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        "titulo" => "Ixekizumab and Psoriasis in the Real WorldIxekizumab y psoriasis&#44; &#191;qu&#233; sucede en el mundo real&#63;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Psoriasis is an autoimmune disease with a complex pathogenesis in which the interaction of immunologic&#44; genetic&#44; and environmental factors results in different clinical forms&#44; as well as different response to treatments&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In recent years&#44; better understanding of the disease pathogenesis has enabled development of agents with new therapeutic targets&#44; with excellent results in clinical trials&#44; particularly in the case of moderate to severe forms of the disease&#46; However&#44; study of the treatment of psoriasis in clinical practice is necessary&#44; as the patients included in clinical trials are not fully representative of those treated in this setting&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Ixekizumab is a humanized recombinant biologic agent that targets IL-17A and that was recently approved for the treatment of moderate to severe plaque psoriasis&#46; The efficacy and safety of the agent has been assessed in randomized clinical trials&#44; although there is limited data on its use in routine clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In this issue&#44; Magdaleno-Tapial et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> describe their study of the efficacy and safety of ixekizumab in patients with psoriasis in routine clinical practice in 2 hospitals in the Mediterranean region&#46; This retrospective&#44; observational study included 75 patients with moderate to severe psoriasis&#44; some of whom had psoriasis in difficult-to-treat locations&#44; and who received ixekizumab for a mean duration of 46 weeks&#46; The authors demonstrated the efficacy and safety of the agent in routine clinical practice and&#44; although this is not the first study in the clinical setting&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a> it is the second largest series to date&#44; and confirms the efficacy findings of previous studies&#46; In addition&#44; this study describes the efficacy of ixekizumab in difficult-to-treat sites such as the scalp&#44; genital area&#44; or palmoplantar region&#46; The safety data are similar to those reported both in clinical trials and in studies in a clinical setting&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In summary&#44; this study provides valuable information on the treatment with ixekizumab of patients with psoriasis vulgaris and psoriasis in difficult-to-treat sites in a clinical practice setting&#46; Nevertheless&#44; larger studies and registries of routine clinical practice will be needed to extend our knowledge in a real-world setting&#46;</p></span>"
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