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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Herpes zoster is caused by reactivation of the varicella zoster virus&#44; which is characterized by a generally localized and painful vesicular skin rash&#46; Its incidence has increased in recent decades&#46; The most frequent complication is postherpetic neuralgia&#44; which affects around 18&#37; of patients with herpes zoster and may cause disabling pain&#46; The incidence of both conditions clearly increases with age&#46; Postherpetic neuralgia affects more than 30&#37; of persons with herpes zoster aged &#62;79 years&#46; The attenuated varicella zoster virus vaccine &#40;aVZV&#41; has an efficacy of 51&#37; for prevention of herpes zoster&#59; this efficacy decreases with age&#46; The vaccine is contraindicated in immunocompromised patients and approved by the United States Food and Drug Administration &#40;FDA&#41; for this indication in immunocompetent patients aged &#8805;50 years&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The FDA recently approved a new recombinant vaccine for treatment of herpes zoster &#40;rVZV&#41; &#40;Shingrix&#44; GlaxoSmithKline&#41;&#46; rVZV contains recombinant glycoprotein E of the varicella zoster virus&#44; together with the adjuvant AS01<span class="elsevierStyleInf">B</span>&#44; and is administered in 2 subcutaneous injections separated by 2&#8211;6 months &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The efficacy of rVZV was evaluated in 2 phase 3 randomized&#44; placebo-controlled clinical trials &#40;ZOE-50<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and ZOE-70<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#41;&#46; Median follow-up was longer than 3 years in both trials&#46; ZOE-50 included 15 411 patients aged &#8805;50 years and reported 6 cases of herpes zoster in the vaccinated group compared with 210 in the placebo group&#46; Overall efficacy in the prevention of herpes zoster was 97&#46;2&#37; &#40;95&#37; CI&#44; 93&#46;7&#8211;99&#46;0&#37;&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> ZOE-70 included 13 900 patients aged &#8805;70 years&#46; Efficacy was 89&#46;8&#37; &#40;95&#37; CI&#44; 84&#46;2&#8211;93&#46;7&#37;&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; for prevention of herpes zoster and 88&#46;8&#37; &#40;95&#37; CI&#44; 68&#46;7&#8211;97&#46;1&#37;&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; for prevention of postherpetic neuralgia&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> A pooled analysis of both studies showed that efficacy was 93&#46;7&#37; &#40;95&#37; CI&#44; 59&#46;5&#8211;99&#46;9&#37;&#41; for the prevention of post&#8211;herpes zoster complications other than postherpetic neuralgia&#44; i&#46;e&#46;&#44; disseminated herpes zoster&#44; secondary vasculitis&#44; encephalic vascular accident&#44; and ophthalmic&#44; neurologic&#44; and visceral disease&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In both studies&#44; the frequency of adverse events was similar in the vaccination and placebo groups&#46; The most frequent adverse events were injection site pain&#44; myalgia&#44; and fatigue&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">rVZV has proven more successful than aVZV for prevention of herpes zoster and postherpetic neuralgia&#46; Furthermore&#44; the cost-effectiveness analysis favored rVZV over aVZV&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Consequently&#44; the Advisory Committee on Immunization Practices in the United States recently recommended rVZV for immunocompetent patients aged &#8805;50 years&#44; even in those previously vaccinated with aVZV and those who have had herpes zoster&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Evidence remains insufficient to recommend rVZV in immunocompetent patients or patients who are receiving immunosuppressive treatment with prednisone &#8805;20 mg&#47;d&#44; although it could&#44; in theory&#44; be administered&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">rVZV is an efficacious and safe alternative for prevention of herpes zoster and postherpetic neuralgia and should be recommended in adults&#46; It could thus help to reduce the morbidity associated with these conditions&#46;</p></span>"
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                  \t\t\t\t">Can be coadministered with other vaccines in adults&#46; Should be injected at different sites&#46;&nbsp;\t\t\t\t\t\t\n
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Resident’s Forum
Vaccine for the Prevention of Herpes Zoster
FR-Nueva vacuna recombinante para la prevención del herpes zóster
D. Morgado-Carrasco
Autor para correspondencia
morgado@clinic.cat

Corresponding author.
, X. Fustà-Novell, P. Giavedoni
Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain
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        "titulo" => "FR-Nueva vacuna recombinante para la prevenci&#243;n del herpes z&#243;ster"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Herpes zoster is caused by reactivation of the varicella zoster virus&#44; which is characterized by a generally localized and painful vesicular skin rash&#46; Its incidence has increased in recent decades&#46; The most frequent complication is postherpetic neuralgia&#44; which affects around 18&#37; of patients with herpes zoster and may cause disabling pain&#46; The incidence of both conditions clearly increases with age&#46; Postherpetic neuralgia affects more than 30&#37; of persons with herpes zoster aged &#62;79 years&#46; The attenuated varicella zoster virus vaccine &#40;aVZV&#41; has an efficacy of 51&#37; for prevention of herpes zoster&#59; this efficacy decreases with age&#46; The vaccine is contraindicated in immunocompromised patients and approved by the United States Food and Drug Administration &#40;FDA&#41; for this indication in immunocompetent patients aged &#8805;50 years&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The FDA recently approved a new recombinant vaccine for treatment of herpes zoster &#40;rVZV&#41; &#40;Shingrix&#44; GlaxoSmithKline&#41;&#46; rVZV contains recombinant glycoprotein E of the varicella zoster virus&#44; together with the adjuvant AS01<span class="elsevierStyleInf">B</span>&#44; and is administered in 2 subcutaneous injections separated by 2&#8211;6 months &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The efficacy of rVZV was evaluated in 2 phase 3 randomized&#44; placebo-controlled clinical trials &#40;ZOE-50<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and ZOE-70<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#41;&#46; Median follow-up was longer than 3 years in both trials&#46; ZOE-50 included 15 411 patients aged &#8805;50 years and reported 6 cases of herpes zoster in the vaccinated group compared with 210 in the placebo group&#46; Overall efficacy in the prevention of herpes zoster was 97&#46;2&#37; &#40;95&#37; CI&#44; 93&#46;7&#8211;99&#46;0&#37;&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> ZOE-70 included 13 900 patients aged &#8805;70 years&#46; Efficacy was 89&#46;8&#37; &#40;95&#37; CI&#44; 84&#46;2&#8211;93&#46;7&#37;&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; for prevention of herpes zoster and 88&#46;8&#37; &#40;95&#37; CI&#44; 68&#46;7&#8211;97&#46;1&#37;&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; for prevention of postherpetic neuralgia&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> A pooled analysis of both studies showed that efficacy was 93&#46;7&#37; &#40;95&#37; CI&#44; 59&#46;5&#8211;99&#46;9&#37;&#41; for the prevention of post&#8211;herpes zoster complications other than postherpetic neuralgia&#44; i&#46;e&#46;&#44; disseminated herpes zoster&#44; secondary vasculitis&#44; encephalic vascular accident&#44; and ophthalmic&#44; neurologic&#44; and visceral disease&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In both studies&#44; the frequency of adverse events was similar in the vaccination and placebo groups&#46; The most frequent adverse events were injection site pain&#44; myalgia&#44; and fatigue&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">rVZV has proven more successful than aVZV for prevention of herpes zoster and postherpetic neuralgia&#46; Furthermore&#44; the cost-effectiveness analysis favored rVZV over aVZV&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Consequently&#44; the Advisory Committee on Immunization Practices in the United States recently recommended rVZV for immunocompetent patients aged &#8805;50 years&#44; even in those previously vaccinated with aVZV and those who have had herpes zoster&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Evidence remains insufficient to recommend rVZV in immunocompetent patients or patients who are receiving immunosuppressive treatment with prednisone &#8805;20 mg&#47;d&#44; although it could&#44; in theory&#44; be administered&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">rVZV is an efficacious and safe alternative for prevention of herpes zoster and postherpetic neuralgia and should be recommended in adults&#46; It could thus help to reduce the morbidity associated with these conditions&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Morgado-Carrasco D&#44; Fust&#224;-Novell X&#44; Giavedoni P&#46; FR-Nueva vacuna recombinante para la prevenci&#243;n del herpes z&#243;ster&#46; Actas Dermosifiliogr&#46; 2020&#59;111&#58;67&#8211;68&#46;</p>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; HZ&#44; herpes zoster&#59; HZ&#47;su&#44; HZ&#47;subunit&#59; aVZV&#44; attenuated varicella zoster vaccine&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Composition&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Administration&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Target Patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Special Situations&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Coadministration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">Recombinant glycoprotein E of varicella zoster virus&#44; which is essential for viral replication and propagation and is the target of the specific immune response&#46; Adjuvant AS01<span class="elsevierStyleInf">B</span> &#40;HZ&#47;su&#41;&#44; which promotes a marked and prolonged CD4 response to recombinant proteins&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Two subcutaneous injections separated by 2&#8211;6<span class="elsevierStyleHsp" style=""></span>mo&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Adults aged &#8805;50 y&#44; even if they have been previously vaccinated with aVZV or affected by HZ&#46; Serological screening for varicella is not recommended&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Not currently recommended for pregnant women&#46; Patients with chronic diseases &#40;chronic kidney failure&#44; diabetes mellitus&#44; chronic lung disease&#41; should be vaccinated&#46; Patients experiencing an acute episode of HZ should not be vaccinated until resolution of the acute phase&#46; Patients receiving prednisone &#60;20<span class="elsevierStyleHsp" style=""></span>mg&#47;d should be vaccinated&#46; Immunocompromised patients or patients receiving prednisone &#8805;20<span class="elsevierStyleHsp" style=""></span>mg&#47;d should not be vaccinated<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Can be coadministered with other vaccines in adults&#46; Should be injected at different sites&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                            4 => "J&#46; Diez-Domingo"
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