Opinion Article
One-Step surgical removal of a cutaneous melanoma: Current evidence
Evidencia actual del tratamiento quirúrgico del melanoma cutáneo en un solo tiempo
F. Russo - de la Torre
Consulta Dermatológica, Algeciras, Cádiz, Spain
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"apellidos" => "Fustà-Novell" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0030"></elsevierMultimedia></p></span>" ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731020301356" "doi" => "10.1016/j.ad.2020.03.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731020301356?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219020302055?idApp=UINPBA000044" "url" => "/15782190/0000011100000007/v1_202009190930/S1578219020302055/v1_202009190930/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>" "titulo" => "One-Step surgical removal of a cutaneous melanoma: Current evidence" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "541" "paginaFinal" => "544" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "F. Russo - de la Torre" "autores" => array:1 [ 0 => array:3 [ "nombre" => "F." "apellidos" => "Russo - de la Torre" "email" => array:1 [ 0 => "russo@aedv.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Consulta Dermatológica, Algeciras, Cádiz, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evidencia actual del tratamiento quirúrgico del melanoma cutáneo en un solo tiempo" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The management of cutaneous melanoma has changed radically in the last 30 years. While initial approaches involved wide excision with 5-cm margins and prophylactic radical lymph node dissection, now the tendency is to use increasingly conservative treatments based on the findings of multicenter clinical trials. New data continue to emerge that are driving changes at a dizzying speed.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The latest version of the National Comprehensive Cancer Network (NCCN) guidelines on the surgical treatment of melanoma recommends narrow excision with margins of 1–3 mm followed by a second surgical intervention to widen margins following histologic determination of Breslow thickness.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Wider margins in the initial procedure are advised against as they could alter local lymphatic drainage patterns and interfere with accurate sentinel lymph node (SLN) identification.</p><p id="par0015" class="elsevierStylePara elsevierViewall">SLN biopsy has been considered a valuable staging tool in cutaneous melanoma for many years, as it provides prognostic information for patients with clinical stage I/II disease (without clinical or radiographic evidence of lymph node involvement) and guides diagnostic and treatment decisions.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">One of the most important implications of SLN biopsy for melanoma management, based on findings from the first multicenter selective lymphadenectomy trial (MSLT I), was that immediate complete lymph node dissection (CLND) was recommended in patients with a positive SLN biopsy.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Nonetheless, the later DeCOG trial showed no significant survival advantage for CLND compared with observation only.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> This lack of advantage was confirmed by the recently published findings from the second MSLT trial (MSLT-II) showing similar survival rates for patients with SLN positivity regardless of whether they underwent CLND or nodal basin ultrasound surveillance.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The results of the above trials led some authors to recommend replacing CLND with nodal basin ultrasound surveillance.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The 2019 NCCN guidelines mention this as an option, that is, they say that a patient with positive SLN status can be observed by nodal basin ultrasound, without the need for CLND. These recommendations have led to a dramatic reduction in the performance of CLND among patients with a positive SLN biopsy at specialized melanoma centers.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Many authors are of the opinion that if SLN biopsy is no longer needed to determine whether or not CLND is indicated, then it should be purely considered a staging procedure and that its role in the management of melanoma needs to be rethought.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> SLN biopsy is starting to lose its status as a standard procedure in melanoma, particularly outside the setting of clinical trials. There are numerous reasons for this, including false-positive and -negative rates, cost,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> and the risk of morbidity (6% of patients develop lymphedema). SLN biopsy may still, however, continue to have a role in the selection of candidates for clinical trials evaluating adjuvant therapy with new biologic drugs.</p><p id="par0035" class="elsevierStylePara elsevierViewall">This latest information should be clearly explained to patients in understandable language so that they can actively participate in decisions regarding their care. The NCCN guidelines have always referred to SLN biopsy as an option that should be "discussed and considered", not just with members of multidisciplinary melanoma committees but also with patients. The latest NCCN guidelines also mention CLND as an option to be discussed with SLN-positive patients.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Equipped with clear information about their options, a considerable proportion of patients will probably choose the “interventional” route, that is, SLN biopsy, followed or not by CLND, and enrolment in a clinical trial investigating adjuvant therapy with biologics. Others will choose the “conservative” route, consisting of wide surgical excision (without SLN biopsy) and close nodal basin ultrasound surveillance.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Those who choose the first route probably consider that this is their best option, as by benefiting from the latest diagnostic and treatment methods, they will trust they are receiving the best possible care. The NCCN strongly encourages enrolment of melanoma patients in clinical trials as it considers this to be the best management option. In addition, clinical trials will obviously help advance existing diagnostic tools and treatments.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Patients who choose the more conservative route probably do so as they consider this to be the safest route, as they will not be exposed to the risks associated with SLN biopsy or CLND or new adjuvant drugs whose adverse effects and efficacy remain to be fully elucidated. Considering the latest findings that do not support the use of CLND in patients with positive SLN status, it is possible that we will see an increase in the percentage of melanoma patients who opt for wide excision and nodal basin ultrasound surveillance. The decision not to perform SLN biopsy can also be influenced by other factors, such as the patient’s age and general health status, presence of the primary tumor in an area with multiple lymphatic drainage pathways, and a high risk of comorbidity (positive SLN in the parotid gland). It should also be noted that not all patients are referred to specialist centers equipped with multidisciplinary melanoma units. Many patients, whether for geographic or personal reasons, may decide not to travel to such centers, opting instead for a local or private hospital that may not have the latest technology or tools for the diagnosis and treatment of melanoma or that may not be participating in a clinical trial.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Patients who for whatever reason do not undergo SLN biopsy are candidates for 1-step melanoma surgery. The NCCN's recommendation for 2-step excision is based on the need to avoid disruption to lymphatic drainage patterns that could interfere with subsequent SLN identification. If, however, there are no plans to perform SLN biopsy, 1-step wide excision is perfectly feasible, as it was before the advent of SLN biopsy.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Noninvasive techniques such as dermoscopy or high-resolution ultrasound can help determine margin size for the excision of tumors with an unknown Breslow thickness. Clear correlations have been found between thickness and certain dermoscopic and histopathologic features. The irregular pigment network observed by dermoscopy, for example, corresponds to atypical melanocytic hyperplasia at the dermal-epidermal junction, which has been shown to be common in early-stage melanoma and much rarer in thicker melanomas because of the destruction of rete ridges. Blue-gray areas, in turn, reflect the presence of pigmented melanocytes or melanophages in the mid reticular dermis and are observed in melanomas that have reached this depth. Other dermoscopic findings observed in thicker tumors are radial streaming and an atypical vascular pattern.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Melanoma thickness measured by high-resolution ultrasound also correlates well with histologic Breslow thickness.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The availability of ultrasound in many dermatology departments has led to an increasing use of this tool for routine preoperative assessment. Integration of clinical characteristics (e.g., macules, papules, nodules, ulceration, > 4 colors) and dermoscopic and ultrasound findings can provide a highly accurate estimate of tumor thickness prior to surgery.</p><p id="par0065" class="elsevierStylePara elsevierViewall">The recommended margin sizes for wide surgical excision of melanoma according to the NCCN are 0.5–1 cm for melanoma in situ, 1 cm for tumors with a Breslow thickness of 1 mm or less, 1–2 cm for tumors with a thickness of 1–2 mm, and 2 cm for tumors with a thickness of 2 mm or more. These sizes may be modified by individual anatomic or functional factors. The prospective multicenter prospective trials on which the NCCN recommendations are based recommend a Breslow thickness of 2 mm as the best cutoff for deciding whether to use an excision margin of 1 or 2 cm.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> In the international prospective study conducted by the World Health Organization, patients with a Breslow thickness of less than 2 mm had similar survival rates regardless of the surgical margins used (1 cm or larger).<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Studies conducted in Sweden<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> and France<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> have confirmed that excision with 1-cm margins does not affect survival in patients with melanomas with a Breslow thickness of less than 2 mm. In addition, a European multicenter trial found that excision with margins of over 2 cm did not provide any survival advantage to patients with a Breslow thickness of over 2 mm.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Being able to distinguish between thin melanoma (Breslow thickness ≤ 2 mm) and intermediate-thickness melanomas (>2 mm) is very useful when planning 1-step melanoma surgery, as one of the limitations of dermoscopic and ultrasound evaluation is their limited ability to differentiate between melanoma in situ and thin melanoma.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Integration of clinical, dermoscopic, and ultrasound findings, however, provides a very accurate means of determining whether a melanoma has a thickness of more or less than 2 mm, guiding thus the decision on whether to use surgical margins of 1 or 2 cm, respectively.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Obviously, this preoperative estimate is not as accurate as postoperative histologic measurement and could give rise to the use of excessively large or small margins. In a recent study of 78 melanomas excised using 1-step melanoma surgery guided by high-resolution ultrasound, 91% of margins were found to be adequate based on subsequent histologic evaluation of Breslow thickness. Just 2 of the 78 melanomas required a repeat intervention due to insufficient margins.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Although the above approach would result in few cases with excessively large or small margins, it is worth analyzing the potential consequences. Excision using 1-cm margins of a melanoma subsequently staged as in situ in the histologic examination would result in an excessive margin of 0.5 cm. The aesthetic consequences would be a slightly longer scar than necessary, but this would be acceptable in most cases. Use of 2-cm margins to remove a melanoma subsequently found to have a Breslow thickness of less than 2 mm, by contrast, would result in an excessive margin of 1 cm. If the melanoma was located in a critical anatomic location, the resulting surgical defect might need complex reconstruction. In such cases, it might be more sensible to perform an excisional biopsy in the event of doubt.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Use of 1-cm margins to remove a melanoma with a Breslow thickness of over 2 mm in the histologic examination would be insufficient and would require a second intervention. This situation would be similar to standard 2-step surgery.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Although high diagnostic accuracy for melanoma has been observed among dermatologists,<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> 1-step surgery should be reserved for lesions with an unequivocal clinical and dermoscopic diagnosis to prevent benign lesions from being excised with excessively large margins.</p><p id="par0100" class="elsevierStylePara elsevierViewall">It could be postulated that wide 1-step surgical removal of a melanoma would rule out the possibility of subsequent SLN biopsy, but findings have shown that wide local excision does not affect SLN identification.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> The NCCN guidelines clearly state that even though its sensitivity might be affected, SLN biopsy is an option to consider after the repair of large defects using turnover flaps or grafts.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Although most lesions suspicious for melanoma can be easily biopsied by excision or saucerization, it is important to explain to the patient that 1-step surgery has the advantage of eliminating the need for a second procedure, saving the patient thus time, travel, and lost hours at work and reducing by half the risk of surgical complications and discomfort associated with local anesthesia and wound dressing.</p><p id="par0110" class="elsevierStylePara elsevierViewall">One-step melanoma surgery also reduces costs, as there is no need for a second procedure or a second histologic study, which in any case, has a very low diagnostic yield, as additional findings are rarely observed.</p><p id="par0115" class="elsevierStylePara elsevierViewall">A re-excision procedure to widen margins can also have a psychological impact on many patients who, despite having been previously informed, may think that something untoward was observed in the first operation that worsened their prognosis, calling for a second, more complex, operation.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">In conclusion, based on current evidence, 1-step melanoma surgery is a perfectly valid option for duly informed patients who opt for the more conservative approach of wide excision and close surveillance without the need for an SLN biopsy. Integration of clinical, dermoscopic, and/or ultrasound findings can be used to estimate tumor thickness (< 2  vs. > 2 mm) before the operation and decide whether to use 1-cm or 2-cm margins, respectively. This approach avoids the need for a second operation to obtain wider margins in a high proportion of patients, bringing many benefits.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-02-01" "fechaAceptado" => "2019-02-18" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Russo de la Torre F. Evidencia actual del tratamiento quirúrgico del melanoma cutáneo en un solo tiempo. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 13 | 11 | 24 |
| 2024 Octubre | 120 | 41 | 161 |
| 2024 Septiembre | 126 | 30 | 156 |
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| 2024 Febrero | 92 | 32 | 124 |
| 2024 Enero | 99 | 42 | 141 |
| 2023 Diciembre | 84 | 23 | 107 |
| 2023 Noviembre | 126 | 31 | 157 |
| 2023 Octubre | 103 | 39 | 142 |
| 2023 Septiembre | 108 | 35 | 143 |
| 2023 Agosto | 91 | 13 | 104 |
| 2023 Julio | 105 | 36 | 141 |
| 2023 Junio | 89 | 25 | 114 |
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| 2023 Abril | 52 | 16 | 68 |
| 2023 Marzo | 94 | 29 | 123 |
| 2023 Febrero | 55 | 17 | 72 |
| 2023 Enero | 31 | 35 | 66 |
| 2022 Diciembre | 58 | 41 | 99 |
| 2022 Noviembre | 46 | 29 | 75 |
| 2022 Octubre | 24 | 21 | 45 |
| 2022 Septiembre | 27 | 36 | 63 |
| 2022 Agosto | 27 | 28 | 55 |
| 2022 Julio | 23 | 30 | 53 |
| 2022 Junio | 24 | 16 | 40 |
| 2022 Mayo | 70 | 39 | 109 |
| 2022 Abril | 75 | 38 | 113 |
| 2022 Marzo | 90 | 50 | 140 |
| 2022 Febrero | 70 | 27 | 97 |
| 2022 Enero | 74 | 36 | 110 |
| 2021 Diciembre | 73 | 32 | 105 |
| 2021 Noviembre | 67 | 40 | 107 |
| 2021 Octubre | 101 | 44 | 145 |
| 2021 Septiembre | 61 | 43 | 104 |
| 2021 Agosto | 55 | 27 | 82 |
| 2021 Julio | 84 | 23 | 107 |
| 2021 Junio | 60 | 30 | 90 |
| 2021 Mayo | 50 | 38 | 88 |
| 2021 Abril | 97 | 52 | 149 |
| 2021 Marzo | 63 | 25 | 88 |
| 2021 Febrero | 45 | 21 | 66 |
| 2021 Enero | 49 | 20 | 69 |
| 2020 Diciembre | 37 | 21 | 58 |
| 2020 Noviembre | 35 | 20 | 55 |
| 2020 Octubre | 58 | 25 | 83 |
| 2020 Septiembre | 73 | 33 | 106 |
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