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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Presentation</span><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 76-year-old woman with no personal history of interest who consulted for a nodular lesion measuring 2<span class="elsevierStyleHsp" style=""></span>cm on her right buttock&#46; The lesion had first appeared 1 year previously&#44; had gradually increased in size&#44; and was accompanied by an adjacent satellite nodule&#46; Both lesions were firm in consistency with an infiltrated subcutaneous base &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Diagnosis</span><p id="par0015" class="elsevierStylePara elsevierViewall">Primary cutaneous marginal zone B-cell lymphoma&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Comment</span><p id="par0020" class="elsevierStylePara elsevierViewall">Dermoscopy revealed a homogeneous salmon-pink nodule with poorly focused prominent linear-irregular vessels distributed mainly on the periphery &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Poorly defined whitish structures were visible in the center of the lesion&#46; There was no desquamation&#44; pigmented base&#44; or ulceration&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Suspicion of cutaneous lymphoma&#44; cutaneous metastasis&#44; amelanotic melanoma&#44; or soft tissue sarcoma prompted us to remove the lesion&#46; Histology revealed a diffuse nodular lymphocytic infiltrate separated from a preserved epidermis by a Grenz zone&#46; Immunohistochemistry revealed positive results for CD20&#44; CD79a&#44; Bcl2&#44; and &#954; light chain restriction&#46; Together with clonal rearrangement of the <span class="elsevierStyleItalic">IGH</span> gene in polymerase chain reaction&#44; these findings confirmed the diagnosis of cutaneous marginal zone B-cell lymphoma&#46; The absence of findings in the extension study confirmed the mainly cutaneous origin&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Cutaneous lymphomas comprise a heterogeneous group of malignant neoplasms with very diverse clinical and histopathological manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a> Therefore&#44; diagnosis is usually complicated&#44; and the lesion may go undetected in the initial phases&#44; even for clinical experts&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> While diagnosis must be confirmed by biopsy and immunohistochemistry&#44; some recent studies indicate that dermoscopy is a useful tool in the initial suspected diagnosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In 2018&#44; Geller et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> reported on the dermoscopic features of a series of 58 cutaneous B-cell lymphomas&#46; The most frequent findings were a homogeneous salmon-pink color &#40;79&#46;3&#37;&#41; and prominent blood vessels &#40;77&#46;6&#37;&#41; that were of serpentine &#40;linear-irregular&#41; morphology &#40;67&#46;2&#37;&#41;&#46; The salmon pink color is thought to be associated with the lymphocytic infiltration and increased vascular flow&#44; whereas the prominent blood vessels are associated with the angiogenesis that accompanies the neoplasm&#46; It is noteworthy that in this study we did not record significant differences in dermoscopy findings between the various B-cell lymphoma histologic subtypes &#40;follicle-center&#44; marginal zone&#44; and diffuse large B-cell&#41; or depending on the anatomic location&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The most common clinical differential diagnosis in this series was with basal cell carcinoma &#40;in up to 17&#46;4&#37; of cases&#41;&#44; squamous cell carcinoma&#44; dermatofibrosarcoma protuberans&#44; cutaneous metastasis&#44; melanoma&#44; cysts&#44; and arthropod bite&#46; Strikingly&#44; agreement between the 2 observing dermoscopy experts was relatively low for the 17 histologically confirmed cases&#44; thus demonstrating the low specificity of these findings&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; we believe that the presence of homogeneous salmon-pink areas and prominent linear-irregular blood vessels in pink nodules should lead us to consider cutaneous lymphoma as a possible diagnosis&#44; although these findings are not completely confirmatory&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Practical Dermoscopy
Slow-Growing Salmon-Pink Nodule on the Buttock
Nódulo rosado de lento crecimiento en glúteo
E. Rodríguez-Lomba
Autor para correspondencia
enriquerlomba@outlook.com

Corresponding author.
, B. Lozano-Masdemont, J.A. Avilés-Izquierdo
Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España
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            "apellidos" => "Avil&#233;s-Izquierdo"
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          0 => array:2 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; Madrid&#44; Espa&#241;a"
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    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "N&#243;dulo rosado de lento crecimiento en gl&#250;teo"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image&#46; Smooth pinkish dome-shaped nodule measuring 2<span class="elsevierStyleHsp" style=""></span>cm on the right buttock&#46; Note the infiltrated subcutaneous base and the adjacent satellite nodule&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Presentation</span><p id="par0005" class="elsevierStylePara elsevierViewall">The patient was a 76-year-old woman with no personal history of interest who consulted for a nodular lesion measuring 2<span class="elsevierStyleHsp" style=""></span>cm on her right buttock&#46; The lesion had first appeared 1 year previously&#44; had gradually increased in size&#44; and was accompanied by an adjacent satellite nodule&#46; Both lesions were firm in consistency with an infiltrated subcutaneous base &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Diagnosis</span><p id="par0015" class="elsevierStylePara elsevierViewall">Primary cutaneous marginal zone B-cell lymphoma&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Comment</span><p id="par0020" class="elsevierStylePara elsevierViewall">Dermoscopy revealed a homogeneous salmon-pink nodule with poorly focused prominent linear-irregular vessels distributed mainly on the periphery &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Poorly defined whitish structures were visible in the center of the lesion&#46; There was no desquamation&#44; pigmented base&#44; or ulceration&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Suspicion of cutaneous lymphoma&#44; cutaneous metastasis&#44; amelanotic melanoma&#44; or soft tissue sarcoma prompted us to remove the lesion&#46; Histology revealed a diffuse nodular lymphocytic infiltrate separated from a preserved epidermis by a Grenz zone&#46; Immunohistochemistry revealed positive results for CD20&#44; CD79a&#44; Bcl2&#44; and &#954; light chain restriction&#46; Together with clonal rearrangement of the <span class="elsevierStyleItalic">IGH</span> gene in polymerase chain reaction&#44; these findings confirmed the diagnosis of cutaneous marginal zone B-cell lymphoma&#46; The absence of findings in the extension study confirmed the mainly cutaneous origin&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Cutaneous lymphomas comprise a heterogeneous group of malignant neoplasms with very diverse clinical and histopathological manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a> Therefore&#44; diagnosis is usually complicated&#44; and the lesion may go undetected in the initial phases&#44; even for clinical experts&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> While diagnosis must be confirmed by biopsy and immunohistochemistry&#44; some recent studies indicate that dermoscopy is a useful tool in the initial suspected diagnosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In 2018&#44; Geller et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> reported on the dermoscopic features of a series of 58 cutaneous B-cell lymphomas&#46; The most frequent findings were a homogeneous salmon-pink color &#40;79&#46;3&#37;&#41; and prominent blood vessels &#40;77&#46;6&#37;&#41; that were of serpentine &#40;linear-irregular&#41; morphology &#40;67&#46;2&#37;&#41;&#46; The salmon pink color is thought to be associated with the lymphocytic infiltration and increased vascular flow&#44; whereas the prominent blood vessels are associated with the angiogenesis that accompanies the neoplasm&#46; It is noteworthy that in this study we did not record significant differences in dermoscopy findings between the various B-cell lymphoma histologic subtypes &#40;follicle-center&#44; marginal zone&#44; and diffuse large B-cell&#41; or depending on the anatomic location&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The most common clinical differential diagnosis in this series was with basal cell carcinoma &#40;in up to 17&#46;4&#37; of cases&#41;&#44; squamous cell carcinoma&#44; dermatofibrosarcoma protuberans&#44; cutaneous metastasis&#44; melanoma&#44; cysts&#44; and arthropod bite&#46; Strikingly&#44; agreement between the 2 observing dermoscopy experts was relatively low for the 17 histologically confirmed cases&#44; thus demonstrating the low specificity of these findings&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; we believe that the presence of homogeneous salmon-pink areas and prominent linear-irregular blood vessels in pink nodules should lead us to consider cutaneous lymphoma as a possible diagnosis&#44; although these findings are not completely confirmatory&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Rodr&#237;guez-Lomba E&#44; Lozano-Masdemont B&#44; Avil&#233;s-Izquierdo JA&#46; N&#243;dulo rosado de lento crecimiento en gl&#250;teo Eczema y urticaria en Portugal&#46; 2019&#59;110&#58;763&#8211;764&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image&#46; Smooth pinkish dome-shaped nodule measuring 2<span class="elsevierStyleHsp" style=""></span>cm on the right buttock&#46; Note the infiltrated subcutaneous base and the adjacent satellite nodule&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopy image&#46; Homogeneous salmon-pink color with multiple prominent poorly focused serpentine &#40;linear-irregular&#41; vessels&#46; The lesions are found mainly on the periphery of the nodule&#46; Note the whitish structures in the center of the lesion&#46;</p>"
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                      "titulo" => "Cutaneous lymphomas&#58; An update Part 1&#58; T-cell and natural killer&#47;T-cell lymphomas and related conditions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46; Kempf"
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                            2 => "K&#46; Kerl"
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                      "doi" => "10.1097/DAD.0b013e318289b1db"
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                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2014"
                        "volumen" => "36"
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                      "titulo" => "Cutaneous lymphomas&#58; An update Part 2&#58; B-cell lymphomas and related conditions"
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                      "doi" => "10.1097/DAD.0b013e318289b20e"
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                      "doi" => "10.1111/jdv.14549"
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