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            2 => "methylisothiazolinone"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Contact dermatitis to cosmetics is a common problem in the general population&#44; although its prevalence appears to be underestimated&#46; We reviewed cases of allergic contact dermatitis to cosmetics diagnosed in our dermatology department over a 7-year period with a view to identifying the allergens responsible&#44; the frequency of occurrence of these allergens&#44; and the cosmetic products implicated&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">Using the database of the skin allergy department&#44; we undertook a search of all cases of allergic contact dermatitis to cosmetics diagnosed in our department from January 2000 through October 2007&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In this period&#44; patch tests were carried out on 2485 patients&#44; of whom 740 were diagnosed with allergic contact dermatitis and the cause was cosmetics in 202 of these patients &#40;170 women and 32 men&#41;&#44; who accounted for 27&#46;3&#37; of all cases&#46; A total of 315 positive results were found for 46 different allergens&#46; Allergens most often responsible for contact dermatitis in a cosmetics user were methylisothiazolinone &#40;19&#37;&#41;&#44; paraphenylenediamine &#40;15&#46;2&#37;&#41;&#44; and fragrance mixtures &#40;7&#46;8&#37;&#41;&#46; Acrylates were the most common allergens in cases of occupational disease&#46; Half of the positive results were obtained with the standard battery of the Spanish Group for Research Into Dermatitis and Skin Allergies &#40;GEIDAC&#41;&#46; The cosmetic products most often implicated among cosmetics users were hair dyes &#40;18&#46;5&#37;&#41;&#44; gels&#47;soaps &#40;15&#46;7&#37;&#41;&#44; and moisturizing creams &#40;12&#46;7&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">Most patients affected were women&#46; Preservatives&#44; paraphenylenediamine&#44; and fragrances were the most frequently detected cosmetic allergens&#44; in line with previous reports in the literature&#46; Finally&#44; in order to detect new cosmetic allergens&#44; cooperation between physicians and cosmetics producers is needed&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La dermatitis de contacto por cosm&#233;ticos es un problema frecuente entre la poblaci&#243;n general&#44; sin embargo&#44; parece ser que su prevalencia est&#225; infraestimada&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Revisamos en este trabajo los casos de dermatitis de contacto al&#233;rgica por cosm&#233;ticos diagnosticados en el Departamento de Dermatolog&#237;a en un periodo de 7 a&#241;os con el objetivo de detectar los alergenos responsables&#44; la frecuencia de los mismos&#44; as&#237; como los productos cosm&#233;ticos implicados&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Utilizando la base de datos de la secci&#243;n de Alergia Cut&#225;nea se realiza una b&#250;squeda de todos los casos de dermatitis de contacto al&#233;rgica por cosm&#233;ticos diagnosticados en nuestro departamento entre enero de 2000 y octubre de 2007&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Durante este periodo se realizaron pruebas epicut&#225;neas a 2&#46;485 pacientes&#46; De todos ellos&#44; 740 fueron diagnosticados de una dermatitis de contacto al&#233;rgica&#44; 202 pacientes &#40;170 mujeres&#47;32 varones&#41;&#44; es decir&#44; el 27&#44;3&#37; lo fueron por cosm&#233;ticos&#46; Se detectaron un total de 315 parches positivos y 46 alergenos diferentes&#46; Los alergenos que con m&#225;s frecuencia produjeron una dermatitis de contacto en el usuario fueron las metilisotiazolinonas &#40;19&#37;&#41;&#44; la parafenilendiamina &#40;15&#44;2&#37;&#41; y la mezcla de perfumes &#40;7&#44;8&#37;&#41;&#46; Los acrilatos fueron los alergenos m&#225;s frecuentes en aquellos casos que ten&#237;an un origen laboral&#46; Con la bater&#237;a est&#225;ndar del Grupo Espa&#241;ol en Investigaci&#243;n en Dermatitis y Alergia Cut&#225;nea &#40;GEIDAC&#41; se detectaron la mitad de las pruebas positivas&#46; Los productos cosm&#233;ticos implicados con mayor frecuencia en el usuario fueron los tintes capilares &#40;18&#44;5&#37;&#41;&#44; los geles&#47;jabones &#40;15&#44;7&#37;&#41; y las cremas hidratantes &#40;12&#44;7&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La mayor&#237;a de los pacientes afectados fueron mujeres&#46; Los conservantes&#44; la parafenilendiamina y los perfumes fueron los alergenos cosm&#233;ticos m&#225;s frecuentes&#44; tal y como hab&#237;a sido publicado previamente en la literatura&#46; Finalmente&#44; con el objetivo de detectar nuevos alergenos cosm&#233;ticos debe existir colaboraci&#243;n entre los facultativos y las casas comerciales&#46;</p>"
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Vol. 100. Issue 1.
Pages 53-60 (January - February 2009)
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Vol. 100. Issue 1.
Pages 53-60 (January - February 2009)
Original articles
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Allergic Contact Dermatitis to Cosmetics
Dermatitis Alérgica de Contacto por Cosméticos
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9054
C. Laguna
Corresponding author
cecipru@comv.es

Correspondence: Servicio de Dermatología, Hospital General Universitario de Valencia, Avda. Tres Cruces, s/n, 46014 Valencia, Spain.
, J. de la Cuadra, B. Martín-González, V. Zaragoza, L. Martínez-Casimiro, V. Alegre
Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain
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Abstract
Introduction

Contact dermatitis to cosmetics is a common problem in the general population, although its prevalence appears to be underestimated. We reviewed cases of allergic contact dermatitis to cosmetics diagnosed in our dermatology department over a 7-year period with a view to identifying the allergens responsible, the frequency of occurrence of these allergens, and the cosmetic products implicated.

Methods

Using the database of the skin allergy department, we undertook a search of all cases of allergic contact dermatitis to cosmetics diagnosed in our department from January 2000 through October 2007.

Results

In this period, patch tests were carried out on 2485 patients, of whom 740 were diagnosed with allergic contact dermatitis and the cause was cosmetics in 202 of these patients (170 women and 32 men), who accounted for 27.3% of all cases. A total of 315 positive results were found for 46 different allergens. Allergens most often responsible for contact dermatitis in a cosmetics user were methylisothiazolinone (19%), paraphenylenediamine (15.2%), and fragrance mixtures (7.8%). Acrylates were the most common allergens in cases of occupational disease. Half of the positive results were obtained with the standard battery of the Spanish Group for Research Into Dermatitis and Skin Allergies (GEIDAC). The cosmetic products most often implicated among cosmetics users were hair dyes (18.5%), gels/soaps (15.7%), and moisturizing creams (12.7%).

Conclusion

Most patients affected were women. Preservatives, paraphenylenediamine, and fragrances were the most frequently detected cosmetic allergens, in line with previous reports in the literature. Finally, in order to detect new cosmetic allergens, cooperation between physicians and cosmetics producers is needed.

Key words:
ontact dermatitis
cosmetics
methylisothiazolinone
paraphenylenediamine
fragrances
acrylates
Resumen
Introducción

La dermatitis de contacto por cosméticos es un problema frecuente entre la población general, sin embargo, parece ser que su prevalencia está infraestimada.

Revisamos en este trabajo los casos de dermatitis de contacto alérgica por cosméticos diagnosticados en el Departamento de Dermatología en un periodo de 7 años con el objetivo de detectar los alergenos responsables, la frecuencia de los mismos, así como los productos cosméticos implicados.

Métodos

Utilizando la base de datos de la sección de Alergia Cutánea se realiza una búsqueda de todos los casos de dermatitis de contacto alérgica por cosméticos diagnosticados en nuestro departamento entre enero de 2000 y octubre de 2007.

Resultados

Durante este periodo se realizaron pruebas epicutáneas a 2.485 pacientes. De todos ellos, 740 fueron diagnosticados de una dermatitis de contacto alérgica, 202 pacientes (170 mujeres/32 varones), es decir, el 27,3% lo fueron por cosméticos. Se detectaron un total de 315 parches positivos y 46 alergenos diferentes. Los alergenos que con más frecuencia produjeron una dermatitis de contacto en el usuario fueron las metilisotiazolinonas (19%), la parafenilendiamina (15,2%) y la mezcla de perfumes (7,8%). Los acrilatos fueron los alergenos más frecuentes en aquellos casos que tenían un origen laboral. Con la batería estándar del Grupo Español en Investigación en Dermatitis y Alergia Cutánea (GEIDAC) se detectaron la mitad de las pruebas positivas. Los productos cosméticos implicados con mayor frecuencia en el usuario fueron los tintes capilares (18,5%), los geles/jabones (15,7%) y las cremas hidratantes (12,7%).

Conclusión

La mayoría de los pacientes afectados fueron mujeres. Los conservantes, la parafenilendiamina y los perfumes fueron los alergenos cosméticos más frecuentes, tal y como había sido publicado previamente en la literatura. Finalmente, con el objetivo de detectar nuevos alergenos cosméticos debe existir colaboración entre los facultativos y las casas comerciales.

Palabras clave:
dermatitis de contacto
cosméticos
metilisotiazolinonas
parafenilendiamina
perfumes
acrilatos
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Copyright © 2009. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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