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En superposición puede observarse IFD con depósitos lineales focales de C3 en membrana basal.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Lobato-Berezo, M.T. Fernández Figueras, J.A. Moreno Romero, R.M. Pujol" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Lobato-Berezo" ] 1 => array:2 [ "nombre" => "M.T." "apellidos" => "Fernández Figueras" ] 2 => array:2 [ "nombre" => "J.A." "apellidos" => "Moreno Romero" ] 3 => array:2 [ "nombre" => "R.M." 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Gil Redondo, V. Melgar Molero, A. Martín Fuentes, E. de Eusebio Murillo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Gil Redondo" ] 1 => array:2 [ "nombre" => "V." "apellidos" => "Melgar Molero" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Martín Fuentes" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "de Eusebio Murillo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731019300626" "doi" => "10.1016/j.ad.2018.04.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731019300626?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019302355?idApp=UINPBA000044" "url" => "/15782190/0000011000000008/v1_201910050935/S1578219019302355/v1_201910050935/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219019302331" "issn" => "15782190" "doi" => "10.1016/j.adengl.2019.07.006" "estado" => "S300" "fechaPublicacion" => "2019-10-01" "aid" => "2143" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2019;110:693-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Parotid Fistula After Skin Biopsy: Treatment With Botulinum Toxin" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "693" "paginaFinal" => "695" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fístula parotídea tras biopsia cutánea: tratamiento con toxina botulínica" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1703 "Ancho" => 1505 "Tamanyo" => 390691 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Indurated subcutaneous plaque of 2.5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>3 cm in diameter in the parotid region. B, Parotid fistula with secretion of saliva from the defect 7 days after skin biopsy. C, Parotid fistula 3 weeks after treatment, before beginning botulinum toxin treatment. Botulinum toxin was injected subcutaneously at the 6 indicated sites around the defect. D, Final outcome after botulinum toxin treatment.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "B. Bancalari, B. Llombart, C. Requena, J.B. Vendrell" "autores" => array:4 [ 0 => array:2 [ "nombre" => "B." "apellidos" => "Bancalari" ] 1 => array:2 [ "nombre" => "B." "apellidos" => "Llombart" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Requena" ] 3 => array:2 [ "nombre" => "J.B." 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Lobato-Berezo, M.T. Fernández Figueras, J.A. Moreno Romero, R.M. Pujol" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Lobato-Berezo" "email" => array:1 [ 0 => "allobe@hotmail.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.T." "apellidos" => "Fernández Figueras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "J.A." "apellidos" => "Moreno Romero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "R.M." "apellidos" => "Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Dermatología, Hospital del Mar-Parc Salut Mar, Barcelona, España" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Dermatología, Hospital Universitari General de Catalunya, Sant Cugat del Vallès, Barcelona, España" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Hospital Universitari General de Catalunya, Sant Cugat del Vallès, Barcelona, España" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Penfigoide gestacional simulando un eritema multiforme con afectación mucosa" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1246 "Ancho" => 1667 "Tamanyo" => 312937 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Exudative erythema multiforme-like lesions on the skin and oral erosions.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pemphigoid gestationis is a relatively rare autoimmune blistering disease that occurs during pregnancy. In very rare cases this process can be complicated by the appearance of generalized lesions with involvement of the oral mucosa.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A healthy, 33-year-old woman in week 35 of her second pregnancy with the same partner was seen for generalized and buccal lesions. The patient reported no previous infectious processes and had not begun treatment with any new medications. Physical examination revealed large, erythematous-edematous plaques around the umbilicus and on the neck. Exudative erythema multiforme-like lesions were observed on the palms and soles, and extensive erosions without vesicles or blisters on the oral mucosa (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Skin biopsy revealed a subepidermal blister with eosinophilic spongiosis, without vacuolar degeneration of the epidermal basement membrane (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Direct immunofluorescence showed linear focal deposits of complement component 3 (C3) in the basement membrane. No anti-BP180 antibodies were detected by indirect immunofluorescence. Serology for <span class="elsevierStyleItalic">Mycoplasma pneumoniae</span> was negative for immunoglobulin (Ig) M and IgG. The patient began corticosteroid treatment with oral prednisone (0.75 mg/kg/d) and topical 0.05% clobetasol propionate cream. The lesions progressively improved and finally disappeared 2 months after the patient gave birth, leaving residual pigmentation. The baby was delivered without complications (eg, preterm birth, low birth weight) and without skin lesions. After 6 months of follow-up the patient remained free of lesions.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Pemphigoid gestationis, formerly known as herpes gestationis, is a rare autoimmune blistering disease associated with pregnancy. It usually occurs during the second or third trimester of pregnancy (68% of cases), with incidence ranging from 1 per 20,000 to 1 per 50,000 population, and tends to resolve after childbirth, although flare-ups can occur after delivery and during menstruation.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The lesions begin as pruritic urticarial papules and plaques that rapidly evolve to vesicles but rarely progress to large blisters. In up to 65% of cases lesions initially appear in the periumbilical area, subsequently spreading to other areas including the abdomen, legs, arms, palms, and soles.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> A case series by Hallaji and coworkers<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> reported no instances of mucosal involvement. In another case series, Castro et al<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> reported involvement of the hard palate mucosa in 1 patient and of the genital mucosa in another. However, neither of those articles specify whether the aforementioned involvement consisted of erosions, ulcers, blisters, or vesicles. Another peculiarity in our case was the appearance on the patient's palms and soles of exudative erythema multiforme-like lesions, which are sporadically but infrequently described in the literature.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Histological findings depend on the intensity and stage of evolution of the lesions. The presence of abundant eosinophils is a consistent finding in pemphigoid gestationis. The key finding in the blistering phase is the presence of a subepidermal blister in the basement membrane. In 100% of cases direct immunofluorescence reveals the presence of linear C3 deposition along the basement membrane. Deposition of IgG1 is observed in 25% to 30% of cases. Depending on the technique used, indirect immunofluorescence can detect IgG against the BP180 antigen in 30% to 100% of cases. However, titers do not always correlate with disease activity.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The first disease that should be included in the differential diagnosis is pruritic urticarial papules and plaques of pregnancy (PUPPP). The absence of striae gravidarum and the presence of periumbilical lesions in pemphigoid gestationis can facilitate distinction of pemphigoid gestationis from PUPPP. Pemphigoid gestationis should also be distinguished from other blistering diseases that can occur during pregnancy, including bullous pemphigoid, dermatitis herpetiformis, linear IgA disease, bullous systemic lupus erythematosus, exudative erythema multiforme, toxic drug reaction, and contact dermatitis.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Prednisolone (0.5–1 mg/kg/d) is one of the most effective and safest forms of treatment during pregnancy. Prolonged systemic corticosteroid therapy can result in an increased incidence of preterm birth or low birth weight. In cases of refractory and progressive pemphigoid gestationis other therapeutic options such as immunoglobulin or ciclosporin treatment can be considered, always bearing in mind the potential risk to the fetus.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4,5</span></a> It should be noted that more severe flare-ups can occur during subsequent pregnancies or in conjunction with contraceptive use.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> In general the fetal prognosis is good: mild involvement in the form of wheals or vesicles is reported in 10% of cases.</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion, we present a case of pemphigoid gestationis, confirmed by histology and direct immunofluorescence, with extensive exudative erythema multiforme-like lesions and involvement of the oral mucosa. Oral involvement in this type of blistering disease is very infrequent.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-12-12" "fechaAceptado" => "2018-02-11" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Lobato-Berezo A, Fernández Figueras MT, Moreno Romero JA, Pujol RM. Pemphigoid Gestationis Mimicking Erythema Multiforme With Mucosal Involvement. Actas Dermosifiliogr. 2019;110:696–697.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1246 "Ancho" => 1667 "Tamanyo" => 312937 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Exudative erythema multiforme-like lesions on the skin and oral erosions.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1468 "Ancho" => 1000 "Tamanyo" => 416901 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Partially re-epithelialized subepidermal blister with neutrophilic and eosinophilic inflammatory infiltrate (hematoxylin-eosin, original magnification ×20). The direct immunofluorescence image (bottom right) shows focal linear C3 deposition in the basement membrane.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pregnancy dermatoses: Diagnosis, management, and controversies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.M. Roth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2165/11532010-000000000-00000" "Revista" => array:6 [ "tituloSerie" => "Am J Clin Dermatol." 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año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 13 | 15 | 28 |
2024 Octubre | 98 | 59 | 157 |
2024 Septiembre | 91 | 39 | 130 |
2024 Agosto | 117 | 80 | 197 |
2024 Julio | 116 | 43 | 159 |
2024 Junio | 112 | 56 | 168 |
2024 Mayo | 118 | 42 | 160 |
2024 Abril | 145 | 30 | 175 |
2024 Marzo | 77 | 25 | 102 |
2024 Febrero | 97 | 41 | 138 |
2024 Enero | 81 | 28 | 109 |
2023 Diciembre | 78 | 21 | 99 |
2023 Noviembre | 86 | 48 | 134 |
2023 Octubre | 111 | 32 | 143 |
2023 Septiembre | 79 | 32 | 111 |
2023 Agosto | 93 | 29 | 122 |
2023 Julio | 90 | 51 | 141 |
2023 Junio | 82 | 35 | 117 |
2023 Mayo | 79 | 54 | 133 |
2023 Abril | 61 | 32 | 93 |
2023 Marzo | 59 | 39 | 98 |
2023 Febrero | 58 | 32 | 90 |
2023 Enero | 57 | 36 | 93 |
2022 Diciembre | 62 | 56 | 118 |
2022 Noviembre | 34 | 30 | 64 |
2022 Octubre | 27 | 34 | 61 |
2022 Septiembre | 28 | 37 | 65 |
2022 Agosto | 25 | 46 | 71 |
2022 Julio | 41 | 48 | 89 |
2022 Junio | 24 | 38 | 62 |
2022 Mayo | 46 | 39 | 85 |
2022 Abril | 68 | 31 | 99 |
2022 Marzo | 81 | 60 | 141 |
2022 Febrero | 55 | 38 | 93 |
2022 Enero | 64 | 49 | 113 |
2021 Diciembre | 46 | 33 | 79 |
2021 Noviembre | 66 | 43 | 109 |
2021 Octubre | 127 | 67 | 194 |
2021 Septiembre | 64 | 40 | 104 |
2021 Agosto | 48 | 33 | 81 |
2021 Julio | 40 | 25 | 65 |
2021 Junio | 50 | 26 | 76 |
2021 Mayo | 48 | 39 | 87 |
2021 Abril | 71 | 72 | 143 |
2021 Marzo | 56 | 30 | 86 |
2021 Febrero | 49 | 24 | 73 |
2021 Enero | 44 | 25 | 69 |
2020 Diciembre | 31 | 16 | 47 |
2020 Noviembre | 33 | 21 | 54 |
2020 Octubre | 41 | 12 | 53 |
2020 Septiembre | 43 | 12 | 55 |
2020 Agosto | 27 | 19 | 46 |
2020 Julio | 44 | 20 | 64 |
2020 Junio | 28 | 18 | 46 |
2020 Mayo | 22 | 9 | 31 |
2020 Abril | 14 | 10 | 24 |
2020 Marzo | 10 | 12 | 22 |
2020 Febrero | 2 | 2 | 4 |