Case and Research Letters
Linear Bowenoid Papulosis
Papulosis bowenoide lineal
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A, Sclerotic dermis with dense collagen and a scar-like appearance (original magnification ×10). B, Detail of a broken hair follicle (original magnification ×40). C, Peripheral multinucleated giant cells (original magnification ×40).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Macías del Toro, M.A. González Domingo, F. Alfageme Roldán" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Macías del Toro" ] 1 => array:2 [ "nombre" => "M.A." "apellidos" => "González Domingo" ] 2 => array:2 [ "nombre" => "F." 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Similar to Bowen disease, histopathology reveals squamous cell carcinoma in situ.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> While the term bowenoid papulosis is not included in the 2016 World Health Organization classification of tumors of the penis,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> the clinical and epidemiological characteristics of the disease and its favorable prognosis lead dermatologists to continue to use the classic nomenclature and consider this condition a differential entity.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Bowenoid papulosis usually manifests as a polygonal planar papular rash on the genital-anal region; however, it may often take on multiple morphologies that should be borne in mind by the physician. We report a case of bowenoid papulosis with an unusual clinical presentation.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was an otherwise healthy 46-year-old uncircumcised man who consulted for a linear lesion on the penis that had first appeared a few weeks previously. He complained of mild pruritus and denied sexual relations outside his habitual partner or injuries in the area. He also denied dysuria or urethral secretion. Physical examination revealed a raised linear lesion that ran parallel to the coronal sulcus along almost all its circumference. It was 1−2<span class="elsevierStyleHsp" style=""></span>mm wide and erythematous-violaceous in color. The lesion was continuous and seemed to be formed by coalescent papules (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). There were no additional lesions in the genital-anal or oral areas or palpable enlarged lymph nodes. Biopsy revealed an irregularly acanthotic epidermis with hyperkeratosis, parakeratosis, and increased cellularity from the basal layer to the surface, with loss of maturation in all its thickness. The cells were large, occasionally multinucleated, with hyperchromatic nuclei and mitosis in the upper layers of the epidermis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). p16 immunohistochemistry revealed intense and diffuse nuclear positivity throughout the thickness of the epidermis (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Serology testing for syphilis, hepatitis B and C virus, and human immunodeficiency virus was negative.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was offered various options for therapy and chose a more conservative approach. After receiving the patient’s consent, we decided to apply topical treatment with sinecatechins 10 % ointment tid. The lesion disappeared completely in 6 weeks, and tolerance of treatment was excellent.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Bowenoid papulosis usually affects young, generally sexually active people between the third and fourth decades of life. The clinical manifestations are polymorphous and comprise macules, papules, and plaques with a flat surface. These are dome-shaped, papillomatous, or verrucous and generally multifocal. While they are frequently pigmented, they may also be erythematous, violaceous, flesh-colored, or leukoplastic.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3–5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinical presentation in the form of linear lesions is very unusual. Our review yielded only 7 cases,<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,5–8</span></a> thus making the present case the eighth to date. Seven patients were men and only 1 was a woman.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In men, the lesion tended to affect the coronal sulcus or adjacent area and was circumferential.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,6,7</span></a> Since the lesions usually take the form of coalescent individual lesions, the linear configuration may be continuous or intermittent, with the result that isolated papules are also frequently found close to the linear lesion.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The case we report is almost identical to that reported by Sweidan et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> in the sense that it involves a single linear, almost filiform lesion in the area of the coronal sulcus with no satellite lesions, thus potentially facilitating the clinical diagnosis.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The mechanism underlying this presentation of bowenoid papulosis is unknown, although it is thought to be associated with a Koebner phenomenon.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Thus, it has been speculated that, since most of these lesions appear close to the coronal sulcus, HPV in the area may be more difficult to eliminate, possibly for anatomical reasons. Therefore, its prolonged persistence in the area could favor this presentation.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Treatment of linear bowenoid papulosis is the same as that of classic disease, which can persist, remit, or recur. Treatment is generally destructive and may comprise conventional surgery, electrocautery, cryotherapy, imiquimod, topical 5-fluorouracil, podophyllin, podophyllotoxin, CO<span class="elsevierStyleInf">2</span> laser therapy, and photodynamic therapy.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Sinecatechins ointment is a standard extract of green tea leaves, which contain a mix of polyphenols with antioxidant, immunostimulatory, antitumor, and antiproliferative properties. It is indicated for genital warts in patients aged ><span class="elsevierStyleHsp" style=""></span>18 years.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Nonetheless, it is curious that, despite the clear involvement of HPV in the etiology and pathogenesis of bowenoid papulosis, we were able to find only 1 patient treated with this approach.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The ointment was successful and very well tolerated in the case we report, as in the abovementioned case.</p><p id="par0050" class="elsevierStylePara elsevierViewall">While we cannot rule out the possibility of spontaneous resolution, which is well documented in bowenoid papulosis, we believe that the treatment we recommended should become standard in this indication.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-02-20" "fechaAceptado" => "2018-05-15" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Allegue F, Fachal C, González-Vilas D, Zulaica A. Papulosis bowenoide lineal. Actas Dermosifiliogr. 2020;111:76–77.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1203 "Ancho" => 905 "Tamanyo" => 166252 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0165" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous-violaceous linear lesion around the penis.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 682 "Ancho" => 905 "Tamanyo" => 190988 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0170" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Epidermis with irregular acanthosis, hyperkeratosis, hypergranulosis, and squamous cells. Dyskeratosis, hyperchromatic nuclei, and multiple nuclei can be observed. Cellular atypia is observed throughout the thickness of the epidermis (hematoxylin-eosin, original magnification, ×200).</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 682 "Ancho" => 905 "Tamanyo" => 262251 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0175" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">p16 immunohistochemistry yields intensely positive results in the cytoplasm and nuclei of keratinocytes throughout the thickness of the epidermis (p16 immunohistochemistry, ×200).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "[1]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bowenoid papulosis in a linear distribution" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W.S. Peng" 1 => "C. Tan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Adv Dermatol Allergol" "fecha" => "2016" "volumen" => "33" "paginaInicial" => "146" "paginaFinal" => "148" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "[2]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Moch" 1 => "A.L. Cubilla" 2 => "P.A. Humphrey" 3 => "V.E. Reuter" 4 => "T.M. Ulbright" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2016.02.029" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2016" "volumen" => "70" "paginaInicial" => "93" "paginaFinal" => "105" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26935559" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "[3]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Les néoplasies intra-épithéliales bowénoïdes HPV-induites du pénis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.N. Dauendorffer" 1 => "B. Cavelier Balloy" 2 => "M. Bagot" 3 => "C. Renaud-Vilmer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.annder.2016.12.002" "Revista" => array:7 [ "tituloSerie" => "Ann Dermatol Venereol" "fecha" => "2017" "volumen" => "144" "paginaInicial" => "220" "paginaFinal" => "224" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28117082" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0890856709631762" "estado" => "S300" "issn" => "08908567" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "[4]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Linear bowenoid papulosis of the genitalia. A possible Koebner phenomenon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.A. Sweidan" 1 => "S.M. Salman" 2 => "S.T. Zaynoun" 3 => "B.A. Sanaknaki" 4 => "A.G. Kibbi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4362.1990.tb03830.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "1990" "volumen" => "29" "paginaInicial" => "430" "paginaFinal" => "431" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2397968" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "[5]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple linear bowenoid papulosis without surrounding papules" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Kumei" 1 => "H. Imanishi" 2 => "D. Tsuruta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1346-8138.2011.01468.x" "Revista" => array:6 [ "tituloSerie" => "J Dermatol" "fecha" => "2012" "volumen" => "39" "paginaInicial" => "862" "paginaFinal" => "863" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22221073" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "[6]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multicentric bowen’s disease of the genitalia: spontaneous regression of lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B.W. Berger" 1 => "Y. Hori" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1978" "volumen" => "114" "paginaInicial" => "1698" "paginaFinal" => "1699" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/757959" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "[7]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bowenoid papulosis. A clinicopathologic study with ultrastructural observations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.W. Patterson" 1 => "G.F. Kao" 2 => "J.H. Graham" 3 => "E.B. Helwig" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1097-0142(19860601)57:11<2235::aid-cncr2820571127>3.0.co;2-o" "Revista" => array:4 [ "tituloSerie" => "Cancer" "fecha" => "1986" "volumen" => "57" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3697922" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "[8]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bowenoid papulosis of the penis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.R. Wade" 1 => "A.W. Kopf" 2 => "A.B. Ackerman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1097-0142(197810)42:4<1890::aid-cncr2820420430>3.0.co;2-c" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1978" "volumen" => "42" "paginaInicial" => "1890" "paginaFinal" => "1903" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/361215" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "[9]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sinecatechins (polyphenon E) ointment for treatment of external genital warts and posible future indications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Stockfleth" 1 => "T. Meyer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Expert Opin Biol Ther" "fecha" => "2014" "volumen" => "14" "paginaInicial" => "1035" "paginaFinal" => "1043" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "[10]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case report of vulvar carcinoma in situ treated with sinecatechins with complete response" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. Gupta" 1 => "E. Rodríguez" 2 => "V. Andikyan" 3 => "S.P. Salob" 4 => "D. Chi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.gynor.2013.06.004" "Revista" => array:6 [ "tituloSerie" => "Gynecologic Oncology Reports" "fecha" => "2013" "volumen" => "6" "paginaInicial" => "10" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24371707" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011100000001/v2_202004200619/S1578219019303518/v2_202004200619/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011100000001/v2_202004200619/S1578219019303518/v2_202004200619/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019303518?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 12 | 6 | 18 |
| 2024 Octubre | 158 | 54 | 212 |
| 2024 Septiembre | 197 | 29 | 226 |
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| 2023 Enero | 86 | 37 | 123 |
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| 2022 Agosto | 54 | 54 | 108 |
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| 2022 Enero | 93 | 62 | 155 |
| 2021 Diciembre | 73 | 42 | 115 |
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| 2021 Octubre | 85 | 58 | 143 |
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| 2021 Agosto | 97 | 35 | 132 |
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| 2021 Febrero | 94 | 30 | 124 |
| 2021 Enero | 81 | 20 | 101 |
| 2020 Diciembre | 64 | 19 | 83 |
| 2020 Noviembre | 70 | 12 | 82 |
| 2020 Octubre | 59 | 10 | 69 |
| 2020 Septiembre | 67 | 24 | 91 |
| 2020 Agosto | 49 | 24 | 73 |
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| 2020 Junio | 35 | 16 | 51 |
| 2020 Mayo | 22 | 12 | 34 |
| 2020 Abril | 35 | 17 | 52 |
| 2020 Marzo | 22 | 9 | 31 |
| 2020 Febrero | 1 | 0 | 1 |
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