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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lisch nodules are included in the diagnostic criteria of type 1 neurofibromatosis when &#8805;2 occur&#46; They are considered to be melanocytic hamartomas of the iris that are frequently observed before the age of 6&#8239;years and increase in number and prevalence with age&#46; They are usually light or dark brown in color and are more apparent in lighter colored eyes&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 9-year-old girl in follow-up for suspected neurofibromatosis presented with 6 caf&#233;-au-lait spots measuring &#62;5&#8239;mm on the trunk and limbs and axillary freckling&#46; Physical examination revealed 3 light brown spots on the right iris &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; The finding was confirmed by the ophthalmologist and corroborated the diagnosis&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A 72-year-old woman with type&#8239;1 neurofibromatosis verified by genetic testing presented with multiple light brown spots on both blue irises &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; In contrast with the previous case&#44; the clinical presentation was very obvious&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Identification of Lisch nodules during the first years of life can confirm a diagnosis in patients who do not yet fulfil a sufficient number of classic criteria&#46; We feel that it is important for the dermatologist to search for this clinical manifestation&#44; which can prove useful in the differential diagnosis of other neurocutaneous syndromes in younger patients&#46;</p></span>"
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Images in Dermatology
Lisch Nodules: A Key Diagnostic Sign of Neurofibromatosis Type 1
Nódulos de Lisch: una clave diagnóstica en neurofibromatosis tipo 1
E. Rodríguez-Lombaa,
Autor para correspondencia
enriquerlomba@outlook.com

Corresponding author.
, B. Lozano-Masdemontb
a Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Servicio de Dermatología, Hospital Universitario de Móstoles, Madrid, Spain
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Información del artículo
ISSN: 15782190
Idioma original: Inglés
DOI:10.1016/j.adengl.2021.02.008
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