Información del artículo
Abstract
Over the past 10 years, there have been significant advancements in our understanding of the biology and natural history of infantile hemangiomas (IH). Research into their pathogenesis has led to many new discoveries including the first mouse model recapitulating hemangioma growth and genes such as the vascular Endothelial Growth Factor Receptor (VEGFR) which may be intimately involved in their proliferation. Large prospective studies have born out important data on the natural history, complications and structural associations of these fascinating vascular tumors. In addition, new therapies have emerged which appear to be very effective. In the following article, a summary of major contributions over the past decade is outlined.
Key words:
hemangioma
infantile hemangioma
hemangioma of infancy
vascular tumors
Resumen
En los últimos 10 años se han producido importantes avances en el conocimiento de la biología y la historia natural de los hemangiomas infantiles. La investigación sobre la patogenia ha dado lugar a nuevos descubrimientos, incluyendo el primer modelo murino que resume el crecimiento de los hemangiomas y los genes, como el receptor del factor de crecimiento endotelial vascular, que pueden estar estrechamente relacionados con su proliferación.
Amplios estudios prospectivos han aportado importantes datos sobre la historia natural, las complicaciones y las asociaciones estructurales de estos tumores vasculares. Además, se han desarrollado nuevas terapias que parecen ser muy efectivas. En el siguiente artículo se esboza un resumen de las principales contribuciones durante la última década.
Palabras clave:
hemangioma
hemangioma infantil
hemangioma de la infancia
tumores vasculares
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