Practical Dermoscopy
The Red flag: Meyerson Phenomenon in Malignant Melanoma
La bandera roja: fenómeno de Meyerson en el melanoma maligno
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(b) Lesión irregular atípica, pigmentada, de color marrón oscuro-negro con un velo azul-blanquecino en el centro, rodeado de eritema y con escasos vasos punteados dentro del halo. (c) Aspecto histopatológico del fenómeno de Meyerson en un melanoma. Proliferación melanocítica confluente atípica intraepidérmica. Espongiosis leve, acantosis epidérmica e infiltrado celular inflamatorio crónico. (Tinción hematoxilina-eosina; aumento original: x20).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "X. Calderón-Castrat, A. Conde-Ferreirós, M. Yuste-Chaves, A. Santos-Briz" "autores" => array:4 [ 0 => array:2 [ "nombre" => "X." "apellidos" => "Calderón-Castrat" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Conde-Ferreirós" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Yuste-Chaves" ] 3 => array:2 [ "nombre" => "A." 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B, <span class="elsevierStyleItalic">S lugdunensis</span> colony growing on blood agar.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.J. García-Malinis, A. Milagro, L. Torres Sopena, Y. Gilaberte" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A.J." "apellidos" => "García-Malinis" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Milagro" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Torres Sopena" ] 3 => array:2 [ "nombre" => "Y." 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"apellidos" => "Requena Caballero" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S000173102030418X" "doi" => "10.1016/j.ad.2019.04.022" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173102030418X?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021000032?idApp=UINPBA000044" "url" => "/15782190/0000011200000003/v1_202103020923/S1578219021000032/v1_202103020923/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Practical Dermoscopy</span>" "titulo" => "The Red flag: Meyerson Phenomenon in Malignant Melanoma" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "259" "paginaFinal" => "260" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "X. Calderón-Castrat, A. Conde-Ferreirós, M. Yuste-Chaves, A. Santos-Briz" "autores" => array:4 [ 0 => array:4 [ "nombre" => "X." "apellidos" => "Calderón-Castrat" "email" => array:1 [ 0 => "xcalderoncastrat@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Conde-Ferreirós" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Yuste-Chaves" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Santos-Briz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología, IMED-ELCHE Hospital, Alicante, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Dermatología, Hospital Universitario de Salamanca, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Patología, Hospital Universitario de Salamanca, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La bandera roja: fenómeno de Meyerson en el melanoma maligno" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1355 "Ancho" => 2500 "Tamanyo" => 394008 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Central pigmented lesion and surrounding eczematous halo. (b) Dermoscopy revealing central pigmented dark brown-black atypical and irregular lesion with a blue-white veil in the center surrounded by erythema and scarce dotted vessels within the halo. (c) Histopathologic appearance of Meyerson phenomenon within a melanoma. Intraepidermal atypical, confluent melanocytic proliferation. Mild spongiosis, epidermal acantosis and chronic inflammatory cell infiltrate. (Hematoxylin-eosin stain; original magnification: ×20).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case presentation</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 65-year-old woman was referred to our Department of Dermatology for a pruriginous lesion on her abdomen that failed to show improvement after 1-month of topical corticosteroid treatment. She presented with a congenital nevus, that 2 months prior consultation developed a red, scaly and pruritic halo. Physical examination showed a pigmented brown-black, 1.6 cm, slightly elevated lesion on the left flank surrounded by an erythematous scaly halo (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>(a)). Dermoscopic appearance revealed an atypical, pigmented, dark brown-black irregular lesion with a blue-white veil in the center surrounded by erythema and scarce dotted vessels within the halo (<a class="elsevierStyleCrossRef" href="#fig0005">Fig.1</a>(b)). Histopathological analysis demonstrated a superficial spreading melanoma with radial and vertical growth phase, Clark Level IV, Breslow depth of 0,98 mm. An acanthotic epidermis with discrete spongiosis and intense chronic inflammatory component was also observed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig.1</a>(c)). After the initial excision, the eczematous halo was soon resolved. Further imaging studies failed to show signs of metastasic disease, followed by a 1-cm surgical margin and selective sentinel lymph node biopsy that resulted negative.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Diagnosis</span><p id="par0010" class="elsevierStylePara elsevierViewall">Clinical, dermoscopic and histological correlation established the diagnosis of malignant melanoma with Meyerson phenomenon.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Commentary</span><p id="par0015" class="elsevierStylePara elsevierViewall">Meyerson phenomenon (MP) refers to a localized eczematous eruption classically associated with benign melanocytic nevi, hence the denomination Meyerson nevus.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Considered rare, but possibly underdiagnosed, MP has generally reflected a sign of banal lesions<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> including dermatofibromas,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> seborrheic keratosis,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> keratosis stucco<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and angiokeratoma,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> among others. However, dysplasic nevi, and few cases of basal cell and squamous carcinomas have also been described.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Only anecdotal reports of melanoma in situ have been reported in medical literature.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Our case particularly reveals an invasive malignant melanoma.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Our case highlights that lesions targeted by the MP are not necessarily benign and thus careful dermoscopic examination is warranted to prevent overlooking malignant melanocytic lesions.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case presentation" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Diagnosis" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Commentary" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Calderón-Castrat X, Conde-Ferreirós A, Yuste-Chaves M, Santos-Briz A. La bandera roja: fenómeno de Meyerson en el melanoma maligno. Actas Dermosifiliogr. 2021;112:259–260.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1355 "Ancho" => 2500 "Tamanyo" => 394008 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Central pigmented lesion and surrounding eczematous halo. (b) Dermoscopy revealing central pigmented dark brown-black atypical and irregular lesion with a blue-white veil in the center surrounded by erythema and scarce dotted vessels within the halo. (c) Histopathologic appearance of Meyerson phenomenon within a melanoma. Intraepidermal atypical, confluent melanocytic proliferation. Mild spongiosis, epidermal acantosis and chronic inflammatory cell infiltrate. (Hematoxylin-eosin stain; original magnification: ×20).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A peculiar papulosquamous eruption involving pigmented nevi" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.B. Meyerson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1971" "volumen" => "34" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Halo dermatitis around tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Tegner" 1 => "A. Björnberg" 2 => "N. 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Kumar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1440-0960.2010.00726.x" "Revista" => array:6 [ "tituloSerie" => "Australas J Dermatol" "fecha" => "2012" "volumen" => "53" "paginaInicial" => "145" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22571567" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Solitary angiokeratoma with Meyerson phenomenon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Oliveira" 1 => "J. Cardoso" 2 => "I. Zalaudek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2016.04.039" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2017" "volumen" => "76" "paginaInicial" => "S16" "paginaFinal" => "S18" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28087017" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0302283819301502" "estado" => "S300" "issn" => "03022838" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meyerson phenomenon as a component of melanoma in situ" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Sezer" 1 => "E. Özturk Durmaz" 2 => "E. Çetin" 3 => "S. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 16 | 13 | 29 |
| 2024 Octubre | 194 | 56 | 250 |
| 2024 Septiembre | 148 | 49 | 197 |
| 2024 Agosto | 215 | 71 | 286 |
| 2024 Julio | 206 | 57 | 263 |
| 2024 Junio | 178 | 55 | 233 |
| 2024 Mayo | 156 | 63 | 219 |
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| 2024 Marzo | 145 | 46 | 191 |
| 2024 Febrero | 141 | 51 | 192 |
| 2024 Enero | 141 | 51 | 192 |
| 2023 Diciembre | 119 | 49 | 168 |
| 2023 Noviembre | 163 | 43 | 206 |
| 2023 Octubre | 126 | 32 | 158 |
| 2023 Septiembre | 123 | 47 | 170 |
| 2023 Agosto | 96 | 35 | 131 |
| 2023 Julio | 109 | 56 | 165 |
| 2023 Junio | 90 | 39 | 129 |
| 2023 Mayo | 117 | 43 | 160 |
| 2023 Abril | 69 | 48 | 117 |
| 2023 Marzo | 137 | 59 | 196 |
| 2023 Febrero | 115 | 47 | 162 |
| 2023 Enero | 73 | 41 | 114 |
| 2022 Diciembre | 95 | 47 | 142 |
| 2022 Noviembre | 72 | 41 | 113 |
| 2022 Octubre | 79 | 41 | 120 |
| 2022 Septiembre | 94 | 51 | 145 |
| 2022 Agosto | 97 | 54 | 151 |
| 2022 Julio | 50 | 45 | 95 |
| 2022 Junio | 42 | 49 | 91 |
| 2022 Mayo | 142 | 49 | 191 |
| 2022 Abril | 167 | 31 | 198 |
| 2022 Marzo | 164 | 50 | 214 |
| 2022 Febrero | 117 | 54 | 171 |
| 2022 Enero | 112 | 55 | 167 |
| 2021 Diciembre | 88 | 50 | 138 |
| 2021 Noviembre | 97 | 48 | 145 |
| 2021 Octubre | 103 | 78 | 181 |
| 2021 Septiembre | 83 | 52 | 135 |
| 2021 Agosto | 96 | 76 | 172 |
| 2021 Julio | 75 | 27 | 102 |
| 2021 Junio | 65 | 39 | 104 |
| 2021 Mayo | 59 | 54 | 113 |
| 2021 Abril | 82 | 78 | 160 |
| 2021 Marzo | 78 | 64 | 142 |
| 2021 Febrero | 27 | 28 | 55 |
| 2021 Enero | 31 | 29 | 60 |
| 2020 Diciembre | 12 | 14 | 26 |
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