosinophil counts at baseline and at relapse were significantly correlated &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;82&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Peripheral blood and cutaneous eosinophils levels may be useful biomarkers for disease activity and treatment outcomes in BP&#46; Monitoring peripheral blood eosinophil counts may allow early detection of relapse&#46;</p></span>"
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      "es" => array:3 [
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El infiltrado inflamatorio d&#233;rmico rico en eosin&#243;filos es una caracter&#237;stica histol&#243;gica destacada de penfigoide ampolloso &#40;PA&#41; y eosinofilia en sangre perif&#233;rica&#44; que se ha documentado en el 50-60&#37; de los pacientes con esta enfermedad&#46; Sin embargo&#44; el impacto de los niveles de eosin&#243;filos circulantes y en infiltrados d&#233;rmicos en el PA sigue sin comprenderse&#46; El objetivo principal de este estudio fue investigar la asociaci&#243;n entre los niveles de eosin&#243;filos en sangre perif&#233;rica y en infiltrados d&#233;rmicos y las caracter&#237;sticas cl&#237;nicas e inmunol&#243;gicas de esta enfermedad&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio de cohorte retrospectivo que incluy&#243; a todos los pacientes con PA entre 2011 y 2020&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El estudio de cohorte incluy&#243; 233 pacientes con PA&#46; El recuento de eosin&#243;filos basal medio en sangre perif&#233;rica fue de 956&#44;3 &#177; 408&#44;6 x10<span class="elsevierStyleSup">6</span>&#47;L y el n&#250;mero medio de eosin&#243;filos tisulares en la zona d&#233;rmica clave fue de 30&#44;5 &#177; 19&#46; Los pacientes con presentaci&#243;n diseminada &#40;es decir&#44; BSA &#62;50&#37;&#41; tuvieron conteos de eosin&#243;filos en sangre perif&#233;rica significativamente superiores &#40;p &#61; 0&#44;028&#41;&#46; El compromiso mucoso estuvo significativamente asociado a un conteo de eosin&#243;filos cut&#225;neo inferior &#40;p &#61; 0&#44;001&#41;&#46; La necesidad de cuidados hospitalarios y las reca&#237;das estuvieron significativamente asociadas a conteos de eosin&#243;filos en sangre perif&#233;rica m&#225;s elevados &#40;p &#61; 0&#44;025&#59; p &#61; 0&#44;020&#44; respectivamente&#41;&#46; Entre los 68 pacientes que experimentaron recidiva&#44; 31 tuvieron eosinofilia en sangre perif&#233;rica &#40;es decir&#44; &#62; 500 x 10<span class="elsevierStyleSup">6</span>&#47;L&#41; en reca&#237;da &#40;44&#44;2&#37;&#41;&#46; Los conteos de eosin&#243;filos en sangre perif&#233;rica basales y en reca&#237;da se correlacionaron significativamente &#40;r &#61; 0&#44;82&#44; p &#60; 0&#44;001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los niveles de eosin&#243;filos en sangre perif&#233;rica y cut&#225;neos pueden constituir biomarcadores &#250;tiles para la actividad de la enfermedad y los resultados terap&#233;uticos en el PA&#46; Supervisar los conteos de eosin&#243;filos en sangre perif&#233;rica puede ayudar a detectar la recidiva tempranamente&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
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        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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        "detalles" => array:1 [
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            "identificador" => "at1"
            "detalle" => "Table "
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">BP&#58; bullous pemphigoid&#44; DPP4&#58; dipeptidyl peptidase-4&#44; ELISA&#58; enzyme-linked immunosorbent assay&#44; <span class="elsevierStyleItalic">n</span>&#58; number&#44; SD&#58; standard deviation&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
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                  \t\t\t\t"><span class="elsevierStyleBold">Descriptive characteristics</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Age at diagnosis&#44; years</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">79&#46;3 &#40;9&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Sex&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">123 &#40;52&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Comorbidities&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Type 2 diabetes mellitus&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">113 &#40;48&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Neurologic disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93 &#40;39&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Malignancy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33 &#40;14&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">DPP-4 inhibitor-associated BP&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72 &#40;30&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Vildagliptin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;15&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Linagliptin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;9&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Sitagliptin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;5&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Anti-PD-1-associated BP&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Distribution of bullous lesions&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Upper limbs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">205 &#40;88&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Lower limbs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">202 &#40;86&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Trunk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">199 &#40;85&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Hands and feet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">169 &#40;72&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Head and neck&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57 &#40;24&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mucosal involvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;16&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Disseminated presentation &#40;i&#46;e&#46; BSA<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">113 &#40;48&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Peripheral blood eosinophil count&#44; baseline &#40;&#215;10</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">6</span></span><span class="elsevierStyleItalic">&#47;L&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">956&#46;3 &#40;408&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Peripheral blood eosinophil levels&#44; baseline&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Normal &#40;&#60;500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;41&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>High &#40;500&#8211;1500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114 &#40;48&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Very high &#40;&#62;1500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;9&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dermal infiltrate eosinophil count &#40;n&#46; cels&#47;hot spot area&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#46;5 &#40;19&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dermal infiltrate eosinophil levels&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;3&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Low &#40;&#60;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;32&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Intermediate &#40;25&#8211;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;28&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>High &#40;&#62;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;35&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Anti-BP180 NC16A IgG ELISA</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ELISA value&#44; mean &#40;SD&#41;&#59; &#40;U&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128&#46;4 &#40;85&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Anti-BP230 IgG ELISA</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ELISA value&#44; mean &#40;SD&#41;&#59; &#40;U&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;0 &#40;27&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Linear deposits of immunoreactants by direct immunofluorescence&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>C3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">226 &#40;97&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>IgG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">208 &#40;89&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>IgA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;7&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>IgM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;2&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Isolated C3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;7&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Treatment&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Oral prednisone &#40;&#62;0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;Kg&#47;day&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">219 &#40;94&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Tetracycline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">109 &#40;46&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Adjuvant immunosuppressant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74 &#40;31&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Isolated topical treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;2&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Number of treatment lines</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;8 &#40;1&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Inpatient care&#59; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 &#40;39&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Relapsing&#59; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;29&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Peripheral blood eosinophil count&#44; relapse &#40;x106&#47;L&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">949&#46;4 &#40;412&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Peripheral blood eosinophil levels&#44; relapse&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Normal &#40;&#60;500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;54&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>High &#40;500&#8211;1500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;27&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Very high &#40;&#62;1500<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;17&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Demographic&#44; clinical&#44; and immunological characteristics of BP patients&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Significant values are shown in bold&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">BP&#58; bullous pemphigoid&#44; DPP4&#58; dipeptidyl peptidase-4&#44; ELISA&#58; enzyme-linked immunosorbent assay&#44; <span class="elsevierStyleItalic">n</span>&#58; number&#44; SD&#58; standard deviation&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Peripheral blood eosinophil count</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dermal infiltrate eosinophil count</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Normal &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">High or very high &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>137&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No-low &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intermediate-high &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>150&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Age at diagnosis&#44; years</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&#46;2 &#40;9&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;7 &#40;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#46;9 &#40;9&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;8 &#40;8&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;478&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sex&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;43&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81 &#40;59&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;054&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;50&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81 &#40;54&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;579&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;56&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;40&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41 &#40;49&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;46&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbidities&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Type 2 diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;56&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59 &#40;43&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;039</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53 &#40;63&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;40&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;012</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>DPP-4 inhibitor-associated BP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neurologic disease&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Malignancy&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Distribution of bullous lesions&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Disseminated presentation &#40;i&#46;e&#46; BSA<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">43 &#40;51&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&#59; &#40;U&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Anti-BP230 IgG ELISA</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&#59; &#40;U&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Linear deposits of immunoreactants by direct immunofluorescence&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">79 &#40;95&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">147 &#40;98&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;794&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IgG&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">78 &#40;81&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">130 &#40;94&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">126 &#40;84&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IgA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IgM&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;2&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Isolated C3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;8&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Oral prednisone &#40;&#62;0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">86 &#40;89&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">81 &#40;97&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">138 &#40;92&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tetracycline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">46 &#40;47&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
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Vol. 113. Issue 9.
Pages 881-887 (October 2022)
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Vol. 113. Issue 9.
Pages 881-887 (October 2022)
Original Article
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Association of Peripheral Blood and Cutaneous Eosinophils With Bullous Pemphigoid Disease Severity and Treatment Outcomes
Asociación entre eosinófilos de sangre periférica y cutáneos con la gravedad del penfigoide ampolloso y los resultados terapéuticos
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P.M. Garridoa,
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pedro.mi.garrido@gmail.com

Corresponding author.
, M. Aguado-Loboa, P. Espinosa-Laraa, L. Soares-Almeidaa,b,c, P. Filipea,b,c
a Dermatology Department, Centro Hospitalar Universitário Lisboa Norte, EPE (CHULN), Lisbon, Portugal
b Dermatology Universitary Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
c Dermatology Research Unit, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
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P.M. Garrido, M. Aguado-Lobo, P. Espinosa-Lara, L. Soares-Almeida, P. Filipe
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Abstract
Background and aims

A dermal inflammatory infiltrate rich in eosinophils is a prominent histological feature of bullous pemphigoid (BP) and peripheral blood eosinophilia has been documented in 50–60% of BP patients. Nevertheless, the impact of circulating and dermal infiltrate eosinophil levels on BP remains poorly understood. The main objective of this work was to investigate the association of peripheral blood and dermal infiltrate eosinophil levels with clinical and immunological characteristics of the disease.

Material and methods

Retrospective cohort study including all patients diagnosed with BP between 2011 and 2020.

Results

The study cohort included 233 patients with BP. The mean baseline peripheral blood eosinophil count was 956.3±408.6×106/L and the mean number of tissue eosinophils at the dermal hot spot area was 30.5±19.0. Patients with disseminated presentation (i.e. BSA>50%) had significantly higher peripheral blood eosinophil counts (P=0.028). Mucosal involvement was significantly associated with lower dermal eosinophil count (P=0.001). Requiring inpatient care and relapsing were significantly associated with high peripheral blood eosinophil count (P=0.025; P=0.020, respectively). Among the 68 patients who experienced a relapse, 31 had peripheral blood eosinophilia (i.e. >500×106/L) at relapse (44.2%). Peripheral blood eosinophil counts at baseline and at relapse were significantly correlated (r=0.82, P<0.001).

Conclusions

Peripheral blood and cutaneous eosinophils levels may be useful biomarkers for disease activity and treatment outcomes in BP. Monitoring peripheral blood eosinophil counts may allow early detection of relapse.

Keywords:
Bullous dermatosis
Bullous pemphigoid
Eosinophilia
Eosinophils
Resumen
Antecedentes y objetivos

El infiltrado inflamatorio dérmico rico en eosinófilos es una característica histológica destacada de penfigoide ampolloso (PA) y eosinofilia en sangre periférica, que se ha documentado en el 50-60% de los pacientes con esta enfermedad. Sin embargo, el impacto de los niveles de eosinófilos circulantes y en infiltrados dérmicos en el PA sigue sin comprenderse. El objetivo principal de este estudio fue investigar la asociación entre los niveles de eosinófilos en sangre periférica y en infiltrados dérmicos y las características clínicas e inmunológicas de esta enfermedad.

Material y métodos

Estudio de cohorte retrospectivo que incluyó a todos los pacientes con PA entre 2011 y 2020.

Resultados

El estudio de cohorte incluyó 233 pacientes con PA. El recuento de eosinófilos basal medio en sangre periférica fue de 956,3 ± 408,6 x106/L y el número medio de eosinófilos tisulares en la zona dérmica clave fue de 30,5 ± 19. Los pacientes con presentación diseminada (es decir, BSA >50%) tuvieron conteos de eosinófilos en sangre periférica significativamente superiores (p = 0,028). El compromiso mucoso estuvo significativamente asociado a un conteo de eosinófilos cutáneo inferior (p = 0,001). La necesidad de cuidados hospitalarios y las recaídas estuvieron significativamente asociadas a conteos de eosinófilos en sangre periférica más elevados (p = 0,025; p = 0,020, respectivamente). Entre los 68 pacientes que experimentaron recidiva, 31 tuvieron eosinofilia en sangre periférica (es decir, > 500 x 106/L) en recaída (44,2%). Los conteos de eosinófilos en sangre periférica basales y en recaída se correlacionaron significativamente (r = 0,82, p < 0,001).

Conclusiones

Los niveles de eosinófilos en sangre periférica y cutáneos pueden constituir biomarcadores útiles para la actividad de la enfermedad y los resultados terapéuticos en el PA. Supervisar los conteos de eosinófilos en sangre periférica puede ayudar a detectar la recidiva tempranamente.

Palabras clave:
Dermatosis ampollosa
Penfigoide ampolloso
Eosinofilia
Eosinófilos
Full Text
Introduction

Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease.1 BP affects mostly elderly patients and is associated with significant rates of morbidity and mortality.2 In the past two decades a trend of growing incidence between 1.9 and 4.3-fold has been reported in data from different European countries.3,4 The increased incidence of BP overtime has been associated with an ageing population, with the increased prevalence of neurologic diseases and with the increasing use of drugs associated with BP development, in particular dipeptidyl peptidase-IV (DPP-4) inhibitors.5

Several observations support a pathogenic role of eosinophils in BP. Dermal inflammatory infiltrate rich in eosinophils is a prominent histological feature and peripheral blood eosinophilia has been documented in 50–60% of BP patients.6,7 Moreover, peripheral blood and cutaneous eosinophil levels have been correlated with disease severity.7,8 Eosinophils seem to be key effector cells in BP initiation and progression. In fact, eosinophil skin infiltration is an early event and precedes blister formation.9 Eosinophils degranulation and release of extracellular eosinophil traps and granule proteins promote lesion formation.10,11

Although increasing evidence of contribution of eosinophils for BP pathogenesis accumulate, the influence of circulating and dermal infiltrate eosinophil levels on the phenotype of BP remains poorly understood. The main objective of this study was to evaluate the association between peripheral blood and cutaneous eosinophil levels and the clinical and immunological characteristics of the disease.

Materials and methods

A retrospective cohort study was conducted on all patients diagnosed with BP between January 1st, 2011 and December 31st, 2020, at a tertiary referral centre. The study was approved by the Local Ethics Committee.

The diagnosis of BP was established according to the following criteria: (1) suggestive clinical and histopathological picture; (2) linear deposits of IgG and/or C3 along the dermal–epidermal junction by direct immunofluorescence (DIF) microscopy of a perilesional skin biopsy; and (3) the presence of circulating IgG autoantibodies against BP180 and/or BP230, as identified by BP180 NC16A/BP230 enzyme-linked immunosorbent assay (ELISA).

We excluded all patients with an alternative cause for peripheral blood and tissue eosinophilia, including atopic dermatitis, asthma, allergic rhinitis, parasitic infection and lymphoma. All patients treated with drugs that affect eosinophil counts in the moment of BP diagnosis, including systemic steroids and immunosuppressants, were also excluded.

Peripheral blood eosinophil counts prior to the administration of any treatment were reviewed. Peripheral blood eosinophil counts were classified as normal if below 500×106/L, high if between 500 and 1500×106/L and very high if above 1500×106/L. The levels of peripheral blood anti-BP180 NC16A and anti-BP230 IgG autoantibodies were measured by ELISA (Euroimmun, Lűbeck, Germany). Seropositivity was determined based on the cut-off values proposed by the manufacturer (i.e., 20U/ml).

Haematoxylin and eosin (H&E)-stained lesional skin specimens were reviewed in terms of eosinophil levels by three Dermatopathologists (MAG, PEL, LSA). In each sample, representative hot spots with the highest density of eosinophils were identified in the dermal inflammatory infiltrate. In each hop spot the number of eosinophils was counted using a single×400 high power field (HPF) objective (one large magnification area hot spot).

Data was analysed using IBM SPSS Statistics® (Statistical Package for the Social Sciences, version 24, SPSS Inc., Chicago, IL, USA). Categorical variables were presented as frequencies and percentages and were compared with use of Chi-square test. Data found to be non-normally distributed were analysed using the Mann–Whitney U test for independent subgroups and the Wilcoxon test for dependent subgroups. Continuous variables were presented as means and standard deviations. These variables were compared with the use of Student's t-test. All reported P values are two-tailed, with a P value of 0.05 indicating statistical significance.

ResultsDescriptive characteristics and comorbidities of the study population

The study cohort included 233 patients with BP, of whom 123 (52.8%) were males. The mean age (SD) at diagnosis was 79.3 (9.3) years and the median age was 81.0 (range 51.0–101.0).

Overall, 113 patients (48.5%) had type-2 diabetes mellitus at the onset of BP. Seventy-two patients (30.9%) developed BP while being treated with DPP-4 inhibitors. The most commonly prescribed DDP-4 inhibitor was vildagliptin (n=36; 50.0%), followed by linagliptin (n=24; 33.3%) and sitagliptin (n=12; 16.7%). The median latency time between the DPP-4 inhibitor introduction and the onset of BP was 18.0 months (range 4.0–96.0 months).

Ninety-three patients (39.9%) had concomitant neurologic disease. The most common associated neurologic disease was dementia (n=48; 20.6%), followed by cerebrovascular disease (n=31; 13.3%), Parkinson disease (n=16; 6.9%) and epilepsy (n=9; 3.9%).

Descriptive characteristics of the patients are detailed in Table 1.

Table 1.

Demographic, clinical, and immunological characteristics of BP patients.

Descriptive characteristics
Age at diagnosis, years
Mean (SD)  79.3 (9.3) 
Sex, n (%)
Male  123 (52.8%) 
Comorbidities, n (%)
Type 2 diabetes mellitus  113 (48.5%) 
Neurologic disease  93 (39.9%) 
Malignancy  33 (14.2%) 
DPP-4 inhibitor-associated BP, n (%)  72 (30.9%) 
Vildagliptin  37 (15.9%) 
Linagliptin  23 (9.9%) 
Sitagliptin  12 (5.1%) 
Anti-PD-1-associated BP, n (%)  1 (0.4%) 
Distribution of bullous lesions; n (%)
Upper limbs  205 (88.0%) 
Lower limbs  202 (86.7%) 
Trunk  199 (85.4%) 
Hands and feet  169 (72.5%) 
Head and neck  57 (24.5%) 
Mucosal involvement  39 (16.7%) 
Disseminated presentation (i.e. BSA>50%)  113 (48.5%) 
Peripheral blood eosinophil count, baseline (×106/L)
Mean (SD)  956.3 (408.6) 
Peripheral blood eosinophil levels, baseline; n (%)
Normal (<500×106/L)  96 (41.2%) 
High (500–1500×106/L)  114 (48.9%) 
Very high (>1500×106/L)  23 (9.9%) 
Dermal infiltrate eosinophil count (n. cels/hot spot area)
Mean (SD)  30.5 (19.0) 
Dermal infiltrate eosinophil levels; n (%)
No (0)  8 (3.4%) 
Low (<25)  75 (32.2%) 
Intermediate (25–50)  67 (28.8%) 
High (>50)  83 (35.6%) 
Anti-BP180 NC16A IgG ELISA
ELISA value, mean (SD); (U/mL)  128.4 (85.2) 
Anti-BP230 IgG ELISA
ELISA value, mean (SD); (U/mL)  32.0 (27.4) 
Linear deposits of immunoreactants by direct immunofluorescence, n (%)
C3  226 (97.0%) 
IgG  208 (89.3%) 
IgA  17 (7.3%) 
IgM  5 (2.1%) 
Isolated C3  18 (7.7%) 
Treatment; n (%)
Oral prednisone (>0.5mg/Kg/day)  219 (94.0%) 
Tetracycline  109 (46.8%) 
Adjuvant immunosuppressant  74 (31.8%) 
Isolated topical treatment  5 (2.1%) 
Number of treatment lines
Mean (SD)  1.8 (1.0) 
Inpatient care; n (%)  89 (39.2%) 
Relapsing; n (%)  68 (29.2%) 
Peripheral blood eosinophil count, relapse (x106/L)
Mean (SD)  949.4 (412.0) 
Peripheral blood eosinophil levels, relapse; n (%)
Normal (<500×106/L)  37 (54.4%) 
High (500–1500×106/L)  19 (27.9%) 
Very high (>1500×106/L)  12 (17.6%) 

BP: bullous pemphigoid, DPP4: dipeptidyl peptidase-4, ELISA: enzyme-linked immunosorbent assay, n: number, SD: standard deviation.

Association between peripheral blood and cutaneous eosinophil levels and features of BP

The mean peripheral blood eosinophil count was 956.3±408.6×106/L. At the dermal hot spot area, the mean number of eosinophils was 30.5±19.0. Dermal infiltrate eosinophil number were directedly correlated with peripheral blood eosinophil counts (r=0.234, P=0.004). The relationship between peripheral blood and dermal infiltrate eosinophil counts and demographic, clinical, and immunological characteristics of BP patients is detailed in Table 2.

Table 2.

Relationship between peripheral blood and dermal infiltrate eosinophil counts and demographic, clinical, and immunological characteristics of BP patients.

  Peripheral blood eosinophil countP-value  Dermal infiltrate eosinophil countP-value 
  Normal (n=96)  High or very high (n=137)    No-low (n=83)  Intermediate-high (n=150)   
Age at diagnosis, years
Mean (SD)  77.2 (9.0)  79.7 (9.8)  0.090  78.9 (9.5)  79.8 (8.8)  0.478 
Sex, n (%)
Male  42 (43.8)  81 (59.1)  0.054  42 (50.6)  81 (54.0)  0.579 
Female  54 (56.3)  56 (40.9)    41 (49.4)  69 (46.0)   
Comorbidities, n (%)
Type 2 diabetes mellitus  54 (56.3)  59 (43.1)  0.039  53 (63.9)  60 (40.0)  0.012 
DPP-4 inhibitor-associated BP  39 (40.7)  33 (24.1)  0.008  33 (39.7)  39 (26.0)  0.013 
Neurologic disease  38 (39.6)  55 (40.1)  0.987  27 (32.5)  66 (44.0)  0.032 
Malignancy  12 (12.5)  21 (15.3)  0.825  15 (18.1)  16 (10.7)  0.162 
Distribution of bullous lesions, n (%)
Upper limbs  79 (82.2)  126 (92.0)  0.141  80 (96.4)  125 (83.3)  0.662 
Lower limbs  78 (81.2)  124 (90.5)  0.204  76 (91.6)  126 (84.0)  0.678 
Trunk  85 (88.5)  114 (83.2)  0.128  78 (94.0)  121 (80.7)  0.566 
Hands and feet  61 (63.5)  108 (78.8)  0.029  58 (69.9)  111 (74.0)  0.082 
Head and neck  28 (29.1)  29 (21.1)  0.207  27 (32.5)  30 (20.0)  0.104 
Mucosal involvement  19 (19.8)  20 (14.6)  0.185  24 (28.9)  15 (10.0)  0.001 
Disseminated presentation (i.e. BSA>50%)  39 (40.6)  74 (54.0)  0.028  43 (51.8)  70 (46.7)  0.868 
Anti-BP180 NC16A IgG ELISA
Mean (SD); (U/mL)  96.7 (84.4)  164.9 (71.5)  <0.001  119.5 (86.9)  134.2 (84.9)  0.419 
Anti-BP230 IgG ELISA
Mean (SD); (U/mL)  23.0 (15.8)  41.5 (36.2)  0.154  22.7 (22.0)  43.0 (28.7)  0.101 
Linear deposits of immunoreactants by direct immunofluorescence, n (%)
C3  92 (95.8)  134 (97.8)  0.563  79 (95.2)  147 (98.0)  0.794 
IgG  78 (81.3)  130 (94.9)  0.223  82 (98.8)  126 (84.0)  0.381 
IgA  7 (7.3)  10 (7.3)  0.799  7 (7.3)  10 (7.3)  0.799 
IgM  2 (2.1)  3 (2.2)  1.000  2 (2.1)  3 (2.2)  1.000 
Isolated C3  8 (8.3)  10 (7.3)  0.656  7 (7.3)  11 (7.3)  1.000 
Treatment; n (%)
Oral prednisone (>0.5mg/kg/day)  86 (89.6)  133 (97.1)  0.487  81 (97.6)  138 (92.0)  0.987 
Tetracycline  46 (47.9)  63 (46.0)  0.632  41 (49.3)  68 (45.3)  0.675 
Adjuvant immunosuppressant  29 (30.2)  45 (32.8)  0.742  29 (34.9)  45 (30.0)  0.557 
Isolated topical treatment  3 (3.1)  2 (1.5)  0.993  2 (2.4)  3 (2.0)  0.887 
Number of treatment lines
Mean (SD)  2.0 (1.1)  2.0 (1.0)  0.928  1.8 (0.9)  1.9 (1.1)  0.455 
Inpatient care; n (%)  29 (30.2)  60 (43.8)  0.025  38 (45.8)  51 (34.0)  0.118 
Relapsing; n (%)  18 (18.8)  50 (36.5)  0.020  27 (32.5)  41 (27.3)  0.626 

Significant values are shown in bold.

BP: bullous pemphigoid, DPP4: dipeptidyl peptidase-4, ELISA: enzyme-linked immunosorbent assay, n: number, SD: standard deviation.

Dermal infiltrate eosinophil counts were significantly higher in patients with BP accompanying neurological disease (P=0.032). In contrast, patients treated with DPP-4 inhibitors had significantly lower counts of eosinophils both at the peripheral blood and at the dermal hot spot area (P=0.008; P=0.013, respectively).

With respect to the anatomical distribution of lesions, presenting a disseminated form of BP (i.e. BSA>50%) was significantly more frequent in the group with high peripheral blood eosinophil counts (P=0.028). Moreover, hands and feet involvement were also more frequent in this group (P=0.029). Mucosal involvement was significantly associated with lower eosinophil count in the dermal infiltrate hot spot area (P=0.001).

The levels of anti-BP180 NC16A IgG antibodies were directly correlated both with peripheral blood and with dermal infiltrate eosinophil counts (r=0.356, P=0.001; r=0.197, P=0.43, respectively). The mean level of anti-BP180 NC16A IgG antibodies was significantly higher in the group with high peripheral blood eosinophil counts (P<0.001). No correlation was found with anti-BP230 IgG antibodies.

Requiring inpatient care was significantly associated with higher baseline peripheral blood eosinophil count (P=0.025). Moreover, relapsing was also more frequent among patients with higher peripheral blood eosinophil counts at presentation (P=0.020). Most relapses occurred within the first six months of the study (n=56/68; 82.4%). Among the 68 patients who experienced a relapse of BP, 19 had high and 12 very high peripheral blood eosinophil counts at relapse (27.9% and 16.6%, respectively). In these patients, peripheral blood eosinophil counts at baseline and at relapse were significantly correlated (r=0.82, P<0.001). Most patients who relapsed and had high baseline peripheral blood eosinophil count also presented peripheral blood eosinophilia at relapse (n=22/31; 71.0%). In contrast, only two patients with non-elevated baseline peripheral blood eosinophil count subsequently presented peripheral blood eosinophilia at relapse (n=2/37; 5.4%).

Discussion

The current study revealed that peripheral blood and cutaneous eosinophil levels are associated with BP severity and with treatment outcomes. Peripheral blood eosinophilia was associated with extensive disease and with hand and feet involvement. Moreover, it predicted a higher risk of requiring inpatient care and relapsing. Peripheral blood and tissue eosinophil levels were associated with high titles of BP180 NC16A IgG antibodies. Eosinophil-poor inflammatory infiltrates predicted an increased prevalence of mucosal involvement.

Previous studies had provided inconclusive conclusions on the influence of peripheral blood eosinophil levels on clinical and immunological features of BP. Peripheral blood eosinophil levels were recently shown to be positively correlated with peripheral blood levels of both IgG and IgE anti-BP180 and with disease severity.7,12 Kridin reported that patients with BP and eosinophilia had a higher rate of palmoplantar involvement and extensive disease. In contrast, patients with normal eosinophil counts tended to had atypical clinical features including higher mucosal and head/neck involvement.7

Although an inflammatory infiltrate rich in eosinophil is a well-known feature of BP, the relation between tissue eosinophil levels and the presentation of BP is yet to be established. Izumi et al. showed that patients who presented with an inflammatory phenotype with erythema and urticarial plaques had an increased seropositivity of BP180 NC16A IgG and a higher number of infiltrating eosinophils in lesional skin sections.13 Moreover, tissue eosinophil levels have been recently correlated with disease severity.8

The current study supports the association of peripheral blood eosinophilia and high dermal eosinophil counts with BP severity. Likewise, we found an association between disseminated forms of disease and high titles of BP180 NC16A IgG, which are well-known to parallel BP activity. In contrast, we found a significant association between mucosal involvement and lower dermal eosinophil levels in concordance with a recent study reporting a higher prevalence of mucosal involvement in patients with a cell-poor inflammatory infiltrate.14

We observed that patients with high peripheral blood eosinophil levels have an increased risk of requiring inpatient care and relapsing after successful disease control. In contrast, dermal infiltrate eosinophil levels were not associated with treatment outcomes. Therefore, high peripheral blood eosinophil levels may signify a more recalcitrant clinical presentation necessitating more aggressive management. Notably, almost half of the patients who experienced a relapse had high or very high peripheral blood eosinophil levels at the time of relapse. Moreover, we found a strong and significant correlation between peripheral blood eosinophil counts at baseline and at relapse. Our present results suggest that peripheral blood eosinophil levels may be a biomarker of BP relapse. Most cases of clinical relapse of BP occur in the first six months of follow-up. Therefore, monitoring peripheral blood eosinophil counts in this period may allow early detection of relapse, particularly in patients with high baseline peripheral blood eosinophil counts.

Our study disclosed a significant association between the comorbidities of BP patients and both peripheral blood and dermal infiltrate eosinophil levels. Similar to previous studies, diabetic patients treated with DPP-4 inhibitors had lower circulating and dermal infiltrate eosinophil counts.15–17 In contrast, we found that BP patients with accompanying neurologic disease likely present high circulating eosinophil levels and an eosinophil-rich inflammatory infiltrate. While the association of neurologic diseases in BP with high levels of peripheral blood eosinophils had been previously reported, its association with high dermal eosinophil levels was only identified in a recently published study.8,18

A pivotal contribution of eosinophils in BP pathogenesis has long been suggested as increasing evidence of its biological actions accumulate. Increased expression of eotaxin-1 and Interleukin (IL) -5, two key mediators in the recruitment and activation of eosinophils, has been demonstrated in peripheral blood and blister fluid of BP patients.19,20 Following activation, in the presence of BP autoantibodies, eosinophils directly contribute to BP blister formation. Eosinophils degranulate and release granular proteins, such as eosinophil cationic protein, eosinophil extracellular traps and matrix metalloproteinase that directly contribute to BP antigens degradation and dermal–epidermal junction cleavage.10,11

Eosinophils may be a target for new therapeutics in BP.21 In fact, the increasing number of cases of successful treatment of BP with omalizumab supports this strategy.22,23 Other potential emerging drugs for BP treatment include bertilimumab, a fully human monoclonal antibody targeting eotaxin-1, and anti-IL5 monoclonal antibodies, such as mepolizumab and benzalizumab.15,24,25 Determination of peripheral blood and dermal eosinophil levels may have a role in patient selection for these treatments. Although clearly promising, further studies are necessary to evaluate the efficacy and safety of eosinophil-directed therapies in the management of BP.

The main limitation of the current study is its retrospective design. Disease severity evaluation was limited by the lack of data on standardised BPADI index for each patient. Besides, eosinophil tissue levels were evaluated on a single lesional punch biopsy. However, biopsies from all patients were obtained from the most inflammatory skin lesion and count was performed by three Dermatopathologists. Selection of more severe and recalcitrant cases may have arisen as the study was carried out in a tertiary referral centre setting. Nevertheless, our study sheds light on a topic that has not been fully investigated so far. Moreover, it provides novel insight regarding the relation between BP clinical and immunological characteristics and peripheral blood and dermal infiltrate eosinophil levels.

In conclusion, circulating and cutaneous eosinophils levels may be useful biomarkers for disease activity and treatment outcomes in BP. Monitoring peripheral blood eosinophil counts may allow early detection of relapse. In addition, inhibition of eosinophil activity may be a strategy for new therapeutics in BP.

Conflict of interests

The authors declare that they have no conflict of interest.

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