Effectiveness of Certolizumab Pegol in the Treatment of Psoriasis in a Cohort of Patients With Psoriatic Arthritis

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"apellidos" => "Vidal" "email" => array:1 [ 0 => "david.vidal@sanitatintegral.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Moisès Broggi de Sant Joan Despí, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Moisès Broggi de Sant Joan Despí, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efectividad de certolizumab pegol en psoriasis en una cohorte de pacientes con artritis psoriásica" ] ] "textoCompleto" => "Certolizumab pegol (CZP) is an anti-TNF agent that has been recently approved for the treatment of moderate to severe plaque psoriasis in adults.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> Rheumatologists, in contrast, have been using the drug in psoriatic arthritis since 2012.<a class="elsevierStyleCrossRef" href="#bib0010">2</a> To assess the effectiveness of CZP in plaque psoriasis, a retrospective observational, multicenter study was conducted in patients treated for psoriatic arthritis who had active plaque psoriasis at the time of treatment initiation. The severity of psoriatic arthritis was assessed using the Disease Activity Score (DAS) 28 while plaque psoriasis was assessed with the 2011 modification of the Investigator Global Assessment (IGA mod 2011) scale (5-point physical global evaluation: 0, clear; 1, almost clear; 2, mild disease; 3, moderate disease; and 4, severe disease).<a class="elsevierStyleCrossRef" href="#bib0015">3</a>The study included 22 adult patients, 16 women (73%) and 6 men (2%), from 4 hospitals in the same province of Spain. The mean duration of plaque psoriasis and psoriatic arthritis was 16 and 12 years, respectively. All patients were diagnosed with psoriatic arthritis according to the CASPAR criteria<a class="elsevierStyleCrossRef" href="#bib0020">4</a> and plaque psoriasis. Nineteen patients had (86%) peripheral psoriatic arthritis, 15 (68%) polyarticular psoriatic arthritis, 13 (59%) dactylitis, 12 (55%) axial psoriatic arthritis, and 12 (55%) ungual psoriasis. Eighteen patients (81%) had received prior biologic therapy, and the regimen for CZP was the usual one for psoriatic arthritis in all cases: 400 mg administered subcutaneously at weeks 0, 2, and 4, followed by 200 mg every 2 weeks.On starting treatment, mean DAS28 was 5.79 and all patients had active plaque psoriasis (IGA mod 2011 ≥ 1): almost clear in 4 (18%), mild in 11 (50%), and moderate-severe in 7 patients (32%) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>After 6 months treatment with CZP, mean DAS28 was 3.4 and the severity of plaque psoriasis improved significantly: 16 patients (72%) were clear or almost clear of lesions, 4 (18%) had mild disease, and 2 (10%) had moderate-severe disease. After 12 months, only 12 patients had an IGA mod 2011 assessment: 9 patients (75%) were clear or almost clear of lesions, 2 (17%) had mild disease, and 1 (8%) had severe disease; and the mean DAS28 was 3.71. The statistical analysis showed significant differences (P < .05) between baseline IGA mod 2011 and that observed at 6 and 12 months, as well as a correlation between the DAS28 and IGA mod 2011 scales.The present study has several biases and limitations, such as a small sample size and a sample comprising patients who had already received prior biologic therapy. In addition, the scale for assessing plaque psoriasis is the IGA mod 2011, given that the Psoriasis Area Severity Index is not a scale used in everyday clinical practice by rheumatologists. Despite these limitations, this study confirms a high degree of effectiveness for CZP in plaque psoriasis in patients with psoriatic arthritis, and so this agent should be considered when treating patients who present with psoriatic arthritis and moderate-severe plaque psoriasis simultaneously.Conflicts of interestReina D and Vidal D have received speaker fees from UCB Pharma." "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:2 [ "identificador" => "xack489891" "titulo" => "Acknowledgments" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Reina D, Vidal D. Efectividad de certolizumab pegol en psoriasis en una cohorte de pacientes con artritis psoriásica. Actas Dermosifiliogr. 2020. https://doi.org/10.1016/j.ad.2019.01.023" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IGA mod 2011 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Treatment Initiation \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">% \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">6 Months Treatment \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">% \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">12 Months Treatment \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">% \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; 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Kielar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2014" "volumen" => "73" "paginaInicial" => "48" "paginaFinal" => "55" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The 5-point Investigator’s Global Assessment (IGA) Scale: A modified tool for evaluating plaque psoriasis severity in clinical trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.G. Langley" 1 => "S.R. Feldman" 2 => "J. Nyirady" 3 => "P. van de Kerkhof" 4 => "C. Papavassilis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/09546634.2013.865009" "Revista" => array:6 [ "tituloSerie" => "J Dermatolog Treat" "fecha" => "2015" "volumen" => "26" "paginaInicial" => "23" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24354461" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification criteria for psoriatic arthritis: development of new criteria from a large international study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W. Taylor" 1 => "D. Gladman" 2 => "P. Helliwell" 3 => "A. Marchesoni" 4 => "P. Mease" 5 => "H. Mielants" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.21972" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2006" "volumen" => "54" "paginaInicial" => "2665" "paginaFinal" => "2673" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16871531" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack489891" "titulo" => "Acknowledgments" "texto" => "We would like to thank Drs. L. Mateo, A. Prior, A. Laíz, and M. Moreno for their collaboration in this study." 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Case and Research Letters

Effectiveness of Certolizumab Pegol in the Treatment of Psoriasis in a Cohort of Patients With Psoriatic Arthritis

Efectividad de certolizumab pegol en psoriasis en una cohorte de pacientes con artritis psoriásica

D. Reinaa, D. Vidalb,

Autor para correspondencia

david.vidal@sanitatintegral.org

Corresponding author.

a Servicio de Reumatología, Hospital Moisès Broggi de Sant Joan Despí, Barcelona, Spain

b Servicio de Dermatología, Hospital Moisès Broggi de Sant Joan Despí, Barcelona, Spain

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      "titulo" => "<span class="elsevierStyleItalic">Ex vivo</span> fluorescence confocal microscopy on a 3-color scale&#58; A new imaging technique"
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    "titulo" => "Effectiveness of Certolizumab Pegol in the Treatment of Psoriasis in a Cohort of Patients With Psoriatic Arthritis"
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        "titulo" => "Efectividad de certolizumab pegol en psoriasis en una cohorte de pacientes con artritis psori&#225;sica"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Certolizumab pegol &#40;CZP&#41; is an anti-TNF agent that has been recently approved for the treatment of moderate to severe plaque psoriasis in adults&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Rheumatologists&#44; in contrast&#44; have been using the drug in psoriatic arthritis since 2012&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> To assess the effectiveness of CZP in plaque psoriasis&#44; a retrospective observational&#44; multicenter study was conducted in patients treated for psoriatic arthritis who had active plaque psoriasis at the time of treatment initiation&#46; The severity of psoriatic arthritis was assessed using the Disease Activity Score &#40;DAS&#41; 28 while plaque psoriasis was assessed with the 2011 modification of the Investigator Global Assessment &#40;IGA mod 2011&#41; scale &#40;5-point physical global evaluation&#58; 0&#44; clear&#59; 1&#44; almost clear&#59; 2&#44; mild disease&#59; 3&#44; moderate disease&#59; and 4&#44; severe disease&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The study included 22 adult patients&#44; 16 women &#40;73&#37;&#41; and 6 men &#40;2&#37;&#41;&#44; from 4 hospitals in the same province of Spain&#46; The mean duration of plaque psoriasis and psoriatic arthritis was 16 and 12 years&#44; respectively&#46; All patients were diagnosed with psoriatic arthritis according to the CASPAR criteria<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and plaque psoriasis&#46; Nineteen patients had &#40;86&#37;&#41; peripheral psoriatic arthritis&#44; 15 &#40;68&#37;&#41; polyarticular psoriatic arthritis&#44; 13 &#40;59&#37;&#41; dactylitis&#44; 12 &#40;55&#37;&#41; axial psoriatic arthritis&#44; and 12 &#40;55&#37;&#41; ungual psoriasis&#46; Eighteen patients &#40;81&#37;&#41; had received prior biologic therapy&#44; and the regimen for CZP was the usual one for psoriatic arthritis in all cases&#58; 400&#8239;mg administered subcutaneously at weeks 0&#44; 2&#44; and 4&#44; followed by 200&#8239;mg every 2 weeks&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On starting treatment&#44; mean DAS28 was 5&#46;79 and all patients had active plaque psoriasis &#40;IGA mod 2011&#8239;&#8805;&#8239;1&#41;&#58; almost clear in 4 &#40;18&#37;&#41;&#44; mild in 11 &#40;50&#37;&#41;&#44; and moderate-severe in 7 patients &#40;32&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">After 6 months treatment with CZP&#44; mean DAS28 was 3&#46;4 and the severity of plaque psoriasis improved significantly&#58; 16 patients &#40;72&#37;&#41; were clear or almost clear of lesions&#44; 4 &#40;18&#37;&#41; had mild disease&#44; and 2 &#40;10&#37;&#41; had moderate-severe disease&#46; After 12 months&#44; only 12 patients had an IGA mod 2011 assessment&#58; 9 patients &#40;75&#37;&#41; were clear or almost clear of lesions&#44; 2 &#40;17&#37;&#41; had mild disease&#44; and 1 &#40;8&#37;&#41; had severe disease&#59; and the mean DAS28 was 3&#46;71&#46; The statistical analysis showed significant differences &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;05&#41; between baseline IGA mod 2011 and that observed at 6 and 12 months&#44; as well as a correlation between the DAS28 and IGA mod 2011 scales&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The present study has several biases and limitations&#44; such as a small sample size and a sample comprising patients who had already received prior biologic therapy&#46; In addition&#44; the scale for assessing plaque psoriasis is the IGA mod 2011&#44; given that the Psoriasis Area Severity Index is not a scale used in everyday clinical practice by rheumatologists&#46; Despite these limitations&#44; this study confirms a high degree of effectiveness for CZP in plaque psoriasis in patients with psoriatic arthritis&#44; and so this agent should be considered when treating patients who present with psoriatic arthritis and moderate-severe plaque psoriasis simultaneously&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">Reina D and Vidal D have received speaker fees from <span class="elsevierStyleGrantSponsor" id="gs0005">UCB Pharma</span>&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Reina D&#44; Vidal D&#46; Efectividad de certolizumab pegol en psoriasis en una cohorte de pacientes con artritis psori&#225;sica&#46; Actas Dermosifiliogr&#46; 2020&#46; https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;ad&#46;2019&#46;01&#46;023</p>"
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                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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      "titulo" => "References"
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                      "titulo" => "Certolizumab pegol for the treatment of chronic plaque psoriasis&#58; Results through 48 weeks of a phase 3&#44; multicenter&#44; randomized&#44; double-blind&#44; etanercept- and placebo-controlled study &#40;CIMPACT&#41;"
                      "autores" => array:1 [
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                          "autores" => array:6 [
                            0 => "M&#46; Lebwohl"
                            1 => "A&#46; Blauvelt"
                            2 => "C&#46; Paul"
                            3 => "H&#46; Sofen"
                            4 => "J&#46; W&#281;g&#322;owska"
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                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2018.04.013"
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                        "tituloSerie" => "J Am Acad Dermatol"
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                0 => array:2 [
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                      "titulo" => "Effect of certolizumab pegol on signs and symptoms in patients with psoriatic arthritis&#58; 24-week results of a Phase 3 double-blind randomised placebo-controlled study &#40;RAPID-PsA&#41;"
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                        0 => array:2 [
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                            2 => "A&#46;A&#46; Deodhar"
                            3 => "J&#46; Wollenhaupt"
                            4 => "M&#46; Khraishi"
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                    ]
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                        "tituloSerie" => "Ann Rheum Dis"
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                        "paginaInicial" => "48"
                        "paginaFinal" => "55"
                      ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The 5-point Investigator&#8217;s Global Assessment &#40;IGA&#41; Scale&#58; A modified tool for evaluating plaque psoriasis severity in clinical trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "R&#46;G&#46; Langley"
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                            3 => "P&#46; van de Kerkhof"
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                          ]
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                      "doi" => "10.3109/09546634.2013.865009"
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                        "tituloSerie" => "J Dermatolog Treat"
                        "fecha" => "2015"
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                    0 => array:2 [
                      "titulo" => "Classification criteria for psoriatic arthritis&#58; development of new criteria from a large international study"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "D&#46; Gladman"
                            2 => "P&#46; Helliwell"
                            3 => "A&#46; Marchesoni"
                            4 => "P&#46; Mease"
                            5 => "H&#46; Mielants"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.21972"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2006"
                        "volumen" => "54"
                        "paginaInicial" => "2665"
                        "paginaFinal" => "2673"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16871531"
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        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0035" class="elsevierStylePara elsevierViewall">We would like to thank Drs&#46; L&#46; Mateo&#44; A&#46; Prior&#44; A&#46; La&#237;z&#44; and M&#46; Moreno for their collaboration in this study&#46;</p>"
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Información del artículo

ISSN: 15782190
Idioma original: Inglés

DOI:10.1016/j.adengl.2019.01.025

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