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            0 => "ontact dermatitis"
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            2 => "methylisothiazolinone"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Contact dermatitis to cosmetics is a common problem in the general population&#44; although its prevalence appears to be underestimated&#46; We reviewed cases of allergic contact dermatitis to cosmetics diagnosed in our dermatology department over a 7-year period with a view to identifying the allergens responsible&#44; the frequency of occurrence of these allergens&#44; and the cosmetic products implicated&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">Using the database of the skin allergy department&#44; we undertook a search of all cases of allergic contact dermatitis to cosmetics diagnosed in our department from January 2000 through October 2007&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In this period&#44; patch tests were carried out on 2485 patients&#44; of whom 740 were diagnosed with allergic contact dermatitis and the cause was cosmetics in 202 of these patients &#40;170 women and 32 men&#41;&#44; who accounted for 27&#46;3&#37; of all cases&#46; A total of 315 positive results were found for 46 different allergens&#46; Allergens most often responsible for contact dermatitis in a cosmetics user were methylisothiazolinone &#40;19&#37;&#41;&#44; paraphenylenediamine &#40;15&#46;2&#37;&#41;&#44; and fragrance mixtures &#40;7&#46;8&#37;&#41;&#46; Acrylates were the most common allergens in cases of occupational disease&#46; Half of the positive results were obtained with the standard battery of the Spanish Group for Research Into Dermatitis and Skin Allergies &#40;GEIDAC&#41;&#46; The cosmetic products most often implicated among cosmetics users were hair dyes &#40;18&#46;5&#37;&#41;&#44; gels&#47;soaps &#40;15&#46;7&#37;&#41;&#44; and moisturizing creams &#40;12&#46;7&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">Most patients affected were women&#46; Preservatives&#44; paraphenylenediamine&#44; and fragrances were the most frequently detected cosmetic allergens&#44; in line with previous reports in the literature&#46; Finally&#44; in order to detect new cosmetic allergens&#44; cooperation between physicians and cosmetics producers is needed&#46;</p>"
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      "es" => array:2 [
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La dermatitis de contacto por cosm&#233;ticos es un problema frecuente entre la poblaci&#243;n general&#44; sin embargo&#44; parece ser que su prevalencia est&#225; infraestimada&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Revisamos en este trabajo los casos de dermatitis de contacto al&#233;rgica por cosm&#233;ticos diagnosticados en el Departamento de Dermatolog&#237;a en un periodo de 7 a&#241;os con el objetivo de detectar los alergenos responsables&#44; la frecuencia de los mismos&#44; as&#237; como los productos cosm&#233;ticos implicados&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Utilizando la base de datos de la secci&#243;n de Alergia Cut&#225;nea se realiza una b&#250;squeda de todos los casos de dermatitis de contacto al&#233;rgica por cosm&#233;ticos diagnosticados en nuestro departamento entre enero de 2000 y octubre de 2007&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Durante este periodo se realizaron pruebas epicut&#225;neas a 2&#46;485 pacientes&#46; De todos ellos&#44; 740 fueron diagnosticados de una dermatitis de contacto al&#233;rgica&#44; 202 pacientes &#40;170 mujeres&#47;32 varones&#41;&#44; es decir&#44; el 27&#44;3&#37; lo fueron por cosm&#233;ticos&#46; Se detectaron un total de 315 parches positivos y 46 alergenos diferentes&#46; Los alergenos que con m&#225;s frecuencia produjeron una dermatitis de contacto en el usuario fueron las metilisotiazolinonas &#40;19&#37;&#41;&#44; la parafenilendiamina &#40;15&#44;2&#37;&#41; y la mezcla de perfumes &#40;7&#44;8&#37;&#41;&#46; Los acrilatos fueron los alergenos m&#225;s frecuentes en aquellos casos que ten&#237;an un origen laboral&#46; Con la bater&#237;a est&#225;ndar del Grupo Espa&#241;ol en Investigaci&#243;n en Dermatitis y Alergia Cut&#225;nea &#40;GEIDAC&#41; se detectaron la mitad de las pruebas positivas&#46; Los productos cosm&#233;ticos implicados con mayor frecuencia en el usuario fueron los tintes capilares &#40;18&#44;5&#37;&#41;&#44; los geles&#47;jabones &#40;15&#44;7&#37;&#41; y las cremas hidratantes &#40;12&#44;7&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La mayor&#237;a de los pacientes afectados fueron mujeres&#46; Los conservantes&#44; la parafenilendiamina y los perfumes fueron los alergenos cosm&#233;ticos m&#225;s frecuentes&#44; tal y como hab&#237;a sido publicado previamente en la literatura&#46; Finalmente&#44; con el objetivo de detectar nuevos alergenos cosm&#233;ticos debe existir colaboraci&#243;n entre los facultativos y las casas comerciales&#46;</p>"
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                      "titulo" => "&#40;GEIDC&#41;&#46; Incidencia de las sensibilizaciones por cosm&#233;ticos &#40;GEIDC-1991&#41;"
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                      "titulo" => "Cosmetic intolerance"
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                            1 => "A&#46; Blondeel"
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                  "referenciaCompleta" => "Directive 2003&#47;15&#47;EC of the European Parliament and Council of 27 February 2003 amending Council Directive 76&#47;768&#47;EEC on the approximation of the laws of the Member Sates relating to cosmetic products&#46; Off J Eur Union&#46; 2003&#59;L66&#58;26-35&#46;"
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                        0 => array:2 [
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                            2 => "J&#46; de la Cuadra"
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                      "titulo" => "Allergic contact dermatitis from cosmetics&#46; Retrospective analysis of 819 patch-tested patients"
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                          "etal" => false
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                      "titulo" => "The allergens in cosmetics"
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                            0 => "A&#46;C&#46; De Groot"
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                            2 => "J&#46;D&#46; Bos"
                            3 => "H&#46;L&#46; van der Meeren"
                            4 => "T&#46; van Joost"
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                  "host" => array:1 [
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