array:24 [
  "pii" => "S1578219016300981"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.04.025"
  "estado" => "S300"
  "fechaPublicacion" => "2016-07-01"
  "aid" => "131400"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2016;107:519-20"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1177
    "formatos" => array:3 [
      "EPUB" => 69
      "HTML" => 938
      "PDF" => 170
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0001731015005153"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2015.04.025"
      "estado" => "S300"
      "fechaPublicacion" => "2016-07-01"
      "aid" => "1314"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2016;107:519-20"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 447
        "formatos" => array:3 [
          "EPUB" => 3
          "HTML" => 360
          "PDF" => 84
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
        "titulo" => "P&#225;pulas foliculares y placas eritematosas en espalda"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "519"
            "paginaFinal" => "520"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Follicular Papules and Erythematous Plaques on the Back"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:6 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 625
                "Ancho" => 1685
                "Tamanyo" => 164213
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "R&#46; Ruiz-Villaverde, I&#46; P&#233;rez-L&#243;pez, J&#46; Aneiros-Fern&#225;ndez"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Ruiz-Villaverde"
              ]
              1 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "P&#233;rez-L&#243;pez"
              ]
              2 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Aneiros-Fern&#225;ndez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219016300981"
          "doi" => "10.1016/j.adengl.2015.04.025"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300981?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015005153?idApp=UINPBA000044"
      "url" => "/00017310/0000010700000006/v1_201606280028/S0001731015005153/v1_201606280028/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219016300750"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.05.005"
    "estado" => "S300"
    "fechaPublicacion" => "2016-07-01"
    "aid" => "1315"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2016;107:521-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 815
      "formatos" => array:3 [
        "EPUB" => 51
        "HTML" => 594
        "PDF" => 170
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Resident&#39;s Forum</span>"
      "titulo" => "Where Should We Position Antimalarial Drug Combinations in the Management of Refractory Cutaneous Lupus Erythematosus&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "521"
          "paginaFinal" => "522"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "FR-&#191;D&#243;nde posicionamos la combinaci&#243;n de antipal&#250;dicos en el manejo del lupus eritematoso cut&#225;neo refractario&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "I&#46; P&#233;rez-L&#243;pez, A&#46; Mart&#237;nez-L&#243;pez, J&#46; Tercedor-S&#225;nchez, R&#46; Ruiz-Villaverde"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "P&#233;rez-L&#243;pez"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;nez-L&#243;pez"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Tercedor-S&#225;nchez"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz-Villaverde"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015005165"
        "doi" => "10.1016/j.ad.2015.07.019"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015005165?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300750?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000006/v2_201704050141/S1578219016300750/v2_201704050141/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219016300713"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.05.003"
    "estado" => "S300"
    "fechaPublicacion" => "2016-07-01"
    "aid" => "1323"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2016;107:517-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 688
      "formatos" => array:3 [
        "EPUB" => 61
        "HTML" => 489
        "PDF" => 138
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>"
      "titulo" => "Tuberous Lesion of 1-Year Duration on the Knee"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "517"
          "paginaFinal" => "518"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Lesi&#243;n tuberosa en la rodilla de un a&#241;o de evoluci&#243;n"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 614
              "Ancho" => 818
              "Tamanyo" => 90677
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Eguren, A&#46; Burdaspal, P&#46; de la Cueva-Dobao"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Eguren"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Burdaspal"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "de la Cueva-Dobao"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015005621"
        "doi" => "10.1016/j.ad.2015.04.026"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015005621?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300713?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000006/v2_201704050141/S1578219016300713/v2_201704050141/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case for Diagnosis</span>"
    "titulo" => "Follicular Papules and Erythematous Plaques on the Back"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "519"
        "paginaFinal" => "520"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "R&#46; Ruiz-Villaverde, I&#46; P&#233;rez-L&#243;pez, J&#46; Aneiros-Fern&#225;ndez"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "R&#46;"
            "apellidos" => "Ruiz-Villaverde"
            "email" => array:1 [
              0 => "ismenios&#64;hotmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "I&#46;"
            "apellidos" => "P&#233;rez-L&#243;pez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Aneiros-Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Unidad de Dermatolog&#237;a M&#233;dico-Quir&#250;rgica y Venereolog&#237;a&#44; Hospital Universitario Virgen de las Nieves&#44; Granada&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Universitario Virgen de las Nieves&#44; Granada&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "P&#225;pulas foliculares y placas eritematosas en espalda"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 401
            "Ancho" => 505
            "Tamanyo" => 149965
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin and eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>x4&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 63-year-old woman with no personal or family background of interest presented a 13-month history of a skin rash formed of papules that coalesced into pruritic plaques affecting the upper third of the back&#44; with no involvement of the limbs or face or of the mucosas&#46; She had previously been treated for 2 months with topical corticosteroids by her family physician&#44; with no response&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination revealed a predominantly follicular erythematous papules and more extensive plaques with a moderate degree of infiltration on the upper half of the back &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; There were no palpable locoregional lymph nodes and no hepatosplenomegaly&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histology</span><p id="par0015" class="elsevierStylePara elsevierViewall">On histopathology&#44; the dermis was infiltrated by a lymphoproliferative process with a perivascular and periadnexal distribution and with minimal epidermal involvement &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The hair follicles presented a lymphoproliferative infiltrate&#44; with the presence of mucin that stained intensely positive with Alcian blue at pH 2&#46;5&#46; Immunohistochemistry was positive for CD3 &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; CD5&#44; and CD7&#44; with deletion of CD2 and partial deletion of CD4&#46; The proliferating cells were negative for CD30&#44; CD56&#44; TIA-1&#44; perforin&#44; and granzyme B&#46; Molecular study showed clonal rearrangement of the gamma chain of the T-cell receptor&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Additional Tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">The results of the metastatic work-up &#40;complete blood count&#44; general biochemistry&#44; lactate dehydrogenase&#44; &#946;<span class="elsevierStyleInf">2</span>-microglobulin&#44; bone marrow aspiration biopsy&#44; protein electrophoresis&#44; and positron emission tomography-computed tomography&#41; were within normal limits&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Follicular mycosis fungoides&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Course and Treatment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Based on the findings of the histology study and additional tests&#44; we made a diagnosis of stage IB &#40;T2b&#44; N0&#44; M0&#44; B0&#41; mycosis fungoides&#46; The case was presented to the Skin Oncology Committee and it was decided to start treatment with psoralen-UV-A &#40;PUVA&#41; therapy following the standard protocol&#46; Little improvement was achieved at the 3-month follow-up and the patient remains pending further evaluation of other treatment options&#46;</p><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Comment</span><p id="par0040" class="elsevierStylePara elsevierViewall">Follicular mycosis fungoides is a variant of mycosis fungoides characterized by the presence of follicular infiltrates that tend mainly to affect the head and neck&#46; It was first described by Kim in 1985&#44; who reported cases of mycosis fungoides limited to the hair follicles and perifollicular dermis&#46; This variant accounts for 10&#37; of cases of MF&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">From an epidemiologic point of view&#44; there appear to be no differences between the sexes&#44; although there is a slight predominance in adult men&#46; The age at presentation does not differ from that of classic mycosis fungoides&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis are not fully understood&#46; It has been postulated that the epithelium of the hair follicles may express higher levels of skin-selective lymphocyte receptors &#40;skin-selective homing&#41; and epidermal adhesion molecules&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> Hodak et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> described the selective expression of intercellular adhesion molecule 1 on the cell membranes of the follicular epithelium in follicular mycosis fungoides lesions&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The disease presents clinically as follicular papules&#44; plaques with follicular accentuation&#44; or cysts and comedones&#46; Although single lesions have been reported in some patients&#44; it is more common to observe multiple plaques&#46; Presentation in the form of tumors&#44; pseudotumors&#44; or erythroderma is rare&#46; Alopecia is common when the scalp is affected&#46; Pruritus occurs frequently&#44; and in 68&#37; of patients requires specific treatment&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Histopathology usually shows a dermal infiltrate with a perivascular and adnexal distribution&#44; with infiltration of the follicular epithelium by atypical lymphocytes of follicular size and with cerebriform nuclei&#46; There may be associated follicular mucinosis&#44; although this is not a constant finding&#44; and syringotropism and even squamous syringometaplasia&#46; Five different basic patterns are recognized&#58; the classic pattern&#44; with or without associated follicular mucinosis&#59; the eosinophilic folliculitis-like pattern&#59; the cystic pattern&#59; the basaloid pattern&#59; and the granulomatous pattern&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">On immunohistochemistry&#44; the neoplastic T lymphocytes are CD3<span class="elsevierStyleSup">&#43;</span>&#44; CD4<span class="elsevierStyleSup">&#43;</span>&#44; and CD8<span class="elsevierStyleSup">&#8722;</span>&#44; and scattered CD30<span class="elsevierStyleSup">&#43;</span> cells may be observed&#46; The presence of more than 15&#37; of CD30<span class="elsevierStyleSup">&#43;</span> or CD30<span class="elsevierStyleSup">&#8722;</span> blast cells is considered a poor prognostic factor&#46; Follicular mycosis fungoides is actually thought to have a poorer prognosis&#44; behaving in a similar or equivalent manner to classic tumor-stage mycosis fungoides &#40;stage IIB&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Electron beam radiation is considered to be a more effective treatment than skin-targeting therapies such as PUVA and the topical nitrogen mustards&#46; Some authors propose a more conservative approach using UV-A and bexarotene as the initial option&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">6&#44;7</span></a> Isolated cases have shown a good response to isotretinoin&#44; chlorambucil&#44; radiotherapy&#44; and interferon alfa&#44; although the responses have usually been transitory&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a></p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of Interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:8 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Medical History"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Physical Examination"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Histology"
        ]
        3 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Additional Tests"
        ]
        4 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Diagnosis"
        ]
        5 => array:3 [
          "identificador" => "sec0030"
          "titulo" => "Clinical Course and Treatment"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Comment"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conflicts of Interest"
        ]
        7 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ruiz-Villaverde R&#44; P&#233;rez-L&#243;pez I&#44; Aneiros-Fern&#225;ndez J&#46; P&#225;pulas foliculares y placas eritematosas en espalda&#46; Actas Dermosifiliogr&#46; 2016&#59;107&#58;519&#8211;520&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 364
            "Ancho" => 980
            "Tamanyo" => 68097
          ]
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 401
            "Ancho" => 505
            "Tamanyo" => 149965
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin and eosin&#44; original magnification<span class="elsevierStyleHsp" style=""></span>x4&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 401
            "Ancho" => 534
            "Tamanyo" => 151174
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemistry positive for CD3&#46; Original magnification<span class="elsevierStyleHsp" style=""></span>&#215;20&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mycosis fungoides&#58; Disease evolution and prognosis of 309 Dutch patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Van Doorn"
                            1 => "C&#46;W&#46; van Haselen"
                            2 => "P&#46;C&#46; van Voorst Vader"
                            3 => "M&#46;L&#46; Geerts"
                            4 => "F&#46; Heule"
                            5 => "M&#46; de Rie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2000"
                        "volumen" => "136"
                        "paginaInicial" => "504"
                        "paginaFinal" => "510"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10768649"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Follicular mycosis fungoides&#58; A clinicohistopathologic study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46;G&#46; Pereyo"
                            1 => "L&#46; Requena"
                            2 => "J&#46; Galloway"
                            3 => "O&#46;P&#46; Sang&#252;eza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1997"
                        "volumen" => "36"
                        "paginaInicial" => "563"
                        "paginaFinal" => "568"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9092742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Follicular cutaneous T-cell lymphoma&#58; A clinicopathological study of nine cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Hodak"
                            1 => "M&#46; Feinmesser"
                            2 => "T&#46; Segal"
                            3 => "G&#46; Yosipovitch"
                            4 => "M&#46; Lapidoth"
                            5 => "L&#46; Maron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "1999"
                        "volumen" => "141"
                        "paginaInicial" => "315"
                        "paginaFinal" => "322"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10468808"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Folliculotropic mycosis fungoides&#58; Clinicopathological features and outcome in a series of 20 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Muniesa"
                            1 => "T&#46; Estrach"
                            2 => "R&#46;M&#46; Pujol"
                            3 => "F&#46; Gallardo"
                            4 => "P&#46; Garc&#237;a-Muret"
                            5 => "J&#46; Climent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2009.03.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2010"
                        "volumen" => "62"
                        "paginaInicial" => "418"
                        "paginaFinal" => "426"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20079954"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The spectrum of histopathologic and immunohistochemical findings in folliculotropic mycosis fungoides"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Gerami"
                            1 => "J&#46; Guitart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/PAS.0b013e3180439bdc"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg Pathol"
                        "fecha" => "2007"
                        "volumen" => "31"
                        "paginaInicial" => "1430"
                        "paginaFinal" => "1438"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17721200"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and histopathological features of folliculotropic mycosis fungoides&#58; A Norwegian patient series"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; Mantaka"
                            1 => "P&#46; Helsing"
                            2 => "P&#46; Gjersvik"
                            3 => "A&#46; Bassarova"
                            4 => "O&#46;P&#46; Clausen"
                            5 => "J&#46; Delabie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2340/00015555-1476"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "2013"
                        "volumen" => "93"
                        "paginaInicial" => "325"
                        "paginaFinal" => "329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23053197"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Folliculotropic mycosis fungoides&#46; Study of four cases &#91;Article in Spanish&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; G&#243;mez-Diez"
                            1 => "C&#46; Maldonado"
                            2 => "A&#46; Fueyo"
                            3 => "F&#46; V&#225;zquez-L&#243;pez"
                            4 => "M&#46;F&#46; Fresno"
                            5 => "N&#46; P&#233;rez-Oliva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2007"
                        "volumen" => "98"
                        "paginaInicial" => "486"
                        "paginaFinal" => "490"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17669304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010700000006/v2_201704050141/S1578219016300981/v2_201704050141/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6154"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case for Diagnosis"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000006/v2_201704050141/S1578219016300981/v2_201704050141/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016300981?idApp=UINPBA000044"
]
Compartir
Información de la revista
Vol. 107. Núm. 6.
Páginas 519-520 (julio - agosto 2016)
Visitas
7027
Vol. 107. Núm. 6.
Páginas 519-520 (julio - agosto 2016)
Case for Diagnosis
Acceso a texto completo
Follicular Papules and Erythematous Plaques on the Back
Pápulas foliculares y placas eritematosas en espalda
Visitas
7027
R. Ruiz-Villaverdea,
Autor para correspondencia
ismenios@hotmail.com

Correponding author.
, I. Pérez-Lópeza, J. Aneiros-Fernándezb
a Unidad de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Virgen de las Nieves, Granada, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Virgen de las Nieves, Granada, Spain
Este artículo ha recibido
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (3)
Mostrar másMostrar menos
Texto completo
Medical History

A 63-year-old woman with no personal or family background of interest presented a 13-month history of a skin rash formed of papules that coalesced into pruritic plaques affecting the upper third of the back, with no involvement of the limbs or face or of the mucosas. She had previously been treated for 2 months with topical corticosteroids by her family physician, with no response.

Physical Examination

Physical examination revealed a predominantly follicular erythematous papules and more extensive plaques with a moderate degree of infiltration on the upper half of the back (Fig. 1). There were no palpable locoregional lymph nodes and no hepatosplenomegaly.

Figure 1
(0.06MB).
Histology

On histopathology, the dermis was infiltrated by a lymphoproliferative process with a perivascular and periadnexal distribution and with minimal epidermal involvement (Fig. 2). The hair follicles presented a lymphoproliferative infiltrate, with the presence of mucin that stained intensely positive with Alcian blue at pH 2.5. Immunohistochemistry was positive for CD3 (Fig. 3), CD5, and CD7, with deletion of CD2 and partial deletion of CD4. The proliferating cells were negative for CD30, CD56, TIA-1, perforin, and granzyme B. Molecular study showed clonal rearrangement of the gamma chain of the T-cell receptor.

Figure 2.

Hematoxylin and eosin, original magnificationx4.

(0.14MB).
Figure 3.

Immunohistochemistry positive for CD3. Original magnification×20.

(0.14MB).
Additional Tests

The results of the metastatic work-up (complete blood count, general biochemistry, lactate dehydrogenase, β2-microglobulin, bone marrow aspiration biopsy, protein electrophoresis, and positron emission tomography-computed tomography) were within normal limits.

What Is Your Diagnosis?

Diagnosis

Follicular mycosis fungoides.

Clinical Course and Treatment

Based on the findings of the histology study and additional tests, we made a diagnosis of stage IB (T2b, N0, M0, B0) mycosis fungoides. The case was presented to the Skin Oncology Committee and it was decided to start treatment with psoralen-UV-A (PUVA) therapy following the standard protocol. Little improvement was achieved at the 3-month follow-up and the patient remains pending further evaluation of other treatment options.

Comment

Follicular mycosis fungoides is a variant of mycosis fungoides characterized by the presence of follicular infiltrates that tend mainly to affect the head and neck. It was first described by Kim in 1985, who reported cases of mycosis fungoides limited to the hair follicles and perifollicular dermis. This variant accounts for 10% of cases of MF.1

From an epidemiologic point of view, there appear to be no differences between the sexes, although there is a slight predominance in adult men. The age at presentation does not differ from that of classic mycosis fungoides.

The etiology and pathogenesis are not fully understood. It has been postulated that the epithelium of the hair follicles may express higher levels of skin-selective lymphocyte receptors (skin-selective homing) and epidermal adhesion molecules.2 Hodak et al.3 described the selective expression of intercellular adhesion molecule 1 on the cell membranes of the follicular epithelium in follicular mycosis fungoides lesions.

The disease presents clinically as follicular papules, plaques with follicular accentuation, or cysts and comedones. Although single lesions have been reported in some patients, it is more common to observe multiple plaques. Presentation in the form of tumors, pseudotumors, or erythroderma is rare. Alopecia is common when the scalp is affected. Pruritus occurs frequently, and in 68% of patients requires specific treatment.

Histopathology usually shows a dermal infiltrate with a perivascular and adnexal distribution, with infiltration of the follicular epithelium by atypical lymphocytes of follicular size and with cerebriform nuclei. There may be associated follicular mucinosis, although this is not a constant finding, and syringotropism and even squamous syringometaplasia. Five different basic patterns are recognized: the classic pattern, with or without associated follicular mucinosis; the eosinophilic folliculitis-like pattern; the cystic pattern; the basaloid pattern; and the granulomatous pattern.4

On immunohistochemistry, the neoplastic T lymphocytes are CD3+, CD4+, and CD8, and scattered CD30+ cells may be observed. The presence of more than 15% of CD30+ or CD30 blast cells is considered a poor prognostic factor. Follicular mycosis fungoides is actually thought to have a poorer prognosis, behaving in a similar or equivalent manner to classic tumor-stage mycosis fungoides (stage IIB).5

Electron beam radiation is considered to be a more effective treatment than skin-targeting therapies such as PUVA and the topical nitrogen mustards. Some authors propose a more conservative approach using UV-A and bexarotene as the initial option.6,7 Isolated cases have shown a good response to isotretinoin, chlorambucil, radiotherapy, and interferon alfa, although the responses have usually been transitory.4

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References
[1]
R. Van Doorn, C.W. van Haselen, P.C. van Voorst Vader, M.L. Geerts, F. Heule, M. de Rie, et al.
Mycosis fungoides: Disease evolution and prognosis of 309 Dutch patients.
Arch Dermatol, 136 (2000), pp. 504-510
[2]
N.G. Pereyo, L. Requena, J. Galloway, O.P. Sangüeza.
Follicular mycosis fungoides: A clinicohistopathologic study.
J Am Acad Dermatol, 36 (1997), pp. 563-568
[3]
E. Hodak, M. Feinmesser, T. Segal, G. Yosipovitch, M. Lapidoth, L. Maron, et al.
Follicular cutaneous T-cell lymphoma: A clinicopathological study of nine cases.
Br J Dermatol, 141 (1999), pp. 315-322
[4]
C. Muniesa, T. Estrach, R.M. Pujol, F. Gallardo, P. García-Muret, J. Climent, et al.
Folliculotropic mycosis fungoides: Clinicopathological features and outcome in a series of 20 cases.
J Am Acad Dermatol, 62 (2010), pp. 418-426
[5]
P. Gerami, J. Guitart.
The spectrum of histopathologic and immunohistochemical findings in folliculotropic mycosis fungoides.
Am J Surg Pathol, 31 (2007), pp. 1430-1438
[6]
P. Mantaka, P. Helsing, P. Gjersvik, A. Bassarova, O.P. Clausen, J. Delabie.
Clinical and histopathological features of folliculotropic mycosis fungoides: A Norwegian patient series.
Acta Derm Venereol, 93 (2013), pp. 325-329
[7]
S. Gómez-Diez, C. Maldonado, A. Fueyo, F. Vázquez-López, M.F. Fresno, N. Pérez-Oliva.
Folliculotropic mycosis fungoides. Study of four cases [Article in Spanish].
Actas Dermosifiliogr, 98 (2007), pp. 486-490

Please cite this article as: Ruiz-Villaverde R, Pérez-López I, Aneiros-Fernández J. Pápulas foliculares y placas eritematosas en espalda. Actas Dermosifiliogr. 2016;107:519–520.

Copyright © 2015. Elsevier España, S.L.U. and AEDV
Descargar PDF
Idiomas
Actas Dermo-Sifiliográficas
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?