Case and Research Letters
Toxic epidermal necrolysis vs. acute cutaneous graft versus host disease after hematopoietic stem cell transplantation: A diagnostic and therapeutic challenge
Necrólisis epidérmica tóxica versus enfermedad injerto contra huésped cutánea aguda después de un trasplante de células madre hematopoyéticas: un desafío diagnóstico y terapéutico
Leído
4824
Vecesse ha leído el artículo
1943
Total PDF
2881
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S1578219020303346" "issn" => "15782190" "doi" => "10.1016/j.adengl.2020.11.002" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "2455" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2021;112:81-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S0001731020303252" "issn" => "00017310" "doi" => "10.1016/j.ad.2019.02.031" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "2455" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2021;112:81-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => "Necrólisis epidérmica tóxica versus enfermedad injerto contra huésped cutánea aguda después de un trasplante de células madre hematopoyéticas: un desafío diagnóstico y terapéutico" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "81" "paginaFinal" => "82" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Toxic Epidermal Necrolysis vs. Acute Cutaneous Graft Versus Host Disease after Hematopoietic Stem Cell Transplantation: A Diagnostic and Therapeutic Challenge" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1078 "Ancho" => 1255 "Tamanyo" => 176710 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Imagen clínica de la paciente 2. B)<span class="elsevierStyleHsp" style=""></span>Hematoxilina-eosina en una biopsia de la paciente 2 (20×). C)<span class="elsevierStyleHsp" style=""></span>Linfocitos CD4+ en una biopsia de piel de la paciente 2 (40×). D<span class="elsevierStyleHsp" style=""></span>Linfocitos CD8+ en una biopsia de piel de la paciente 2 (40×). Nótese que en el infiltrado linfocitario de la dermis la relación CD8/CD4 es de 2,5, menor de 4, por lo que este caso es más sugestivo de EICH.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Rodríguez Tejero, J. Badiola González, L. Roldán Mateo, A. Molina Leyva" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Rodríguez Tejero" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Badiola González" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Roldán Mateo" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Molina Leyva" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219020303346" "doi" => "10.1016/j.adengl.2020.11.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020303346?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731020303252?idApp=UINPBA000044" "url" => "/00017310/0000011200000001/v1_202012220631/S0001731020303252/v1_202012220631/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S1578219020303693" "issn" => "15782190" "doi" => "10.1016/j.adengl.2020.12.004" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "2456" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2021;112:83-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Intravenous Immunoglobulin Therapy for Gestational Pemphigoid Refractory to Conventional Treatment" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "83" "paginaFinal" => "85" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento con inmunoglobulinas intravenosas del penfigoide gestacional refractario al tratamiento convencional" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 678 "Ancho" => 905 "Tamanyo" => 90752 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Highly pruritic erythematous plaques on the abdomen.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Boria, R. Maseda, F. Albízuri, M. de la Calle" "autores" => array:4 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Boria" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Maseda" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Albízuri" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "de la Calle" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731020303264" "doi" => "10.1016/j.ad.2019.04.016" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731020303264?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020303693?idApp=UINPBA000044" "url" => "/15782190/0000011200000001/v1_202101161046/S1578219020303693/v1_202101161046/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S1578219020303838" "issn" => "15782190" "doi" => "10.1016/j.adengl.2020.12.013" "estado" => "S300" "fechaPublicacion" => "2021-01-01" "aid" => "2457" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2021;112:79-80" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Cryptococcoid Sweet Syndrome: A Clinical and Histologic Imitator of Cryptococcosis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "79" "paginaFinal" => "80" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de Sweet criptococoide: simulador de criptococosis tanto clínica como histológicamente" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 629 "Ancho" => 750 "Tamanyo" => 110458 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Immune staining with myeloperoxidase (hematoxylin–eosin, ×400).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.E. Mazzei, A. Guerra, L. Dufrechou, M. Vola" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M.E." "apellidos" => "Mazzei" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Guerra" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Dufrechou" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Vola" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731020303276" "doi" => "10.1016/j.ad.2019.03.022" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731020303276?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020303838?idApp=UINPBA000044" "url" => "/15782190/0000011200000001/v1_202101161046/S1578219020303838/v1_202101161046/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Toxic epidermal necrolysis vs. acute cutaneous graft versus host disease after hematopoietic stem cell transplantation: A diagnostic and therapeutic challenge" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor</span>:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "81" "paginaFinal" => "82" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Rodríguez Tejero, J. Badiola González, L. Roldán Mateo, A. Molina Leyva" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Rodríguez Tejero" "email" => array:1 [ 0 => "andrea_13_3217@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Badiola González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "L." "apellidos" => "Roldán Mateo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Molina Leyva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "UGC Dermatología Hospital Virgen de las Nieves de Granada. Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "UGC Hematologías Hospital Virgen de las Nieves de Granada. Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "UGC Anatomía Patológica Hospital Virgen de las Nieves de Granada. Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Necrólisis epidérmica tóxica versus enfermedad injerto contra huésped cutánea aguda después de un trasplante de células madre hematopoyéticas: un desafío diagnóstico y terapéutico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1078 "Ancho" => 1255 "Tamanyo" => 176710 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">A.</span> Clinical image of patient two. <span class="elsevierStyleBold">B.</span> Hematoxylin-Eosin on a biopsy of patient two (20x). <span class="elsevierStyleBold">C</span>. CD4+ lymphocytes on a skin biopsy of patient two (40x)<span class="elsevierStyleBold">. D.</span> CD8+ lymphocytes on a skin biopsy of patient two (40x). Note that in the dermal lymphocytic infiltrate, a CD8 / CD4 ratio of 2.5, less than 4 and more suggestive in this case of GHVD.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Toxic epidermal necrolysis (TEN) is a life-threatening blistering skin disease induced by a medication. The incidence and main features of TEN in patients with hematopoietic stem cell transplantation (HSCT) have been poorly evaluated and there are only a few documented cases in the literature.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The extensive blistering and desquamation presentation of the cutaneous acute graft versus host disease (GVHD) is the most severe variant of this condition and it mimics a TEN.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Both skin diseases have exhibit clinical and histological similarities which makes it virtually impossible to differentiate between them in the context of HSCT.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Clinical cases</span><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Patient one:</span> A 47-year-old man with myelodysplastic syndrome undergoing allogeneic HSCT. On day +84, the patient referred the development of a pruritic generalized acute erythema, associating fever and lichenoid erosions in the oral mucosa. A severe GVHD was suspected and intensification of treatment with sirolimus, ruxolitinib and extracorporeal photopheresis was decided. However, the eruption progressed with blistering and epidermolysis. Given the lack of response, TEN was suspected and all not strictly necessary drugs were withdrawn, while immunosuppressive treatment is reduced. From this moment on, the patient improved and epithelization of all the detached surface was achieved in some weeks. After numerous complications, on the day +229, the patient was released from the hospital with cutaneous, hepatic and ocular chronic GVHD, that was treated with immunosuppressive therapy until day +322, when he died from respiratory infection.</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Patient two</span>: An allogeneic HSCT was performed in a 61-year-old woman with chronic lymphatic leukemia. The day +16 she developed a gastric GVHD treated with corticosteroid and cyclosporine. On day +38, the patient reported a worsening of her digestive symptoms, associating fever and mild skin rash. Sirolimus was initiated and it coincided with the appearance of a more significant, painful and confluent rash, with serous blisters, epidermal denudation and fibrinoid exulcerations in oral mucosa. Sirolimus was interrupted, along with most of the prophylactic treatments of HSCT, but the rest of the immunosuppressive therapy, with high doses of corticosteroids, cyclosporine, ruxolitinib and photoapheresis, was prolonged. Progressive re-epithelialization and correct clinical-analytical stability are achieved. The patient was discharged from hospital on day +80, and later she showed typical lesions of chronic cutaneous GVHD (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">In the common scenario of an allogenic HSCT, it is very difficult to clearly separate a TEN from a severe acute cutaneous GVHD.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Acute cutaneous GVHD usually debuts in the first 4–6 weeks after allogeneic hematopoietic stem cell transplantation (HSCT), with common association with digestive and hepatic symptoms. The severe forms involve more than 50% of the body surface area (stage III) with even blistering and epidermolysis (stage IV). It corresponds to interface dermatitis with keratinocyte necrosis and dermal lymphocytic infiltrate predominantly T CD8, adding formation of a subepidermal cleavage in grade III and dermo-epidermal separation in grade IV.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Regarding the treatment, the use of glucocorticoids, usually topical and systemic, is accepted as the first line. The second line is not clearly defined, being valid different combinations of immunosuppressants as well as extracorporeal photopheresis.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Given that clinically and histologically TEN and severe acute cutaneous GVHD can be identical, dual moderate management is usually chosen. However, it is important to promote studies that define criteria for differential diagnosis, since optimal management of each entity runs in some differences.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The following points may be useful for the differential diagnosis:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0050" class="elsevierStylePara elsevierViewall">Appearance of NET in the 4 weeks following the incorporation of a new medication, with discontinuity of denudation once the suspect drug has been removed. On the contrary, in GVHD it is possible that skin reactions progress or recur, even in a changing manner.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0055" class="elsevierStylePara elsevierViewall">The coexistence of gastrointestinal or hepatic GVHD, supports the diagnosis of severe acute cutaneous GVHD.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0060" class="elsevierStylePara elsevierViewall">Although the histology may be similar, and immunofluorescence lacks of value because it is negative or non-specific, the immunohistochemistry in both reflects a clear predominance of T CD8 lymphocytes in the dermal infiltrate. Recent studies advocate for a CD8 / CD4 ratio higher in the NET, where at least it will be > 4.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall">The determination, during the first hours of the suspicious eruption, of certain elevated serum biomarkers like elafin, regenerating islet-derived 3-α (REG3α) or soluble interleukin-2 receptor-α (sIL-2Rα), is a non-invasive procedure that can guide both for the diagnosis of the onset of GVHD, as to predict the evolution towards severe GVHD. In particular, the three biomarkers mentioned, measured jointly just when the symptomatology appears, constitute a composite panel that has shown with statistical significance, to be able to differentiate non-GVHD versus any degree GVHD. The analysis in recent literature of the ROC curve of this panel to diagnose GVHD at the time of onset of symptoms, describes a specificity of 100% and a sensitivity of 55.6%.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a></p></li></ul></p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion, we present two clinical cases in which the diagnostic difficulty between these two entities and the importance of looking for clinical, analytical and anatomopathological data that allow to focus therapeutic management, is reflected.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Clinical cases" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Discussion" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Rodríguez Tejero A, Badiola González J, Roldán Mateo L, Molina Leyva A. Necrólisis epidérmica tóxica versus enfermedad injerto contra huésped cutánea aguda después de un trasplante de células madre hematopoyéticas: un desafío diagnóstico y terapéutico. Actas Dermosifiliogr. 2021;112:81–82.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1078 "Ancho" => 1255 "Tamanyo" => 176710 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">A.</span> Clinical image of patient two. <span class="elsevierStyleBold">B.</span> Hematoxylin-Eosin on a biopsy of patient two (20x). <span class="elsevierStyleBold">C</span>. CD4+ lymphocytes on a skin biopsy of patient two (40x)<span class="elsevierStyleBold">. D.</span> CD8+ lymphocytes on a skin biopsy of patient two (40x). Note that in the dermal lymphocytic infiltrate, a CD8 / CD4 ratio of 2.5, less than 4 and more suggestive in this case of GHVD.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Review of Cutaneous Graft-vs-Host Disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Ballester-Sanchez" 1 => "M. Navarro-Mira" 2 => "J. Sanz-Caballer" 3 => "R. Botella-Estrada" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2015.10.003" "Revista" => array:7 [ "tituloSerie" => "Actas dermo-sifiliograficas." "fecha" => "2016" "volumen" => "107" "numero" => "3" "paginaInicial" => "183" "paginaFinal" => "193" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26626500" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and management of acute graft-versus-host disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.L. Dignan" 1 => "A. Clark" 2 => "P. Amrolia" 3 => "J. Cornish" 4 => "G. Jackson" 5 => "P. Mahendra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2141.2012.09129.x" "Revista" => array:7 [ "tituloSerie" => "British journal of haematology." "fecha" => "2012" "volumen" => "158" "numero" => "1" "paginaInicial" => "30" "paginaFinal" => "45" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22533831" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extensive toxic epidermal necrolysis versus acute graft versus host disease after allogenic hematopoietic stem-cell transplantation: challenges in diagnosis and management" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.I. Macedo" 1 => "J. Faris" 2 => "L.G. Lum" 3 => "A. Gabali" 4 => "J.P. Uberti" 5 => "V. Ratanatharathorn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/heapol/czaa031" "Revista" => array:7 [ "tituloSerie" => "Journal of burn care & research" "fecha" => "2014" "volumen" => "35" "numero" => "6" "paginaInicial" => "e431" "paginaFinal" => "5" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33450768" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A pilot study comparing histological and immunophenotypic patterns in stage 4 skin graft vs host disease from toxic epidermal necrolysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Naik" 1 => "S. Lockwood" 2 => "A. Saavedra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cup.12986" "Revista" => array:7 [ "tituloSerie" => "Journal of cutaneous pathology." "fecha" => "2017" "volumen" => "44" "numero" => "10" "paginaInicial" => "857" "paginaFinal" => "860" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28626936" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toxic epidermal necrolysis versus cutaneous Graft-Versus-Host Disease in a hematopoietic stem cell transplant recipient: the role of elafin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Chen" 1 => "K. Chao" 2 => "L. Rodriguez" 3 => "W. Munday" 4 => "S. Worswick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ceca.2020.102333" "Revista" => array:7 [ "tituloSerie" => "Leukemia & lymphoma." "fecha" => "2018" "volumen" => "59" "numero" => "9" "paginaInicial" => "2261" "paginaFinal" => "2263" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33450506" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Composite biomarker panel for prediction of severity and diagnosis of acute GVHD with T-cell-depleted allogeneic stem cell transplants-single centre pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.S. Min" 1 => "V. Mehra" 2 => "J. Clay" 3 => "G.F. Cross" 4 => "A. Douiri" 5 => "T. Dew" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jclinpath-2017-204399" "Revista" => array:7 [ "tituloSerie" => "Journal of clinical pathology" "fecha" => "2017" "volumen" => "70" "numero" => "10" "paginaInicial" => "886" "paginaFinal" => "890" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28450387" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011200000001/v1_202101161046/S1578219020303346/v1_202101161046/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011200000001/v1_202101161046/S1578219020303346/v1_202101161046/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020303346?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 6 | 7 | 13 |
| 2024 Octubre | 75 | 48 | 123 |
| 2024 Septiembre | 71 | 21 | 92 |
| 2024 Agosto | 99 | 63 | 162 |
| 2024 Julio | 81 | 32 | 113 |
| 2024 Junio | 84 | 26 | 110 |
| 2024 Mayo | 69 | 45 | 114 |
| 2024 Abril | 81 | 41 | 122 |
| 2024 Marzo | 89 | 24 | 113 |
| 2024 Febrero | 72 | 43 | 115 |
| 2024 Enero | 67 | 37 | 104 |
| 2023 Diciembre | 63 | 25 | 88 |
| 2023 Noviembre | 56 | 27 | 83 |
| 2023 Octubre | 59 | 19 | 78 |
| 2023 Septiembre | 45 | 25 | 70 |
| 2023 Agosto | 45 | 17 | 62 |
| 2023 Julio | 43 | 27 | 70 |
| 2023 Junio | 59 | 23 | 82 |
| 2023 Mayo | 59 | 23 | 82 |
| 2023 Abril | 44 | 26 | 70 |
| 2023 Marzo | 58 | 29 | 87 |
| 2023 Febrero | 49 | 23 | 72 |
| 2023 Enero | 39 | 32 | 71 |
| 2022 Diciembre | 59 | 46 | 105 |
| 2022 Noviembre | 30 | 25 | 55 |
| 2022 Octubre | 30 | 24 | 54 |
| 2022 Septiembre | 27 | 36 | 63 |
| 2022 Agosto | 35 | 35 | 70 |
| 2022 Julio | 24 | 43 | 67 |
| 2022 Junio | 33 | 38 | 71 |
| 2022 Mayo | 55 | 43 | 98 |
| 2022 Abril | 77 | 48 | 125 |
| 2022 Marzo | 69 | 70 | 139 |
| 2022 Febrero | 53 | 41 | 94 |
| 2022 Enero | 67 | 51 | 118 |
| 2021 Diciembre | 68 | 52 | 120 |
| 2021 Noviembre | 58 | 58 | 116 |
| 2021 Octubre | 66 | 85 | 151 |
| 2021 Septiembre | 67 | 59 | 126 |
| 2021 Agosto | 61 | 57 | 118 |
| 2021 Julio | 47 | 45 | 92 |
| 2021 Junio | 41 | 48 | 89 |
| 2021 Mayo | 52 | 59 | 111 |
| 2021 Abril | 169 | 110 | 279 |
| 2021 Marzo | 89 | 62 | 151 |
| 2021 Febrero | 77 | 53 | 130 |
| 2021 Enero | 55 | 38 | 93 |
| 2020 Diciembre | 46 | 28 | 74 |
| 2020 Noviembre | 13 | 6 | 19 |
Mostrar todo
