Información del artículo
Abstract
Dermatologists face diagnostic and therapeutic difficulties when psoriasis coexists with human immunodeficiency virus (HIV) infection.
This article will review some of the aspects of this coexistence from the epidemiologic, pathogenic, histopathologic, clinical, and prognostic point of view. The main skin diseases that should be included in the differential diagnosis are described. Also analyzed are the different therapeutic options in these patients according to the degree of immunodeficiency. Possibilities include antiretroviral treatment, topical treatment, retinoids, and classic immunosuppressants. The review will also cover current literature on the use of new biologic therapies in patients with HIV infection. Finally, we will discuss the risk of drug interactions during psoriasis treatment in these patients, who receive multiple pharmacologic therapies.
Key words:
psoriasis
HIV
drug interactions
biologic therapies
immunodeficiency
Resumen
La coexistencia de psoriasis con la infección por el virus de la inmunodeficiencia humana (VIH) implica dificultades diagnósticas y terapéuticas para el especialista en Dermatología.
En este artículo se revisan las peculiaridades de dicha coexistencia desde el punto de vista epidemiológico, patogénico, anatomopatológico, clínico y pronóstico. Se describen las principales dermatosis que se incluyen en el diagnóstico diferencial. También se analizan las diferentes posibilidades terapéuticas en estos pacientes, dependiendo del grado de inmunosupresión. Se incluyen como opción de tratamiento la terapia antirretroviral, el tratamiento tópico, los retinoides, los fármacos inmunosupresores clásicos y se revisa la literatura actual sobre el uso de las nuevas terapias biológicas en pacientes con infección por el VIH. Finalmente, se describe el riesgo de interacciones farmacológicas que tienen lugar en el tratamiento de la psoriasis en estos pacientes, que reciben múltiples fármacos.
Palabras clave:
psoriasis
VIH
interacciones farmacológicas
terapias biológicas
inmunosupresión
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