Información del artículo
Abstract
Actinic keratoses (AK) represent the most common carcinoma in situ of the skin and show continuously increasing incidences worldwide. Clinically, AK occur as multiple lesions in sun-exposed areas, which has been referred to as field cancerization. Novel treatment modalities for actinic field cancerization include 3% diclofenac in 2.5% hyaluronic acid (HA). Recent investigations have gained insights in the mode of action of diclofenac in HA, showing that the induction of apoptosis is the major mode of action of this treatment.
Herein, we give an overview about actinic keratosis focusing on treatment with the COX-2 inhibitor diclofenac 3% gel and summarize current concepts of its antineoplastic mode of action.
Key words:
actinic keratoses
carcinoma in situ
diclofenac
hyaluronic acid
apoptosis
COX-2
Resumen
Las queratosis actínicas representan el carcinoma intraepidérmico más frecuente de la piel y muestran un incremento continuo de la incidencia mundialmente. Clínicamente, las queratosis actínicas aparecen de forma múltiple en áreas fotoexpuestas, lo que se conoce como campo de cancerización. Las nuevas opciones para el tratamiento del campo de cancerización actínico incluyen diclofenaco al 3% en ácido hialurónico al 2,5%. Investigaciones recientes han revelado el principal mecanismo de acción de diclofenaco, que consiste en la inducción de la apoptosis.
En este artículo aportaremos una visión de conjunto sobre las queratosis actínicas, centrándonos en el tratamiento con un inhibidor de la enzima COX-2, diclofenaco al 3%, y resumiremos los conceptos actuales sobre su mecanismo de acción antineoplásico.
Palabras clave:
queratosis actínicas
carcinoma intraepidérmico
diclofenaco
ácido hialurónico
apoptosis
COX-2
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