We would like to discuss on the publication on “Acute Parvovirus B19 Infection in Adults.1” Rodríguez Bandera et al. noted that “This infection should be suspected on observing signs of purplish skin rashes, no matter the location or pattern of distribution, or vasculitis, especially if accompanied by fever and joint pain in young women in the spring.1” It is no doubt that skin rash is an important clinical presentation of parvovirus B19 infection. However, it should be noted that not all cases present with skin lesion. According to a recent report by Parra et al.,2 skin rash could be seen in only 58%. The other non-dermatological manifestation that should be known include “glove-and-socks” syndrome, red cell aplasia and arthropathy.3 The dermatologist should not forget to look for those problems in any cases with confirmed parvovirus B19 infection.